*  Tetrahydrocannabinol - Wikipedia, ang malayang ensiklopedya
nɒl/ tet-rə-HY-drə-kə-NAB-i-nol;[5] THC), o mas tumpak ay ang pangunahing isomer (−)-trans-Δ9-tetrahydrocannabinol ((6aR,10aR)-delta-9-tetrahydrocannabinol) ang pangunahing sangkap na sikoaktibo o cannabinoid ng halamang cannabis o marijuana. Ito ay unang ihiniwalay noong 1964 ng mga siyentipikong Israeli na sina Raphael Mechoulam, Yechiel Gaoni at mga kasama nito sa Hebrew University of Jerusalem.[6][7][8] Ang isang pormulasyong pharmaceutical ng (−)-trans-Δ9-tetrahydrocannabinol na kilala sa INN dronabinol ay makukuha sa pamamagitan ng pagrereseta sa Estados Unidos at Canada sa ilalim ng pangalang Marinol. Ito ay isang aromatic terpenoid na may napakababang solubilidad sa tubig ngunit mabuting solubilidad sa karamihan ng mga organikong solvent sa spesipiko ay mga lipid at alkohol.[3]. Ang mga aksiyong parmakolohikal nito ay nagreresulta mula sa parsiyal na gawaing agonista sa cannabinoid receptor CB1 (Ki=10nM[13]) na matatagpuan sa sentral na sistemang nerbiyos at CB2 receptor ...
  https://tl.wikipedia.org/wiki/Tetrahydrocannabinol
*  Ajulemic acid, a synthetic cannabinoid acid, induces an antiinflammatory profile of eicosanoids in human synovial cells. -...
AIMS To better understand mechanisms whereby Ajulemic acid (AjA), a synthetic antiinflammatory cannabinoid, promotes resolution of acute and chronic inflammation in animal models, we investigated its influence on cyclooxygenase 2 (COX2) expression and eicosanoid production in human fibroblast-like synovial cells (FLS). MAIN METHODS FLS isolated from tissue obtained at joint replacement surgery or cultured from synovial fluid were treated for 60 min with AjA (10-30 microM), then stimulated with tumor necrosis factor alpha (TNFalpha). COX2 mRNA was measured by hybridization/colorimetric assay of whole cell lysates collected 4 h after stimulation. To determine effects on arachidonic acid release, FLS were incubated with (14)C-arachidonic acid for 20 h then treated with AjA (8-32 microM). Arachidonic acid release was measured by scintillation counting. Prostaglandins (PG) were measured by enzyme linked immunosorbent assay (ELISA) in cell supernatants collected 4 and 24 h after stimulation. KEY FINDINGS
  https://www.semanticscholar.org/paper/Ajulemic-acid-a-synthetic-cannabinoid-acid-induces-Stebulis-Johnson/17e223f2e6a7047f0c378b278b2fe952f0e8d506
*  Effect of Delta-9-Tetrahydrocannabinol on the Prevention of Chronic Pain in Patients With Acute CRPS (ETIC-Study) - Full Text...
Recent animal data suggest that the endocannabinoid system is a promising target in the prevention of chronic pain. It has been shown that the endocannabinoid system modifies excitatory and inhibitory currents in structures involved in the development of chronic pain such as the amygdala.. CRPS is a neuropathic pain condition, which is known to become chronic in a significant percentage. The study compares the effect of low dose Delta9-Tetrahydrocannabinol (90 days) and placebo in acute CRPS. All patients will receive a standard treatment consisting of drug therapy and physiotherapy. ...
  https://clinicaltrials.gov/ct2/show/NCT00377468?recr=Open&cond=%22Complex+Regional+Pain+Syndromes%22&rank=1
*  Effect of delta-9-tetrahydrocannabinol on altered antioxidative enzyme defense mechanisms and lipid peroxidation in mice testes...
