*  CLNS1A - Wikipedia
... "pICln inhibits snRNP biogenesis by binding core spliceosomal proteins". Mol. Cell. Biol. 19 (6): 4113-20. PMC 104370 . PMID ... Tang CJ, Tang TK (1998). "The 30-kD domain of protein 4.1 mediates its binding to the carboxyl terminus of pICln, a protein ... "Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln". Curr. Biol. 11 (24): ... "A novel WD repeat protein component of the methylosome binds Sm proteins". J. Biol. Chem. 277 (10): 8243-7. doi:10.1074/jbc. ...
  https://en.wikipedia.org/wiki/CLNS1A
*  Frontiers | GIGANTEA - an emerging story | Plant Science
Although it is known that both GI transcript and GI protein are clock controlled, the regulation of its abundance and functions ... Although it is known that both GI transcript and GI protein are clock controlled, the regulation of its abundance and functions ... is a plant specific nuclear protein and functions in diverse physiological processes such as flowering time regulation, light ... is a plant specific nuclear protein and functions in diverse physiological processes such as flowering time regulation, light ...
  https://www.frontiersin.org/articles/10.3389/fpls.2015.00008/full
*  Small nuclear RNA - Wikipedia
Each snRNP particle is composed of a snRNA component and several snRNP-specific proteins (including Sm proteins, a family of ... All of these uridine-rich snRNA, with the exception of U7, form the core of the spliceosome. Splicing, or the removal of ... Kiss, Tamás (1 December 2004). "Biogenesis of small nuclear RNPs". Journal of Cell Science. 117 (25): 5949-5951. doi:10.1242/ ... The initial step of splicing is the bonding of the U1 snRNP and its associated proteins to the 5' splice end to the hnRNA. This ...
  https://en.wikipedia.org/wiki/Small_nuclear_RNA
*  Small nuclear ribonucleoprotein D2 - Wikipedia
Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1998). "Multiple protein: protein interactions between the snRNP common core ... It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Alternative splicing occurs at this locus ... protein interactions between the snRNP common core proteins". Exp. Cell Res. UNITED STATES. 237 (1): 63-9. doi:10.1006/excr. ... The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. ...
  https://en.wikipedia.org/wiki/Small_nuclear_ribonucleoprotein_D2
*  LSm - Wikipedia
"Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure". EMBO J. 20 (1-2): 187-96. ... The SMN complex (described under "Biogenesis of snRNPs") is composed of the SMN protein and Gemin2-8. Two of these, Gemin 6 and ... became known as the Sm core proteins, or simply Sm proteins. The snRNAs are complexed with the Sm core proteins and with other ... "snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions". ...
  https://en.wikipedia.org/wiki/LSm
*  Olga V Makarova - University of Leicester
The tri-snRNP particle consisting of U4, U5, and U6 delivers parts of the spliceosomal catalytic core - U6 RNA and U5snRNP. The ... These proteins present numerous targets for therapeutic interventions.. Our core expertise lies in the use of ... biogenesis and the transport of mRNA in axons. In contrast, very little is known about the nuclear functions of SMN. We have ... The nuclear role of the SMN protein.. The survival of motor neurons (SMN) protein is indispensable for normal organism ...
  https://www2.le.ac.uk/departments/molcellbiol/staff/makarova
*  SNRPD3 - Wikipedia
Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1998). "Multiple protein: protein interactions between the snRNP common core ... It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. SNRPD3 has been shown to interact with: ... The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. ... "Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure". EMBO J. 20 (1-2): 187-96. ...
  https://en.wikipedia.org/wiki/SNRPD3
*  SNRPB - Wikipedia
Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1997). "Multiple protein: protein interactions between the snRNP common core ... Will CL, Lührmann R (2001). "Spliceosomal UsnRNP biogenesis, structure and function". Curr. Opin. Cell Biol. 13 (3): 290-301. ... and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013-21. doi:10.1016/S0092- ... is a protein that in humans is encoded by the SNRPB gene. The protein encoded by this gene is one of several nuclear proteins ...
  https://en.wikipedia.org/wiki/SNRPB
*  Requirements for nuclear localization of the Lsm2-8p complex and competition between nuclear and cytoplasmic Lsm complexes |...
