*  American Cancer Society Guidelines for Breast Cancer Screening: Update 2003 - Smith - 2008 - CA: A Cancer Journal for...
Probability of carrying a mutation of breast-ovarian cancer gene BRCA1 based on family history. J Natl Cancer Inst 1997; 89:227 ... Determining carrier probabilities for breast cancer-susceptibility genes BRCA1 and BRCA2. Am J Hum Genet 1998; 62:145-158. * ... Breast cancer family history as a risk factor for early onset breast cancer. Breast Cancer Res Treat 1988; 11:263-267. * ... Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium. Am J Hum Genet 1995; 56:265- ...
  http://onlinelibrary.wiley.com/doi/10.3322/canjclin.53.3.141/references?globalMessage=0
*  c-Myc activates BRCA1 gene expression through distal promoter elements in breast cancer cells | BMC Cancer | Full Text
... of all genes in the human genome and results from a high throughput screen suggest that BRCA1 is one of its targets. In this ... c-Myc was depleted using c-Myc-specific siRNAs in cultured breast cancer cells. BRCA1 mRNA expression and BRCA1 protein ... Furthermore, breast cancer cells with reduced BRCA1 expression due to depletion of c-Myc exhibited impaired DNA repair activity ... BRCA1 inactivation contributes to breast cancer tumorigenesis. An increasing number of transcription factors have been shown to ...
  https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-11-246
*  Breast Cancer Risk Assessment in 64,659 Women at a Single High-Volume Mammography Clinic
Probability of carrying a mutation of breast-ovarian cancer gene BRCA1 based on family history. J Natl Cancer Inst. 1997 Feb 5; ... Parmigiani G, Berry D, Aguilar O. Determining carrier probabilities for breast cancer-susceptibility genes BRCA1 and BRCA2. Am ... American Cancer Society Breast Cancer Advisory Group. American Cancer Society guidelines for breast screening with MRI as an ... Breast Imaging Reporting and Data System.. 13. U.S. National Institutes of Health, National Cancer Institute. Breast Cancer ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3261722/?lang=en-ca
*  Patent US8133737 - Systems and methods for breast cancer detection and risk assessment - Google Patents
... or cancer of the breast. A method is described whereby a breast cancer marker is detected in breast fluid. In a particular ... correlates very well with the disease status of the breast cancer subjects from which the fluids were obtained. Screening test ... The appearance in breast fluids of a marker that is detected by an aldehyde detecting reagent, such as a Schiff's reagent, ... embodiment, the method involves treating samples of breast fluids with an aldehyde detecting reagent without any prewashing. ...
  http://www.google.com/patents/US8133737?dq=6272333
*  List of events in NHGRI history - Wikipedia
... show that three specific alterations in the breast cancer genes BRCA1 and BRCA2 are associated with an increased risk of breast ... funded scientists find a new tumor suppressor gene involved in breast, prostate and other cancers on human chromosome 7. A ... scientists use microarray technology to develop a gene test that differentiates hereditary from sporadic types of breast cancer ... announce the first three cancers that will be studied in the pilot phase of The Cancer Genome Atlas (TCGA). The cancers to be ...
  https://en.wikipedia.org/wiki/List_of_events_in_NHGRI_history
*  Patent US6783977 - Internal ribosome entry site and vector containing same - Google Patents
53, 3860-3864), ERB-2 gene which is overexpressed in cancers of the breast and the pancreas (Harris et al., 1994, Gene Therapy ... Cancer Res. 57, 461-465), APC which is overexpressed in colorectal cancers, BRCA-1 and 2 (Wooster et al., 1995, Nature 378, 789 ... The vectors are generally obtained by deletion of at least part of the viral genes which are replaced by the therapeutic genes ... There may be mentioned in particular the promoters of the MUC-1 gene which is overexpressed in breast and prostate cancers ( ...
  http://www.google.ca/patents/US6783977
*  Interactions between human BRCA2 protein and the meiosis‐specific recombinase DMC1 | The EMBO Journal
Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of BRCA1, BRCA2, BRCA1/BRCA2, BRCA1 ... Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol Cell 2 ... This work was supported by Cancer Research UK, the EU DNA Repair Consortium, the Breast Cancer Campaign, and the Jeantet ... RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene BRCA2. J Biol Chem ...
  http://emboj.embopress.org/content/26/12/2915
*  Link Between BRCA1 Gene And ATM Protein May Explain Increased Breast Cancer Risk (dateline November 11, 1999) | Breast Health...