The present study examined the adverse effects of delta-9-tetrahydrocannabinol (i.p injection in albino mice) on free radical damage of testicular lipids (lipid peroxidation) at low doses and the role of antioxidant enzymes defense system at high dose and particularly at the withdrawal of the drug after applying higher dose (recovery dose). At lower doses (total doses ranging from 6 mg to 28 mg), there was a significant increase of lipid peroxidation and decrease in testicular lipid content. But the effects were slightly lowered at high dose (total dose 70 mg) and at the withdrawal of the drug (recovery dose). Similarly, marked decrease of antioxidant enzyme systems (superoxide dismutase, catalase, and glutathione peroxidase) and glutathione content were noticed at low doses. But the effects were slightly higher at high dose and at the withdrawal of the drug. Similarly, low-dose treatments caused significant shrinkage of tubular diameter and detrimental changes in seminiferous epithelium of testis
  https://www.semanticscholar.org/paper/Effect-of-delta-9-tetrahydrocannabinol-on-altered-Mandal-Das/b5aa42beee48efbc4fd49faaf6ba4fad2cac8186
*  dronabinol | Health Encyclopedia | Dartmouth-Hitchcock
Dronabinol is a man-made form of cannabis (also known as marijuana). Dronabinol is used to treat loss of appetite that causes weight loss in people with AIDS. Dronabinol is also used to treat severe nausea and vomiting caused by cancer chemotherapy. Dronabinol is for use only when other medications have been unable to...
  http://www.cheshire-med.com/health_wellness/health_encyclopedia/d00866a1
*  CANNABINOIDS: THE ACTIVE INGREDIENTS OF MARIJUANA
CANNABINOIDS: THE ACTIVE INGREDIENTS OF MARIJUANA Cannabis is unique in many ways. Of all plants, it is the only genus known to produce chemical substances known as cannabinoids. The cannabinoids are the psychoactive ingredients of marijuana; they are what get you high. By 1974, 37 naturally occurring cannabinoids had been discovered 115,118. Most of the cannabinoids appear in very small amounts (less than .01 percent of total cannabinoids) and are not considered psychoactive, or else not important to the high. Many are simply homologues or analogues (similar structure or function) to the few major cannabinoids which are listed.. 1. (-)-delta 9-trans-tetrahydrocannabinol ((There are several numbering systems used for cannabinoids. The system in this book is most common in American publications and is based on formal chemical rules for numbering pyran compounds. Another common system is used more by Europeans and is based on a monoterpenoid system which is more useful considering the biogenesis ...
  http://www.lycaeum.org/~sky/data/grow/c2.html
*  Psychoactive ingredient levels in cannabis have 'TRIPLED in the last 20 years' | Daily Mail Online
Scientists from University of Mississippi revealed THC levels in marijuana increased from four to 12 per cent over the past 20 years - corresponding to an uptick in weed-related emergency room visits.
  http://www.dailymail.co.uk/health/article-3439625/Pot-getting-potent-Level-psychoactive-ingredient-cannabis-TRIPLED-20-years-experts-warn.html
*  Marinol, Syndros (dronabinol) dosing, indications, interactions, adverse effects, and more
Medscape - Chemotherapy-induced nausea & vomiting dosing for Marinol, Syndros (dronabinol), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.
  https://reference.medscape.com/drug/marinol-syndros-dronabinol-342047
*  Marinol (Dronabinol) Basics, Side Effects & Reviews - Iodine.com
What to expect, side effects, reviews, cost, tips, and pros and cons of Marinol (Dronabinol), from expert pharmacists and people like you
  http://www.iodine.com/drug/marinol
*  MARINOL (Dronabinol) dosage, indication, interactions, side effects | EMPR - Renal and Urology News
MARINOL (Dronabinol) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
  http://www.renalandurologynews.com/marinol/drug/1488/
*  Marinol - Uses, Side Effects, Interactions - Canoe.com
Marinol: Dronabinol is a member of the family of medications known as cannabinoids. Dronabinol is also known as THC (delta-9-tetrahydrocannabinol). This medication was developed after it was discovered that the THC found in marijuana was effective in treating severe nausea and vomiting associated with cancer chemotherapy.
