*  Caspase 8 - Wikipedia
The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD ... Guo Y, Srinivasula SM, Druilhe A, Fernandes-Alnemri T, Alnemri ES (April 2002). "Caspase-2 induces apoptosis by releasing ... a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death". Proc. Natl. Acad ... Zhan Y, Hegde R, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES (April 2002). "Death effector domain-containing proteins DEDD ...
  https://en.wikipedia.org/wiki/CASP8
*  Bcl-2-interacting killer - Wikipedia
This protein shares a critical BH3 domain with other death-promoting proteins, BAX and BAK. Bcl-2-interacting killer has been ... encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)". EMBO ... Hegde R, Srinivasula SM, Ahmad M, Fernandes-Alnemri T, Alnemri ES (1998). "Blk, a BH3-containing mouse protein that interacts ... a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and ...
  https://en.wikipedia.org/wiki/Bcl-2-interacting_killer
*  Decoy receptor 3 - Wikipedia
The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death and T cell ... Unlike most of the other members of TNFR superfamily, TNFRSF6 is a soluble protein which contains no transmembrane domain. This ... is a soluble protein of the tumor necrosis factor receptor superfamily which inhibits Fas ligand-induced apoptosis. Dcr3 was ... TNFRSF6B has been shown to interact with: TNFSF14 Fas ligand. GRCh38: Ensembl release 89: ENSG00000243509 - Ensembl, May 2017 " ...
  https://en.wikipedia.org/wiki/Decoy_receptor_3
*  DEDD - Wikipedia
Zhan Y, Hegde R, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES (2002). "Death effector domain-containing proteins DEDD and ... At least three transcript variants encoding the same protein have been found for this gene. DEDD has been shown to interact ... Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from ... This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by ...
  https://en.wikipedia.org/wiki/DEDD
*  Highly parallel identification of essential genes in cancer cells | Proceedings of the National Academy of Sciences
1995) FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81: ... Lander ES, *Sabatini DM. (2006) Genome-scale loss-of-function screening with a lentiviral RNAi library. Nat Methods 3:715-719. ... 1996) Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell 85: ... p300/CREB binding protein-related protein p270 is a component of mammalian SWI/SNF complexes. Mol Cell Biol 18:3596-3603. ...
  http://www.pnas.org/content/105/51/20380
*  CRADD - Wikipedia
The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. ... Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction ... Guo Y, Srinivasula SM, Druilhe A, Fernandes-Alnemri T, Alnemri ES (2002). "Caspase-2 induces apoptosis by releasing ... Death domain-containing protein CRADD is a protein that in humans is encoded by the CRADD gene. ...
  https://en.wikipedia.org/wiki/CRADD
*  Caspase-14, an apoptotic protease, nucleic acids encoding and methods of use - Patent # 6432628 - PatentGenius
... a Novel Death Domain-Containing Protein Interacts with the Death Doamin of Fas and Initiates Apoptosis," Cell 81: 505-512, 1995 ... The EST is a sequence of 483 nucleotides in length.. The EST was derived from a mouse cell clone, which was obtained from IMAGE ... "A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain," J. ... Apoptosis, also referred to as physiological cell death or programmed cell death, is a normal physiological process of cell ...
  http://www.patentgenius.com/patent/6432628.html
*  Caspase 3 - Wikipedia
... a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death". Proceedings of ... Guo Y, Srinivasula SM, Druilhe A, Fernandes-Alnemri T, Alnemri ES (April 2002). "Caspase-2 induces apoptosis by releasing ... Suzuki Y, Nakabayashi Y, Takahashi R (July 2001). "Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein ... "Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis". ...
  https://en.wikipedia.org/wiki/Caspase_3
*  GLUT4 - Wikipedia
GLUT4 has been shown to interact with death-associated protein 6, also known as Daxx. Daxx, which is used to regulate apoptosis ... allowing for Rab protein to change from its GDP to GTP bound state. Inhibition of the GTPase-activating domain leaves proteins ... Glycolysis and Gluconeogenesis edit]] The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_ ... UBX-domains, such as the one found in GLUT4, have been shown to associate with apoptotic signaling. So this interaction aids in ...
  https://en.wikipedia.org/wiki/GLUT4
*  Fas receptor - Wikipedia
... a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis". Cell. 81 (4): 505-12 ... MacFarlane M, Ahmad M, Srinivasula SM, Fernandes-Alnemri T, Cohen GM, Alnemri ES (October 1997). "Identification and molecular ... This allows the adaptor molecule FADD to bind the death domain of Fas through its own death domain. FADD also contains a death ... "Apoptosis-linked gene 2 binds to the death domain of Fas and dissociates from Fas during Fas-mediated apoptosis in Jurkat cells ...
