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*  Laminin assembles into separate basement membrane and fibrillar matrices in Schwann cells | Journal of Cell Science
By contrast, β1-integrin did not appear to be required for basement membrane assembly and instead mediated the formation of a ... Talts, J. F., Andac, Z., Gohring, W., Brancaccio, A. and Timpl, R. ( 1999). Binding of the G domains of laminin alpha1 and ... Fibroblasts, even though they secrete basement membrane components, do not assemble their own basement membranes. The data from ... basement membrane (i.e. a laminin-based ECM with classical ultrastructural morphology of a basement membrane, but still lacking ...
  http://jcs.biologists.org/content/115/5/1005
*  FoxC1 is essential for vascular basement membrane integrity and hyaloid vessel morphogenesis
... revealed disruptions in basement membrane integrity. Finally, co-depletion of laminin alpha-1 and foxC1 uncovered a genetic ... together downstream of integrin signaling and were shown to be required for proper maintenance of the basement membrane ... The delay in retinal lamination found in foxC1dMO eyes may also be explained by the lack of a mature basement membrane on the ... We posit that basement membrane defects result in the increased permeability and hemorrhaging in CNS vessels that were observed ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3651675/?lang=en-ca
*  Search Results - - 115 Results - Digital Library
... integrin subunits reduced invasion of a reconstituted basement membrane. Integrins {alpha}1 and {alpha}2, which contributed ... Alpha1 and Alpha2 Integrins Mediate Invasive Activity of Mouse Mammary Carcinoma Cells through Regulation of Stromelysin-1 ... Reciprocal interactions between Beta1-integrin and epidermal growth factor in three-dimensional basement membrane breast ... interfered with cell adhesion to basement membrane constituents. Blocking antibodies against {alpha}1 integrins impaired only ...
  https://digital.library.unt.edu/search/?q5=%22Tumor%20Cells%22&t5=dc_subject&searchType=advanced
*  Anti-TNFα Antibody, clone MPG-XT3 | 05-168
Adhesion to novel basement membrane component BM180 in the presence of laminin-1 promotes stimulus-secretion coupling in ... Anti-laminin-1 antibodies, particularly against sites in the beta1 and gamma1 chains, but not alpha1 chains, partially ... Without effect were RGD peptide and antibodies against entactin, the beta1-integrin subunit, and several growth factors. ... Regulated peroxidase secretion was unaffected by basement membrane coat concentration and was detectable at reduced levels in ...
  http://www.merckmillipore.com/INTL/en/product/Anti-TNF-Antibody-clone-MPG-XT3,MM_NF-05-168
*  Promoting differentiation of cultured myoblasts using biomimetic surfaces that present alpha-laminin-2 peptides | SpringerLink
Sanes JR (2003) The basement membrane/basal lamina of skeletal muscle. J Biol Chem 278:12601-12604CrossRefGoogle Scholar ... a laminin alpha1-derived peptide, interacts with integrins and increases protease activity of a human salivary gland adenoid ... Xu H, Christmas P, Wu XR, Wewer UM, Engvall E (1994a) Defective muscle basement membrane and lack of M-laminin in the ... Ehrig K, Leivo I, Argraves WS, Ruoslahti E, Engvall E (1990) Merosin, a tissue-specific basement membrane protein, is a laminin ...
  https://link.springer.com/article/10.1007%2Fs10616-016-0006-y
*  Collagen, type XVII, alpha 1 - Wikipedia
The membrane proximal part of the ectodomain, within amino acids 506-519, is responsible for binding to alpha 6 integrin, this ... Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane ... Collagen XVII is a homotrimer of three alpha1(XVII)-chains and a transmembrane protein in type II orientation. Each 180 kD a- ... Clinical hallmarks, in addition to blisters and erosions of the skin and mucous membranes, include nail dystrophy, loss of hair ...
  https://en.wikipedia.org/wiki/Collagen,_type_XVII,_alpha_1
*  Molecular analysis of the interaction of LCMV with its cellular receptor α-dystroglycan
DG is expressed in most developing and adult tissues, typically in cell types that adjoin basement membranes (Durbeej et al., ... Restricted distribution of laminin alpha1 chain in normal adult mouse tissues. Matrix Biol. 18:557-568. [PubMed] ... Localization of beta 1 integrins and their extracellular ligands in human lymphoid tissues. Am. J. Pathol. 143:1098-1110. [ ... A role for dystroglycan in basement membrane assembly. Cell. 95:859-870. [PubMed] ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2198839/
*  Collagen-IV and laminin-1 regulate estrogen receptor α expression and function in mouse mammary epithelial cells | Journal of...
