Neumega - FDA prescribing information, side effects and uses
interleukins Proleukin, oprelvekin, aldesleukin. platelet-stimulating agents Promacta, eltrombopag, Nplate, romiplostim, ... Primary osteoblasts and mature osteoclasts express mRNAs for both IL-11 receptor (IL-11R alpha) and gp130. Both bone-forming ... Interleukin eleven (IL-11) is a thrombopoietic growth factor that directly stimulates the proliferation of hematopoietic stem ... Interleukin 11: review of molecular, cell biology and clinical use. Blood. 1997;89(11):3897-3908. ...https://www.drugs.com/pro/neumega.html
CD8+ T Cell-Mediated Delayed Rejection of Orthotopic Guinea Pig Cornea Grafts in Mice Deficient in CD4+ T Cells | IOVS | ARVO...
Deletion of the Chemokine Receptor CCR1 Prolongs Corneal Allograft Survival. A Model of Corneal Graft Rejection in Semi-Inbred ... Topical interleukin-1 receptor antagonistic promotes corneal transplant survival Transplantation 63,1501-1507 [CrossRef] [ ... Signaling through NK1.1 triggers NK cells to die but induces NK T cells to produce interleukin-4 Immunology 93,296-305 [PubMed] ... B cells with an antibody product that could arm Fc receptor bearing leukocytes that mediate antibody-dependent cell mediated ...https://iovs.arvojournals.org/article.aspx?articleid=2162795
Neuro-Immune Crosstalk in CNS Diseases | SpringerLink
Interleukin-18 stimulates synaptically released glutamate and enhances post-synaptic AMPA receptor responses in the CA1 region ... Interleukin 1beta facilitates bone cancer pain in rats by enhancing NMDA receptor NR-1 subunit phosphorylation. Neuroscience ... Kishimoto T (2005) Interleukin-6: from basic science to medicine - 40 years in immunology. Ann Rev Immunol 23:1-21Google ... Tsai HH, Frost E, To V, Robinson S, Ffrench-Constant C, Geertman R, Ransohoff RM, Miller RH (2002) The chemokine receptor CXCR2 ...https://link.springer.com/chapter/10.1007%2F400_2009_6
Interleukin-1 receptor type 1 (IPR004076) | InterPro | EMBL-EBI
... including the interleukin-6 receptor. A novel method for virus immune evasion has been proposed in which the product of one or ... these have been termed type I and type II receptors [PMID: 8702856]. The receptors both exist in transmembrane (TM) and soluble ... A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist.. Nature 386 194 ... Crystallographic refinement of interleukin 1 beta at 2.0 A resolution.. Proc. Natl. Acad. Sci. U.S.A. 86 9667-71 1989 ...http://www.ebi.ac.uk/interpro/entry/IPR004076
Interleukin 12 receptor, beta 1 subunit - Wikipedia
"Genetic variations in the interleukin-12/interleukin-23 receptor (beta1) chain, and implications for IL-12 and IL-23 receptor ... 1998). "Interleukin-12 induces tyrosine phosphorylation of an 85-kDa protein associated with the interleukin-12 receptor beta 1 ... "A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits". Proc. Natl. Acad. Sci. U ... Interleukin 12 receptor, beta 1 is a subunit of the interleukin 12 receptor. IL12RB1, is its human gene. IL12RB1 is also known ...https://en.wikipedia.org/wiki/Interleukin_12_receptor,_beta_1_subunit
Julio Licinio - Wikipedia
Licinio, J.; Wong, M.-L.; Gold, P. W. (July 1991). "Localization of interleukin-1 receptor antagonist mRNA in rat brain". ... "Association of a corticotropin-releasing hormone receptor 1 haplotype and antidepressant treatment response in Mexican- ... They also showed that interleukin 1 receptor antagonist is an endogenous neuroprotective agent. They have shown that the ... Licinio, J.; Wong, M.-L. (March 1994). "Localization of interleukin 1 type I receptor mRNA in rat brain". Neuroimmunomodulation ...https://en.wikipedia.org/wiki/Julio_Licinio
Interleukin-1 receptor associated kinase - Wikipedia
Toll-like receptors (TLRs) are important innate immune receptors that recognize pathogen associated molecular patterns (PAMPs) ... and the B-cell activating receptor belonging to the TNF family (BAFF receptor). The alternative NF-κB pathway involves the ... Interleukin 1 is a cytokine that acts locally and systemically in the innate immune system. IL-1a and IL-1ß are known for ... The interleukin-1 receptor (IL-1R) associated kinase (IRAK) family plays a crucial role in the protective response to pathogens ...https://en.wikipedia.org/wiki/Interleukin-1_receptor_associated_kinase
Interleukin-1 Receptor Antagonist Expression in Human Endothelial Cells and Atherosclerosis | Arteriosclerosis, Thrombosis, and...