... develop breast cancer more frequently than women with BRCA1 mutations alone. Women with mutated BRCA1 genes currently account ... Link Between BRCA1 Gene And ATM Protein May Explain Increased Breast Cancer Risk (dateline November 11, 1999). ... Women with malfunctioning BRCA1 or BRCA2 genes also have a 20% to 60% chance of developing ovarian cancer.(1) ... In 1994, researchers discovered that women with mutated BRCA1 or BRCA2 genes have an increased risk of developing breast and ...
  http://www.imaginis.com/breast-health-news/link-between-brca1-gene-and-atm-protein-may-explain-increased-breast-cancer-risk-dateline-november-1
*  BRCA1/2 Mutations and Risk of Breast and Ovarian Cancer | Breast Cancer | JAMA | The JAMA Network
This genetic epidemiology study reports that risk of breast and ovarian cancer among women with BRCA1 and BRCA2 mutations ... A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science. 1994;266(5182):66-71.PubMedGoogle ... segments across the intronic and exonic regions of the BRCA1 or BRCA2 genes associated with different breast vs ovarian cancer ... with ovarian cancer, 272 (2%) with breast and ovarian cancer, and 4766 (40%) without cancer. In BRCA1, we identified 3 breast ...
  https://jamanetwork.com/journals/jama/fullarticle/2214084
*  High Prevalence of Preinvasive Lesions Adjacent to BRCA1/2-Associated Breast Cancers | Cancer Prevention Research
The Breast Cancer Linkage ConsortiumGenetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer ... Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer. J Natl Cancer Inst 199991943-9. ... Breast Cancer Linkage ConsortiumPathology of familial breast cancer: differences between breast cancers in carriers of BRCA1 or ... Histopathological features of breast tumours in BRCA1, BRCA2 and mutation-negative breast cancer families. Breast Cancer Res ...
  http://cancerpreventionresearch.aacrjournals.org/content/2/2/122.full
*  OTUD4 - Wikipedia
"BRCA1-like" breast tumors". Cancer Res. 63 (9): 2024-7. PMID 12727813. "Entrez Gene: OTUD4 OTU domain containing 4". Bonaldo MF ... 1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from ... OTU domain-containing protein 4 is a protein that in humans is encoded by the OTUD4 gene. Two alternatively spliced transcript ... 2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome ...
  https://en.wikipedia.org/wiki/OTUD4
*  Cancers | Free Full-Text | BRCA1 and Oxidative Stress | HTML
Finally, we consider its significance in prevention and/or treatment of BRCA1-related cancers. ... Thus, it is essential to understand the function of BRCA1 in oxidative stress regulation. In this review, we briefly summarize ... Increasing evidence suggests that BRCA1 regulates oxidative stress and this may be another mechanism in preventing ... BRCA1's many binding partners and mechanisms, and discuss data supporting the function of BRCA1 in oxidative stress regulation ...
  http://www.mdpi.com/2072-6694/6/2/771/htm
*  Gene Expression Literature Detail
... Symbol. Name. ID Brca2 breast cancer 2, early onset. MGI:109337 ... J:40064 Rajan JV, Marquis ST, Gardner HP, Chodosh LA, Developmental expression of Brca2 colocalizes with Brca1 and is ... Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc ... Indicates gene expression was analyzed but not necessarily detected. Age. E6.5. E13.5. E18.5. P. ...
  http://www.informatics.jax.org/gxdlit/key/7056
*  Study Offers Insight Into Age-Specific Breast, Ovarian Cancer Risk for BRCA-Positive Women
BRCA1,/em, or ,em,BRCA2 ,/em,mutation raises a woman's lifetime risk of developing breast and ovarian cancer. ... risk also varied by whether the mutation was located outside versus within specific positions in the BRCA1 and BRCA2 genes.. ... mutations depend on the extent of the woman's family history of cancer and the position of the specific fault within the gene ... The cumulative risk of contralateral breast cancer 20 years after a breast cancer diagnosis was 40% for BRCA1 carriers (95% CI ...
  http://www.onclive.com/web-exclusives/study-offers-insight-into-agespecific-breast-ovarian-cancer-risk-for-brcapositive-women
*  VAT1 - Wikipedia
1994). "A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1". Science. 266 (5182): 66-71. doi: ... Jul 1995). "22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families ... 1995). "The search for BRCA1". Cancer Res. 54 (24): 6374-82. PMID 7987831. Matoba R, Okubo K, Hori N, et al. (1994). "The ... 1995). "Comparison of the positional cloning methods used to isolate the BRCA1 gene". Hum. Mol. Genet. 4 (8): 1259-66. doi: ...
  https://en.wikipedia.org/wiki/VAT1
*  EZH1 - Wikipedia
1995). "22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and ... "Entrez Gene: EZH1 enhancer of zeste homolog 1 (Drosophila)". Ezhkova E, Lien WH, Stokes N, Pasolli HA, Silva JM, Fuchs E (Mar ... 1996). "Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21". Genomics. 28 (3): 530-42. doi: ... Histone-lysine N-methyltransferase EZH1 is an enzyme that in humans is encoded by the EZH1 gene. In mice, EZH1 and EZH2 ...
  https://en.wikipedia.org/wiki/EZH1
*  Oral Contraceptive Use and Risk of Early-Onset Breast Cancer in Carriers and Noncarriers of BRCA1 and BRCA2 Mutations | Cancer...