  http://chealth.canoe.com/drug/getdrug/marinol
*  THCA, QUANTITATIVE, SERUM
THCA is the primary metabolite of THC. (delta-9-tetrahydrocannabinol, marijuana's major psychoactive ingredient). This test cannot differentiate between prescribed (e.g. Marinol), medical marijuana, or illicit forms of marijuana. This test cannot distinguish between active or passive marijuana exposure, or if the patient is under the influence of marijuana at the time of the specimen collection ...
  http://www.legacyhealth.org/for-health-professionals/refer-a-patient/laboratory-services/test-table/thca-quantitative-serum.aspx
*  Biological Sciences
9-tetrahydrocannabinol (THC), marijuana's principal psychoactive component, is known to suppress resistance to bacterial, viral and protozoan infections. However, the effect of THC on resistance to fungal infections is unclear. Recently, we found that chronic THC treatment decreased resistance to the yeast Candida albicans (C. albicans) in immune competent mice. However, nothing is known about how THC affects resistance to a fungal infection in an immunocompromised mouse. Our objective was to assess how chronic THC affects an immunocompromised mouse's ability to ward off systemic candidiasis in an acute and secondary model of infection. 5-fluorouracil (5-F) is a commonly prescribed anti-cancer drug and is also a potent immunosuppressor, increasing susceptibility to C. albicans infection. We found that 5-F treatment severely decreased survival, white blood cell count, splenic IL-12p40 production and increased kidney fungal load. To investigate the effect of THC on resistance to C. albicans in ...
  http://broncoscholar.library.cpp.edu/handle/10211.3/189856
*  Biological Sciences
9-tetrahydrocannabinol (THC), marijuana's principal psychoactive component, is known to suppress resistance to bacterial, viral and protozoan infections. However, the effect of THC on resistance to fungal infections is unclear. Recently, we found that chronic THC treatment decreased resistance to the yeast Candida albicans (C. albicans) in immune competent mice. However, nothing is known about how THC affects resistance to a fungal infection in an immunocompromised mouse. Our objective was to assess how chronic THC affects an immunocompromised mouse's ability to ward off systemic candidiasis in an acute and secondary model of infection. 5-fluorouracil (5-F) is a commonly prescribed anti-cancer drug and is also a potent immunosuppressor, increasing susceptibility to C. albicans infection. We found that 5-F treatment severely decreased survival, white blood cell count, splenic IL-12p40 production and increased kidney fungal load. To investigate the effect of THC on resistance to C. albicans in ...
  http://broncoscholar.library.cpp.edu/handle/10211.3/189856?show=full
*  Watson Launches Generic MARINOL(R... ( CORONA Calif. June 30 /- WatsonPh...)
Health,... CORONA Calif. June 30 /- WatsonPharmaceu...Under the terms of the supply agreement Solvay Pharmaceuticals wills...About Dronabinol ...Dronabinol should not be used by any patient who has a history ofhype...,Watson,Launches,Generic,MARINOL(R),Capsules,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
  http://www.bio-medicine.org/medicine-news-1/Watson-Launches-Generic-MARINOL-28R-29-Capsules-22911-1/
*  House of Commons - Home Affairs - Memoranda
2.1 Messages pass along the nerve fibres as electrical impulses and cross the gaps between nerve cells as chemicals (neurotransmitters). These are the brains natural 'drugs', each having a particular shape to fit the receptor site on the membrane of the next cell, rather like a key fitting a lock. Unfortunately, the brain cannot distinguish between these neurotransmitters and the 'mind altering' drugs that people take. Cannabis mimics the neurotransmitter anandamide (ananda: Sanskrit for 'bliss') to give the 'high'. It also occupies the same receptors sites as the opiates possibly explaining its pain control properties. The psychoactive ingredient THC (tetrahydrocannabinol) dissolves in the far rich cell membranes and remains there. 50 per cent will still be there a week later and ten per cent after a month. Traces in the hair and urine will be detectable for weeks ...
  https://publications.parliament.uk/pa/cm200102/cmselect/cmhaff/318/318m14.htm
*  Marinol - Drugs.com
Marinol is a medicine available in a number of countries worldwide. A list of US medications equivalent to Marinol is available on the Drugs.com website.
  https://www.drugs.com/international/marinol.html
*  Delta9-tetrahydrocannabinol induces apoptosis in macrophages and lymphocytes: involvement of Bcl-2 and caspase-1.
