Chronic CD4+ T-Cell Activation and Depletion in Human Immunodeficiency Virus Type 1 Infection: Type I Interferon-Mediated...
CD25, the alpha chain of the interleukin 2 (IL-2) receptor, is up-regulated within 2 days of activation and is down-regulated ... Regulation of interleukin 2 receptor expression: effects of phorbol diester, phospholipase C, and reexposure to lectin or ... or primarily by type I interferons (e.g., STAT1 and 9-27) (17). Although up-regulated to a lesser extent, some type II ... the major type I interferon-producing cell type, to the location of active viral replication. In the setting of HIV-1 infection ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2258719/?lang=en-ca
Interleukin 12 receptor, beta 1 subunit - Wikipedia
"A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits". Proc. Natl. Acad. Sci. U ... "Genetic variations in the interleukin-12/interleukin-23 receptor (beta1) chain, and implications for IL-12 and IL-23 receptor ... 1998). "Interleukin-12 induces tyrosine phosphorylation of an 85-kDa protein associated with the interleukin-12 receptor beta 1 ... Interleukin 12 receptor, beta 1 is a subunit of the interleukin 12 receptor. IL12RB1, is its human gene. IL12RB1 is also known ...https://en.wikipedia.org/wiki/Interleukin_12_receptor,_beta_1_subunit
Interleukin 1 receptor, type II - Wikipedia
... type II (IL-1R2) also known as CD121b (Cluster of Differentiation 121b) is an interleukin receptor. IL1R2 also denotes its ... "Type I and type II interleukin-1 receptor expression in rat, mouse, and human testes". Biology of Reproduction. 56 (6): 1513-26 ... "Interleukin-13 and interleukin-4 act as interleukin-6 inducers in human microglial cells". Cytokine. 8 (8): 636-41. doi:10.1006 ... Potential role for type II receptor in regulation of IL-1 responses". Journal of Immunology. 153 (12): 5802-9. PMID 7989776. Re ...https://en.wikipedia.org/wiki/Interleukin_1_receptor,_type_II
Interleukin-1 receptor type 1 (IPR004076) | InterPro | EMBL-EBI
... these have been termed type I and type II receptors [PMID: 8702856]. The receptors both exist in transmembrane (TM) and soluble ... Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA.. J. Biol. Chem. 271 20965 ... including the interleukin-6 receptor. A novel method for virus immune evasion has been proposed in which the product of one or ... A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist.. Nature 386 194 ...http://www.ebi.ac.uk/interpro/entry/IPR004076
Interleukin-1 Receptor Antagonist Genotype Is Associated With Coronary Atherosclerosis in Patients With Type 2 Diabetes |...
Univariate comparison of type 2 diabetes patients with (n = 196) and without CAD (n = 54) showed that hypertension (51.9 vs. ... Type 2 diabetes is associated with an increased risk of cardiovascular disease. A series of metabolic risk factors have been ... The interleukin-1 receptor antagonist (IL-1ra) is a major modulator of the interleukin-1 pro-inflammatory pathway. We studied ... Patients with type 2 diabetes had significantly lower IL-1ra concentrations than nondiabetic patients (P = 0.001, Mann-Whitney ...http://diabetes.diabetesjournals.org/content/51/12/3582
Anti-Interleukin 10 Receptor Monoclonal Antibody Is an Adjuvant for T Helper Cell Type 1 Responses to Soluble Antigen Only in...
