Klein BK, Feng Y, McWherter CA, Hood WF, Paik K, McKearn JP (1997). "The receptor binding site of human interleukin-3 defined ... "Interleukin-3 and interleukin-3 receptors in the brain". Ann. N. Y. Acad. Sci. 840 (1): 107-16. Bibcode:1998NYASA.840..107T. ... interleukin-3 (IL-3), and interleukin-5 (IL-5) receptor complexes to chromosome 22q13.1". Human Genetics. 93 (2): 198-200. doi: ... in order to clear pathogens by changing the abundance of various cell populations via binding at the interleukin-3 receptor. IL ...

Interleukin-6 biology is coordinated by membrane-bound. and soluble receptors: role in inflammation and cancer. J Leukoc Biol. ... bind to human hormone receptors. In the climacteric, when hormone levels are low, there are "empty" hormone receptors. Plant ... Production of ex vivo lipopolysaccharide-induced tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 is ... similar enough to bind to human hormone receptors and have an effect on hormone levels. These plant substances are called ...

Loss of type III transforming growth factor-beta receptor expression is due to methylation silencing of the transcription ... Aberrant DNA methylation of GATA binding protein 3 (GATA3), interleukin-4 (IL-4), and transforming growth factor-β (TGF-β) ... GATA binding protein 3; H.pylori: Helicobacter pylori; IFN-γ: interferon-γ; IL: interleukin; MALDI-TOF-MS: matrix-assisted ... GATA binding protein 3 is a very important transcription factor in regulating the differentiation of T helper cells and the ...

Monoclonal antibody that directly binds to the alpha-subunit of the human interleukin-5 receptor to reduce the production and ... Binds free IgE thereby preventing IgE from binding to the high-affinity IgE receptor on mast cells and basophils. Also ... Monoclonal antibody that binds free interleukin-5 (IL-5) to reduce the production and survival of eosinophils, a cell type ... The S-enantiomer does not bind to beta2-receptors, but may be responsible for some adverse effects of racemic albuterol, ...

Binding of human recombinant interleukin 2 to murine erythrocytes is erythropoietin receptor mediated. Comparative Haematology ... Moyes, R. B., Kirch, H., & DeLoach, J. R. (1996). Enhanced biological activity of human recombinant interleukin 2 coupled to ... Effect of targeted erythrocytes coated with recombinant human interleukin 2 on T-lymphocyte proliferation in vitro. ... Kogut, M. H., Lowry, V. K., Moyes, R. B., Bowden, L. L., Bowden, R., Genovese, K., & Deloach, J. R. (1998). Lymphokine- ...

Gan L, Li L. Regulations and roles of the interleukin-1 receptor associated kinases (IRAKs) in innate and adaptive immunity. ... Direct functional interactions between insulin-like growth factor-binding protein-3 and retinoid X receptor-α regulate ... Expression of peroxisome proliferator-activated receptor and CCAAT/enhancer binding protein transcription factors in cultured ... Regulation of SREBP1c gene expression in skeletal muscle: role of retinoid X receptor/liver X receptor and forkhead-O1 ...

... binding the Toll-like Receptor (TLR) present on an active macrophage. ... Other cytokines that signal through receptors containing gp130 are Interleukin-11 (IL-11), ciliary neurotrophic factor (CNTF), ... IL-6 triggers the formation of protein complexes of gp130 and the IL-6 receptor activating the receptor. These complexes bring ... some research has been done into preventing its binding. However, it has been found somewhat more effective to bind IL-1 and ...

The mouse behaviors were evaluated by locomotion, nesting building, Y-maze and Morris water maze tests; levels of interleukin ( ... Transient receptor potential ankyrin 1 (TRPA1) channel plays an important role in pain and inflammation. However, little is ... Measurement of DNA-binding activity on NF-κB and NFAT. The DNA-binding activity of NF-κB and NFAT in primary astrocytes and ... ELISA of (c-f) IL-1β, IL-6, IL-4 and IL-10 secretion and (g, h) NF-κB and NFAT DNA binding activity in brain specimens from 8- ...

Interleukin-6 (IL-6) is a multifunctional cytokine that regulates pleiotropic roles in immune regulation, inflammation, ... Soluble IL-6 receptor (sIL-6R) is a 50-55 kDa ligand binding protein, derived from the extracellular part of the gp80 receptor ... Soluble Interleukin-6 receptor (sIL-6R). Scientific background. Interleukin-6 (IL-6) is a multifunctional cytokine that ... The receptor complex mediating the biological activities consists of two distinct membrane-bound glycoproteins:. *IL-6 Receptor ...

Here we describe molecular and cellular responses, as well as survival, in A2A adenosine receptor (AR) agonist treated and ... Adenosine can bind to four G protein coupled receptors, A1, A2A, A2B, and A3. The A2A adenosine receptor (AR) is present on ... Hack CE, Hart M, van Schijndel RJ, Eerenberg AJ, Nuijens JH, Thijs LG, Aarden LA: Interleukin-8 in sepsis: relation to shock ... Moore, C.C., Martin, E.N., Lee, G.H. et al. An A2Aadenosine receptor agonist, ATL313, reduces inflammation and improves ...

