The Cardiac Renin-Angiotensin System | Circulation Research
Xiang J, Linz W, Becker H, Ganten D, Lang RE, Scholkens B, Unger T. Effects of converting enzyme inhibitors: ramipril and ... which is cleaved by renin to form angiotensin I (Ang I). Ang I is converted to Ang II by angiotensin-converting enzyme (ACE). ... Prorenin, renin, angiotensinogen, and angiotensin converting enzyme in normal and failing hearts: evidence for renin binding. ... Gondo M, Maruta H, Arakawa K. Direct formation of angiotensin II without renin or converting enzyme in the ischemic dog heart. ...http://circres.ahajournals.org/content/85/7/643
Randomised controlled trial of dual blockade of renin-angiotensin system in patients with hypertension, microalbuminuria, and...
Angiotensin converting enzyme inhibitors and angiotensin receptor blockers both reduce blood pressure and microalbuminuria in ... Additive effects of combined angiotensin-converting enzyme inhibition and angiotensin II antagonism on blood pressure and renin ... of angiotensin converting enzyme gene on progression of diabetic nephropathy during inhibition of angiotensin converting enzyme ... Addition of angiotensin II receptor blockade to maximal angiotensin-converting enzyme inhibition improves exercise capacity in ...http://www.bmj.com/content/321/7274/1440?ijkey=f41c5f5f91002a6a14b3ebb436105c6b8d08f887&keytype2=tf_ipsecsha
Personalized Medicine in Heart Failure | JACC: Cardiovascular Imaging
The renin-angiotensin-aldosterone system is complex. It is well documented that within weeks after initiation of ACE inhibitor ... 2001) Lesser response to angiotensin-converting-enzyme inhibitor therapy in black as compared with white patients with left ... 2003) Efficacy of angiotensin-converting enzyme inhibitors and beta-blockers in the management of left ventricular systolic ... angiotensin-converting enzyme (ACE) inhibitors, or aldosterone antagonists than left ventricular ejection fraction measurements ...http://imaging.onlinejacc.org/content/5/4/419
Angiotensin-II Receptor Antagonists: Their Place in Therapy - American Family Physician
These drugs are selective for angiotensin II (type 1 receptor); unlike angiotensin-converting enzyme inhibitors, they do not ... Cough occurs much less often with these agents than with angiotensin-converting enzyme inhibitors, and they do not adversely ... Clinical trials indicate that angiotensin-II receptor antagonists are effective and safe in the treatment of hypertension. ... Angiotensin-II receptor antagonists (or blockers) are a newer class of antihypertensive agents. ...http://www.aafp.org/afp/1999/0601/p3140.html
Patent US5403856 - Method of treating cardiac insufficiency using angiotensin-converting enzyme ... - Google Patents
... or tri-cyclic heterocyclic ring system. The invention furthermore relates to compounds of the formula I and agents containing ... Use of inhibitors of the renin-angiotensin system in the prevention of cardiovascular events. ... Angiotensin-converting enzyme inhibitors. US4591598 *. Jul 3, 1984. May 27, 1986. Hoechst Aktiengesellschaft. Derivatives of 2- ... Preparation of angiotensin-converting enzyme inhibitors. US4849524 *. Nov 19, 1987. Jul 18, 1989. Hoechst Aktiengesellschaft. ...http://www.google.com/patents/US5403856?dq=3984803
On the Biological Actions of Intracellular Angiotensin | Hypertension
Effect of angiotensin converting enzyme inhibitor upon brain angiotensin II binding. J Hypertens.. 1992;10:545-552. ... Angiotensin II and the heart: on the intracrine renin-angiotensin system. Hypertension.. 2000;35:1183-1188. ... The cardiac renin-angiotensin system: conceptual, or a regulator of cardiac function? Circ Res. 1999;85:643-650. ... A role for the renin-angiotensin system in the evolution of cardiac memory. J Cardiovasc Electrophysiol. 1999;10:545-551. ...http://hyper.ahajournals.org/content/35/6/1189
Preventing Congestive Heart Failure - American Family Physician
Early intervention with angiotensin converting enzyme inhibitors in patients with chronic left ventricular dysfunction can ... activation of the sympathetic nervous system and the renin angiotensin system is often implicated in sodium retention, edema ... Effects of the angiotensin converting enzyme inhibitor enalapril on the long-term progression of left ventricular dysfunction ... Early intervention with angiotensin converting enzyme inhibitors in patients with chronic left ventricular dysfunction can ...https://www.aafp.org/afp/1998/0415/p1901.html
Angiotensin II Induces Interleukin-1β-Mediated Islet Inflammation and β-Cell Dysfunction Independently of Vasoconstrictive...
Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers for prevention of type 2 diabetes: a meta-analysis of ... Effects of renin-angiotensin system blockade on islet function in diabetic rats. J Endocrinol Invest 2010;33:13-19pmid:20203537 ... Angiotensin-converting-enzyme inhibitors suppress synthesis of tumour necrosis factor and interleukin 1 by human peripheral ... The direct effects of the angiotensin-converting enzyme inhibitors, zofenoprilat and enalaprilat, on isolated human pancreatic ...http://diabetes.diabetesjournals.org/content/64/4/1273
Fosinopril - Wikipedia
Fosinopril is an angiotensin converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of chronic ... Contribution of cardiac renin-angiotensin system to ventricular remodelling in myocardial-infarcted rats. Journal of Molecular ... Renin converts the inactive angiotensinogen into angiotensin I, which is converted to angiotensin II (AII) by angiotensin ... an Angiotensin-Converting Enzyme Inhibitor in Healthy Subjects. Journal of Clinical Pharmacology, 31(1):58-64. Erhardt L., ...https://en.wikipedia.org/wiki/Fosinopril
Plasma Molecular Signatures in Hypertensive Patients With Renin-Angiotensin System SuppressionNovelty and Significance |...
... disease and renal disease under chronic treatment with either angiotensin-converting enzyme inhibitors or angiotensin receptor ... The activation immune system in hypertensive patients with high albuminuria under chronic renin-angiotensin system (RAS) ... probably facilitated by an inappropriate therapeutic response to angiotensin-converting enzyme inhibitors or angiotensin ... Angiotensin-receptor blockade versus converting-enzyme inhibition in type 2 diabetes and nephropathy. N Engl J Med. 2004;351: ...http://hyper.ahajournals.org/content/68/1/157
Newer Insights into the Biochemical Physiology of the Renin-Angiotensin System: Role of Angiotensin-(1-7), Angiotensin...
Knowledge of the mechanisms by which the rennin-angiotensin system contributes to cardiovascular pathology continues to advance ... is a novel mammalian metallocarboxypeptidase and a homologue of angiotensin-converting enzyme insensitive to ACE inhibitors. ... A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ Res. 2000 ... Circulating activities of angiotensin-converting enzyme, its homolog, angiotensin-converting enzyme 2, and neprilysin in a ...https://link.springer.com/chapter/10.1007/978-1-4419-0528-4_2
Does the Angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism modify the response to ACE inhibitor therapy?...
