Biomedical Imaging: Reporters, Dyes, and Instrumentation | (1999) | Publications | Spie
Many tumor cells are characterized by the overexpression of highly specific transferrin receptors. Transferrin is bound to its ... Transferrin-mediated tumor delivery of contrast media for optical imaging and magnetic resonance imaging Author(s): Andreas ... We conclude that transferrin-modified contrast agents for optical imaging and MRI can be specifically delivered to tumor tissue ... Design and development of receptor-avid peptide conjugates for in-vivo targeting of cancer Author(s): Wynn A. Volkert; Timothy ...http://spie.org/Publications/Proceedings/Volume/3600
The chianti zebrafish mutant provides a model for erythroid-specific disruption of transferrin receptor 1 | Development
... motif in the transferrin receptor is required for binding to transferrin. Biochem. J. 341,11 -14. ... Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary ... Mutational analysis of the transferrin receptor reveals overlapping HFE and transferrin binding sites. J. Mol. Biol. 313,385 - ... Structural reorganization of the transferrin c-lobe and transferrin receptor upon complex formation: the c-lobe binds to the ...http://dev.biologists.org/content/131/24/6225
Patent US5182107 - Transferrin receptor specific antibody-neuropharmaceutical or diagnostic ... - Google Patents
Other aspects of this invention include a delivery system comprising an antibody reactive with a transferrin receptor linked to ... of an antibody-neuropharmaceutical or diagnostic agent conjugate wherein the antibody is reactive with a transferrin receptor. ... In-Vivo Binding of OX-26 Murine Monoclonal Antibody to Rat Transferrin Receptor. Dose Range. The anti-rat transferrin receptor ... Portions of the transferrin receptor include those portions sufficient for binding of the receptor to an anti-transferrin ...http://www.google.com/patents/US5182107?dq=5,381,459
Clinical value of serum transferrin measurements - IFCC
Each ectodomain can bind one molecule of transferrin and thus the transferrin receptor can bind two molecules of transferrin ... Transferrin receptors. " Two different receptors for transferrin are known: transferrin receptor 1 and the newly discovered ... In this review transferrin receptor (TfR) alludes to transferrin receptor 1. ". The transferrin receptor is a type II ... The transferrin receptor binds diferric transferrin with high affinity but not apotransferrin at the pH found in blood. In the ...http://www.ifcc.org/ifcc-communications-publications-division-cpd/ifcc-publications/ejifcc-journal/e-journal-volumes/ejifcc-2002-vol-13/vol-13-no-2/clinical-value-of-serum-transferrin-measurements/
Dawn forex and gold
... preventing its binding to IRE, and thereby causing the degradation of the transferrin-receptor mRNA. Wilson, goldd dawn forex ... 3 Dierks, Tim and Christopher Allen (1999). 7 Page 449 Hartwell, ...http://retzepti.ru/dawn-forex-and-gold-1.html
Transferrin - Wikipedia
Transferrin bound to its receptor. Transferrin receptor complex. The liver is the main site of transferrin synthesis but other ... Beta-2 transferrin Transferrin receptor Total iron-binding capacity Transferrin saturation Ferritin GRCh38: Ensembl release 89 ... Transferrin glycoproteins bind iron tightly, but reversibly. Although iron bound to transferrin is less than 0.1% (4 mg) of ... For the iron ion to bind, an anion is required, preferably carbonate (CO2− 3). Transferrin also has a transferrin iron-bound ...https://en.wikipedia.org/wiki/Transferrin
Transferrin receptor 2 - Wikipedia
1998). "The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding". ... 2001). "Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary ... 2003). "Heterotypic interactions between transferrin receptor and transferrin receptor 2". Blood. 101 (5): 2008-14. doi:10.1182 ... "Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family". J. Biol. Chem. 274 (30): ...https://en.wikipedia.org/wiki/Transferrin_receptor_2
Pharmaceutics | Free Full-Text | From Molecular to Nanotechnology Strategies for Delivery of Neurotrophins: Emphasis on Brain...