Anti-Interleukin 10 Receptor Monoclonal Antibody Is an Adjuvant for T Helper Cell Type 1 Responses to Soluble Antigen Only in ... Anti-Interleukin 10 Receptor Monoclonal Antibody Is an Adjuvant for T Helper Cell Type 1 Responses to Soluble Antigen Only in ... 1996) A critical role for transforming growth factor β but not interleukin 4 in the suppression of T helper type 1-mediated ... 1993) In vivo role of interleukin 4 in T cell tolerance induced by aqueous protein antigens. J. Exp. Med. 177:457-463, pmid: ...http://jem.rupress.org/content/192/10/1529
Interleukin-1 beta - Proteopedia, life in 3D
5] Guy P. A. Vigers, Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1β, Nature 1997,386,190- ... the primary receptors(IL-1R) first bind their corresponding cytokine ligands(IL-1β) and then engage the accessory receptor(IL- ... 3] Mizutani H, Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human ... Human Interleukin-1 Beta THREE-DIMENSIONAL STRUCTURE OF IL-1β The molecule contains 12 antiparallel β-strands. The molecule has ...http://proteopedia.org/wiki/index.php/Interleukin-1_beta
Alberto Mantovani - Wikipedia
Mantovani was able to identify the operating principle of the decoy receptor for interleukin - 1. In 1993, his team showed ... His team demonstrated in 2005 that the chemokine receptor D6 acts as a decoy and scavenger receptor for inflammatory chemokines ... His works revealed the existence of decoy receptors in cell-signalling. He has been the most cited scientist in Italy, and one ... His works help to establish the concept of "decoy receptors". From the study of the regulation of the cytokines, ...https://en.wikipedia.org/wiki/Alberto_Mantovani
Acetate supplementation modulates brain histone acetylation and decreases interleukin-1β expression in a rat model of...
Further, in rats subjected to lipopolysaccharide-induced neuroinflammation, the pro-inflammatory cytokine interleukin-1β ... on brain histone acetylation and interleukin-1β expression in a rat model of lipopolysaccharide-induced neuroinflammation. The ... Aravalli RN, Peterson PK, Lokensgard JR: Toll-like receptors in defense and damage of the central nervous system. J Neuroimmune ... Basu A, Krady JK, Levison SW: Interleukin-1: a master regulator of neuroinflammation. J Neurosci Res 2004, 78:151-156.View ...https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-9-51
Interleukin-1 receptor associated kinase - Wikipedia
Inflammation signalling is known to be a major factor in many cancer types, and an inflammatory microclimate is a key aspect of ... Toll-like receptors (TLRs) are important innate immune receptors that recognize pathogen associated molecular patterns (PAMPs) ... and the B-cell activating receptor belonging to the TNF family (BAFF receptor). The alternative NF-κB pathway involves the ... Interleukin 1 is a cytokine that acts locally and systemically in the innate immune system. IL-1a and IL-1ß are known for ...https://en.wikipedia.org/wiki/Interleukin-1_receptor_associated_kinase
MyD88 (Myeloid Differentiation Primary Response Gene 88) | Springer for Research & Development
SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol. 2003;4(9):920-7.PubMed ... IRF5 was found to be crucial for the induction of proinflammatory cytokines and type I IFNs by all TLRs tested (Takaoka et al. ... MyD88 Myeloid differentiation primary response gene 88, IL-33 Interleukin-33 receptor, NF-κB nuclear factor-κB, IKK inhibitor ... MyD88-dependent pathway of Toll-like receptor signaling involves TIR dimerization between the receptor and the Mal. Recruitment ...https://rd.springer.com/referenceworkentry/10.1007/978-3-319-67199-4_588
Interleukin 1 receptor, type I - Wikipedia
... type I (IL1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL1R1 also denotes its human ... The protein encoded by this gene is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein is a ... Chua AO, Gubler U (1990). "Sequence of the cDNA for the human fibroblast type interleukin-1 receptor". Nucleic Acids Res. 17 ( ... 1987). "The cell surface receptors for interleukin-1 alpha and interleukin-1 beta are identical". Nature. 324 (6094): 266-8. ...https://en.wikipedia.org/wiki/Interleukin_1_receptor,_type_I
CCK-induced inhibition of presympathetic vasomotor neurons: dependence on subdiaphragmatic vagal afferents and central NMDA...
