DNA repair-related functional assays for the classification of BRCA1 and BRCA2 variants: a critical review and needs assessment...
Inherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for ... A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 1994;266:66-71.doi:10.1126/science. ... Characterization of a breast Cancer cell line derived from a germ-line BRCA1 mutation carrier. Cancer Res 1998;58:3237-42. ... BRCA1 and BRCA2 as cancer genes. In the 1990s, pathogenic variants in BRCA1 and BRCA2 were found to be associated with ...http://jmg.bmj.com/content/54/11/721.full
Male Breast Cancer Treatment (PDQ )
... although the risks appear to be higher with inherited BRCA2 than with BRCA1 mutations.   Genes other than BRCA may also ... Wooster R, Bignell G, Lancaster J, et al.: Identification of the breast cancer susceptibility gene BRCA2. Nature 378 (6559): ... Stage Information for Male Breast Cancer. Treatment Option Overview for Male Breast Cancer. Treatment Options for Male Breast ... The pathology of male breast cancer is similar to that of female breast cancer, and infiltrating ductal cancer is the most ...http://www.meb.uni-bonn.de/cancer.gov/CDR0000062745.html
Epigenetics in Rheumatoid Arthritis | SpringerLink
In many human diseases, especially in cancers, but also in autoimmune diseases, epigenetic aberrations have been found. ... Methylation of the BRCA1 gene in sporadic breast cancer. Cancer Res 57:3347-3350PubMedGoogle Scholar ... Ermann J, Fathman CG (2001) Autoimmune diseases: genes, bugs and failed regulation. Nat Immunol 2:759-761PubMedCrossRefGoogle ... Otterson GA, Khleif SN, Chen W, Coxon AB, Kaye FJ (1995) CDKN2 gene silencing in lung cancer by DNA hypermethylation and ...https://link.springer.com/article/10.1007%2Fs12016-009-8166-6
Breast Cancer Genes and Inheritance
There are however, differences in these genes. The high incidence of ovarian cancer-linked to the BRCA1 gene, but the BRCA2 ... Breast cancer susceptible genes BRCA1 and BRCA2. Medicine 77:208-26.. 2.-Ormiston W. 1995. Hereditary breast cancer. European ... Breast Cancer Genes and Inheritance. Viviana Rivera-Varas. Copyright 1998. Breast cancer is the most common cancer that affects ... of families in which there are both breast cancer and ovarian cancer.. The life time risk of breast cancer in BRCA1 mutations ...https://www.ndsu.edu/pubweb/~mcclean/plsc431/students98/rivera.htm
Genomewide high-density SNP linkage analysis of non-BRCA1/2 breast cancer families identifies various candidate regions and has...
The two major breast cancer susceptibility genes BRCA1 and BRCA2 are involved in 30% of hereditary breast cancer cases, but the ... discovery of additional breast cancer predisposition genes for the non-BRCA1/2 breast cancer families has so far been ... We identified six regions on chromosomes 2, 3, 4, 7, 11 and 14 as candidates to contain genes involved in breast cancer ... we have performed a whole genome screen of 19 non-BRCA1/2 breast cancer families using 4720 genomewide SNPs with Illumina ...https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-8-299
Pilot studies on the p53 gene in nipple aspirate fluid from patients with breast cancer | SpringerLink
... from patients with breast cancer is a potential source of exfoliated tumour material amenable to molecular biological study, ... Crook T, Crossland S, Crompton MR, Osin P, Gusterson BA: p53 mutations in BRCA1-associated breast cancer. Lancet 350: 638-639, ... Jacobson DR, Mills NE: A highly sensitive assay for mutant ras genes and its application to the study of presentation and ... Pilot studies on the p53 gene in nipple aspirate fluid from patients with breast cancer. ...https://link.springer.com/article/10.1023%2FA%3A1006487315587
American Cancer Society Guidelines for Breast Cancer Screening: Update 2003 - Smith - 2008 - CA: A Cancer Journal for...
