*  Laminin assembles into separate basement membrane and fibrillar matrices in Schwann cells | Journal of Cell Science
By contrast, β1-integrin did not appear to be required for basement membrane assembly and instead mediated the formation of a ... Talts, J. F., Andac, Z., Gohring, W., Brancaccio, A. and Timpl, R. ( 1999). Binding of the G domains of laminin alpha1 and ... Fibroblasts, even though they secrete basement membrane components, do not assemble their own basement membranes. The data from ... basement membrane (i.e. a laminin-based ECM with classical ultrastructural morphology of a basement membrane, but still lacking ...
  http://jcs.biologists.org/content/115/5/1005
*  FoxC1 is essential for vascular basement membrane integrity and hyaloid vessel morphogenesis
... revealed disruptions in basement membrane integrity. Finally, co-depletion of laminin alpha-1 and foxC1 uncovered a genetic ... together downstream of integrin signaling and were shown to be required for proper maintenance of the basement membrane ... The delay in retinal lamination found in foxC1dMO eyes may also be explained by the lack of a mature basement membrane on the ... We posit that basement membrane defects result in the increased permeability and hemorrhaging in CNS vessels that were observed ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3651675/?lang=en-ca
*  Collagen, type XVII, alpha 1 - Wikipedia
The membrane proximal part of the ectodomain, within amino acids 506-519, is responsible for binding to alpha 6 integrin, this ... Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane ... Collagen XVII is a homotrimer of three alpha1(XVII)-chains and a transmembrane protein in type II orientation. Each 180 kD a- ... Clinical hallmarks, in addition to blisters and erosions of the skin and mucous membranes, include nail dystrophy, loss of hair ...
  https://en.wikipedia.org/wiki/Collagen,_type_XVII,_alpha_1
*  Molecular analysis of the interaction of LCMV with its cellular receptor α-dystroglycan
DG is expressed in most developing and adult tissues, typically in cell types that adjoin basement membranes (Durbeej et al., ... Restricted distribution of laminin alpha1 chain in normal adult mouse tissues. Matrix Biol. 18:557-568. [PubMed] ... Localization of beta 1 integrins and their extracellular ligands in human lymphoid tissues. Am. J. Pathol. 143:1098-1110. [ ... A role for dystroglycan in basement membrane assembly. Cell. 95:859-870. [PubMed] ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2198839/
*  Collagen-IV and laminin-1 regulate estrogen receptor α expression and function in mouse mammary epithelial cells | Journal of...
... α6 and β1 integrin subunits. Our results indicate that integrin-mediated response to specific basement membrane components, ... Lochter, A., Navre, M., Werb, Z. and Bissell, M. J. (1999). alpha1 and alpha2 integrins mediate invasive activity of mouse ... A reconstituted basement membrane (rBM) stabilizes ERα expression levels in primary mammary epithelial cells. To determine to ... Reconstituted basement membrane (rBM) allows partial maintenance of ERα protein levels in primary mammary epithelial cells, but ...
  http://jcs.biologists.org/content/116/14/2975
*  Laminin, alpha 5 - Wikipedia
... a possible mechanism of basement membrane and integrin alterations". The American Journal of Pathology. 158 (2): 723-34. doi: ... Pierce RA, Griffin GL, Miner JH, Senior RM (Dec 2000). "Expression patterns of laminin alpha1 and alpha5 in human lung during ... affinity-purified human meprin alpha is functionally active and cleaves components of the basement membrane in vitro". FEBS ... protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. ...
  https://en.wikipedia.org/wiki/Laminin,_alpha_5
*  Laminin, gamma 1 - Wikipedia
1999). "Absence of basement membranes after targeting the LAMC1 gene results in embryonic lethality due to failure of endoderm ... 2000). "Integrin binding specificity of laminin-10/11: laminin-10/11 are recognized by alpha 3 beta 1, alpha 6 beta 1 and alpha ... 2000). "Posttranslational modifications and beta/gamma chain associations of human laminin alpha1 and laminin alpha5 chains: ... Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They ...
  https://en.wikipedia.org/wiki/Laminin,_gamma_1
*  Laminin - Wikipedia
They also bind to cell membranes through integrin receptors and other plasma membrane molecules, such as the dystroglycan ... macro-plaques or mini-basement membranes in human term fetal membranes?". Philosophical Transactions of the Royal Society of ... For example, the laminin alpha1 and alpha2 chains each have five C-terminal laminin G domains, where only domains LG4 and LG5 ... Basement membrane assembly is a cooperative process in which laminins polymerise through their N-terminal domain (LN or domain ...
  https://en.wikipedia.org/wiki/Laminin
*  Laminin, alpha 1 - Wikipedia
Leivo I, Engvall E (1986). "C3d fragment of complement interacts with laminin and binds to basement membranes of glomerulus and ... "The N-terminal globular domain of the laminin alpha1 chain binds to alpha1beta1 and alpha2beta1 integrins and to the heparan ... Laminin subunit alpha-1 is a protein that in humans is encoded by the LAMA1 gene. Laminin, alpha 1 has been shown to interact ... O'Grady P, Thai TC, Saito H (1998). "The Laminin-Nidogen Complex is a Ligand for a Specific Splice Isoform of the Transmembrane ...