Functional and neurochemical characterization of angiotensin type 1A receptor-expressing neurons in the nucleus of the solitary ... Kurosawa M, Uvnas-Moberg K, Miyasaka K, and Lundeberg T. Interleukin-1 increases activity of the gastric vagal afferent nerve ... Central NMDA receptor blockade.. Administration of the centrally active noncompetitive NMDA receptor antagonist dizocilpine had ... it is likely that the NMDA receptors located in the NTS and/or caudal ventrolateral medulla play a role. NMDA receptor blockade ...http://ajpregu.physiology.org/content/287/4/R809
IL1R2 cDNA ORF Clone,Mouse | SinoBiological
... type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 ... Cardiovascular,,Angiogenesis,,Cytokine & Receptor,,Interleukin & Receptor,,IL-1 Family & Receptor,,IL-1 Family Receptor ... receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I ( ... and binds to specific plasma membrane receptors on cells. Two distinct types of IL1 receptors which are able to bind IL1 ...http://www.sinobiological.com/Mouse-IL1R2-Gene-cDNA-Clone-full-length-ORF-Clone-expression-ready-C-His-tagged-p107522.html
Interleukin 12 receptor, beta 2 subunit - Wikipedia
"A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits". Proc. Natl. Acad. Sci. U ... Interleukin 12 receptor, beta 2 subunit is a subunit of the interleukin 12 receptor. IL12RB2 is its human gene. IL12RB2 ... The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor ... 2002). "The interleukin-12 and interleukin-12 receptor system in normal and transformed human B lymphocytes". Haematologica. 87 ...https://en.wikipedia.org/wiki/Interleukin_12_receptor,_beta_2_subunit
CiNii 論文 - イヌの血管柄付下顎骨同種他家移植
Immunolocalization of interleukin-1 α in rat mandibular molars and its enhancement after in vivo injection of epidermal growth ... Epidermal Growth Factor and Epidermal Growth Factor - Receptor Expression in the Mouse Dental Follicle during Tooth Eruption ... Immunostaining and transcriprional enhancement of interleukin-1 receptor type I in the rat dental follicle WISE G. E. ... The contrasting effects of colony-stimulating factor-1 and epidermal growth factor on tooth eruption in the rat CIELINSKI M. J ...https://ci.nii.ac.jp/naid/10018954561
Increased Levels of Serum Protein Complexes Are Associated with Type 2 Diabetes
C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA. 2001;286:327-334 ... The Toll-like receptor 4 agonist MRP8/14 protein complex is a sensitive indicator for disease activity and predicts relapses in ... Pathogenesis of type 2 diabetes. Endocr Res. 2007;32:19-37 3. Pickup JC. Inflammation and activated innate immunity in the ... C-Reactive Protein is a Strong Independent Predictor of Death in Type 2 Diabetes: Association with Multiple Facets of the ...http://www.medsci.org/v15p0210.htm
KAKEN - Research Projects | Study on the calcification by periodental ligament fibroblasts in the periodonta regeneration ...
Publications] H.H.Chou,S.Takashiba,M.Takigawa,F.Nishimura,H.Arai,Y.Murayama: 'Role of Type II Interleukin-1 Receptor Exressed ... 25-dihydroxyvitamin D3 receptor (VDR), ALP activity and OC productivity at different phases of culture. The level of VDR gene ... 2 inhibits interleukin-6 release but not its transcription in human gingival fibroblasts stimulated with interleukin-1β or ... 2 inhibits interleukin-6 release but not its transcription in human gingival fibroblasts stimulated with interleukin-1beta or ...https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06454540/
MAP3K14 - Wikipedia
It participates in an NF-κB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF ... family and to the interleukin-1 type-I receptor. MAP3K14 has been shown to interact with: CHUK, IKK2, and TRAF2. ... Hu WH, Johnson H, Shu HB (1999). "Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-kappaB and JNK ... Kumar A, Eby MT, Sinha S, Jasmin A, Chaudhary PM (2001). "The ectodermal dysplasia receptor activates the nuclear factor-kappaB ...https://en.wikipedia.org/wiki/MAP3K14
Interleukin-1 Receptor Antagonist Expression in Human Endothelial Cells and Atherosclerosis | Arteriosclerosis, Thrombosis, and...