The neurotrophic proteins operate by binding to two types of receptors: a common receptor, p75NTR, which is a member of the ... Receptor-mediated delivery of neurotrophins through the transferrin and insulin receptors has also been done by fusion proteins ... The occurring cooperative binding activates the receptor through receptor dimerization . Indeed, the amino acid structural ... The neurotrophin binding to the TrkB receptor controls three major intracellular signaling pathways . Receptor ...http://www.mdpi.com/1999-4923/5/1/127/htm
ASMscience | Biology and Pathogenicit
The staphylococcal transferrin receptor: a glycolytic enzyme with novel functions. Trends Microbiol. 8:231-237.. ... The staphylococcal transferrin-binding protein is a cell wall glyceraldehyde-3-phosphate dehydrogenase. Infect. Immun. 67:1086- ... Receptor-mediated recognition and uptake of iron from human transferrin by Staphylococcus aureus and Staphylococcus epidermidis ... The Staphylococcus aureus and Staphylococcus epidermidis transferrin-binding proteins are expressed in vivo during infection. ...http://www.asmscience.org/content/book/10.1128/9781555816513.chap46
Transferrin receptor-like, dimerisation domain (IPR007365) | InterPro | EMBL-EBI
... and exocytosis of the iron transport protein transferrin (Tf). TfR binds iron-loaded (diferric) Tf at the cell surface and ... Transferrin receptor-like, dimerisation domain (IPR007365). Short name: TFR-like_dimer_dom ... This entry represents the dimerisation domain found in the transferrin receptor, as well as in a number of other proteins ... The transferrin receptor (TfR) assists iron uptake into vertebrate cells through a cycle of endo- ...http://www.ebi.ac.uk/interpro/entry/IPR007365
Deficits in receptor-mediated endocytosis and recycling in cells from mice with Gpr107 locus disruption | Journal of Cell...
Substantially less transferrin was internalized by knockout cells than by reconstituted cells, and less transferrin bound to ... Transferrin receptor recycling was defined by the ratio between the radioactivity of transferrin in the medium and total ... Knockout cells were found to exhibit a higher rate of transferrin internalization and transferrin receptor recycling than ... The kinetics of transferrin internalization was analyzed by plotting the ratio of internal transferrin to surface transferrin ...http://jcs.biologists.org/content/127/18/3916
Porphyria cutanea tarda, C282Y, H63D and S65C HFE Gene Mutations and Hepatitis C Infection: A Study from Southern France -...
The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proc Natl ... Dereure O, Esculier C, Aguilar-Martinez P, Dessis D, Guillot B, Guilhou JJ: No evidence of Y250X transferrin receptor type 2 ... HFE mutations and transferrin receptor polymorphism analysis in porphyria cutanea tarda: A prospective study of 36 cases from ... Trinder D, Olynyk JK, Sly WS, Morgan EH: Iron uptake from plasma transferrin by the duodenum is impaired in the HFE knockout ...https://www.karger.com/Article/Abstract/68895
Iron and the Anemia of Chronic Disease | Cancer Network | The Oncology Journal
... decreased transferrin saturation, increased serum ferritin, increased reticuloendothelial iron stores, increased erythrocyte- ... Disordered iron metabolism as manifested by a low serum iron, decreased serum transferrin, ... Sawyer ST, Krantz SB, Goldwasser E: Binding and. receptor-mediated endocytosis of erythropoietin in Friend virus-infected. ... Indeed, it is highly likely that abnormalities such as reduced iron absorption and decreased erythroblast transferrin-receptor ...http://www.cancernetwork.com/review-article/iron-and-anemia-chronic-disease
Prof. Dr. Monika Schäfer-Korting • Pharmazie • Fachbereich Biologie, Chemie, Pharmazie
Interactions kinetics of tetramethylrhodamine transferrin with human transferrin receptor studied by fluorescence correlation ... Trier U, Olah, Z, Kleuser B, Schäfer-Korting M: Fusion of the binding domain of Raf-1 kinase with green fluorescent protein for ... Hammer S, Spika I, Sippl W, Jessen G, Kleuser B, Holtje HD, Schafer-Korting M: Glucocorticoid receptor interactions with ... Involvement of the ABC-transporter ABCC1 and the sphingosine 1-phosphate receptor subtype S1P(3) in the cytoprotection of human ...http://www.bcp.fu-berlin.de/pharmazie/pharmakologie/msk/
The trans-membrane protein p25 forms highly specialized domains that regulate membrane composition and dynamics | Journal of...