Probability of carrying a mutation of breast-ovarian cancer gene BRCA1 based on family history. J Natl Cancer Inst 1997; 89:227 ... Determining carrier probabilities for breast cancer-susceptibility genes BRCA1 and BRCA2. Am J Hum Genet 1998; 62:145-158. * ... Breast cancer family history as a risk factor for early onset breast cancer. Breast Cancer Res Treat 1988; 11:263-267. * ... Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium. Am J Hum Genet 1995; 56:265- ...http://onlinelibrary.wiley.com/doi/10.3322/canjclin.53.3.141/references?globalMessage=0
c-Myc activates BRCA1 gene expression through distal promoter elements in breast cancer cells | BMC Cancer | Full Text
... of all genes in the human genome and results from a high throughput screen suggest that BRCA1 is one of its targets. In this ... c-Myc was depleted using c-Myc-specific siRNAs in cultured breast cancer cells. BRCA1 mRNA expression and BRCA1 protein ... Furthermore, breast cancer cells with reduced BRCA1 expression due to depletion of c-Myc exhibited impaired DNA repair activity ... BRCA1 inactivation contributes to breast cancer tumorigenesis. An increasing number of transcription factors have been shown to ...https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-11-246
Screening of exon 11 of BRCA1 gene using the high resolution melting approach for diagnosis in Moroccan breast cancer patients ...
It has previously been reported that mutations in BRCA1 and BRCA2 genes are linked to breast cancer. Here, we evaluated the use ... HRM analysis was used to screen exon 11 from 71 breast cancer patients in order to detect different variants. Conventional ... approach to screen for mutations in exon 11 of BRCA1 gene in Moroccan patients. ... Identification of specific mutations in cancer patients may lead to the discovery of genes, which can affect susceptibility and ...https://bmccancer.biomedcentral.com/articles/10.1186/s12885-015-1040-4
Similar Effects of Brca2 Truncation and Rad51 Paralog Deficiency on Immunoglobulin V Gene Diversification in DT40 Cells Support...
Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1 ... The relationship between the roles of BRCA genes in DNA repair and cancer predisposition. Trends Mol. Med. 8:571-576. ... Individuals carrying germ line mutations of the BRCA2 gene have a high risk of developing breast and ovarian cancer (40, 45, 76 ... BRCA2 is a tumor suppressor gene that is linked to hereditary breast and ovarian cancer. Although the Brca2 protein ...https://mcb.asm.org/content/25/3/1124?ijkey=865d58a40e7552408e6685e8f6b7ccbed7c4d85c&keytype2=tf_ipsecsha
Breast Cancer Risk Assessment in 64,659 Women at a Single High-Volume Mammography Clinic
Probability of carrying a mutation of breast-ovarian cancer gene BRCA1 based on family history. J Natl Cancer Inst. 1997 Feb 5; ... Parmigiani G, Berry D, Aguilar O. Determining carrier probabilities for breast cancer-susceptibility genes BRCA1 and BRCA2. Am ... American Cancer Society Breast Cancer Advisory Group. American Cancer Society guidelines for breast screening with MRI as an ... Breast Imaging Reporting and Data System.. 13. U.S. National Institutes of Health, National Cancer Institute. Breast Cancer ...http://pubmedcentralcanada.ca/pmcc/articles/PMC3261722/?lang=en-ca
Patent US8133737 - Systems and methods for breast cancer detection and risk assessment - Google Patents