... α6 and β1 integrin subunits. Our results indicate that integrin-mediated response to specific basement membrane components, ... Lochter, A., Navre, M., Werb, Z. and Bissell, M. J. (1999). alpha1 and alpha2 integrins mediate invasive activity of mouse ... A reconstituted basement membrane (rBM) stabilizes ERα expression levels in primary mammary epithelial cells. To determine to ... Reconstituted basement membrane (rBM) allows partial maintenance of ERα protein levels in primary mammary epithelial cells, but ...
  http://jcs.biologists.org/content/116/14/2975
*  Laminin, alpha 5 - Wikipedia
... a possible mechanism of basement membrane and integrin alterations". The American Journal of Pathology. 158 (2): 723-34. doi: ... Pierce RA, Griffin GL, Miner JH, Senior RM (Dec 2000). "Expression patterns of laminin alpha1 and alpha5 in human lung during ... affinity-purified human meprin alpha is functionally active and cleaves components of the basement membrane in vitro". FEBS ... protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. ...
  https://en.wikipedia.org/wiki/Laminin,_alpha_5
*  Laminin, gamma 1 - Wikipedia
1999). "Absence of basement membranes after targeting the LAMC1 gene results in embryonic lethality due to failure of endoderm ... 2000). "Integrin binding specificity of laminin-10/11: laminin-10/11 are recognized by alpha 3 beta 1, alpha 6 beta 1 and alpha ... 2000). "Posttranslational modifications and beta/gamma chain associations of human laminin alpha1 and laminin alpha5 chains: ... Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They ...
  https://en.wikipedia.org/wiki/Laminin,_gamma_1
*  Laminin, alpha 1 - Wikipedia
Leivo I, Engvall E (1986). "C3d fragment of complement interacts with laminin and binds to basement membranes of glomerulus and ... "The N-terminal globular domain of the laminin alpha1 chain binds to alpha1beta1 and alpha2beta1 integrins and to the heparan ... Laminin subunit alpha-1 is a protein that in humans is encoded by the LAMA1 gene. Laminin, alpha 1 has been shown to interact ... O'Grady P, Thai TC, Saito H (1998). "The Laminin-Nidogen Complex is a Ligand for a Specific Splice Isoform of the Transmembrane ...
  https://en.wikipedia.org/wiki/Laminin,_alpha_1
*  Laminin - Wikipedia
They also bind to cell membranes through integrin receptors and other plasma membrane molecules, such as the dystroglycan ... macro-plaques or mini-basement membranes in human term fetal membranes?". Philosophical Transactions of the Royal Society of ... For example, the laminin alpha1 and alpha2 chains each have five C-terminal laminin G domains, where only domains LG4 and LG5 ... Basement membrane assembly is a cooperative process in which laminins polymerise through their N-terminal domain (LN or domain ...
  https://en.wikipedia.org/wiki/Laminin
*  Collagen-derived matricryptins promote inhibitory nerve terminal formation in the developing neocortex | JCB
Basement membranes: structure, assembly and role in tumour angiogenesis. Nat. Rev. Cancer. 3:422-433. doi:10.1038/nrc1094. ... rabbit anti-integrin α3 (diluted 1:1,000 for IHC and 1:3,000 for Western blot; EMD Millipore), rat anti-integrin β1 (diluted 1: ... Ubiquitous expression of the alpha1(XIX) collagen gene (Col19a1) during mouse embryogenesis becomes restricted to a few tissues ... Esophageal muscle physiology and morphogenesis require assembly of a collagen XIX-rich basement membrane zone. J. Cell Biol. ...