7A). Even more strikingly, the distributions of p25SS and the transferrin receptor (labeled with Cy5-transferrin), a classical ... Tp24 was originally named putative T1/ST2 receptor binding protein (see Emery et al., 2000). (B) Schematic representation of ... At the cell surface, the p25SS mutant segregates away from both the transferrin receptor and markers of lipid rafts, which are ... At the cell surface, overexpressed p25SS segregates away from rafts and the transferrin receptor and distributes within ...http://jcs.biologists.org/content/116/23/4821
Rapid Cycling of Lipid Raft Markers between the Cell Surface and Golgi Complex | JCB
For the folate receptor (which is GPI-anchored), our data confirmed a distribution within transferrin-labeled early and ... The lipid-binding B subunits of shiga and cholera toxins (STxB and CTxB, respectively) are the second class of markers we used ... Folate receptor enters transferrin-labeled endosomes significantly more efficiently (2% per min; Mayor et al. 1998) than the ... We found that, unlike the folate receptor, CD59 and GPI-GFP do not accumulate within transferrin-labeled endosomes (Mayor et al ...http://jcb.rupress.org/content/153/3/529.long
WikiGenes - Artifacts
An artefact explains the apparent association of the transferrin receptor with a ras gene product. Harford, J. Nature (1984) [ ... Detection and removal of an artefact fatty acid from the binding site of recombinant Bombyx mori pheromone-binding protein. ... Structure-activity analysis of binding kinetics for NMDA receptor competitive antagonists: the influence of conformational ... I present here evidence that the apparent association of p21 and the transferrin receptor is an artefact of the ...https://www.wikigenes.org/e/mesh/e/11377.html
Mutational analysis of the transferrin receptor reveals overlapping HFE and transferrin binding sites. J Mol Biol. 2001;313:385 ... Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary ... saline TBST Tris buffered saline Tween 20 Tf/TF Transferrin TfR1/TFR1 Transfe rrin receptor 1 TfR2/TFR2 Transferrin receptor 2 ... The hemochromatosis protein HFE competes with transferrin for binding to the transferrin receptor. J Mol Biol. 1999;294:239 45 ...http://ufdc.ufl.edu/UFE0042392/00001
Citations for Immunoprecipitation with Dynabeads | Thermo Fisher Scientific
Binding proteins selected from combinatorial libraries of an alpha-helical bacterial receptor domain. 1997. Nat Biotechnol. ... Analysis and isolation of human transferrin receptor using the OKT-9 monoclonal antibody covalently crosslinked to magnetic ... DNA and RNA binding proteins. FMR1 protein: conserved RNP family domains and selective RNA binding. 1993. Science. DNA and RNA ... Interleukin-21 receptor gene induction in human T cells is mediated by T-cell receptor-induced Sp1 activity. 2005. Mol Cell ...https://www.thermofisher.com/au/en/home/life-science/protein-biology/protein-assays-analysis/immunoprecipitation/dynabeads-magnetic-beads-citations.html
Internalization of LDL-receptor superfamily yolk-protein receptors during mosquito oogenesis involves transcriptional...
