*  Purification method which prevents denaturation of an antibody - Patent # 8470328 - PatentGenius
... protein A affinity chromatography. More specifically, the present invention provides a technique relating to an elution buffer ... "A study of the interactions between an IgG-binding domain based on the B domain of staphylococcal protein A and rabbit IgG," ( ... Staphylococcal Protein A ("protein A" hereinafter), an Fc receptor derived from a microbe,exhibits extremely high affinity for ... Utilizing the high affinity of protein A for antibody Fc domains requires the use of protein A as the ligand binding the ...
  http://www.patentgenius.com/patent/8470328.html
*  Patent US7687069 - Time release patch containing phage associated lytic enzymes for treating ... - Google Patents
Immunoglobulin a binding protein. US5571667. Jul 8, 1993. Nov 5, 1996. Chu; Albert E.. Elongated membrane flow-through ... Method of treating mastitis and other staphylococcal infections. EP0510907A2. Apr 21, 1992. Oct 28, 1992. Agricultural And Food ... Bacterial plasmin binding protein and methods of use thereof. US6238661. Apr 18, 2000. May 29, 2001. New Horizons Diagnostics ... Streptococcal immunoglobulin a binding protein encoded by emmL2.2. US5360617. Mar 13, 1991. Nov 1, 1994. Agricultural And Food ...
  http://www.google.com/patents/US7687069?dq=6948823
*  Patent US6685937 - Chewing gum containing phage associated lytic enzymes for treating ... - Google Patents
Bacterial plasmin binding protein and methods of use thereof. US6238661 *. Apr 18, 2000. May 29, 2001. New Horizons Diagnostics ... Method of treating mastitis and other staphylococcal infections. EP0510907A2. Apr 21, 1992. Oct 28, 1992. Agricultural And Food ... Fibronectin and fibrinogen binding protein from group A streptococci. US6399097 *. Sep 1, 2000. Jun 4, 2002. New Horizons ... Immunoglobulin a binding protein. US5571667. Jul 8, 1993. Nov 5, 1996. Chu; Albert E.. Elongated membrane flow-through ...
  http://www.google.com/patents/US6685937?dq=6,272,646
*  Colloidal gold - Wikipedia
"Staphylococcal protein a bound to colloidal gold: A useful reagent to label antigen-antibody sites in electron microscopy". ... The biocompatibility and high surface energy of Au allow it to bind to a large amount of protein without altering its activity ... To prevent this, one can add a stronger binding agent, like a thiol (in particular, alkanethiols), which will bind to gold, ... effects on particle size and analysis of plasma protein binding profiles". Nanomedicine: Nanotechnology, Biology and Medicine. ...
  https://en.wikipedia.org/wiki/Colloidal_gold
*  Frontiers | Molecular Recognition of Gangliosides and Their Potential for Cancer Immunotherapies | Immunology
In this review, we describe how proteins recognize gangliosides, focusing on the molecular recognition of gangliosides ... In this review, we describe how proteins recognize gangliosides, focusing on the molecular recognition of gangliosides ... and also by regulating signaling proteins through lateral interaction in the membrane. Through both mechanisms, tumor- ... and also by regulating signaling proteins through lateral interaction in the membrane. Through both mechanisms, tumor- ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2014.00325/full
*  ASMscience | Biology and Pathogenicit
The staphylococcal transferrin-binding protein is a cell wall glyceraldehyde-3-phosphate dehydrogenase. Infect. Immun. 67:1086- ... The fibrinogen binding protein of Staphylococcus epidermidis is a target for opsonic antibodies. Infect. Immun. 72:3081-3083.. ... Staphylococcal iron requirements, siderophore production, and iron-regulated protein expression. Infect. Immun. 62:2309-2314.. ... A fibrinogen-binding protein of Staphylococcus epidermidis. Infect. Immun. 66:2666-2673.. ...