  http://jcb.rupress.org/content/212/6/721
*  Infection of Dendritic Cells by Lymphocytic Choriomeningitis Virus | Springer for Research & Development
Kramer R. H, Rosen S. D, and McDonald K. A. (1988). Basement-membrane components associated with the extracellular matrix of ... van den Berg T. K, van der Ende M, Dopp E. A, Kraal G, and Dijkstra C. D. (1993). Localization of beta 1 integrins and their ... Talts J. F, Andac Z, Gohring W, Brancaccio A, and Timpl R. (1999). Binding of the G domains of laminin alpha1 and alpha2 chains ... A role for dystroglycan in basement membrane assembly. Cell 95 859-870PubMedCrossRefGoogle Scholar ...
  https://rd.springer.com/chapter/10.1007/978-3-662-06508-2_6
*  Laminin, beta 1 - Wikipedia
Lohi J, Leivo I, Franssila K, Virtanen I (1997). "Changes in the distribution of integrins and their basement membrane ligands ... 2000). "Posttranslational modifications and beta/gamma chain associations of human laminin alpha1 and laminin alpha5 chains: ... Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1 ... Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They ...
  https://en.wikipedia.org/wiki/Laminin,_beta_1
*  Functional Impact of Collagens on the Activity Directed by the Promoter of the α5 Integrin Subunit Gene in Corneal Epithelial...
Disruption of the basement membrane after corneal debridement. Invest Ophthalmol Vis Sci. 2000 ; 41: 1045-1053. ... Human alpha1 type IV collagen NC1 domain exhibits distinct antiangiogenic activity mediated by alpha1beta1 integrin. J Clin ... Rewiring Integrin-Mediated Signaling and Cellular Response with the Peripheral Myelin Protein 22 and Epithelial Membrane ... Martin GR, Timpl R. Laminin and other basement membrane components. Annu Rev Cell Biol. 1987 ; 3: 57-85. ...
  https://iovs.arvojournals.org/article.aspx?articleid=2451413
*  WikiGenes - GLYCOPROTEIN - (2S)-2-acetamido-N'-[(3R,4R,5S,6R)-3...
Properties of a basement membrane-related glycoprotein synthesized in culture by a mouse embryonal carcinoma-derived cell line. ... The Drosophila PS2 antigen is an invertebrate integrin that, like the fibronectin receptor, becomes localized to muscle ... Effect of electroconvulsive therapy on serum concentration of alpha-1-acid glycoprotein. DeVane, C.L., Lim, C., Carson, S.W., ... Properties of a basement membrane-related glycoprotein synthesized in culture by a mouse embryonal carcinoma-derived cell line ...
  http://www.wikigenes.org/e/chem/e/439212.html
*  Collagen, type VI, alpha 1 - Wikipedia
Kuo HJ, Maslen CL, Keene DR, Glanville RW (1997). "Type VI collagen anchors endothelial basement membranes by interacting with ... Collagen alpha-1(VI) chain is a protein that in humans is encoded by the COL6A1 gene. The collagens are a superfamily of ... is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins ... The basic structural unit of collagen VI is a heterotrimer of the alpha1(VI), alpha2(VI), and alpha3(VI) chains. The alpha2(VI ...
  https://en.wikipedia.org/wiki/Collagen,_type_VI,_alpha_1
*  NC1 Long and NC3 Short Splice Variants of Type XII Collagen Are Overexpressed during Corneal Scarring | IOVS | ARVO Journals
... head arrow points to preserved basement membrane, arrow points to reformed irregular basement membrane. (C, D) Central stroma. ... El-Shabrawi Y Kublin CL Cintron C. mRNA levels of alpha1(VI) collagen, alpha1(XII) collagen, and beta Ig in rabbit cornea ... Bystrom B Carracedo S Behndig A Gullberg D Pedrosa-Domellof F. Alpha11 integrin in the human cornea: importance in development ... head arrow points to preserved basement membrane, arrow points to reformed irregular basement membrane. (C, D) Central stroma. ...
