Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA...
Background Constitutive and regulated internalization of cell surface proteins has been extensively investigated. The regulated ... Cyclic AMP-dependent protein kinase and protein kinase C phosphorylate N-methyl-D-aspartate receptors at different sites. J ... Gardoni F, Bellone C, Cattabeni F, Di Luca M. Protein kinase C activation modulates alpha-calmodulin kinase II binding to NR2A ... Src kinases: a hub for NMDA receptor regulation. Nat Rev Neurosci. 2004;5:317-28.CrossRefPubMedGoogle Scholar ...https://rd.springer.com/article/10.1186/s13041-015-0167-1
Neuronal memory allocation - Wikipedia
Nguyen, P. V., & Woo, N. H. (2003). Regulation of hippocampal synaptic plasticity by cyclic AMP-dependent protein kinases. ... Hippocampal synaptic metaplasticity requires inhibitory autophosphorylation of Ca2+/calmodulin-dependent kinase II. The Journal ... For example, the cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA) pathways appear to participate in neuronal ... cyclic AMP responsive element-binding protein) in this process. Certain synapses on recruited neurons are more likely to ...https://en.wikipedia.org/wiki/Neuronal_memory_allocation
Ethanol Stimulates cAMP-Responsive Element (CRE)-Mediated Transcription via CRE-Binding Protein and cAMP-Dependent Protein...
CREB phosphorylation is regulated by PKA and by other protein kinases such as Ca2+/calmodulin-dependent kinase (CaMK) (Matthews ... 1998a) Chronic ethanol administration decreases phosphorylation of cyclic AMP response element-binding protein in granule cells ... cAMP response element-binding protein. Cα. catalytic subunit of PKA. CaMK. Ca2+/calmodulin-dependent kinase. PKC. protein ... 1994) Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression. Mol ...http://jpet.aspetjournals.org/content/301/1/66
Control of GluR1 AMPA Receptor Function by cAMP-Dependent Protein Kinase | Journal of Neuroscience
Inhibition of cyclic AMP-dependent kinase by expression of a protein kinase inhibitor/enhanced green fluorescent fusion protein ... 1997) Identification of the Ca2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in the α-amino-3- ... 5 C) or indirect effects of other kinases that act on Ser831. These results are consistent with biochemical studies that show ... 1996) Transient activation of cyclic AMP-dependent protein kinase during hippocampal long-term potentiation. J Biol Chem 271: ...http://www.jneurosci.org/content/20/1/89?ijkey=6516d0f6e54ae4839e5d63ec1a2689b2c1d8909e&keytype2=tf_ipsecsha
Sustained β1-Adrenergic Stimulation Modulates Cardiac Contractility by Ca2+/Calmodulin Kinase Signaling Pathway | Circulation...
Pak Y, Pham N, Rotin D. Direct binding of the β1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange ... G protein-coupled receptors. III. New roles for receptor kinases and β-arrestins in receptor signaling and desensitization. J ... Activity of cAMP-dependent protein kinase and Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human hearts. ... Ca2+/Calmodulin-Dependent Protein Kinase II Phosphorylation Regulates the Cardiac Ryanodine Receptor. Circ Res. 2004; 94: e61- ...http://circres.ahajournals.org/content/95/8/798
An update on nuclear calcium signalling | Journal of Cell Science
... interaction and modulation by calcium/calmodulin-dependent protein kinase II. J. Biol. Chem. 280, 15912-15920. ... factor that is regulated by both nuclear and cytosolic Ca2+ signals is cyclic AMP response element-binding protein (CREB). The ... Shibasaki, F., Price, E. R., Milan, D. and McKeon, F. (1996). Role of kinases and the phosphatase calcineurin in the nuclear ... Proteins in excess of ∼50 kDa require energy-dependent movement across the NPC. Such large proteins are often designated for ...http://jcs.biologists.org/content/122/14/2337
Long-Term Potentiation Induced by θ Frequency Stimulation Is Regulated by a Protein Phosphatase-1-Operated Gate | Journal of...
Differential inactivation of postsynaptic density-associated and soluble Ca2+/calmodulin-dependent protein kinase II by protein ... 1999) Cyclic AMP induces functional presynaptic boutons in hippocampal CA3-CA1 neuronal cultures. Nat Neurosci 2:24-30. ... including the inhibition of protein kinases or phosphatases and the activation of β-adrenergic receptors (Coussens and Teyler, ... PP1 inhibition seems to promote the activation of Ca2+/calmodulin-dependent protein kinase (CaMKII), because (1) a CaMKII ...http://www.jneurosci.org/content/20/21/7880.long
Intracellular A-beta amyloid, A sign for worse things to come? | SpringerLink
Differential phosphorylation of tau by cyclic AMP-dependent protein kinase and Ca2+/calmodulin-dependent protein kinase II: ... 1997) A novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. ... protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM ... Mitogen-activated protein kinase-dependent and protein kinase C-dependent pathways link the ml muscarinic receptor to beta- ...https://link.springer.com/article/10.1385%2FMN%3A26%3A2-3%3A299
Autocrine Activation of Neuronal NMDA Receptors by Aspartate Mediates Dopamine- and cAMP-Induced CREB-Dependent Gene...
