Fusion proteins comprising annexin V and Kunitz protease inhibitors are highly potent thrombogenic site-directed anticoagulants...
Protease nexin-2/amyloid β-protein precursor regulates factor VIIa and the factor VIIa-tissue factor complex. Thromb Res. 2000; ... Concomitantly, plasma factor VII/VIIa binds to the vessel wall tissue factor (TF) and initiates a sequence of coagulation ... Factor VIIa-tissue factor: functional importance of protein membrane interaction. Thromb Haemost. 1997;78: 112-116. ... factor VIIIa/factor IXa), prothrombinase (factor Va/factor Xa), and factor XIa complexes on PS-exposed activated platelets. We ...http://www.bloodjournal.org/content/105/10/3902?sso-checked=true
Systems Biology of Coagulation Initiation: Kinetics of Thrombin Generation in Resting and Activated Human Blood
Phospholipid regulates the activation of factor X by tissue factor/factor VIIa (TF/VIIa) via substrate and product interactions ... Platelet activity of high-dose factor VIIa is independent of tissue factor. Br J Haematol. 1997;99:542-547. [PubMed] ... Also, the addition of 20 µg/ml anti-TF, 20 µg/ml anti-VII/VIIa ( Figure 5E ) or 1 µM active site inhibited factor VIIa, VIIai ( ... Surface plasmon resonance studies of the interaction between factor VII and tissue factor. Demonstration of defective tissue ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2947981/
Novel Oral Anticoagulants:New Challenges for Anesthesiologists in Bleeding Patients | Anesthesiology | ASA Publications
Monroe DM, Hoffman M, Oliver JA, Roberts HR: Platelet activity of high-dose factor VIIa is independent of tissue factor. Br J ... Kjalke M, Ezban M, Monroe DM, Hoffman M, Roberts HR, Hedner U: High-dose factor VIIa increases initial thrombin generation and ... The most prominent modes of action by these novel drugs are direct factor Xa inhibition (rivaroxaban and apixaban) or thrombin ... The most important possibilities are replenishment of relatively deficient coagulation factors in an environment of an ...http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1933586
Can a Subset of Intracerebral Hemorrhage Patients Benefit From Hemostatic Therapy With Recombinant Activated Factor VII? |...
Platelet activity of high-dose factor VIIa is independent of tissue factor. Br J Haematol. 1997; 99: 542-547. ... Recombinant-activated coagulation factor VIIa (NovoSeven): current development. Vox Sang. 2007; 92: 281-288. ... Background and Purpose- In the Factor Seven for Acute Hemorrhagic Stroke (FAST) trial, 80 μg/kg of recombinant activated factor ... Several baseline factors have been shown to be important determinants of poor outcome in patients with ICH. Advanced age, poor ...http://stroke.ahajournals.org/content/40/3/833
Beta-secretase enzyme compositions and methods - Elan Pharmaceuticals, Inc.
Dennis et al., "Kunitz Domain Inhibitors of Tissue Factor-Factor VIIa," J. Biol. Chem., 269(35):22129-22136 (1994). Diedrich et ... factor. ). (. Enzyme. . . sol. .. . vol. ). . . (. Incub. .. . time. . . h. ). (. Enzyme. . . conc. .. . μg. /. vol ... factor. ). (. Enzyme. . . sol. .. . vol. ). . (. Incub. .. . time. . . h. ). . (. Enzyme. . . conc. .. . mg. /. vol ... D. β-secretase Assays of Crude Cell or Tissue Extracts. Cells or tissues were extracted in extraction buffer (20 mM HEPES, pH ...http://www.freepatentsonline.com/7276349.html
PAPOLA - Wikipedia
"Binding of factor VIIa to tissue factor induces alterations in gene expression in human fibroblast cells: up-regulation of poly ... end-processing factor. FIP1L1 gene fusions between it and either the platelet-derived growth factor receptor, alpha (PGDFRA) or ... PAPOLA binds to FIP1L1 (Factor interacting with PAPOLA and CPSF1), a subunit of the cleavage and polyadenylation specificity ... 2005). "Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein ...https://en.wikipedia.org/wiki/PAPOLA
Bjorquist, P. and Bostrom, S. Determination of the kinetic constants of tissue factor/factor VII/factor VIIA and antithrombin/ ... Thrombosis Research 85: 225-236; (1997).. (4) O'Shannessy, D. J. et al Determination of rate and equilibrium binding constants ...https://www.sprpages.nl/data-fitting-top-navigation/theory-top-nav
LDL Increases Inactive Tissue Factor on Vascular Smooth Muscle Cell Surfaces | Circulation
Analysis of the factor VIIa binding site on human tissue factor: effects of tissue factor mutations on the kinetics and ... Relations between factor VIIa binding and expression of factor VIIa/tissue factor catalytic activity on cell surfaces. J Biol ... Wild-type tissue factor and a tissue factor mutant lacking cytoplasmic tail both enhance tissue factor activity; activity of ... and with wild-type tissue factor cDNA or a mutant tissue factor that lacked the cytoplasmic domain of tissue factor. Mutant ...http://circ.ahajournals.org/content/99/13/1753
OpenAIRE - Publication: Protease-activated receptor 2 ...
Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa. Proc Natl Acad Sci USA 97: ... Chuang HH, Prescott ED, Kong H, Shields S, Jordt SE, Basbaum AI, Chao MV, Julius D (2001) Bradykinin and nerve growth factor ... Shu X, Mendell LM (1999) Nerve growth factor acutely sensitizes the response of adult rat sensory neurons to capsaicin. ... Ishihara H, Connolly AJ, Zeng D, Kahn ML, Zheng YW, Timmons C, Tram T, Coughlin SR (1997) Protease-activated receptor 3 is a ...https://www.openaire.eu/search/publication?articleId=core_ac_uk__::6115d5311e0a5a8c4f40dfa0b06d109a
US4287180A - Method for treating blood clotting factor inhibitors - Google Patents
... factor VIIa, about from 8-80; total factor IX, about from 15-112; factor IX precursor, 0 to about 30; factor X, about from 1-30 ... and factor Xa, about from 1-10 are used in therapeutically effective amounts to treat blood clotting factor inhibitors. ... Compositions including, in units/ml, factor VIII correctional activity, about from 2-35; prothrombin, about from 1-10; thrombin ... less than about 0.003; factor VII, about from 37-190; ... dose factor VIIa is independent of tissue factor. Saito et al. ...https://patents.google.com/patent/US4287180?oq=flatulence
US5437864A - Method of inhibiting blood coagulation in extracorporeal circulation by inhibiting human tissue factor -...
The method prevents complex formation between tissue factor and factor VII/VIIa and thus inhibits coagulation of blood in ... effective amount of a monoclonal antibody which inhibits the ability of tissue factor to bind to factor VII/VIIa. ... Anti-tissue factor monoclonal antibodies produced by hybridoma cell lines TFS-5G9 or TF9-6B4 may be used in the claimed methods ... tissue factor (TF). The bimolecular procoagulant complex of TF and factor VII/VIIa [TF:VII/VIIa], activates factors X and IX by ...https://patents.google.com/patent/US5437864?oq=flatulence
293 [HEK-293] ATCC® CRL-1573™
Substrate recognition by tissue factor-factor VIIa. J. Biol. Chem. 271: 21752-21757, 1996. PubMed: 8702971 ... Substrate recognition by tissue factor-factor VIIa. J. Biol. Chem. 271: 21752-21757, 1996. PubMed: 8702971 ... Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain ... Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain ...https://www.atcc.org/Standards/Quality_Control_Strains/By_Instrument/CRL-1573.aspx
Patent US6936298 - Antithrombogenic membrane mimetic compositions and methods - Google Patents
Gir, S. et al., "A numerical analysis of factor X activation in the presence of tissue factor-factor VIIa complex in a flow ... Bj rquist, P. et al., "Determination of the inetic constants of tissue factor/factor VII/factor VIIA and antithrombin/heparin ... Gemmell, C.H. et al., "The effects of shear rate on the enzymatic activity of the tissue factor-factor VIIa complex," (1990) ... An example of this effect is the enhanced catalytic efficiency of the Factor X activation complex (tissue factor: factor VIIIa ...http://www.google.com/patents/US6936298?dq=5166694
Involvement of Tissue Factor Pathway Inhibitor in the Coronary Circulation of Patients With Acute Coronary Syndromes |...