  http://www.asmscience.org/content/book/10.1128/9781555816513.chap46
*  Yeast Nucleoporins Involved in Passive Nuclear Envelope Permeability | JCB
1987) A synthetic IgG-binding domain based on staphylococcal protein A. Protein Eng 1:107-113, pmid:3507693.. ... Nuclear localization signals in mRNA-binding proteins and the role of Ran and RNA. J. Biol. Chem. 274:29031-29037, pmid: ... Signal-bearing proteins are bound by soluble targeting receptors, most of which belong to the karyopherin/importin (Kap) β ... 1988) Nuclear protein migration involves two stepsrapid binding at the nuclear envelope followed by slower translocation ...
  http://jcb.rupress.org/content/149/5/1027.long
*  RNA-induced silencing complex - Wikipedia
TRBP is a protein with three double-stranded RNA-binding domains. Argonaute 2 is an RNase and is the catalytic centre of RISC. ... Tudor-staphylococcal nuclease; Vig, vasa intronic gene. Regardless, it is apparent that Argonaute proteins are present and are ... The RLC consists of dicer, the human immunodeficiency virus transactivating response RNA-binding protein (TRBP) and Argonaute 2 ... preventing the binding of the 60S ribosomal subunit binding to the mRNA can repress translation. Translation can be regulated ...
  https://en.wikipedia.org/wiki/RNA-induced_silencing_complex
*  Viruses | Free Full-Text | Molecular Signatures of Hepatitis C Virus (HCV)-Induced Type II Mixed Cryoglobulinemia (MCII) | HTML
... the involvement of complement factors and the specific role of some HCV proteins. In this review, we will analyze the host and ... In particular, IgM molecules are good acceptors of C1q and indeed can favor indirect binding of HCV core protein to endothelial ... Domiati-Saad, R.; Attrep, J.F.; Brezinschek, H.P.; Cherrie, A.H.; Karp, D.R.; Lipsky, P.E. Staphylococcal enterotoxin d ... Ghebrehiwet, B.; Peerschke, E.I. Structure and function of gc1q-r: A multiligand binding cellular protein. Immunobiology 1998, ...
  http://www.mdpi.com/1999-4915/4/11/2924/htm
*  Virulence factors of Staphylococcus aureus strains causing infective endocarditis : a comparison with strains from skin...
... production and binding capacity to the extracellular matrix proteins: fibronectin, collagen type I, collagen type II and bone ... The potential virulence factors studied were Staphylococcal enterotoxin A-D (SEA, SEB, SEC, SED) and toxic shock syndrome toxin ... BSP binding was more often found in the control group with skin infections. Endocarditis patients with previous damage of the ... infective endocarditis, S-aureus, enterotoxin, extracellular matrix proteins, virulence factors National Category Medical and ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:83306
*  KAKEN - Research Projects | Elucidation of mechanisms of molecular recognition and signal transduction of immunoglobulin-Fc...
1998, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Physical pharmacy ... Publications] H.Gouda et al.: 'NMR study of the interaction between the B domain of Staphylococcal protein A and the Fc portion ... has completely lost the ability to bind to sFcgammaRII.We have investigated binding to sFcgammaRII of a variety of Fc analogs ... Publications] H.Gouda etal.: 'NMR study of the interaction between the B domain of Staphylococcal protein A and the Fc portion ...
  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09672186/
*  Static Biofilm Cultures of Gram‐Positive Pathogens Grown in a Microtiter Format Used for Anti‐Biofilm Drug Discovery - Current...
An in vitro assay is presented for culturing staphylococcal biofilms and biofilms of nonmotile Gram‐positive bacteria under ... A novel Staphylococcus aureus biofilm phenotype mediated by the fibronectin‐binding proteins, FnBPA and FnBPB. J. Bacteriol. ... An in vitro assay is presented for culturing staphylococcal biofilms and biofilms of nonmotile Gram‐positive bacteria under ... Role of the accessory gene regulator (agr) in pathogenesis of staphylococcal osteomyelitis. Infect. Immun. 63:3373‐3380. ...
