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*  CLNS1A - Wikipedia
... "pICln inhibits snRNP biogenesis by binding core spliceosomal proteins". Mol. Cell. Biol. 19 (6): 4113-20. PMC 104370 . PMID ... Tang CJ, Tang TK (1998). "The 30-kD domain of protein 4.1 mediates its binding to the carboxyl terminus of pICln, a protein ... "Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln". Curr. Biol. 11 (24): ... "A novel WD repeat protein component of the methylosome binds Sm proteins". J. Biol. Chem. 277 (10): 8243-7. doi:10.1074/jbc. ...
  https://en.wikipedia.org/wiki/CLNS1A
*  Frontiers | GIGANTEA - an emerging story | Plant Science
Although it is known that both GI transcript and GI protein are clock controlled, the regulation of its abundance and functions ... Although it is known that both GI transcript and GI protein are clock controlled, the regulation of its abundance and functions ... is a plant specific nuclear protein and functions in diverse physiological processes such as flowering time regulation, light ... is a plant specific nuclear protein and functions in diverse physiological processes such as flowering time regulation, light ...
  https://www.frontiersin.org/articles/10.3389/fpls.2015.00008/full
*  Small nuclear RNA - Wikipedia
Each snRNP particle is composed of a snRNA component and several snRNP-specific proteins (including Sm proteins, a family of ... All of these uridine-rich snRNA, with the exception of U7, form the core of the spliceosome. Splicing, or the removal of ... Kiss, Tamás (1 December 2004). "Biogenesis of small nuclear RNPs". Journal of Cell Science. 117 (25): 5949-5951. doi:10.1242/ ... The initial step of splicing is the bonding of the U1 snRNP and its associated proteins to the 5' splice end to the hnRNA. This ...
  https://en.wikipedia.org/wiki/Small_nuclear_RNA
*  Small nuclear ribonucleoprotein D2 - Wikipedia
Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1998). "Multiple protein: protein interactions between the snRNP common core ... It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Alternative splicing occurs at this locus ... protein interactions between the snRNP common core proteins". Exp. Cell Res. UNITED STATES. 237 (1): 63-9. doi:10.1006/excr. ... The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. ...
  https://en.wikipedia.org/wiki/Small_nuclear_ribonucleoprotein_D2
*  LSm - Wikipedia
"Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure". EMBO J. 20 (1-2): 187-96. ... The SMN complex (described under "Biogenesis of snRNPs") is composed of the SMN protein and Gemin2-8. Two of these, Gemin 6 and ... became known as the Sm core proteins, or simply Sm proteins. The snRNAs are complexed with the Sm core proteins and with other ... "snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions". ...
  https://en.wikipedia.org/wiki/LSm
*  Olga V Makarova - University of Leicester
The tri-snRNP particle consisting of U4, U5, and U6 delivers parts of the spliceosomal catalytic core - U6 RNA and U5snRNP. The ... These proteins present numerous targets for therapeutic interventions.. Our core expertise lies in the use of ... biogenesis and the transport of mRNA in axons. In contrast, very little is known about the nuclear functions of SMN. We have ... The nuclear role of the SMN protein.. The survival of motor neurons (SMN) protein is indispensable for normal organism ...
  https://www2.le.ac.uk/departments/molcellbiol/staff/makarova
*  SNRPD3 - Wikipedia
Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1998). "Multiple protein: protein interactions between the snRNP common core ... It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. SNRPD3 has been shown to interact with: ... The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. ... "Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure". EMBO J. 20 (1-2): 187-96. ...
  https://en.wikipedia.org/wiki/SNRPD3
*  Requirements for nuclear localization of the Lsm2-8p complex and competition between nuclear and cytoplasmic Lsm complexes |...
A role for the yeast La protein in U6 snRNP assembly: evidence that the La protein is a molecular chaperone for RNA polymerase ... a novel U6 snRNA-associated protein with significant similarity to core proteins of small nuclear ribonucleoproteins. EMBO J. ... One of the major functions of Lsm2-8p is in U6 snRNP biogenesis and stability, and repression of LSM8 transcription stops cell ... J. L. (1995). Structurally related but functionally distinct yeast SmD core small nuclear ribonucleoprotein particle proteins. ...
  http://jcs.biologists.org/content/120/24/4310.full
*  Chemical Approaches for Structure and Function of RNA in Postgenomic Era
... methyltransferase is a non-snRNP cytoplasmic protein that requires a binding site on the Sm core domain," Molecular and ... G. Dreyfuss, M. J. Matunis, S. Piñol-Roma, and C. G. Burd, "hnRNP proteins and the biogenesis of mRNA," Annual Review of ... They are present in complexes as RNP with proteins specific for each RNA as well as some common snRNP proteins such as the Sm ... Tgs 1 Interacting Proteins. Genetic and biochemical analysis of Tgs1 interacting proteins reveals a wide range of proteins ...
  https://www.hindawi.com/journals/jna/2012/369058/
*  Frontiers | The Spliceosome-Activating Complex: Molecular Mechanisms Underlying the Function of a Pleiotropic Regulator | Plant...