... or cancer of the breast. A method is described whereby a breast cancer marker is detected in breast fluid. In a particular ... correlates very well with the disease status of the breast cancer subjects from which the fluids were obtained. Screening test ... The appearance in breast fluids of a marker that is detected by an aldehyde detecting reagent, such as a Schiff's reagent, ... embodiment, the method involves treating samples of breast fluids with an aldehyde detecting reagent without any prewashing. ...http://www.google.com/patents/US8133737?dq=6272333
BACH1 Ser919Pro variant and breast cancer risk | BMC Cancer | Full Text
The BACH1 gene was screened for germ line alterations among probands from 43 Finnish BRCA1/2 negative breast cancer families. ... the protein product of one of the major genes for hereditary predisposition to breast cancer. Previously, two BACH1 germ line ... have been identified in early-onset breast cancer patients with and without family history of breast and ovarian cancer. In ... age at cancer diagnosis, family history of cancer, or survival. Our results suggest that the BACH1 Ser919 is not a breast ...https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-6-19
List of events in NHGRI history - Wikipedia
... show that three specific alterations in the breast cancer genes BRCA1 and BRCA2 are associated with an increased risk of breast ... funded scientists find a new tumor suppressor gene involved in breast, prostate and other cancers on human chromosome 7. A ... scientists use microarray technology to develop a gene test that differentiates hereditary from sporadic types of breast cancer ... announce the first three cancers that will be studied in the pilot phase of The Cancer Genome Atlas (TCGA). The cancers to be ...https://en.wikipedia.org/wiki/List_of_events_in_NHGRI_history
No germline mutations in the histone acetyltransferase gene EP300 in BRCA1 and BRCA2 negative families with breast cancer and...
... multiple-case breast and ovarian cancer families. The histone acetyltransferase gene EP300 may function as a tumour suppressor ... gene because it is sometimes somatically mutated in breast, colorectal, gastric and pancreatic cancers, and is located on a ... screened the entire coding region of EP300 for mutations in the youngest affected members of 23 non-BRCA1/BRCA2 breast cancer ... The frequency of the Ser211 variant did not differ significanlty between a series of 352 breast cancer patients (4.0%) and 254 ...https://0-breast--cancer--research-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/bcr803
Patent US6783977 - Internal ribosome entry site and vector containing same - Google Patents
53, 3860-3864), ERB-2 gene which is overexpressed in cancers of the breast and the pancreas (Harris et al., 1994, Gene Therapy ... Cancer Res. 57, 461-465), APC which is overexpressed in colorectal cancers, BRCA-1 and 2 (Wooster et al., 1995, Nature 378, 789 ... The vectors are generally obtained by deletion of at least part of the viral genes which are replaced by the therapeutic genes ... There may be mentioned in particular the promoters of the MUC-1 gene which is overexpressed in breast and prostate cancers ( ...http://www.google.ca/patents/US6783977
Interactions between human BRCA2 protein and the meiosis‐specific recombinase DMC1 | The EMBO Journal
Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of BRCA1, BRCA2, BRCA1/BRCA2, BRCA1 ... Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol Cell 2 ... This work was supported by Cancer Research UK, the EU DNA Repair Consortium, the Breast Cancer Campaign, and the Jeantet ... RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene BRCA2. J Biol Chem ...http://emboj.embopress.org/content/26/12/2915
Link Between BRCA1 Gene And ATM Protein May Explain Increased Breast Cancer Risk (dateline November 11, 1999) | Breast Health...