e, icIL-1ra type I (510 bp) and sIL-1ra (533 bp) mRNA transcripts in human atherosclerotic and DCM coronary arteries (lanes 2 ... Endothelin receptor mRNA expression in renal medulla identified by in situ RT PCR. Am J Physiol.. 1995;269:F449-F457. ... Interleukin-1β in coronary arteries of patients with ischemic heart disease. Arterioscler Thromb Vasc Biol.. 1996;16:1000-1006. ... Interleukin-1 in myocardium and coronary arteries of patients with dilated cardiomyopathy. J Mol Cell Cardiol.. 1998;30:215-223 ...http://atvb.ahajournals.org/content/20/11/2394
Inhibition of T1/St2 during Respiratory Syncytial Virus Infection Prevents T Helper Cell Type 2 (Th2)- but Not Th1-Driven...
Selective expression and functions of interleukin 18 receptor on T helper (Th) type 1 but not Th2 cells. J. Exp. Med. 1998;188: ... T cells secreting interleukin (IL)-4 and IL-5 (T helper cell type 2 [Th2] cells) play a detrimental role in a variety of ... independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function. Proc. Natl. Acad. Sci ... chemokine receptors 3 and 4 (references 4, 9, and 10), and the orphan receptor T1/ST2 (references 1112131415). Resting murine ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2193366/
Interleukin 20 receptor, alpha subunit - Wikipedia
2001). "Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types". J. Immunol. 167 ... Interleukin 20 receptor, alpha subunit is a subunit for the interleukin-20 receptor. IL20RA is its human gene. The protein ... The receptor of IL20 is a heterodimeric receptor complex consisting of this protein and interleukin 20 receptor beta (IL20B). ... 2003). "Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions ...https://en.wikipedia.org/wiki/Interleukin_20_receptor,_alpha_subunit
MYD88 - Wikipedia
"Toll-like receptor 3 mediates a more potent antiviral response than Toll-like receptor 4". Journal of Immunology. 170 (7): 3565 ... Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (Jul 1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor ... type I RAC1 TLR 4 Various single nucleotide polymorphisms (SNPs) of the MyD88 have been identified. and for some of them an ... "Toll-like receptor 3 mediates a more potent antiviral response than Toll-like receptor 4". Journal of Immunology. 170 (7): 3565 ...https://en.wikipedia.org/wiki/MYD88
... soluble tumor necrosis factor-alpha receptor type I and II, and soluble E-selectin serum levels in multiple sclerosis patients ... Perini, P., Tiberio, M., Sivieri, S., Facchinetti, A., Biasi, G. and Gallo, P., Interleukin-1 receptor antagonist, ... Scand J Immunol 1997. 45: 366-370. *Ferrarini, A. M., Sivieri, S., Buttarello, M., Facchinetti, A., Perini, P. and Gallo, P., ... J Neuroimmunol 1997. 73: 117-123.. *B iasi, G., Facchinetti, A., Mezzalira, S. and MacDonald, H. R., Selective lysis of ...https://www.utwente.nl/en/tnw/ctctrap/people/iov/facchinetti/
Interleukin 10 receptor, alpha subunit - Wikipedia
"Receptors for interleukin (IL)-10 and IL-6-type cytokines use similar signaling mechanisms for inducing transcription through ... Interleukin 10 receptor, alpha subunit is a subunit for the interleukin-10 receptor. IL10RA, is its human gene. IL10RA has also ... Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Interleukin 10 receptor, alpha subunit ... Ho AS, Liu Y, Khan TA, Hsu DH, Bazan JF, Moore KW (1994). "A receptor for interleukin 10 is related to interferon receptors". ...https://en.wikipedia.org/wiki/Interleukin_10_receptor,_alpha_subunit