  https://en.wikipedia.org/wiki/Laminin,_alpha_1
*  Infection of Dendritic Cells by Lymphocytic Choriomeningitis Virus | Springer for Research & Development
Kramer R. H, Rosen S. D, and McDonald K. A. (1988). Basement-membrane components associated with the extracellular matrix of ... van den Berg T. K, van der Ende M, Dopp E. A, Kraal G, and Dijkstra C. D. (1993). Localization of beta 1 integrins and their ... Talts J. F, Andac Z, Gohring W, Brancaccio A, and Timpl R. (1999). Binding of the G domains of laminin alpha1 and alpha2 chains ... A role for dystroglycan in basement membrane assembly. Cell 95 859-870PubMedCrossRefGoogle Scholar ...
  https://rd.springer.com/chapter/10.1007/978-3-662-06508-2_6
*  Laminin, beta 1 - Wikipedia
Lohi J, Leivo I, Franssila K, Virtanen I (1997). "Changes in the distribution of integrins and their basement membrane ligands ... 2000). "Posttranslational modifications and beta/gamma chain associations of human laminin alpha1 and laminin alpha5 chains: ... Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1 ... Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They ...
  https://en.wikipedia.org/wiki/Laminin,_beta_1
*  Collagen, type VI, alpha 1 - Wikipedia
Kuo HJ, Maslen CL, Keene DR, Glanville RW (1997). "Type VI collagen anchors endothelial basement membranes by interacting with ... Collagen alpha-1(VI) chain is a protein that in humans is encoded by the COL6A1 gene. The collagens are a superfamily of ... is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins ... The basic structural unit of collagen VI is a heterotrimer of the alpha1(VI), alpha2(VI), and alpha3(VI) chains. The alpha2(VI ...
  https://en.wikipedia.org/wiki/Collagen,_type_VI,_alpha_1
*  Antiangiogenic gene therapy of cancer: recent developments | Journal of Translational Medicine | Full Text
Other basement membrane cleavage products include vastatin, a fragment of the NC1 domain of collagen VIII. Vastatin was shown ... 26-kDa NC1 domain of the alpha1 chain of type IV collagen, activity mediated by alpha1beta1 integrin ... Kalluri R: Basement membranes: structure, assembly and role in tumour angiogenesis. Nat Rev Cancer. 2003, 3: 422-433. 10.1038/ ... The picture of integrins and their ligands is very complex. The αvβ3 integrin is expressed on proliferating ECs such as those ...
  https://translational-medicine.biomedcentral.com/articles/10.1186/1479-5876-2-22
*  Perineurial glia regulate morphology of the Drosophila nervous system - UBC Library Open Collections
1.5) in that axons are insulated by multiple layers of glial membrane and surrounded by a basement membrane. Axons in ... Furthermore, we demonstrate that basigin is located in a complex with integrin and may bind integrin directly in cis. We were ... alpha1. J Biol Chem 271, 18074--‐18081. Takagi, Y., Ui--‐Tei, K., Miyake, T., and Hirohashi, S. (1998). Laminin--‐dependent ... required for basement membrane initiation and is responsible for recruiting other ECM proteins to assemble basement membranes, ...
  https://open.library.ubc.ca/cIRcle/collections/ubctheses/24/items/1.0300655
*  Collagen, type XVIII, alpha 1 - Wikipedia
... against multiplexin collagens demonstrate that type XV and XVIII collagens are expressed in specialized basement membranes". ... Collagen alpha-1(XVIII) chain is a protein that in humans is encoded by the COL18A1 gene. This gene encodes the alpha chain of ... 2001). "Interaction of endostatin with integrins implicated in angiogenesis". Proc. Natl. Acad. Sci. U.S.A. 98 (3): 1024-9. doi ... 1998). "Zinc-dependent dimers observed in crystals of human endostatin". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10443-8. doi: ...
  https://en.wikipedia.org/wiki/Collagen,_type_XVIII,_alpha_1
*  Publikationen - Zentrum für Zahn-, Mund- und Kieferheilkunde
Basement membrane deposition of nidogen 1 but not nidogen 2 requires the nidogen binding module of the laminin γ1 chain.. J. ... Alpha1(XX) collagen: a new member of the FACIT subfamily of collagens. J. Biol. Chem. 276(25):23120-23126 (2001) ... Integrin a3 subunit regulates events linked to epithelial repair, including keratinocyte migration and protein expression. ... The epidermal basement membrane is a composite of separate laminin- or collagen IV-containing networks connected by aggregated ...