The peptide hormone, prolactin, binds to the prolactin receptor (PRLR) to initiate the lactogenic response. There are at least ... The peptide hormone, prolactin, binds to the prolactin receptor (PRLR) to initiate the lactogenic response. There are at least ... Ligand-receptor interaction activates constitutively-associated JAK family kinases and subsequent recruitment/activation of ... Ligand-receptor interaction activates constitutively-associated JAK family kinases and subsequent recruitment/activation of ...

... research since the value of the innate immune system as a drug target is demonstrated by the efficacy of interleukin-1 receptor ... Indeed, Toll-like receptors are a class of membrane receptors that sense extracellular microbes and trigger anti-pathogen ... considers recent work on the function of these receptors, notably Nod-like receptors and the antiviral proteins RIG-I and Mda5 ... A growing number of receptors for intracellular pathogens and endogenous danger signals are being discovered. These components ...

IL-1ra binding to IL-1 RI competitively blocks IL-1 ( alpha or beta ) binding to the same receptor. This results in receptor ... DIRA; ICIL-1ra; IL1F3; IL-1F3; IL1ra; IL-1ra; IL-1ra3; IL1RN; IL-1RN; interleukin 1 receptor antagonist; IRAP; MVCD4 ... There are two type I transmembrane glycoprotein receptors for IL-1ra. The first is the bioactive 80 kDa type I IL-1 receptor ( ... all molecules bind to the same receptors, all show a beta -trefoil structure, and all are believed to have evolved from a ...

... despite exposure of these cells to a deciduogenic stimulus and normal progesterone receptor expression. These molecular ... Steroid receptor coactivator-3 (SRC-3; also known as NCOA3 or AIB1) is a member of the multifunctional p160/SRC family of ... Steroid receptor coactivator-3 is a member of the multifunctional p160/SRC family of coactivators, which also includes SRC-1 ... Interleukin 15; IGFBP-1, insulin like growth factor binding protein-1; INHBA, inhibin beta A; IRB, Institutional review board; ...

Serum levels of Interleukin-6 type Cytokines and soluble Interleukin-6 receptor in patients with rheumatoid arthritis. ... Differential binding of Sarilumab and Tocilizumab to IL-6Ralpha and effects of receptor occupancy on clinical parameters. J ... A recent large registry study demonstrated that anti-interleukin-6 receptor antibodies (aIL-6R) and Janus kinase inhibitors ( ... Japan college of rheumatology 2009 guidelines for the use of Tocilizumab, a Humanized anti-Interleukin-6 receptor Monoclonal ...

Receptors, Interleukin-7. Short form: RECEPT IL 7; receptors present on T cells and B cell precursors but not ... a cardiac- ... To begin the infection process, the spike protein on the surface of SARS-CoV-2 must bind to ACE2, a receptor on the surface of ... FAS1 domains, a family of cell adhesion molecules, have a carotenoid-binding function in an astaxanthin-binding protein AstaP ... A unique microalgal FAS1-containing astaxanthin (AXT)-binding protein (AstaP) binds a broad repertoire of carotenoids by a ...

Denosumab binds to the receptor activator of nuclear factor-kappa B ligand (RANKL), a transmembrane or soluble protein ... Increased osteoclast development after estrogen loss: mediation by interleukin-6. Science. 1992 Jul 3. 257(5066):88-91. [QxMD ... Selective Estrogen Receptor Modulator. Class Summary. Selective estrogen receptor modulators (SERMs) affect some of the ... The biological actions of raloxifene are largely mediated through binding to estrogen receptors, which results in activation of ...

... protein and nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome after TBI, and reduce the release of pro- ... After establishing the TBI model, the hypothalamus region was covered with LIFUS radiation, and an orexin receptor 1 (OXR1) ... nucleotide-binding domain-like receptor protein 3; IL, interleukin; TNF, tumor necrosis factor. ... nucleotide-binding domain-like receptor protein 3; OX-A: orexin-A; OXR1: orexin receptor 1; PBS: phosphate-buffered saline; PRF ...

... belongs to a family of erythrocyte chemokine receptors that bind C-X-C and C-C chemokines such as interleukin 8 (IL-8), ... Binding of HIV-1 to RBCs involves the Duffy antigen receptors for chemokines (DARC). ... In the present study, we show that HIV-1 binds to RBCs from Caucasian individuals via DARC making RBCs able to transmit HIV to ... In eucaryotic cells, small GTP-binding proteins of the Ras superfamily appear to be involved in different steps of membrane ...

A novel oligosaccharide compound AVR-25 selectively binds to the TLR4 protein (IC50 = 0.15 µM) in human peripheral blood ... Influence of hypercortisolemia on soluble tumor necrosis factor receptor II and interleukin-1 receptor antagonist responses to ... AVR-25 binds to TLR4 with an IC50 of 0.15 µM and is selective for TLR4 over TLR2 protein. Binding to TLR4 activated M2 ... AVR-25 has a binding potency similar to the binding of chitohexaose with TLR4 (Supplementary Fig. S2); hence, we hypothesized ...