A role for the yeast La protein in U6 snRNP assembly: evidence that the La protein is a molecular chaperone for RNA polymerase ... a novel U6 snRNA-associated protein with significant similarity to core proteins of small nuclear ribonucleoproteins. EMBO J. ... One of the major functions of Lsm2-8p is in U6 snRNP biogenesis and stability, and repression of LSM8 transcription stops cell ... J. L. (1995). Structurally related but functionally distinct yeast SmD core small nuclear ribonucleoprotein particle proteins. ...
  http://jcs.biologists.org/content/120/24/4310.full
*  Frontiers | The Spliceosome-Activating Complex: Molecular Mechanisms Underlying the Function of a Pleiotropic Regulator | Plant...
... named after its core E3 ubiquitin ligase subunit PRP19. NTC, isolated recently from Arabidopsis, occurs in a complex with the ... named after its core E3 ubiquitin ligase subunit PRP19. NTC, isolated recently from Arabidopsis, occurs in a complex with the ... protein is one of the earliest acting NTC proteins, which is essential for loading the U4/U6.U5 tri-snRNP during complex A to B ... By contrast, several proteins found in association with the NTC core in yeast and humans, including PRP45/SKIP (MAC6), ECM2-1a/ ...
  https://www.frontiersin.org/articles/10.3389/fpls.2012.00009/full
*  Retroviral mRNA nuclear export elements regulate protein function and virion assembly | The EMBO Journal
Fractions 3 and 4 contain membrane‐associated proteins and, potentially, demembranated immature viral cores. (B) Indirect ... For example, we liken these findings in the HIV and ALV systems to some previous studies of U snRNA biogenesis and fate (Ohno ... as the U1 snRNP). Our results using HIV further support the concept that RNA nuclear export and associated processes can ... While many proteins are important for the nuclear export of RNA and proteins, NXF1 (also called Tap) and Crm1 (also called ...
  http://emboj.embopress.org/content/23/13/2632
*  Addressing protein localization within the nucleus | The EMBO Journal
We also did not include core histone proteins in our analysis. As a comparison we sampled 50 proteins that have been reported ... Proteins in Cajal bodies, nuclear domains that are thought to be involved in snRNP maturation and hence are functionally ... the events of rDNA processing and ribosome biogenesis predominantly occur within the nucleolus (Lamond and Earnshaw, 1998). ... Hence, chromatin‐associated proteins may act as landing pads for many other proteins or protein complexes. The single most ...
  http://emboj.embopress.org/content/21/6/1248
*  SMART: Secondary literature for Fibrillarin domain
... where core protein-protein interactions are maintained by the bridging biogenesis factors, to the mature snoRNP. ... Lastly, we provide in vivo evidence demonstrating that Sm protein sDMA modification is required for snRNP biogenesis in human ... NAF1 and all of the core proteins except GAR1 are recruited to the site of transcription. NAF1 binds one of the core proteins, ... We have analyzed the in vitro protein-protein interactions between the assembly factors and core box C/D proteins. Surprisingly ...
  http://smart.embl-heidelberg.de/smart/show_secondary.cgi?domain=Fibrillarin
*  Evolutionary Conservation and Expression of Human RNA-Binding Proteins and Their Role in Human Genetic Disease | SpringerLink
RNA-binding proteins (RBPs) are effectors and regulators of posttranscriptional gene regulation (PTGR). RBPs regulate stability ... Thomson T, Lin H (2009) The biogenesis and function of PIWI proteins and piRNAs: progress and prospect. Annu Rev Cell Dev Biol ... Fabrizio P, Laggerbauer B, Lauber J et al (1997) An evolutionarily conserved U5 snRNP-specific protein is a GTP-binding factor ... Pasternack SM, Refke M, Paknia E et al (2013) Mutations in SNRPE, which encodes a core protein of the spliceosome, cause ...