Apoptosis is programed cell death characterized by certain cellular changes and regulated by various gene products including Bcl-2 and caspase-1. The marijuana cannabinoid, Delta9tetrahydrocannabinol (THC), has been reported to suppress in culture th
  http://www.biomedsearch.com/nih/Delta9-tetrahydrocannabinol-induces-apoptosis-in/9694974.html
*  Strains nach Indikation Archives - 1000Seeds
Was ist Tetrahydrocannabivarin (THCV) und wie entsteht es? Wie der Name vermuten lässt, ist Tetrahydrocannabivarin (THCV) sehr ähnlich zu dem berühmtesten Cannabinoid, Tetrahydrocannabinol (THC). Die chemische Struktur von THC und THCV ist nahezu identisch, aber ihre Entstehung läuft unterschiedlich ab. Anders als THC , Cannabidiol (CBD) , und Cannabichromen (CBC) , beginnt THCV nicht als Continue reading » ...
  http://1000seeds.info/wordpress/tag/strains-nach-indikation/
*  Could medical marijuana treat Alzheimer's? - CNN
A study found THC, the psychoactive ingredient in cannabis, stimulates the removal of toxic plaque in the brain and blocks inflammation, which damages neurons.
  http://edition.cnn.com/2016/07/25/health/alzheimers-medical-marijuana/
*  World's first marijuana-based prescription drug aiming to get FDA approval | Drugs-Forum
[ATTACH]A quarter-century after the U.S. Food and Drug Administration approved the first prescription drugs based on the main psychoactive ingredient in marijuana, additional medicines derived...
  https://drugs-forum.com/ams/worlds-first-marijuana-based-prescription-drug-aiming-to-get-fda-approval.16938/
*  Marinol - FDA prescribing information, side effects and uses
Marinol official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more.
  https://www.drugs.com/pro/marinol.html
*  Nabitan - Wikipedia's Nabitan as translated by GramTrans
Nabitan ( Nabutam, Benzopyranoperidine, SP-106, Abbott 40656) estas sintetikaĵo canabinoida analogaĵo de dronabinol (Marinol). [1] Ĝi elmontras kontraŭvoman kaj sendoloriga0efikojn, plej verŝajne per ligado al kaj aktivigado de la CB1 kaj CB2 canabinoidaj receptoroj, kaj reduktita intraokula premo en besttestoj, igante ĝin eble utila en la terapio de glaŭkomo.. Nabitan havas la avantaĝon de esti hidrosovebla, male al la plej multaj canabinoidaj derivaĵoj, kaj estis esplorita por ebla uzo kiel kontraŭdolorilo aŭ sedativo, [3] kvankam ĝi neniam estis evoluigita por klinika uzo kaj ne estas nuntempe uzita en medicino, kiam dronabinol aŭ nabilono estis sentitaj esti pli utilaj. Tamen ĝi foje estas uzita en esplorado en la eblajn terapiajn aplikojn de canabinoidoj.. ...
  https://epo.wikitrans.net/Nabitan
*  ET 06/03: Marijuana-derived compound targets pain, inflammation
esearchers are developing a marijuana-derived synthetic compound to relieve pain and inflammation without the mood-altering side effects associated with other marijuana based drugs. They say the compound could improve treatment of a variety of conditions, including chronic pain, arthritis and multiple sclerosis. The compound, called ajulemic acid, has produced encouraging results in animal studies of pain and inflammation. It is undergoing tests in a group of people with chronic pain and could be available by prescription within two to three years, the researchers say. We believe that [the compound] will replace aspirin and similar drugs in most applications primarily because of a lack of toxic side effects, says Sumner Burstein, Ph.D., lead investigator in the study and a professor in the department of biochemistry and molecular pharmacology at the University of Massachusetts Medical School in Worcester. The indications so far are that it's safe and effective, he added. At a safety trial of the ...
  http://sdearthtimes.com/et0603/et0603s24.html