... named after its core E3 ubiquitin ligase subunit PRP19. NTC, isolated recently from Arabidopsis, occurs in a complex with the ... named after its core E3 ubiquitin ligase subunit PRP19. NTC, isolated recently from Arabidopsis, occurs in a complex with the ... protein is one of the earliest acting NTC proteins, which is essential for loading the U4/U6.U5 tri-snRNP during complex A to B ... By contrast, several proteins found in association with the NTC core in yeast and humans, including PRP45/SKIP (MAC6), ECM2-1a/ ...
  https://www.frontiersin.org/articles/10.3389/fpls.2012.00009/full
*  SNRPB - Wikipedia
Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1997). "Multiple protein: protein interactions between the snRNP common core ... Will CL, Lührmann R (2001). "Spliceosomal UsnRNP biogenesis, structure and function". Curr. Opin. Cell Biol. 13 (3): 290-301. ... and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013-21. doi:10.1016/S0092- ... is a protein that in humans is encoded by the SNRPB gene. The protein encoded by this gene is one of several nuclear proteins ...
  https://en.wikipedia.org/wiki/SNRPB
*  Coordination of DNA Replication and Histone Synthesis During S Phase | SpringerLink
The replication fork, core histone segregation and terminal structures. J Mol Biol. 1986;189(1):189-204.PubMedCrossRefGoogle ... Goh PY, Surana U. Cdc4, a protein required for the onset of S phase, serves an essential function during G(2)/M transition in ... Sabath I, Skrajna A, Yang XC, Dadlez M, Marzluff WF, Dominski Z. 3′-End processing of histone pre-mRNAs in Drosophila: U7 snRNP ... A conserved interaction that is essential for the biogenesis of histone locus bodies. J Biol Chem. 2014;289(49):33767-82. ...
  https://link.springer.com/chapter/10.1007/978-3-319-24696-3_11
*  Retroviral mRNA nuclear export elements regulate protein function and virion assembly | The EMBO Journal
Fractions 3 and 4 contain membrane‐associated proteins and, potentially, demembranated immature viral cores. (B) Indirect ... For example, we liken these findings in the HIV and ALV systems to some previous studies of U snRNA biogenesis and fate (Ohno ... as the U1 snRNP). Our results using HIV further support the concept that RNA nuclear export and associated processes can ... While many proteins are important for the nuclear export of RNA and proteins, NXF1 (also called Tap) and Crm1 (also called ...
  http://emboj.embopress.org/content/23/13/2632
*  Frontiers | Interplay between the alpharetroviral Gag protein and SR Proteins SF2 and SC35 in the nucleus | Microbiology
The full-length viral RNA can be used for the translation of the Gag and Gag-Pol structural proteins or as the genomic RNA ( ... When the nuclear export signal of RSV Gag is mutated (Gag.L219A), the protein accumulates in discrete subnuclear foci ... When the nuclear export signal of RSV Gag is mutated (Gag.L219A), the protein accumulates in discrete subnuclear foci ... for encapsidation into new virions by the Gag protein. The mechanism by which Gag selectively incorporates unspliced gRNA into ...
  https://www.frontiersin.org/articles/10.3389/fmicb.2015.00925/full
*  Spinal Muscle Atrophy: Background, Pathophysiology, Etiology
SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta. Hum Mol Genet. ... SMN1 encodes the SMN protein, which is part of a multiprotein complex required for the biogenesis of small nuclear ... Pandey R, Chandratre S, Roberts A, Dwyer JS, Sewry C, Quinlivan R. Central core myopathy with RYR1 mutation masks 5q spinal ... SMN mutants of spinal muscular atrophy patients are defective in binding to snRNP proteins. Proc Natl Acad Sci U S A. 1999 Sep ...
  https://emedicine.medscape.com/article/1264401-overview
*  http://ufdc.ufl.edu/UFE0041491/00001
... protein (Ogino and Wilson, 2004) SMN plays an integral part in snRNP biogenesis and mutations produce a global affect in ... Samples were submitted to the UF ICBR Proteomic Core facility for liquid chromatography mass spectrometry (LCMS) analysis to ... and the protein concentration was quantitated with the NonInterfering Protein Assay (Genotech). Total protein lysates from ... First, protein kinase R (PKR) is a doublestranded RNA (dsRNA) binding protein that functions in innate immunity by interacting ...
  http://ufdc.ufl.edu/UFE0041491/00001
*  SMART: Secondary literature for Fibrillarin domain
... where core protein-protein interactions are maintained by the bridging biogenesis factors, to the mature snoRNP. ... Lastly, we provide in vivo evidence demonstrating that Sm protein sDMA modification is required for snRNP biogenesis in human ... NAF1 and all of the core proteins except GAR1 are recruited to the site of transcription. NAF1 binds one of the core proteins, ... We have analyzed the in vitro protein-protein interactions between the assembly factors and core box C/D proteins. Surprisingly ...