Renin-angiotensin system gene polymorphisms influence blood pressure and the response to angiotensin converting enzyme ... Angiotensin-converting enzymepharmacogeneticsACE I/D polymorphism. Background. Angiotensin-converting enzyme (ACE) inhibitors ... polymorphism of the angiotensin-converting enzyme gene on response to angiotensin-converting enzyme inhibitors in patients with ... Strippoli GF, Craig M, Deeks JJ, Schena FP, Craig JC: Effects of angiotensin converting enzyme inhibitors and angiotensin II ...https://trialsjournal.biomedcentral.com/articles/10.1186/1468-6708-6-16
Speedel Reports on Data Published at Hypertension 2008 MedicalCongress - Drugs.com MedNews
... there was a trend for the highest dose of SPP301 to be more effective than an angiotensin converting enzyme (ACE) inhibitor ( ... A study in transgenic rats (expressing human renin and angiotensinogen) with a strongly activated renin angiotensin system ... a direct thrombin inhibitor) in Phase II, the next generation renin inhibitors SPP635 (in Phase Il), SPP1148 and SPP676 (both ... SPP635 is the most advanced compound in the SPP600 series and is one of several new proprietary renin inhibitors invented by ...https://www.drugs.com/clinical_trials/speedel-reports-data-published-hypertension-2008-medicalcongress-4887.html
ACE Inhibition Versus Angiotensin Type 1 Receptor Antagonism | Hypertension
renin. *angiotensin-converting enzyme. Angiotensin-converting enzyme (ACE) inhibitors reduce the incidence of cardiovascular ... a nonpeptide angiotensin II receptor antagonist, on the renin-angiotensin-aldosterone system in hypertensive patients. ... Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on ... Comparative effects of estrogen and angiotensin-converting enzyme inhibition on plasminogen activator inhibitor-1 in healthy ...http://hyper.ahajournals.org/content/40/6/859
Angiotensin II-induced inotropism requires an endocardial endothelium-nitric oxide mechanism in the in-vitro heart of Anguilla...
... angiotensin II competitive binding inhibitors and converting enzyme inhibitor in elasmobranch fish. Neth. J. Zool. 45,117 -120. ... In The Renin-Angiotensin System. Comparative Aspects. Zoophysiology, vol 35 (ed. S. D. Bradshaw, W. Burggren, H. C. Heller, S. ... angiotensin-converting enzyme. ANG II. angiotensin II. EE. endocardial endothelium. GC. guanylate cyclase. ISO. isoproterenol. ... Opdyke, D. F. and Holcombe, R. (1976). Response to angiotensins I and II and to AI converting-enzyme inhibitor in a shark. Am. ...http://jeb.biologists.org/content/206/15/2675
Signaling by the Angiotensin-Converting Enzyme | Circulation Research
Circulating angiotensin II (Ang II) is the main effector of the renin-angiotensin system (RAS) and is involved in the global ... Protein kinase C and phosphatase inhibitors block the ability of angiotensin I-converting enzyme inhibitors to resensitize the ... Angiotensin I-converting enzyme inhibition but not angiotensin II suppression alters angiotensin I-converting enzyme gene ... N-domain-specific substrate and C-domain inhibitors of angiotensin-converting enzyme: angiotensin-(1-7) and keto-ACE. ...http://circres.ahajournals.org/content/98/7/887
IJMS | Free Full-Text | Angiotensin-Converting Enzymes Play a Dominant Role in Fertility | HTML
An accumulating body of evidence has shown that the renin-angiotensin system is involved in the fertility problems observed in ... alterations in the expression of angiotensin-converting enzyme-1, angiotensin-converting enzyme-2, and angiotensin-converting ... However, as a pseudogene in humans, further studies are needed to explore whether the abnormal angiotensin-converting enzyme-3 ... In this review, the relationship between angiotensin-converting enzymes and fertile ability is summarized, and a new procedure ...http://mdpi.com/1422-0067/14/10/21071/htm
Renin-Angiotensin System Blockade and Improved Clinical Outcomes in Chronic Aortic Regurgitation | JACC: Journal of the...