An Alu-mediated 6-kb duplication in the BRCA1 gene: a new founder mutation? Am J Hum Genet 1999;64:300-2. ... were tested for mutations in both genes, identifying 47 BRCA1 mutation carriers and 36 BRCA2 mutation carriers. ... multiple breast cancer primaries, both breast and ovarian cancer, or male breast cancer; at least three first-degree relatives ... Genetic variants of GPX1 and SOD2 and breast cancer risk at the Ontario site of the Breast Cancer Family Registry. Cancer ...
  http://cebp.aacrjournals.org/content/14/2/350
*  Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer | Journal of...
Mutations and alternative splicing of the BRCA1 gene in UK breast/ovarian cancer families. Genes Chromosomes Cancer 18, 102-110 ... Frequent mutation of the PIK3CA gene in ovarian and breast cancers. Clin. Cancer Res. 11, 2875-2878. ... in the ovarian cancer cell line (A2780) and in the breast cancer cell line (MCF7), all of which express endogenous wild-type ... Fox Chase Cancer Center, Philadelphia, PA), and the MCF7 breast cancer line were used to compare neoplastic lines with wild- ...
  http://jcs.biologists.org/content/121/5/664
*  The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1‐dependent hyperphosphorylation and interacts with Rad53...
1994) A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science, 266, 66-71. ... Mutation of mitotic checkpoint genes in human cancers. Nature, 392, 300-303. ... which is often mutated in familial breast and ovarian cancers (Futreal et al., 1994; Miki et al., 1994). Brca1 is regulated ... The best evidence for a link between checkpoints and cancer comes from studies of ATM, the gene mutated in the cancer‐prone ...
  http://emboj.embopress.org/content/17/19/5679
*  PSME3 - Wikipedia
"A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1". Science. 266 (5182): 66-71. Bibcode:1994Sci... ... "A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21". Nat Genet. 7 (4): 472-9. doi:10.1038/ng0894-472 ... PSME3 human gene location in the UCSC Genome Browser. PSME3 human gene details in the UCSC Genome Browser.. ... "Comparison of the positional cloning methods used to isolate the BRCA1 gene". Hum. Mol. Genet. 4 (8): 1259-66. doi:10.1093/hmg/ ...
  https://en.wikipedia.org/wiki/PSME3
*  Researchers Hope Function of BRCA1 Gene Holds Key to New Treatments | Cancer Network | The Oncology Journal
... various mutations of which have been shown to cause breast and ovarian cancers, may help researchers develop treatments for ... New knowledge about the normal function of the BRCA1 gene, ... that mutant BRCA1 genes do not inhibit growth or suppress ... Holt's group observed that although the BRCA1. gene is rarely mutated in sporadic breast or ovarian cancer, levels of. BRCA1 ... Holt reported that the wild-type BRCA1 gene inhibits the growth. of sporadic breast and ovarian cancer cell lines in vitro and ...
  http://www.cancernetwork.com/articles/researchers-hope-function-brca1-gene-holds-key-new-treatments
*  Androgen receptor - Wikipedia
"Breast cancer susceptibility gene 1 (BRCAI) is a coactivator of the androgen receptor". Cancer Research. 60 (21): 5946-9. PMID ... a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells". Proceedings of the National ... "Increase of androgen-induced cell death and androgen receptor transactivation by BRCA1 in prostate cancer cells". Proceedings ... "Androgen receptor gene CAG repeat length varies in a race-specific fashion in men without prostate cancer". Urology. 53 (2): ...
  https://en.wikipedia.org/wiki/Androgen_receptor
*  ATM mutations in Finnish breast cancer patients | Journal of Medical Genetics
In Finland, mutations in the two major breast cancer susceptibility genes BRCA11 and BRCA22 appear to account for a ... A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science1994;266:66-71. ... bilateral breast cancer, or (4) multiple tumours including breast cancer in the same person. Additionally, 85 sporadic breast ... in a cohort of 215 breast cancer cases from 162 cancer families, as well as in 85 sporadic breast cancer patients. Altogether, ...
  http://jmg.bmj.com/content/39/3/192
*  CHEK2 - Wikipedia
"Pathology and gene expression of hereditary breast tumors associated with BRCA1, BRCA2 and CHEK2 gene mutations". Oncogene. 25 ... The estimated fraction of breast cancer attributed to this variant is reported to be around 1.2% in the US. Two more CHEK2 gene ... Genes & Development. 12 (3): 382-95. doi:10.1101/gad.12.3.382. PMC 316487 . PMID 9450932. Matsuoka S, Huang M, Elledge SJ (Dec ... Inherited mutations in the CHEK2 gene have been linked to certain cases of breast cancer. Most notably, the deletion of a ...
  https://en.wikipedia.org/wiki/CHEK2
*  Genetic Screening for Breast Cancer
BRCA1, that has had an unprecedented impact on the study of cancer genetics. BRCA1 is a breast cancer susceptibility gene, ... Just a year later, a second breast cancer susceptibility gene, BRCA2, was discovered. Mutations in these two genes alone appear ... BRCA1 and BRCA2. As already mentioned, BRCA1 was the first breast cancer gene to be isolated. This was accomplished through ... The major obstacle in developing successful screening techniques involves the size and complexity of breast cancer genes. BRCA1 ...
  https://www.ndsu.edu/pubweb/~mcclean/plsc431/students/mickelson.html