Endothelin receptor mRNA expression in renal medulla identified by in situ RT PCR. Am J Physiol.. 1995;269:F449-F457. ... Interleukin-1β in coronary arteries of patients with ischemic heart disease. Arterioscler Thromb Vasc Biol.. 1996;16:1000-1006. ... Interleukin-1 in myocardium and coronary arteries of patients with dilated cardiomyopathy. J Mol Cell Cardiol.. 1998;30:215-223 ... Interleukin-1 Receptor Antagonist Expression in Human Endothelial Cells and Atherosclerosis. Rachael Dewberry, Hazel Holden, ...http://atvb.ahajournals.org/content/20/11/2394
KAKEN - Research Projects | Immunohistochemical studies on the localization of Interleukin-1 and its receptor in the...
The localization of Interleukin-1 (IL-1alpha, IL-1beta) and receptors (IL-1RtI,IL-1RtII) was immunohistochemically examined in ... Interleukin-1 / Interleukin-1 receptor / Immunohistochemistry / brain ischemia. Research Abstract. ... Immunohistochemical studies on the localization of Interleukin-1 and its receptor in the hippocampal CA-1 region of the ... Immunoreactivities for both types of IL-1 (alpha or beta) were found in reactive astrocytes, microglias and endothelial cells ...https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07680827/
Interleukin-1 Receptor Antagonist Genotype Is Associated With Coronary Atherosclerosis in Patients With Type 2 Diabetes |...
The interleukin-1 receptor antagonist (IL-1ra) is a major modulator of the interleukin-1 pro-inflammatory pathway. We studied ... The interleukin-1 (IL-1) pathway is a central mediator of inflammatory reactions. Increased activation of the IL-1 ... Interleukin-1 Receptor Antagonist Genotype Is Associated With Coronary Atherosclerosis in Patients With Type 2 Diabetes. ... Blakemore AI, Tarlow JK, Cork MJ, Gordon C, Emery P, Duff GW: Interleukin-1 receptor antagonist gene polymorphism as a disease ...http://diabetes.diabetesjournals.org/content/51/12/3582
Interleukin 1 receptor, type II - Wikipedia
... is an interleukin receptor. IL1R2 also denotes its human gene. The protein encoded by this gene is a decoy receptor for certain ... "Interleukin-13 and interleukin-4 act as interleukin-6 inducers in human microglial cells". Cytokine. 8 (8): 636-41. doi:10.1006 ... Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this ... "Entrez Gene: IL1R2 interleukin 1 receptor, type II". McMahan CJ, Slack JL, Mosley B, Cosman D, Lupton SD, Brunton LL, Grubin CE ...https://en.wikipedia.org/wiki/Interleukin_1_receptor,_type_II
Genetic and cellular evidence of decreased inflammation associated with reduced incidence of posttraumatic arthritis in MRL/MpJ...
Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis. J Clin ... Expression of MDC/CCL22 and its receptor CCR4 in rheumatoid arthritis, psoriatic arthritis and osteoarthritis. Cytokine 2010; ... Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist. Nature 1990; ... Prevention of murine collagen-induced arthritis in the knee and ipsilateral paw by local expression of human interleukin-1 ...http://onlinelibrary.wiley.com/doi/10.1002/art.37796/references
IL1RL1 - Wikipedia
The ligand for ST2 is the cytokine Interleukin-33(IL-33). Binding of IL-33 to the ST2 receptor, in response to cardiac disease ... 1998). "T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10 ... and a membrane-bound receptor form (referred to as the ST2 receptor or ST2L). When the myocardium is stretched, the ST2 gene is ... Interleukin 1 receptor-like 1, also known as IL1RL1 and ST2, is a protein that in humans is encoded by the IL1RL1 gene. IL1RL1 ...https://en.wikipedia.org/wiki/IL1RL1
Sickness behavior - Wikipedia
"Different receptor mechanisms mediate the pyrogenic and behavioral effects of interleukin 1". Proceedings of the National ... Goehler, L. E.; Gaykema, R. P.; Nguyen, K. T.; Lee, J. E.; Tilders, F. J.; Maier, S. F.; Watkins, L. R. (1999). "Interleukin- ... Banks, W. A.; Ortiz, L.; Plotkin, S. R.; Kastin, A. J. (1991). "Human interleukin (IL) 1 alpha, murine IL-1 alpha and murine IL ... Banks, W. A.; Kastin, A. J.; Gutierrez, E. G. (1994). "Penetration of interleukin-6 across the murine blood-brain barrier". ...https://en.wikipedia.org/wiki/Sickness_behavior
Interleukin-1 receptor - Wikipedia
The type I receptor is primarily responsible for transmitting the inflammatory effects of interleukin-1 (IL-1) while type II ... Receptors, Interleukin-1 at the US National Library of Medicine Medical Subject Headings (MeSH). ... is a cytokine receptor which binds interleukin 1. Two forms of the receptor exist. ... Arend WP (1991). "Interleukin 1 receptor antagonist. A new member of the interleukin 1 family". J. Clin. Invest. 88 (5): 1445- ...https://en.wikipedia.org/wiki/Interleukin-1_receptor
Expression of Interleukin-1 Receptor-Associated Kinase-1 (IRAK-1) in Non-Small Cell Lung Carcinoma and Preneoplastic Lesions
9. Kopp EB, Medzhitov R. The Toll-receptor family and control of innate immunity. Curr Opin Immunol. 1999;11:13-18. [PubMed] ... Expression of Interleukin-1 Receptor-Associated Kinase-1 (IRAK-1) in Non-Small Cell Lung Carcinoma and Preneoplastic Lesions. ... Li X, Qin J. Modulation of Toll-interleukin 1 receptor mediated signaling. J Mol Med. 2005;83:258-266. [PubMed] ... Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2811365/
Interleukin 13 receptor, alpha 1 - Wikipedia
The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 ... 2005). "Characterization of the interaction between interleukin-13 and interleukin-13 receptors". J. Biol. Chem. 280 (26): ... Interleukin 13 receptor, alpha 1, also known as IL13RA1 and CD213A1 (cluster of differentiation 213A1), is a human gene. ... Interleukin-13 receptor GRCh38: Ensembl release 89: ENSG00000131724 - Ensembl, May 2017 GRCm38: Ensembl release 89: ...https://en.wikipedia.org/wiki/Interleukin_13_receptor,_alpha_1
Frontiers | The Vagus Nerve in the Neuro-Immune Axis: Implications in the Pathology of the Gastrointestinal Tract | Immunology
... and post-ganglionic neurons which binds to nicotinic receptors and nicotinic or muscarinic receptors, respectively. The VN is ... Blockade of interleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: evidence for vagal mediation of immune-brain ... Beta adrenergic receptors in lymphocyte subpopulations. J Allergy Clin Immunol (1980) 65(1):29-33. doi:10.1016/0091-6749(80) ... Corticotropin-releasing factor receptor-1: a therapeutic target for cardiac autonomic disturbances. Expert Opin Ther Targets ( ...https://www.frontiersin.org/articles/10.3389/fimmu.2017.01452/full
Experimental Arthritis Summary Report | CureHunter
Interleukin-10 (Interleukin 10)IBA 12/01/2000 - "In the rat adjuvant arthritis model, treatment with systemic murine IL-10 (mIL ... Interleukin-1 (Interleukin 1)IBA 04/01/2008 - "Development of interleukin-1 receptor antagonist mutants with enhanced ... 02/01/2003 - "Efficacy of interleukin-10 gene electrotransfer into skeletal muscle in mice with collagen-induced arthritis.". ... "To determine the efficacy of local human interleukin-1 receptor antagonist (HuIL-1Ra) gene therapy in murine collagen-induced ...http://www.curehunter.com/public/keywordSummaryD001169-Experimental-Arthritis.do
Anti-Interleukin 10 Receptor Monoclonal Antibody Is an Adjuvant for T Helper Cell Type 1 Responses to Soluble Antigen Only in...