  http://www.currentprotocols.com/WileyCDA/CPUnit/refId-ph13a08.html?quicktabs_cp=abstract
*  JCI - Antimicrobial resistance: the example of Staphylococcus aureus
I. The DNA-binding protein BlaI binds to the operator region, thus repressing RNA transcription from both blaZ and blaR1-blaI. ... Changing staphylococci and staphylococcal infections. A ten-year study of bacteria and cases of bacteremia. N. Engl. J. Med. ... mecA is responsible for synthesis of penicillin-binding protein 2a (PBP2a; also called PBP2′) a 78-kDa protein (43-45). PBPs ... Utsui, Y, Yokota, T. Role of an altered penicillin-binding protein in methicillin- and cephem-resistant Staphylococcus aureus. ...
  https://www.jci.org/articles/view/18535
*  Jayakar V. Nayak, MD, PhD | Stanford Medicine Profiles
These studies document the immunodominance of the VH-restricted Fab binding site on staphylococcal protein A and demonstrate ... we treated neonatal BALB/c mice with a form of staphylococcal protein A (MS) devoid of Fcgamma binding activity, which retains ... In vitro studies of several naturally occurring proteins have characterized VH family-specific B lymphocyte binding and ... B cell superantigens are proteins that are capable of immunoglobulin variable region mediated binding interactions with the ...
  https://med.stanford.edu/profiles/jayakar-nayak
*  Frontiers | Staphylococcus aureus Quorum Regulator SarA Targeted Compound, 2-[(Methylamino)methyl]phenol Inhibits Biofilm and...
Thus, inhibiting the production or blocking SarA protein might influence the down regulation of biofilm and virulence factors. ... Thus, inhibiting the production or blocking SarA protein might influence the down regulation of biofilm and virulence factors. ... Fibronectin binding protein (FnBP) is one of the essential virulence factors that favor S. aureus for its anchorage with ... Staphylococcal α-hemolysin toxins are secreted as an outcome of virulence mechanisms that are under the QS control in S. aureus ...
  https://www.frontiersin.org/articles/10.3389/fmicb.2017.01290/full
*  Manipulating and enhancing the RNAi response
... encode interacting proteins; rde-4 encodes a dsRNA binding protein and rde-1 encodes a PAZ-PIWI/Argonaute protein. RDE-4 ... TSN-1contains five staphylococcal/micrococcal nuclease domain repeats, the last of which is fused to a tudor domain. Although ... The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans. Cell. 2002; ... ERI-1 contains a SAP domain found in DNA binding proteins and a DEDDh-like 3′ → 5′ exonuclease domain, which is also found in ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2737212/
*  US20050049181A1 - Synergistic antimicrobial compositions and methods of inhibiting biofilm formation - Google Patents
Bezkorovainy, "Antimicrobial properties of iron-binding proteins", Adv. Exp. Med. Biol., 135:139-154, 1981 ... Fallgren, et al., "In vitro anti-Staphylococcal activity of heparinized biomaterials bonded with combinations of rifampin", ... A61L29/044-Proteins; Polypeptides; Degradation products thereof * A61L29/048-Other specific proteins or polypeptides not ... basic protein composition for killing or inhibiting microbial cells. US6592814B2 (en) 1998-10-02. 2003-07-15. Johnson & Johnson ...
  https://patents.google.com/patent/US20050049181A1/en
*  Enterotoxin type B - Wikipedia
Additionally, this protein is one of the causative agents of toxic shock syndrome. The function of this protein is to ... "eMedicine - CBRNE - Staphylococcal Enterotoxin B". eMedicine. Retrieved 2011-02-06. Nema V, Agrawal R, Kamboj DV, Goel AK, ... The N-terminal domain is also referred to as OB-fold, or in other words the oligonuclucleotide binding fold. This region ... Each superantigen possesses slightly different binding mode(s) when it interacts with MHC class II molecules or the T-cell ...
  https://en.wikipedia.org/wiki/Enterotoxin_type_B
*  Patent US20050031626 - Binding agents with differential activity - Google Patents
This is useful if the binding agent is intended to bind both an effector cell and a target to be destroyed, because the ... whereby certain activities of a first part of the binding agent are reduced or prevented until binding to a target occurs. ... Such binding agents are useful in the treatment of cancer, for example. ... Binding agents with differential activity can be provided, ... The staphylococcal protein will usually be coupled to a solid ...