Woolley JA, Seleem S, Hills FA, Salem H, el-Nashar E and Chard T (1996). Raised circulating levels of interleukin-6 in women ... Crawford RAF, Hills FA, Farkas A and Chard T (1995). Elevated levels of insulin-like growth factor binding protein-1 in fetal ... Pieber D, Allport VC, Hills F, Johnson M, Bennett PR (2001). Interactions between progesterone receptor isoforms in myometrial ... Progesterone represses interleukin-8 and cyclo-oxygenase-2 in human lower segment fibroblast cells and amnion epithelial cells ...

... where the cleavage by an RNase III ribonuclease is mediated by binding of a mature miRNA, the binding is at a miRNA recognition ... Oligonucleotide-based compounds as inhibitors of toll-like receptors US10717980B2 (en) 2020-07-21. MicroRNA-200 based ... miR-200c expression also down-regulated interleukin (IL)-6, IL-8, and chemokine (C-C motif) ligand (CCL)-5 under ... PMIS-200c reduces binding activity of miR-200c to the 3′UTR of IL-6, IL-8, and CCL-5 and the function of miR-200c. A)-C) ...

Correlation of estradiol, parathyroid hormone, interleukin-6, and soluble interleukin-6 receptor during the normal menstrual ... Diurnal rhythm of plasma 1,25-dihydroxyvitamin D and vitamin D-binding protein in postmenopausal women: relationship to plasma ... 17 beta-estradiol increases Ca(2+) influx and down regulates interleukin-2 receptor in mouse thymocytes. Azenabor AA, Hoffman- ... Gorai I, Taguchi Y, Chaki O, Kikuchi R, Nakayama M, Yang BC, Yokota S, Minaguchi H. Serum soluble interleukin-6 receptor (sIL- ...

Polymorphisms in the interleukin-4 and interleukin-4 receptor alpha chain genes confer susceptibility to asthma and atopy in a ... Identification of the high affinity receptor binding region in human immunoglobulin E. The Journal of biological chemistry. 271 ... Genetic association studies of interleukin-13 receptor alpha1 subunit gene polymorphisms in asthma and atopy. European ... ST2 being the receptor for IL33. In particular we and other have shown that genetic polymorphisms spanning the IL33 and IL1RL1 ...

Bile acid sequestrants bind C difficile toxin and other proteins. Although not as effective as primary therapy for C difficile ... Neurokinin-1 (NK-1) receptor is required in Clostridium difficile- induced enteritis. J Clin Invest. 1998 Apr 15. 101(8):1547- ... A common polymorphism in the interleukin 8 gene promoter is associated with Clostridium difficile diarrhea. Am J Gastroenterol ... Cholestyramine binds toxins A and B of C difficile, but the clinical experience of different investigators has shown marked ...

The secreted form of the interleukin-1 receptor antagonist (IL-1Ra) is an acute-phase protein intervening in the ... The interleukin-1 receptor antagonist (IL-1Ra) is a member of the interleukin (IL)-1 family that binds to IL-1 receptors ... interleukin; IL-1Ra, interleukin-1 receptor antagonist; LPS, lipopolysaccharide; PMA, phorbol myristate acetate; PPAR-γ, ... Regulation of the interleukin-1 receptor antagonist in THP-1 cells by ligands of the peroxisome proliferator-activated receptor ...

M5 monoclonal antibody specifically binds to human CD126 which is also known as the alpha subunit of the human IL-6 Receptor ( ... Receptor. The IL-6Rα subunit associates with the 130-160 kDa gp130 subunit (IL-6 Receptor β chain, CD130), that is shared with ... Receptor. The IL-6Rα subunit associates with the 130-160 kDa gp130 subunit (IL-6 Receptor β chain, CD130), that is shared with ... M5 monoclonal antibody specifically binds to human CD126 which is also known as the alpha subunit of the human IL-6 Receptor ( ...

This fact was confirmed by changes detected in a cytokine profile in blood serum samples [MIP-1α, interleukin 1 (IL-1) α, IL-2 ... IFN-gamma and IL-10 inhibit induction of IL-1 receptor type I and type II gene expression by IL-4 and IL-13 in human monocytes ... Interleukin-1β promotes oligodendrocyte death through glutamate excitotoxicity. Ann Neurol (2003) 53(5):588-95. doi:10.1002/ana ... The administration of IL-18 binding protein leads to attenuated apoptotic cell death and improved neurological outcome in mice ...

Quantitation of estrogen receptors and relaxin binding in human anterior cruciate ligament fibroblasts. In Vitro Cell Dev Biol ... Gorai I, Taguchi Y, Chaki O, Kikuchi R, Nakayama M, Yang BC, Yokota S, Minaguchi H. Serum soluble interleukin-6 receptor and ... passive range of motion and expression of relaxin receptor isoforms via 5α-Dihydrotestosterone and androgen receptor binding. ... Dehghan F, Muniandy S, Yusof A, Salley N. Sex-steroid regulation of relaxin receptor isoforms (RXFP1 & RXFP2) expression in the ...