Anti-Interleukin 10 Receptor Monoclonal Antibody Is an Adjuvant for T Helper Cell Type 1 Responses to Soluble Antigen Only in ... Anti-Interleukin 10 Receptor Monoclonal Antibody Is an Adjuvant for T Helper Cell Type 1 Responses to Soluble Antigen Only in ... 1993) In vivo role of interleukin 4 in T cell tolerance induced by aqueous protein antigens. J. Exp. Med. 177:457-463, pmid: ... 1993) Interleukin-10 deficient mice develop chronic enterocolitis. Cell. 75:263-274, pmid:8402911.. ...http://jem.rupress.org/content/192/10/1529
In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy.
... synovial fibroblasts coexpress interleukin-I receptor type I and type I1 mRNA the increased level of the interleukin-I receptor ... Dose-range and dose-frequency study of recombinant human interleukin-I receptor antagonist in patients with rheumatoid ... Suppression of intraarticular responses to interleukin-I by transfer of the interleukin-1 receptor antagonist gene to synovium ... IL-1Ra = interleukin-1 receptor antagonist. iP , 0.04 versus lac Z group by Student's t-test. $ P , 0.01 versus lac Z group by ...https://www.docme.ru/doc/2175460/in-vivo-suppression-of-early-experimental-osteoarthritis-..
Physiopathology, Diagnosis, and Treatment of Secondary Female Hypogonadism | SpringerLink
Human peripheral blood mononuclear cells express gonadotropin-releasing hormone (GnRH), GnRH receptor, and interleukin-2 ... GnRH and GnRH receptor genes in the human genome. Endocrinology. 2002;143(3):737-43.PubMedCrossRefGoogle Scholar ... Gonadotropin-releasing hormone receptor transcripts in human sperm. Biol Reprod. 2002;67(6):1741-9.PubMedCrossRefGoogle Scholar ... Endogenous regulation of the GnRH receptor by GnRH in the human placenta. Mol Hum Reprod. 2001;7(1):89-95.PubMedCrossRefGoogle ...https://link.springer.com/referenceworkentry/10.1007/978-3-319-44444-4_9
Standardization of methods to record Vagus nerve activity in mice | SpringerLink
To study the receptor dependency of LPS-induced responses, we used LPS-receptor TLR4 knock out (TLR4 KO) mice. Wild type mice ... Interleukin-1 induces c-Fos immunoreactivity in primary afferent neurons of the vagus nerve. Brain Res. 1998;804:306-10. ... Importantly, vagus neurogramactivity in wild type and TLR4 receptor knock out mice exhibits receptor dependency of endotoxin ... Binding of acetylcholine to its cognate receptor, α-7 nicotinic acetylcholine receptor (α7nAChR), on cytokine producing cells ...https://link.springer.com/article/10.1186/s42234-018-0002-y
Immune cells subpopulations in cerebrospinal fluid and peripheral blood of patients with Aneurysmal Subarachnoid Hemorrhage |...
Wang Y, Zhong M, Tan X-X, Yang Y-J, Chen W-J, Liu W, Zheng K (2007) Expression change of interleukin-8 gene in rabbit basilar ... in 1993 reported that IL-2 receptor and soluble CD8 levels were increased in CSF of SAH patients suggesting the role of ... 2012). Pro-inflammatory cytokines such as interleukin-6 (IL-6), IL-1, TNF-α and complement have been detected in CSF of aSAH ... Stimulation through CD28 and T Cell Receptor (TCR) can provide a potent co-stimulatory signal to T cells for the production of ...https://springerplus.springeropen.com/articles/10.1186/s40064-015-0970-2
Interleukin-1 beta - Proteopedia, life in 3D
... the primary receptors(IL-1R) first bind their corresponding cytokine ligands(IL-1β) and then engage the accessory receptor(IL- ... 3] Mizutani H, Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human ... Human Interleukin-1 Beta THREE-DIMENSIONAL STRUCTURE OF IL-1β The molecule contains 12 antiparallel β-strands. The molecule has ... 5] Guy P. A. Vigers, Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1β, Nature 1997,386,190- ...http://proteopedia.org/wiki/index.php/Interleukin-1_beta