  https://link.springer.com/chapter/10.1007%2F978-1-4939-1221-6_1
*  http://ufdc.ufl.edu/IR00000757/00001
While a core kinase cascade leading from the protein kinase Hippo (Hpo) (Mst1/2 in mammals) to the transcription coactivator ... WDR 46 is a homologue of the yeast protein Utp7, which functions in ribosome biogenesis, kinetochore organization, and ... Initial yeast two hybrid screens retrieve a putative snRNP, further suggesting Nlr1's involvement in transcriptional regulation ... U2AF 35 proteins identify splice acceptor s ites during RNA processing and function through protein protein interactions. ...
  http://ufdc.ufl.edu/IR00000757/00001
*  IJMS | Free Full-Text | New Insights into Functional Roles of the Polypyrimidine Tract-Binding Protein | HTML
Initially described as a pre-mRNA splicing regulator, PTB is now widely accepted as a multifunctional protein shuttling between ... Accordingly, PTB can interact with selected RNA targets, structural elements and proteins. There is increasing evidence that ... is an intensely studied RNA binding protein involved in several post-transcriptional regulatory events of gene expression. ... mRNA stability and initiation of protein translation. Furthermore, it is well established that PTB recruitment in internal ...
  http://www.mdpi.com/1422-0067/14/11/22906/htm
*  Site‐specific cross‐linking analyses reveal an asymmetric protein distribution for a box C/D snoRNP | The EMBO Journal
2000) A common core RNP structure shared between the small nucleoar box C/D RNPs and the spliceosomal U4 snRNP. Cell, 103, 457- ... linked proteins exactly correspond to the size of any protein so far implicated in snoRNP biogenesis (Filipowicz and Pogacic, ... Four core proteins are associated with each snoRNP class. The box C/D class contains fibrillarin (yeast Nop1p, the ... In addition to providing a map of the interactions between core proteins and conserved box elements, the data surprisingly ...
  http://emboj.embopress.org/content/21/14/3816
*  Protein 61K, encoded by a gene (PRPF31) linked to autosomal dominant retinitis pigmentosa, is required for U4/U6·U5 tri‐snRNP...
... specific proteins since no binding was observed with 10S U5 or U1 snRNP core particles (lanes 5 and 6, respectively) or with ... Nucleolar KKE/D repeat proteins Nop56p and Nop58p interact with Nop1p and are required for ribosome biogenesis. Mol Cell Biol, ... Protein 61K interacts with the U5 snRNP‐specific 102K protein. The 61K protein could promote tri‐snRNP formation in at least ... However, protein-protein interactions are believed to play a major part in tri‐snRNP formation. Indeed, the tri‐snRNP particle ...
  http://emboj.embopress.org/content/21/5/1148
*  The WD-repeat protein superfamily in Arabidopsis: conservation and divergence in structure and function | BMC Genomics | Full...
... portion of Pfs2/FY proteins in other eukaryotes might similarly link core RNA-processing machinery with regulatory proteins [71 ... Instead, the yeast and human PRL1 homologs were identified as non-snRNP components of the spliceosome [67, 68], a large pre- ... Purdue PE, Lazarow PB: Peroxisome biogenesis. Annu Rev Cell Dev Biol. 2001, 17: 701-752. 10.1146/annurev.cellbio.17.1.701.View ... Where studied, repeated WD motifs act as a site for protein-protein interaction, and proteins containing WD repeats (WDRs) are ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-4-50
*  Sm) Peptides as Antigens - Tài liệu text
erythematosus autoantibody class recognizes the E, F, and G Sm snRNP proteins as an. E-F-G complex but not in their denatured ... eight copies of the peptide are synthesized on a polylysine core. After cleavage from the synthesis resin, the resulting MAP ... 20] C.L. Will, R. Luhrmann, Spliceosomal UsnRNP biogenesis, structure and function, Curr.. Opin. Cell Biol. 13 (2001) 290-301. ... protein LSm4, and their interaction with the SMN protein, RNA 7 (2001) 1531-1542.. [34] H. Brahms, J. Raymackers, A. Union, F. ...