Probable regulation of factor VIIa-tissue factor and prothrombinase by factor Xa-TFPI and TFPI in vivo. Br J Haematol. 1996; 95 ... Co-localization of tissue factor and tissue factor pathway inhibitor in coronary atherosclerosis. J Pathol. 1999; 188: 180-188. ... Heightened tissue factor associated with tissue factor pathway inhibitor and prognosis in patients with unstable angina. ... The lipoprotein-associated coagulation inhibitor that inhibits the factor VII-tissue factor complex also inhibits factor Xa: ...http://circ.ahajournals.org/content/108/23/2864
Platelets and Thrombin Generation | Arteriosclerosis, Thrombosis, and Vascular Biology
... the factor Xa-dependent plasma inhibitor of factor VIIa/tissue factor). Thromb Res. 1987; 48: 11-22. ... In the initiation, factor VIIa bound to TF activates factor IX and also factor X. Factor Xa then activates factor V on the TF- ... f.XI indicates factor XI; f.X(a), either factor X or factor Xa; f.Va, factor Va; f.IX(a), either factor IX or factor IXa; and f ... factor XII, prekallikrein (PK), factor XI, factor IX, factor VIII, factor X, factor V, and prothrombin (II), which is converted ...http://atvb.ahajournals.org/content/22/9/1381.long
Effect of ω-3 Fatty Acids and Simvastatin on Hemostatic Risk Factors and Postprandial Hyperlipemia in Patients With Combined...
... and factor Xa that affect their ability to interact and to inhibit factor VIIa/tissue factor: evidence for a two-step model of ... The tissue factor pathway of coagulation: factor VII, tissue factor, and tissue factor pathway inhibitor. In: Bloom AL, Forbes ... Activation of factor IX by the reaction product of tissue factor and factor VII: additional pathway for initiating blood ... Quantitation of activated factor VII levels in plasma using a tissue factor mutant selectively deficient in promoting factor ...http://atvb.ahajournals.org/content/20/1/259
Neutrophils and the kallikrein-kinin system in proteinase-activated receptor 4-mediated inflammation in rodents - Houle - 2009 ...
Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa. Proc. Natl. Acad. Sci. U.S.A. ... HENDERSON, L.M., FIGUEROA, C.D., MULLER-ESTERL, W. & BHOOLA, K.D. (1994). Assembly of contact-phase factors on the surface of ... GRIESBACHER, T., RAINER, I., TIRAN, B. & EVANS, D.M. (2002). Involvement of tissue kallikrein but not plasma kallikrein in the ... FIGUEROA, C.D., MACIVER, A.G. & BHOOLA, K.D. (1989). Identification of a tissue kallikrein in human polymorphonuclear ...http://onlinelibrary.wiley.com/doi/10.1038/sj.bjp.0706371/references
US5055289A - Interferon antibody therapeutic compositions having an extended serum half-life - Google Patents
Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex ... streptokinase and tissue plasminogen activator, growth factors such as nerve growth factors, and platelet activating factor. ... Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor EP2336179A1 (en) 2002-11-08. 2011-06-22. Ablynx N.V.. ... Apolipoprotein e/growth factor complexes and methods of use KR20080056315A (en) 2001-02-12. 2008-06-20. 리서치 디벨럽먼트 파운데이션. An ...https://patents.google.com/patent/US5055289?oq=flatulence
Cyclooxygenase-2-Derived Prostacyclin Regulates Arterial Thrombus Formation by Suppressing Tissue Factor in a Sirtuin-1...