  https://en.wikipedia.org/wiki/Fas_receptor
*  Myc - Wikipedia
Structure[edit]. Myc protein belongs to Myc family of transcription factors, which also includes N-Myc and L-Myc genes. Myc ... Billin AN, Eilers AL, Queva C, Ayer DE (December 1999). "Mlx, a novel Max-like BHLHZip protein that interacts with the Max ... upregulates ribosomal RNA and proteins), apoptosis (downregulates Bcl-2), differentiation, and stem cell self-renewal. Myc is a ... Pelengaris S, Khan M, Evan G (October 2002). "c-MYC: more than just a matter of life and death". Nature Reviews. Cancer. 2 (10 ...
  https://en.wikipedia.org/wiki/C-myc
*  A novel role for Gab2 in bFGF-mediated cell survival during retinoic acid-induced neuronal differentiation
... domain, a central proline-rich domain, and multiple tyrosine residues that are recognized by SH2 domain-containing proteins. ... We confirmed that cell death occurred via apoptosis by Annexin-V (Fig. 2 C) and Hoechst (not depicted) staining. In agreement ... Gab2 was cloned as an SHP2 interacting protein and binds to many of the same proteins as Gab1. It functions in many cellular ... We determined the number of ES cells that survived differentiation in the presence or absence of PD173074. For both P19 and ES ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2171408/?lang=en-ca
*  Geminin - Wikipedia
"A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition". ... Yellajoshyula D, Patterson ES, Elitt MS, Kroll KL (2011). "Geminin promotes neural fate acquisition of embryonic stem cells by ... Since geminin knockdown leads to cell death in many cancer cell lines but not primary cell lines, it has been proposed as a ... Geminin, DNA replication inhibitor, also known as GMNN, is a protein in humans encoded by the GMNN gene. Geminin is a nuclear ...
  https://en.wikipedia.org/wiki/Geminin
*  The cell biology of autophagy in metazoans: a developing story | Development
... elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9. Cell 93,519 -529. ... domain. In C. elegans, EGL-1 functions as a positive regulator of apoptosis by interacting directly with the anti-apoptotic CED ... In an in vitro model of mouse embryonic cavitation using embryoid bodies derived from ES cells, it was found that disruption of ... Also referred to as type II programmed cell death, autophagic cell death is distinguished from type I (apoptotic) cell death by ...
  http://dev.biologists.org/content/135/14/2347
*  Bcl-2 - Wikipedia
Apoptosis Apoptosome Bcl-2 homologous antagonist killer (BAK) Bcl-2-associated X protein (BAX) Bcl-xL BH3 interacting domain ... is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inducing (pro- ... Guo Y, Srinivasula SM, Druilhe A, Fernandes-Alnemri T, Alnemri ES (Apr 2002). "Caspase-2 induces apoptosis by releasing ... encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)". The ...
  https://en.wikipedia.org/wiki/Bcl-2
*  APAF1 - Wikipedia
This protein contains (from the N terminal) a caspase recruitment domain (CARD), an ATPase domain (NB-ARC), few short helical ... Song Q, Kuang Y, Dixit VM, Vincenz C (Jan 1999). "Boo, a novel negative regulator of cell death, interacts with Apaf-1". The ... This gene encodes a cytoplasmic protein that forms one of the central hubs in the apoptosis regulatory network. ... Slee EA, Harte MT, Kluck RM, Wolf BB, Casiano CA, Newmeyer DD, Wang HG, Reed JC, Nicholson DW, Alnemri ES, Green DR, Martin SJ ...
  https://en.wikipedia.org/wiki/APAF1
*  Bcl2l11 - Bcl-2-like protein 11 - Mus musculus (Mouse) - Bcl2l11 gene & protein
Induces apoptosis and anoikis. The isoforms vary in cytotoxicity with isoform BimS being the most potent and isoform BimEL ... View protein in InterPro. IPR014771. Apoptosis_Bim_N. IPR017288. Bcl-2-like_11. IPR015040. Bcl-x_interacting_BH3_dom. IPR036834 ... Index of protein domains and families ,p>This will take you to the BLAST page where you can edit options ,/p>,p>,a href="/help/ ... "Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 ( ...