2003) Regulation of hippocampal synaptic plasticity by cyclic AMP-dependent protein kinases. Prog Neurobiol 71:401-437. ... 1994) Calcium/Calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression. Mol ... 1991) cAMP response element-binding protein is activated by Ca2+/calmodulin- as well as cAMP-dependent protein kinase. Proc ... the mitogen-activated protein kinase (MAPK) pathway, or Ca2+/calmodulin-dependent kinases (CaMKs), depending on the activating ...http://www.jneurosci.org/content/29/40/12702.long
Mitogen-Activated Protein Kinases (Erk1,2) Phosphorylate Lys-Ser-Pro (KSP) Repeats in Neurofilament Proteins NF-H and NF-M |...
Cyclic AMP-dependent protein kinase (PKA) and protein kinase C (PKC) are the principal kinases targeting the head domain of NF- ... its regulation by calmodulin. J Biol Chem 261:13023-13030. ... 1992) Association of cyclic-AMP-dependent protein kinase with ... 1990) Effect of phosphorylation on 68 kDa neurofilament subunit protein assembly by the cyclic AMP dependent protein kinase in ... 1993) Tau protein kinase II has similar characteristics to cdc2 kinases for phosphorylating neurofilament proteins. J Biol Chem ...http://www.jneurosci.org/content/18/11/4008
Isolation and characterization of the highly phosphorylated repeat domain of distinct heavy neurofilament subunit (NF-H)...
Dosemeci, A., and Pont, H. C. (1992). Association of cyclic AMP dependent protein kinase with neurofilaments.Biochem. J. 282: ... Ca2+-calmodulin-dependent protein kinase II phosphorylates various types of non-epithelial intermediate filament proteins. ... Roder, H. M., and Ingram, V. M. (1991). Two novel kinases phosphorylate tau and the KSP site of heavy neurofilament subunits in ... Gonda, Y., Nishizawa, Y., Ando, S., Kitamura, S., Minoura, Y., Nshi, Y., and Inagaki, M. (1990). Involvement of protein kinase ...https://link.springer.com/article/10.1007/BF02150227
Role of urokinase and its receptor in basal and stimulated colonic epithelial cell migration in vitro | Gut
Evidence for cyclic AMP-dependent and protein kinase C-dependent pathways. Circ Res 72:330-340. ... such as focal adhesion kinase,11 protein kinase C (PKC),8extracellular signal regulated kinase,11 12 Janus associated kinases, ... 1994) Role of actin and calmodulin in migration and proliferation of rabbit gastric mucosal cells in culture. J Gastroenterol ... protein kinase C. ON. oligonucleotide. PMA. phorbol-12-myristate-13-acetate. u-PA. urokinase-type plasminogen activator. u-PAR ...http://gut.bmj.com/content/47/1/105
The Role of Calcium/Calmodulin-Dependent Protein Kinase Cascade in Glucose Upregulation of Insulin Gene Expression | Diabetes
Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain. EMBO J8 :2023 -2028,1989. ... Enslen H, Soderling TR: Roles of calmodulin-dependent protein kinases and phosphatase in calcium-dependent transcription of ... Park IK, Soderling TR: Activation of Ca2+/calmodulin-dependent protein kinase (CaM-kinase) IV by CaM-kinase kinase in Jurkat T ... Activation mechanisms for Ca2+/calmodulin-dependent protein kinase IV: identification of a brain CaM-kinase IV kinase. J Biol ...http://diabetes.diabetesjournals.org/content/53/6/1475
CREB1 - Wikipedia
Shimomura A, Ogawa Y, Kitani T, Fujisawa H, Hagiwara M (Jul 1996). "Calmodulin-dependent protein kinase II potentiates ... "Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires ... The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal ... Pandey SC (Oct 2004). "The gene transcription factor cyclic AMP-responsive element binding protein: role in positive and ...https://en.wikipedia.org/wiki/CREB1
ATF1 - Wikipedia
... cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and ... Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene. This gene encodes an ... of activating transcription factor-1 and the cAMP response element-binding protein by Ca2+/calmodulin-dependent protein kinases ... 1996). "Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 ...https://en.wikipedia.org/wiki/ATF1
Tau phosphorylation in neuronal cell function and dysfunction | Journal of Cell Science
Tau protein is phosphorylated by cyclic AMP-dependent protein kinase and calcium/calmodulin-dependent protein kinase II within ... tau is a substrate for many protein kinases; however, the number of protein kinases that actually phosphorylate tau in vivo is ... PKA and calcium/calmodulin-dependent protein kinase II might contribute to the phosphorylation of these sites in vivo (Drewes ... Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau- ...http://jcs.biologists.org/content/117/24/5721
CAMK1 - Wikipedia
Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification ... 1999). "Regulation of neuronal nitric-oxide synthase by calmodulin kinases". J. Biol. Chem. 274 (29): 20597-602. doi:10.1074/ ... calmodulin-dependent protein kinase I by calmodulin and by Ca2+/calmodulin-dependent protein kinase kinase". J. Biol. Chem. 273 ... Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein ...https://en.wikipedia.org/wiki/CAMK1
Direct Evidence for Biphasic cAMP Responsive Element-Binding Protein Phosphorylation during Long-Term Potentiation in the Rat...