  https://iovs.arvojournals.org/article.aspx?articleid=2127852
*  Vanderbilt Center for Kidney Disease
Selective binding of integrins from different renal cell types to the NC1 domain of alpha3 and alpha1 chains of type IV ... Glomerular basement membrane. Identification of a fourth chain, alpha 4, of type IV collagen.. Gunwar S, Saus J, Noelken ME, ... Glomerular basement membrane: evidence for collagenous domain of the alpha 3 and alpha 4 chains of collagen IV.. Fagg WR, ... Bovine glomerular basement membrane. Properties of the collagenous domain.. West TW, Fox JW, Jodlowski M, Freytag JW, Hudson BG ...
  http://www.vckd.org/vckd-members/billy-hudson
*  Antiangiogenic gene therapy of cancer: recent developments | Journal of Translational Medicine | Full Text
Other basement membrane cleavage products include vastatin, a fragment of the NC1 domain of collagen VIII. Vastatin was shown ... 26-kDa NC1 domain of the alpha1 chain of type IV collagen, activity mediated by alpha1beta1 integrin ... Kalluri R: Basement membranes: structure, assembly and role in tumour angiogenesis. Nat Rev Cancer. 2003, 3: 422-433. 10.1038/ ... The picture of integrins and their ligands is very complex. The αvβ3 integrin is expressed on proliferating ECs such as those ...
  https://translational-medicine.biomedcentral.com/articles/10.1186/1479-5876-2-22
*  Perineurial glia regulate morphology of the Drosophila nervous system - UBC Library Open Collections
1.5) in that axons are insulated by multiple layers of glial membrane and surrounded by a basement membrane. Axons in ... Furthermore, we demonstrate that basigin is located in a complex with integrin and may bind integrin directly in cis. We were ... alpha1. J Biol Chem 271, 18074--‐18081. Takagi, Y., Ui--‐Tei, K., Miyake, T., and Hirohashi, S. (1998). Laminin--‐dependent ... required for basement membrane initiation and is responsible for recruiting other ECM proteins to assemble basement membranes, ...
  https://open.library.ubc.ca/cIRcle/collections/ubctheses/24/items/1.0300655
*  Collagen, type XVIII, alpha 1 - Wikipedia
... against multiplexin collagens demonstrate that type XV and XVIII collagens are expressed in specialized basement membranes". ... Collagen alpha-1(XVIII) chain is a protein that in humans is encoded by the COL18A1 gene. This gene encodes the alpha chain of ... 2001). "Interaction of endostatin with integrins implicated in angiogenesis". Proc. Natl. Acad. Sci. U.S.A. 98 (3): 1024-9. doi ... 1998). "Zinc-dependent dimers observed in crystals of human endostatin". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10443-8. doi: ...
  https://en.wikipedia.org/wiki/Collagen,_type_XVIII,_alpha_1
*  Partial epithelial-mesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming...
However, evidence of basement membrane breakdown in keloid scar was not observed. The results suggest that keloid keratinocytes ... The apparent gaps in laminin-332 and integrin α6 basement membrane staining were likely due to the absence of detectable ... SMAD and p38 MAPK signaling pathways independently regulate alpha1(I) collagen gene expression in unstimulated and transforming ... Analysis of basement membrane integrity in keloid scars. Basement membrane breakdown is a critical step in type I EMT during ...
  https://burnstrauma.biomedcentral.com/articles/10.1186/s41038-016-0055-7
*  PRL-3 promotes the motility, invasion, and metastasis of LoVo colon cancer cells through PRL-3-integrin β1-ERK1/2 and-MMP2...
Knockdown of integrin β1 by siRNA or lentivirus were detected with Western blot and RT-PCR. The effect of PRL-3 on integrin β1 ... Depletion of integrin β1 with siRNA, not only abrogated the activation of ERK1/2 stimulated by PRL-3, but also abolished PRL-3- ... Moreover, PRL-3-stimulated lung metastasis of LoVo cells in a nude mouse model was inhibited when integrin β1 expression was ... In our previous study, we observed that PRL-3 could decrease tyrosine phosphorylation of integrin β1 and enhance activation of ...
  https://molecular-cancer.biomedcentral.com/articles/10.1186/1476-4598-8-110