... oligonucleotides halts efficient transferrin receptor (YxxØ-type signal) but not LDL receptor (FxNPxY) internalization (Keyel ... Protein-binding assays. Liposome-binding assays (200 μl) contained 0.4 mg/ml control or PtdIns(4,5)P2 liposomes, 100 μg/ml BSA ... In most vertebrate members of the LDL receptor superfamily, such as the LDL receptor, the LDL-receptor-related protein 1 (LRP1 ... the vitellogenin and lipophorin receptors. Both these mosquito receptors are members of the low-density-lipoprotein-receptor ...http://jcs.biologists.org/content/121/8/1264
PSYC Call for Commentators: BIOCHEMICAL BASIS OF COMA (969 lines)
In the post-dopamine D1 receptor endosome system, transferrin and the D1 receptor-dopamine complex co-localize in the same ... by promoting agonist binding to the receptor protein (Liu et al, 1994). These anaesthetics also inhibit muscarinic receptors ( ... inhibit GABAergic transmission by enhancing the receptor binding of GABA and increasing the receptivity of the GABA receptor ... It used to be thought that when a receptor located in the membrane bound a molecule of the transmitter/modulator it underwent a ...http://www.bio.net/bionet/mm/neur-sci/1999-September/040643.html
Piet Borst - Wikipedia
Variation in the transferrin receptor allows African trypanosomes to efficiently take up transferrin in a range of mammals, ... Proc Natl Acad Sci U S A. 2015;112(21):6601-6. Jansen RS, Mahakena S, de Haas M, Borst P, van de Wetering K. ATP-binding ... Trypanosomes change their transferrin receptor expression to allow effective uptake of host transferrin. Mol Microbiol. 2005;58 ... Bitter W, Gerrits H, Kieft R, Borst P. The role of transferrin-receptor variation in the host range of Trypanosoma brucei. ...https://en.wikipedia.org/wiki/Piet_Borst
Frontiers | New Progress on the Role of Glia in Iron Metabolism and Iron-Induced Degeneration of Dopamine Neurons in Parkinson...
... non-transferrin-bound iron; OPC, oligodendrocyte precursor cell; Tf/TfR1, transferrin/transferrin receptor 1; TRPC, resident ... which is an iron-binding protein belonging to the transferrin family. Lf-Lf receptor (LfR) transfers Fe3+ ions by a receptor- ... Scara5 can bind to L-ferritin or Tf (but not HFt) and mediate its endocytosis (Li et al., 2009). The discovery of receptor- ... 2009). Scara5 is a ferritin receptor mediating non-transferrin iron delivery. Dev. Cell 16, 35-46. doi: 10.1016/j.devcel. ...https://www.frontiersin.org/articles/10.3389/fnmol.2017.00455/full
Mechanisms of cell death in canine parvovirus-infected cells provide intuitive insights to developing nanotools for medicine
Canine and feline parvoviruses can use human or feline transferrin receptors to bind, enter, and infect cells. J Virol. 2001;75 ... 38 CPV uses transferrin receptor (TfR) to enter canine or feline cells and has been shown to bind to human TfR, but there is no ... 57 CPV enters cells by binding to the transferrin receptor followed by clathrin mediated endocytosis.46,47 However, in CPV- ... Taking into account its lytic infection, the ability to bind human TfR, and its nonpathogenicity in humans, CPV has the ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2950399/
Retroviral mRNA nuclear export elements regulate protein function and virion assembly | The EMBO Journal
... or directly by immunoblot using a transferrin receptor (TR)‐specific antibody raised in mice (Zymed), an HRP‐conjugated ... Segref A, Sharma K, Doye V, Hellwig A, Huber J, Luhrmann R, Hurt E (1997) Mex67p, a novel factor for nuclear mRNA export, binds ... Maddon PJ, Dalgleish AG, McDougal JS, Clapham PR, Weiss RA, Axel R (1986) The T4 gene encodes the AIDS virus receptor and is ... Strack B, Calistri A, Craig S, Popova E, Gottlinger HG (2003) AIP1/ALIX is a binding partner for HIV‐1 p6 and EIAV p9 ...http://emboj.embopress.org/content/23/13/2632