  http://smart.embl-heidelberg.de/smart/show_secondary.cgi?domain=Fibrillarin
*  Addressing protein localization within the nucleus | The EMBO Journal
We also did not include core histone proteins in our analysis. As a comparison we sampled 50 proteins that have been reported ... Proteins in Cajal bodies, nuclear domains that are thought to be involved in snRNP maturation and hence are functionally ... the events of rDNA processing and ribosome biogenesis predominantly occur within the nucleolus (Lamond and Earnshaw, 1998). ... Hence, chromatin‐associated proteins may act as landing pads for many other proteins or protein complexes. The single most ...
  http://emboj.embopress.org/content/21/6/1248
*  Human Metabolome Database: Showing metabocard for Chloride ion (HMDB0000492)
Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core ... such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. ... Involved in protein serine/threonine kinase activity. Specific function:. Protein kinase that plays an important role in ... 1. Protein arginine N-methyltransferase 3. General function:. Involved in protein methyltransferase activity. Specific function ...
  http://www.hmdb.ca/metabolites/HMDB0000492
*  Heat stress-responsive transcriptome analysis in heat susceptible and tolerant wheat (Triticum aestivum L.) by using Wheat...
... ribosomal proteins, primary and secondary metabolisms, as well as proteins related to other stresses. A total of 313 probe sets ... these putative heat responsive genes encode transcription factors and proteins involved in phytohormone biosynthesis/signaling ... Except for heat shock protein (HSP) and heat shock factor (HSF) genes, ... U3 snoRNP protein, U2 snRNP auxiliary factor, nuclear RNA binding protein and valyl-tRNA synthetase; (3) protein biosynthesis ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-9-432
*  Arginine methylation mediated by the Arabidopsis homolog of PRMT5 is essential for proper pre-mRNA splicing | PNAS
In addition to hnRNPs, it has been reported that U snRNP Sm core proteins are affected by arginine methylation inhibitors (21, ... 2010) Methylation of ribosomal protein S10 by protein-arginine methyltransferase 5 regulates ribosome biogenesis. J Biol Chem ... and WD repeat protein/MEP50 (13-15). In this complex, U1, 2, 4, 5 snRNP Sm proteins Sm B/B′, D1, D3, and U6 snRNP-specific Sm- ... 2001) Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln. Curr Biol 11: ...
  http://www.pnas.org/content/107/44/19114?ijkey=a256d52ccb84460fc8c45fe7647fe543af8854c1&keytype2=tf_ipsecsha
*  Evolutionary Conservation and Expression of Human RNA-Binding Proteins and Their Role in Human Genetic Disease | SpringerLink
RNA-binding proteins (RBPs) are effectors and regulators of posttranscriptional gene regulation (PTGR). RBPs regulate stability ... Thomson T, Lin H (2009) The biogenesis and function of PIWI proteins and piRNAs: progress and prospect. Annu Rev Cell Dev Biol ... Fabrizio P, Laggerbauer B, Lauber J et al (1997) An evolutionarily conserved U5 snRNP-specific protein is a GTP-binding factor ... Pasternack SM, Refke M, Paknia E et al (2013) Mutations in SNRPE, which encodes a core protein of the spliceosome, cause ...
  https://link.springer.com/chapter/10.1007%2F978-1-4939-1221-6_1
*  MAPPFinder using GO and GenMAPP to study gene expression | Rna Splicing | Metabolism
... repair Protein folding Cytoplasm organization and biogenesis Establishment and/or maintenance of chromatin architecture Protein ... Table 2 (continued) GO name 26S proteasome Endoplasmic reticulum 20S core proteasome Nuclear membrane Cytoskeleton Collagen ... 4.4 snRNP recycling spliceosome assembly splicing AT-AC intron spling GT-AG intron + RNA capping + RNA modification 0/0 0%, 0/0 ... Biological process unknown Protein-ligand dependent protein degradation Ubiquitin-dependent protein degradation Protein-nucleus ...
  https://www.scribd.com/document/2511329/MAPPFinder-using-GO-and-GenMAPP-to-study-gene-expression
*  Site‐specific cross‐linking analyses reveal an asymmetric protein distribution for a box C/D snoRNP | The EMBO Journal
2000) A common core RNP structure shared between the small nucleoar box C/D RNPs and the spliceosomal U4 snRNP. Cell, 103, 457- ... linked proteins exactly correspond to the size of any protein so far implicated in snoRNP biogenesis (Filipowicz and Pogacic, ... Four core proteins are associated with each snoRNP class. The box C/D class contains fibrillarin (yeast Nop1p, the ... In addition to providing a map of the interactions between core proteins and conserved box elements, the data surprisingly ...
  http://emboj.embopress.org/content/21/14/3816
*  IJMS | Free Full-Text | New Insights into Functional Roles of the Polypyrimidine Tract-Binding Protein | HTML
Initially described as a pre-mRNA splicing regulator, PTB is now widely accepted as a multifunctional protein shuttling between ... Accordingly, PTB can interact with selected RNA targets, structural elements and proteins. There is increasing evidence that ... is an intensely studied RNA binding protein involved in several post-transcriptional regulatory events of gene expression. ... mRNA stability and initiation of protein translation. Furthermore, it is well established that PTB recruitment in internal ...
  http://www.mdpi.com/1422-0067/14/11/22906/htm