  http://www.uniprot.org/uniprot/O54918
*  Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis
... specifically in inhibition of cell death by necrosis. Cell death is generally classified as either apoptosis or necrosis, a ... Our findings identify a role for EYA4 and possibly interacting SIX and DACH proteins in MPNSTs and suggest the EYA4 pathway as ... Kroemer G, Galluzzi L, Vandenabeele P, Abrams J, Alnemri ES, Baehrecke EH, et al. Classification of cell death: recommendations ... The NF1-GAP related domain (GRD) regulates expression of DACH1 in MPNST cells. The NF1-GRD is the best characterized domain of ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2809821/
*  Occludin - Wikipedia
These 5 domains are separated by the 4 transmembrane domains of the protein. The nine domains are as follows: N-terminus domain ... "Occludin is required for apoptosis when claudin-claudin interactions are disrupted." Cell death & disease 3.2 (2012): e273. ... Occludin has been shown to interact with Tight junction protein 2, YES1 and Tight junction protein 1. ENSG00000273814 GRCh38: ... Wittchen ES, Haskins J, Stevenson BR (2000). "Protein interactions at the tight junction. Actin has multiple binding partners, ...
  https://en.wikipedia.org/wiki/Occludin
*  XIAP - Wikipedia
... receptor-interacting mage homologue is an inducible inhibitor of apoptosis protein-interacting protein that augments cell death ... three BIR domains and a RING finger were found on the protein, which became known as X-linked Inhibitor of Apoptosis Protein. ... Deveraux QL, Roy N, Stennicke HR, Van Arsdale T, Zhou Q, Srinivasula SM, Alnemri ES, Salvesen GS, Reed JC (April 1998). "IAPs ... X-linked inhibitor of apoptosis protein (XIAP), also known as inhibitor of apoptosis protein 3 (IAP3) and baculoviral IAP ...
  https://en.wikipedia.org/wiki/XIAP
*  Caspase-9 - Wikipedia
Davoodi J, Lin L, Kelly J, Liston P, MacKenzie AE (September 2004). "Neuronal apoptosis-inhibitory protein does not interact ... The N-terminal pro-domain is also called the long pro-domain and this contains the caspase activation domain (CARD) motif. The ... a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 ... Guo Y, Srinivasula SM, Druilhe A, Fernandes-Alnemri T, Alnemri ES (April 2002). "Caspase-2 induces apoptosis by releasing ...
  https://en.wikipedia.org/wiki/Caspase-9
*  Genomic Alterations in Human Malignant Glioma Cells Associate with the Cell Resistance to the Combination Treatment with Tumor...
FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 1995;81:505 ... MacFarlane M, Ahmad M, Srinivasula SM, Fernandes-Alnemri T, Cohen GM, Alnemri ES. Identification and molecular cloning of two ... TRAIL interacts with its death receptors DR4 and DR5 to recruit intracellular Fas-associated death domain (FADD; ref. 12) and ... 19, 20). In the cytosol, Smac interacts with X-linked inhibitor of apoptosis protein to release its inhibition of caspase-3 (17 ...
  http://clincancerres.aacrjournals.org/content/12/9/2716
*  ADP-ribosylation - Wikipedia
... in multi-protein complexes with A and B domains not directly interacting, prior to processing. Upon activation, bAREs ADP- ... synthesis in cells undergoing apoptosis: an attempt to face death before PARP degradation". European Journal of Histochemistry ... Scarpa ES, Fabrizio G, Di Girolamo M (2013). ". A role in intracellular mono-ADP-ribosylation in cancer biology". FEBS Journal ... as single polypeptide chains with A and B domains covalently linked; second, in multi-protein complexes with A and B domains ...
  https://en.wikipedia.org/wiki/ADP-ribosylation
*  Death receptor 5 - Wikipedia
... a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. DR5 has been shown to ... MacFarlane M, Ahmad M, Srinivasula SM, Fernandes-Alnemri T, Cohen GM, Alnemri ES (Oct 1997). "Identification and molecular ... interact with: Caspase 8, Caspase 10, FADD, and TRAIL. Monoclonal antibodies targeting DR5 have been developed and are ... The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This ...
  https://en.wikipedia.org/wiki/Death_receptor_5
*  Baculoviral IAP repeat-containing protein 3 - Wikipedia
2001). "A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death". Mol. Cell. 8 ... The cIAP2 protein contains three BIR domains, a UBA domain, a CARD domain and a RING finger domain. Transcript variants ... The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to ... Alnemri ES, Salvesen GS, Reed JC (1998). "IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct ...
  https://en.wikipedia.org/wiki/Baculoviral_IAP_repeat-containing_protein_3