  http://www.google.com/patents/US20050031626?dq=6272333
*  Patent US7078492 - Human antipneumococcal antibodies from non-human animals - Google Patents
The invention described herein provides human antibodies produced in non-human animals that specifically bind to Streptococcus ... We also screened the hybridoma supernatants for binding to staphylococcal protein A (SPA; ... protein glycosylation, protein cleavage, protein secretion, intracellular protein localization and extracellular protein homing ... "Fusion proteins" refer to chimeric proteins comprising amino acid sequences of two or more different proteins. Typically, ...
  http://www.google.com/patents/US7078492?dq=5910382
*  Death by a B Cell Superantigen | JEM
Staphylococcal protein A induces biased production of Ig by VH3-expressing B lymphocytes. J. Immunol. 153:2974-2984. ... preferential IgM rheumatoid factor production and VH3 mRNA expression by protein A-binding B cells. J. Clin. Immunol. 15:145- ... These binding interactions and the B cell targeting properties of SpA do not involve the site by which SpA binds Fcγ (2). ... as this secreted membrane protein contains five homologous Ig-binding domains in tandem, and although the native pentameric Ig- ...
  http://jem.rupress.org/content/197/9/1125
*  Desmoglein-1 - Wikipedia
Chen X, Bonne S, Hatzfeld M, van Roy F, Green KJ (March 2002). "Protein binding and functional characterization of plakophilin ... Hanakawa Y, Schechter NM, Lin C (2002). "Molecular mechanisms of blister formation in bullous impetigo and staphylococcal ... Chen X, Bonne S, Hatzfeld M (2002). "Protein binding and functional characterization of plakophilin 2. Evidence for its diverse ... The protein encoded by this gene has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus ...
  https://en.wikipedia.org/wiki/Desmoglein-1
*  IgVH genes from different anatomical regions, with different histopathological patterns, of a rheumatoid arthritis patient...
The structural basis of germline-encoded VH3 immunoglobulin binding to staphylococcal protein A. J Exp Med. 1993, 178: 331-336 ... Domiati-Saad R, Lipsky PE: Staphylococcal enterotoxin A induces survival of VH3-expressing human B-cells by binding to the Vh ... Kristiansen SV, Pascual V, Lipsky PE: Straphylococcal protein A induces biased production of Ig by VH3-expressing B lymphocytes ... This expansion derived from configurational stability due to antigen binding and somatic mutations, nonconservative mutations ...
  https://arthritis-research.biomedcentral.com/articles/10.1186/ar105
*  METHOD FOR DOUBLE STAINING IN IMMUNOHISTOCHEMISTRY - Patent application
... receptor domain Z of staphylococcal protein A (Nord et al., "Binding Proteins Selected from Combinatorial Libraries of an α- ... binds to a nuclear marker protein for a cancer cell and the second ligand binds to a nuclear cell cycle marker protein, and ... first ligand binds to a nuclear marker protein for a cancer cell and the second ligand binds to a nuclear cell cycle marker ... affibodies for specificity for binding to marker proteins of interest. [0037]The marker proteins of interest, which are to be ...
  http://www.patentsencyclopedia.com/app/20100151447
*  A Mutational Analysis of the Binding of Staphylococcal Enterotoxins B and C3 to the T Cell Receptor β Chain and Major...
1996) A mutational analysis of the binding of two different proteins to the same antibody. Biochemistry 35:9667-9776, pmid: ... staphylococcal enterotoxin A. SEB. staphylococcal enterotoxin B. SEC. staphylococcal enterotoxin C. SED. staphylococcal ... 1991) Staphylococcal toxins bind to different sites on HLA-DR. J Immunol 147:3876-3881, pmid:1940373.. ... As in the case of the wild-type proteins, the binding of all SEC3 and SEB mutants tested was characterized by very fast on- and ...
  http://jem.rupress.org/content/187/6/823