  https://toc.123doc.org/document/2650562-sm-peptides-as-antigens.htm
*  Defining early steps in mRNA transport: mutant mRNA in myotonic dystrophy type I is blocked at entry into SC-35 domains | JCB
Multiple proteins such as CUG-binding protein (Timchenko et al., 1996, 2001; Philips et al., 1998), heterogeneous nuclear RNP H ... If the normal biogenesis and export of DMPK RNA are accomplished via SC-35 domains, these reports raise the possibility that ... The X chromosome is organized into a gene-rich outer rim and an internal core containing silenced nongenic sequences. Proc. ... Intranuclear localization of snRNP antigens. J. Cell Biol. 102:137-144.. OpenUrlAbstract/FREE Full Text ...
  http://jcb.rupress.org/content/178/6/951
*  Plus it
Protein degradation.. CUL4B1 is a core component of E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and ... GTPBP41,3 is a GTPase involved in the biogenesis of the 60S ribosomal subunit. ... and SNRNP2001 are involved in pre-mRNA splicing as components of the U4/U6-U5 tri-snRNP complex, one of the building blocks of ... We do not know whether and, if so, how protein-to-protein association of NFAT5 with these other proteins affects them, but the ...
  http://physiolgenomics.physiology.org/content/48/4/290
*  SMART: Secondary literature for Ala racemase C domain
PilY2 is a small protein that appears to play a subtle role in fimbrial biogenesis and represents a new class of protein. ... YBL0425 is related to the D1 core polypeptide of the small nuclear ribonucleoprotein (snRNP) particles involved in the splicing ... This gene encodes a protein homologous to the beta subunit of the mammalian Sec61 protein complex functioning in protein ... Role of BfpF, a member of the PilT family of putative nucleotide-binding proteins, in type IV pilus biogenesis and in ...
  http://smart.embl-heidelberg.de/smart/show_secondary.cgi?domain=Ala_racemase_C
*  u1 small nuclear ribonucleoprotein
The U1 small nuclear ribonucleoprotein particle (U1 snRNP) 70K protein (U1-70K), one of the three U1 snRNP-specific proteins, ... These findings indicate that SMN complex interaction with SL1 is sequence-specific and critical for U1 snRNP biogenesis, ... Nucleo-cytoplasmic transport of U snRNPs: definition of a nuclear location signal in the Sm core domain that binds a transport ... The product of the U1 small nuclear ribonucleoprotein particle (U1 snRNP) 70K (U1-70K) gene, a U1 snRNP-specific protein, has ...
  https://www.labome.org/topics/chemicals/and/proteins/carrier/rna/ribonucleoproteins/small/u1-small-nuclear-ribonucleoprotein-14367.html
*  Intracellular trafficking of yeast telomerase components | EMBO Reports
Mattaj, I.W. (1986) Cap trimethylation of U snRNA is cytoplasmic and dependent on U snRNP protein binding. Cell, 46, 905-911. ... Will, C.L. and Luhrmann, R.U.R. (2001) Spliceosomal UsnRNP biogenesis, structure and function. Curr. Opin. Cell Biol., 13, 290- ... Telomerase activity requires Est2p and TLC1, which together make up the catalytic core (Lingner et al., 1997b). We reasoned ... Flach, J., Bossie, M., Vogel, J., Corbett, A., Jinks, T., Willins, D.A. and Silver, P.A. (1994) A yeast RNA‐binding protein ...
  http://embor.embopress.org/content/3/7/652