  http://zahnklinik.uk-koeln.de/institut-fuer-orale-und-muskuloskeletale-biologie/forschung/
*  Epidermolysis bullosa
Localizes to the anchoring filaments of the lamina lucida and also within the lamina densa of the basement membrane zone. ... Alpha6beta4 integrin-Beta 4 integrin subunit is noncovalently bound to alpha6 subunit. Trasmembrane alpha6beta4 integrin ... wild-type protein that destabilizes trimerization of pro-alpha1 (VII) chains and disturbs anchoring fibril assembly ... Collagen VII-Collagen variant present in the skin basement membrane within the anchoring fibrils. COL7A1 gene encodes for the ...
  http://www.thedoctorsdoctor.com/diseases/epidermolysis_bullosa.htm
*  2015 Group 5 Project - CellBiology
These Laminin- 332 molecules act as anchoring filaments holding the integrin molecules down toward the basement membrane.This ... J F Talts, Z Andac, W Göhring, A Brancaccio, R Timpl Binding of the G domains of laminin alpha1 and alpha2 chains and perlecan ... an important aspect in the assembly of the basement membrane. With the β1 and γ1 chains of Laminin 111 no basement membranes ... Normally in the cutaneous basement membrane zone (BMZ) the transmembrane protein α6β4 integrin located in hemidesmosomes enters ...
  https://cellbiology.med.unsw.edu.au/cellbiology/index.php/2015_Group_5_Project
*  Plus it
... and αvβ8 integrins (22-24). Integrins, heterodimeric membrane glycoproteins composed of α and β subunits, promote cell ... Activation of the FAK-src molecular scaffolds and p130Cas-JNK signaling cascades by alpha1-integrins during colon cancer cell ... Tight glycemic control regulates fibronectin expression and basement membrane thickening in retinal and glomerular capillaries ... Integrin subunits (integrin αv, α1, α3, α5, β1, β3; Abcam, Cambridge, U.K.) were immobilized on the antibodies to integrins for ...
  http://diabetes.diabetesjournals.org/content/61/6/1599
*  Collagen - Wikipedia
Basement membrane (Type IV) Multiplexin (Multiple Triple Helix domains with Interruptions) (Type XV, XVIII) MACIT (Membrane ... Collagen may be attached to cell membranes via several types of protein, including fibronectin and integrin. Vitamin C ... Triple alpha helical structure is formed inside the endoplasmic reticulum from two alpha-1 chains and one alpha-2 chain. ... Alport Syndrome and Thin Basement Membrane Nephropathy Archived 2017-12-25 at the Wayback Machine.)", in RA Pagon, TD Bird, CR ...
  https://en.wikipedia.org/wiki/Collagen
*  Gene Expression Literature Summary - MGI
O-glycosylation modulates integrin and FGF signalling by influencing the secretion of basement membrane components. Nat Commun ... Laminin alpha1 is essential for mouse cerebellar development. Matrix Biol. 2012 Jan;31(1):17-28 ... J:154054 Lange A, Wickstrom SA, Jakobson M, Zent R, Sainio K, Fassler R, Integrin-linked kinase is an adaptor with essential ... J:229358 Teo ZL, McQueen-Miscamble L, Turner K, Martinez G, Madakashira B, Dedhar S, Robinson ML, de Iongh RU, Integrin linked ...
  http://www.informatics.jax.org/gxdlit/marker/MGI:87986
*  RECOMBINANT LAMININ-521 - Patent application
0003] Basal laminae (basement membranes) are sheet-like, cell-associated extracellular matrices that play a central role in ... 0239] It has been demonstrated that α6 and β1 integrins are the most abundantly expressed integrin isoforms in human ES cells ... that contains alpha-1, beta-1 and gamma-1 chains. Four structurally defined family groups of laminins have been identified. The ... These properties are illustrated by the kidney glomerular basement membrane, which functions as an important filtration ...
  http://www.patentsencyclopedia.com/app/20120156254
*  The β-Cell/EC Axis: How Do Islet Cells Talk to Each Other? | Diabetes
The vascular basement membrane: a niche for insulin gene expression and beta cell proliferation. Dev Cell 2006;10:397-405pmid: ... Expression of alpha-1 proteinase inhibitor in human islet microvascular endothelial cells. Diabetes 1999;48:1773-1778pmid: ... Blockade of beta1 integrin-laminin-5 interaction affects spreading and insulin secretion of rat beta-cells attached on ... The peri-islet basement membrane, a barrier to infiltrating leukocytes in type 1 diabetes in mouse and human. Diabetes 2013;62: ...
  http://diabetes.diabetesjournals.org/content/63/1/3.full
*  Plus it
7 D). In the βcyt/ βcyt mice, laminin was normally expressed at basement membrane interfaces formed by glial endfeet (Fig. 7 F ... 2007) Beta1 integrins in radial glia but not in migrating neurons are essential for the formation of cell layers in the ... 2005) Laminin-alpha1 globular domains 3 and 4 induce heterotrimeric G protein binding to alpha-syntrophin's PDZ domain and ... Dystroglycan stabilizes the basement membrane at the glia limitans and thus supports the cellular infrastructure necessary for ...
  http://www.jneurosci.org/content/30/43/14560