... develop breast cancer more frequently than women with BRCA1 mutations alone. Women with mutated BRCA1 genes currently account ... Link Between BRCA1 Gene And ATM Protein May Explain Increased Breast Cancer Risk (dateline November 11, 1999). ... Women with malfunctioning BRCA1 or BRCA2 genes also have a 20% to 60% chance of developing ovarian cancer.(1) ... In 1994, researchers discovered that women with mutated BRCA1 or BRCA2 genes have an increased risk of developing breast and ...http://www.imaginis.com/breast-health-news/link-between-brca1-gene-and-atm-protein-may-explain-increased-breast-cancer-risk-dateline-november-1
Distinct functions of BRCA1 and BRCA2 in double-strand break repair | Breast Cancer Research | Full Text
The BRCA1 and BRCA2 proteins are required for homologous recombination and DNA break repair, leading to the suggestion that ... We discuss the interaction of BRCA1 with the BACH1 and BARD1 proteins, and suggest that the pleiotropic nature of mutations in ... However, direct evidence of a stable BRCA1/BRCA2 complex has not been demonstrated. Rather, the two proteins have been found as ... BRCA1 may be associated with defects in protein-protein interactions. In contrast, the role of BRCA2 in DNA repair may be more ...https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr417
BRCA1/2 Mutations and Risk of Breast and Ovarian Cancer | Breast Cancer | JAMA | The JAMA Network
This genetic epidemiology study reports that risk of breast and ovarian cancer among women with BRCA1 and BRCA2 mutations ... A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science. 1994;266(5182):66-71.PubMedGoogle ... segments across the intronic and exonic regions of the BRCA1 or BRCA2 genes associated with different breast vs ovarian cancer ... with ovarian cancer, 272 (2%) with breast and ovarian cancer, and 4766 (40%) without cancer. In BRCA1, we identified 3 breast ...https://jamanetwork.com/journals/jama/fullarticle/2214084
Risk factors of female breast carcinoma: A case control study at Puducherry Balasubramaniam S M, Rotti S B, Vivekanandam S -...
The Indian Journal of Cancer is an official publication of the Indian Cancer Society and Indian Society of Oncology. ... 2] Inherited breast cancer is associated with germline mutations in BRCA1, BRCA2, p53 and PTEN genes. There have been ... TaqI polymorphism of VDR gene contributes to breast cancer risk. Hua Wang,Wenjian Wang,Dongjie Yang,Shenming Wang. ... Breast Cancer Res 2003;5:88-102. 10.. Hajjian-Tilaki KO, Kaveh-Ahangar T. Reproductive factors associated with breast cancer ...http://www.indianjcancer.com/article.asp?issn=0019-509X
OTUD4 - Wikipedia
"BRCA1-like" breast tumors". Cancer Res. 63 (9): 2024-7. PMID 12727813. "Entrez Gene: OTUD4 OTU domain containing 4". Bonaldo MF ... 1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from ... OTU domain-containing protein 4 is a protein that in humans is encoded by the OTUD4 gene. Two alternatively spliced transcript ... 2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome ...https://en.wikipedia.org/wiki/OTUD4
High Prevalence of Preinvasive Lesions Adjacent to BRCA1/2-Associated Breast Cancers | Cancer Prevention Research
The Breast Cancer Linkage ConsortiumGenetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer ... Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer. J Natl Cancer Inst 199991943-9. ... Breast Cancer Linkage ConsortiumPathology of familial breast cancer: differences between breast cancers in carriers of BRCA1 or ... Histopathological features of breast tumours in BRCA1, BRCA2 and mutation-negative breast cancer families. Breast Cancer Res ...http://cancerpreventionresearch.aacrjournals.org/content/2/2/122.full
Mammographic breast density as a biomarker of effects of isoflavones on the female breast | Breast Cancer Research | Full Text
Increased mammographic breast density is associated with an elevated risk of breast cancer, although the mechanism underlying ... Breast density may therefore serve as a biomarker of estrogenic or anti-estrogenic effects of a treatment on breast tissue. The ... However, two intervention studies of markers of proliferation on breast tissue have raised concerns that soy isoflavones may ... Estrogens increase and anti-estrogens decrease breast density. ... effect of isoflavones on breast density is under investigation. ...https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr410
Ovarian Epithelial, Fallopian, & Peritoneal Cancer Treatment (PDQ®)-Health Professional Version - National Cancer Institute
Get detailed information about these cancers, (newly diagnosed or recurrent) and how they are treated in this summary for ... and primary peritoneal cancer treatments include surgery, chemotherapy, targeted therapy, and PARP inhibitors. ... Miki Y, Swensen J, Shattuck-Eidens D, et al.: A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. ... and although most of these are linked to mutations in either the BRCA1 or BRCA2 gene, several other genes have been implicated ...https://www.cancer.gov/types/ovarian/hp/ovarian-epithelial-treatment-pdq