Extrinsic-pathway activation in cancer with high factor VIIa and tissue factor. Lancet. 1995;346:1004-1005. ... For factor Xa generation, carotid artery homogenate was incubated with factor VIIa and CaCl2, and then human factor X was added ... Lipopolysaccharide induction of tissue factor in THP-1 cells involves Jun protein phosphorylation and nuclear factor kappaB ... To demonstrate TF dependence of factor Xa generation, experiments were performed in the absence of factor VIIa and after ...http://circ.ahajournals.org/content/126/11/1373
Tissue Factor Encryption | Arteriosclerosis, Thrombosis, and Vascular Biology
Relations between factor VIIa binding and expression of factor VIIa/tissue factor catalytic activity on cell surfaces. J Biol ... The tissue factor/factor VIIa/factor Xa complex: a model built by docking and site-directed mutagenesis. Proteins. 2003; 53: ... Activation of factor VII bound to tissue factor: a key early step in the tissue factor pathway of blood coagulation. Proc Natl ... Structure of the extracellular domain of human tissue factor: location of the factor VIIa binding site. Biochemistry. 1994; 33 ...http://atvb.ahajournals.org/content/26/3/456
An anti-tissue factor monoclonal antibody which inhibits TF VIIa complex is a potent anticoagulant in plasma. Thromb Haemost ... The protein was detected using anti-human tissue factor antibody, specific for the infused human truncated tissue factor and ... Dimerization of tissue factor supports solution-phase autoactivation of factor VII without influencing proteolytic activation ... 5F and G) confirms that the small amounts of tissue factor detected by Western blot analysis were due to clearance and not ...http://cancerres.aacrjournals.org/content/65/23/11109
Factor Vlla inhibitors - Aventis Pharma Deutschland GmbH
... when complexed to factor Xa, can directly inhibit the proteolytic activity of factor VIIa/tissue factor. In order to maintain ... A method of inhibiting factor VIIa comprising contacting factor VIIa or a material containing factor VIIa with a compound as ... As time progresses, the activity of the factor VIIa/tissue factor complex (extrinsic pathway) is suppressed by a Kunitz-type ... Thus, the invention provides a method of specifically inhibiting factor VIIa activity by contacting factor VIIa with a compound ...http://www.freepatentsonline.com/6287794.html
Factor Xa Generation at the Surface of Cultured Rat Vascular Smooth Muscle Cells in an in Vitro Flow System | Journal of...
... of the present investigation was to explore the effects of well-defined flow conditions on the activity of tissue factor (TF) ... cells were then placed in a parallel plate flow chamber and perfused with Hank's Balanced Salt Solution containing factor VIIa ... factor X (FX), and calcium. The chamber effluent was collected and assayed for factor Xa (FXa) and the steady-state flux of FXa ... Factor Xa Generation at the Surface of Cultured Rat Vascular Smooth Muscle Cells in an in Vitro Flow System C. L. Hall, M. B. ...http://biomechanical.asmedigitalcollection.asme.org/article.aspx?articleid=1401411
Functionalization of Tumor Necrosis Factor-α Using Phage Display Technique and PEGylation Improves Its Antitumor Therapeutic...
Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease factor VIIa. ... Van Ostade X, Tavernier J, Fiers W. Structure-activity studies of human tumour necrosis factors. Protein Eng 1994;7:5-22. ... Ashkenazi A. Targeting death and decoy receptors of the tumour-necrosis factor superfamily. Nat Rev Cancer 2002;2:420-30. ... Kimura K, Taguchi T, Urushizaki I, et al Phase I study of recombinant human tumor necrosis factor. Cancer Chemother Pharmacol ...http://clincancerres.aacrjournals.org/content/10/24/8293.long
New Tricks for Old Dogs | Circulation Research
Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa. Proc Natl Acad Sci U S A. ... In the circulation, factor Xa and its cofactor Va activate thrombin, and the activation of Xa is controlled by tissue factor, a ... Zucker S, Mirza H, Conner CE, Lorenz AF, Drews MH, Bahou WF, Jesty J. Vascular endothelial growth factor induces tissue factor ... Conversely, we now know that vascular endothelial and smooth muscle cells (SMCs) produce proteins like tissue factor that ...http://circres.ahajournals.org/content/88/10/987
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