Much of what we know about the impact of angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs ... 2004) Angiotensin-converting enzyme inhibitor captopril prevents volume overload cardiomyopathy in experimental chronic aortic ... 2008) Effectiveness of angiotensin-converting enzyme inhibitors in pediatric patients with mid to severe aortic valve ... 2011) Impact of renin-angiotensin system blockade therapy on outcome in aortic stenosis. J Am Coll Cardiol 58:570-576. ...http://www.onlinejacc.org/content/58/20/2092
Moexipril - Wikipedia
Moexipril hydrochloride is a potent orally active nonsulfhydryl angiotensin converting enzyme inhibitor (ACE inhibitor) which ... Rosendorff, C (1996). "The renin-angiotensin system and vascular hypertrophy". Journal of the American College of Cardiology. ... The role of angiotensin-converting enzyme inhibitors". American Heart Journal. 135 (2 Pt 2): 21-30. doi:10.1053/hj.1998. ... "Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity ...https://en.wikipedia.org/wiki/Moexipril
Lisinopril - Wikipedia
Lisinopril is an ACE Inhibitor, meaning it blocks the actions of angiotensin converting enzyme (ACE) in the renin-angiotensin- ... aldosterone system (RAAS), keeping Angiotensin I from being converted to Angiotensin II. The inhibition of this system causes ... Lisinopril is a drug of the angiotensin-converting enzyme (ACE) inhibitor class used primarily in treatment of high blood ... John Wiley & Sons, Apr 3, 2013 ISBN 9781118354469 Menard J and Patchett A. "Angiotensin-Converting Enzyme Inhibitors". pp. 14- ...https://en.wikipedia.org/wiki/Lisinopril
Enhanced Angiotensin II Activity in Heart Failure | Circulation Research
Effects of angiotensin-converting enzyme inhibitors and angiotensin II type I receptor antagonists in rats with heart failure. ... Raised blood pressure, not renin-angiotensin systems, causes cardiac fibrosis in TGR m(Ren2)27 rats. Cardiovasc Res. 2000;47:57 ... Angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade prevent cardiac remodeling in pigs after ... Two of the most powerful cardiovascular regulators are the β-adrenergic and the renin-angiotensin system (RAS). The strength of ...http://circres.ahajournals.org/content/88/7/654
Renin-angiotensin system - Wikipedia
ACE inhibitors-inhibitors of angiotensin-converting enzyme are often used to reduce the formation of the more potent ... to angiotensin I. Angiotensin I is subsequently converted to angiotensin II by the enzyme angiotensin-converting enzyme (ACE) ... The renin-angiotensin system (RAS) or the renin-angiotensin-aldosterone system (RAAS) is a hormone system that regulates blood ... with renin they form angiotensin I, and locally expressed angiotensin-converting enzyme, chymase or other enzymes can transform ...https://en.wikipedia.org/wiki/Renin%E2%80%93angiotensin_system
Medical management of myxomatous mitral valve disease: An evidence-based veterinary medicine approach
Angiotensin-converting enzyme inhibitors in the treatment of congestive heart failure Angiotensin-converting enzyme inhibitors ... Ma, T.K., Kam, K.K., Yan, B.P. & Lam, Y.Y., 2010, 'Renin-angiotensin-aldosterone system blockade for cardiovascular diseases: ... An ACE in the hole? The role of angiotensin-converting enzyme inhibitors in the management of myxomatous mitral valve disease ... Angiotensin-converting enzyme inhibitors in delaying the onset of congestive heart failure ...http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S1019-91282014000100046&lng=en&nrm=iso&tlng=en
Controlling Hypertension in Patients with Diabetes - American Family Physician
Barring contraindications, angiotensin-converting enzyme inhibitors are considered first-line therapy in patients with diabetes ... JNC VI recommends angiotensin-converting enzyme (ACE) inhibitors as preferred agents, with calcium channel blockers (CCBs) and ... Randomised controlled trial of dual blockade of reninangiotensin system in patients with hypertension, microalbuminuria, and ... Influence of the angiotensin converting enzyme inhibitor cilazapril, the beta-blocker propranolol and their combination on ...https://www.aafp.org/afp/2002/1001/p1209.html
Effects of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Type 1 Receptor Antagonist in Deoxycorticosterone Acetate...
The renin-angiotensin-aldosterone system in experimental mineralocorticoid-salt-induced cardiac fibrosis. Am J Physiol. 1996; ... Paracrine systems in the cardioprotective effect of angiotensin-converting enzyme inhibitors on myocardial ischemia/reperfusion ... Effects of angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists in rats with heart failure: ... Effects of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Type 1 Receptor Antagonist in Deoxycorticosterone Acetate- ...http://hyper.ahajournals.org/content/37/3/974
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