A number of protein kinases, including cAMP-dependent protein kinase A (PKA) and Ca2+/calmodulin-dependent kinase II (CaMKII), ... stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A. ... 1994) Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and IV involves phosphorylation of a ... 1991) Effects of KN-62, a specific inhibitor of calcium/calmodulin-dependent protein kinase II, on long-term potentiation in ...http://www.jneurosci.org/content/19/13/5683
Article) - Biology Online
Calmodulin-dependentprotein kinase II promotes smooth muscle relaxation by decreasingthe sensitivity of MLC kinase for Ca2+. ... ß-adrenergicreceptors and cyclic AMP) or agonist bioavailability (endotheliumdysfunction, reduced nitric oxide and cyclic GMP ... Pharmacomechanical coupling: the role of calcium, G-proteins, kinases and phosphatases. Rev Physiol Biochem Pharmacol 134: 201- ... DG, along with Ca2+, activatesprotein kinase C (PKC), which phosphorylates specific targetproteins. There are several isozymes ...http://www.biology-online.org/articles/smooth_muscle_contraction_relaxation/article.html
AMP-activated protein kinase - Wikipedia
... liver kinase B1 (LKB1) which works in a complex with STRAD and MO25, calcium-/calmodulin-dependent kinase kinase 2 (]]CAMKK2, ... It should not be confused with cyclic AMP-activated protein kinase (protein kinase A). AMPK is a heterotrimeric protein complex ... STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade". J. Biol. 2 (4): 28. doi ... "AMP-activated protein kinase kinase activity and phosphorylation of AMP-activated protein kinase in contracting muscle of ...https://en.wikipedia.org/wiki/AMP-activated_protein_kinase
Memory in the enteric nervous system | Gut
23 Induction and maintenance of LTP involves several kinases, at least PKC,24 calcium/calmodulin dependent protein kinase (CaM ... cyclic AMP and its analogues, and phorbol esters (protein kinase C (PKC) activators) can mimic slow EPSPs in AH neurones.16-18 ... 1997) Postsynaptic inhibitors of calcium/calmodulin-dependent protein kinase type II block induction but not maintenance of ... 1997) Mediation by protein kinases C and A of Go-linked slow responses of enteric neurons to 5-HT. J Neurosci 17:1011-1024. ...http://gut.bmj.com/content/47/suppl_4/iv60
CK2-An Emerging Target for Neurological and Psychiatric Disorders
Second messenger-dependent protein kinases, such as protein kinase A and protein kinase C, or CK1α, are also involved in GPCR ... One example of an in vivo CK2 substrate that links cyclic AMP (cAMP) signaling to nuclear responses, changes histone ... Primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and ... It was shown that the Ca2+/calmodulin-dependent protein kinase II (CaMKII), activated through activity-induced calcium influx, ...http://pubmedcentralcanada.ca/pmcc/articles/PMC5374411/
Activity-regulated cytoskeleton-associated protein - Wikipedia
Ca2+/calmodulin-dependent protein kinase II mRNA association to polysomes". The Journal of Neuroscience : the Official Journal ... The common factor for these signaling molecules involves activation of cyclic-AMP and its downstream target protein kinase A ( ... Note that the MAPK cascade is a signaling pathway involving multiple kinases acting sequentially [MAPKKK--> MAPKK--> MAPK]. ... The Arc transcript is dependent upon activation of the mitogen-activated protein kinase or MAP kinase (MAPK) cascade, a pathway ...https://en.wikipedia.org/wiki/Activity-regulated_cytoskeleton-associated_protein
CAMK4 - Wikipedia
Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification ... 1999). "Regulation of neuronal nitric-oxide synthase by calmodulin kinases". J. Biol. Chem. 274 (29): 20597-602. doi:10.1074/ ... calmodulin-dependent protein kinase I by calmodulin and by Ca2+/calmodulin-dependent protein kinase kinase". J. Biol. Chem. 273 ... and activation of Ca2+-calmodulin-dependent protein kinase IV by Ca2+-calmodulin-dependent protein kinase Ia kinase. ...https://en.wikipedia.org/wiki/CAMK4
Signal transduction - Wikipedia
cAMP-dependent pathway: In humans, cAMP works by activating protein kinase A (PKA, cAMP-dependent protein kinase) (see picture ... Some of them create second messengers such as cyclic AMP and IP3, the latter controlling the release of intracellular calcium ... Histidine-specific protein kinases are structurally distinct from other protein kinases and are found in prokaryotes, fungi, ... For example, calcium ions bind to the EF hand domains of calmodulin, allowing it to bind and activate calmodulin-dependent ...https://en.wikipedia.org/wiki/Signal_transduction
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