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*  The MC159 Protein from the Molluscum Contagiosum Poxvirus Inhibits NF-κB Activation by Interacting with the IκB Kinase Complex ...
Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis. Proc. Natl. ... MC159 contains two tandem protein-protein interaction domains called death effector domains (DEDs; DEDA, DEDB) (17, 18). MC159 ... The MC159 protein is a viral FLIP and, as such, possesses two tandem death effector domains (DEDs). We show in this article ... The death effector domains (DEDs) of the molluscum contagiosum virus MC159 v-FLIP protein are not functionally interchangeable ...
  http://www.jimmunol.org/content/188/5/2371
*  Death Domain database - Wikipedia
... a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis". Cell. 81 (4): 505-512 ... DEATH: DEATH domain, found in proteins involved in cell death (apoptosis)., retrieved 3 November 2016 O'Neill, LA; Dunne, A; ... The Death Domain database is a secondary database of protein-protein interactions (PPI) of the death domain superfamily. ... There are four types of death domain subfamilies: death effector domain (DED), caspase recruitment domain (CARD), pyrin domain ...
  https://en.wikipedia.org/wiki/Death_Domain_database
*  Caspase-independent Cell Killing by Fas-associated Protein with Death Domain
FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell. 1995;81: ... Fas-associated protein with death domain (FADD), to the death domain of the Fas cytoplasmic region. This binding causes ... A novel protein that interacts with the death domain of Fas/ APO1 contains a sequence motif related to the death domain. J Biol ... Fas-associated protein with death domain. FKBP. FK506 binding protein. HA. hemagglutinin. PARP. poly(ADP-ribose) polymerase. ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2133085/?lang=en-ca
*  Sindbis virus induces apoptosis through a caspase-dependent, CrmA-sensitive pathway. - Semantic Scholar
The specificity of CrmA indicates that the Sindbis virus-induced death pathway is similar to that induced by Fas or tumor ... inhibited Sindbis virus-induced cell death, suggesting that cellular caspases facilitate apoptosis induced by Sindbis virus. ... To study the role of caspases in virus-induced apoptosis, we determined the effects of specific caspase inhibitors on Sindbis ... cells and of neurons in mouse brains leads to programmed cell death exhibiting the classical characteristics of apoptosis. ...
  https://www.semanticscholar.org/paper/Sindbis-virus-induces-apoptosis-through-a-pathway.-Nava-Ros%C3%A9n/c2eb607b659f44b25893e5f957476e35fa3524ad
*  Transduction of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand into Hematopoietic Cells Leads to Inhibition of...
Fas-associated protein with death domain (FADD)-independent recruitment of c-FLIPL to death receptor 5. J Biol Chem. 2004;279: ... Yang X, Khosravi-Far R, Chang HY, Baltimore D. Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell. 1997; ... 4E), and the increased apoptosis was accompanied by positive staining of TRAIL protein in the tumor tissue (Fig. 4E), which ... TRAIL and apoptosis induction by TNF-family death receptors. Oncogene. 2003;22:8628-33. [PubMed] ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2941891/
*  Fas receptor - Wikipedia
... a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis". Cell. 81 (4): 505-12 ... "Apoptosis-linked gene 2 binds to the death domain of Fas and dissociates from Fas during Fas-mediated apoptosis in Jurkat cells ... This allows the adaptor molecule FADD to bind the death domain of Fas through its own death domain. FADD also contains a death ... "Regulation of Fas-associated death domain interactions by the death effector domain identified by a modified reverse two-hybrid ...
  https://en.wikipedia.org/wiki/Fas_receptor
*  Overview of Eukaryotic In Vitro Translation and Expression Systems - Current Protocols
FADD, a novel death domain‐containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81:505‐512 ... Bik, a novel death‐inducing protein, shares a distinct sequence motif with Bcl‐2 family proteins and interacts with viral and ... Proteinprotein interaction between the transcriptional repressor E4BP4 and the TBP‐binding protein Dr1. Nucl. Acid Res. 24: ... Synthesizing proteins in vitro by transcription and translation of cloned genes. In Current Protocols in Molecular Biology (F.A ...
  http://www.currentprotocols.com/WileyCDA/CPUnit/refId-cb1101.html?quicktabs_cp=abstract
*  T cells in the pathogenesis of type 1 diabetes | SpringerLink
... expression of dominant-negative Fas-associated death domain protein in beta cells protects against Fas ligand-induced apoptosis ... Thomas HE, Darwiche R, Corbett JA, Kay TW: Evidence that beta cell death in the nonobese diabetic mouse is Fas independent. J ... Amrani A, Verdaguer J, Thiessen S, et al.: IL-1alpha, IL-1beta, and IFN-gamma mark beta cells for Fas-dependent destruction by ... Yamada K, Takane-Gyotoku N, Yuan X, et al.: Mouse islet cell lysis mediated by interleukin-1-induced Fas. Diabetologia 1996, 39 ...
  https://link.springer.com/article/10.1007%2Fs11892-008-0019-9
*  Tumor necrosis factor receptor 1 - Wikipedia
"Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally ... death domain and induces apoptosis". J. Biol. Chem. 274 (15): 10145-53. doi:10.1074/jbc.274.15.10145. PMID 10187798. Okura T, ... "A protein related to a proteasomal subunit binds to the intracellular domain of the p55 TNF receptor upstream to its 'death ... "Two-hybrid cloning of a gene encoding TNF receptor-associated protein 2, a protein that interacts with the intracellular domain ...
  https://en.wikipedia.org/wiki/Tumor_necrosis_factor_receptor_1
*  Distinct Pathways of Apoptosis Triggered by FTY720, Etoposide, and Anti-Fas Antibody in Human T-Lymphoma Cell Line (Jurkat...
... or agonistic antibody results in receptor trimerization and recruitment of Fas receptor-associated protein with death domains ( ... In Fas-mediated apoptosis, Ac-DEVD-CHO strongly inhibited caspase 3, but not caspase 8. Thus, in Fas-mediated apoptosis, ... Caspase 8 is the most apical in Fas-mediated apoptosis (Muzio et al., 1996). Triggering of the Fas receptor with its cognate ... Determination of Protein.. The protein concentration was determined with the DC protein assay kit (Bio-Rad) by using bovine ...
  http://jpet.aspetjournals.org/content/300/3/939
*  Caspase 8 - Wikipedia
The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD ... death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis". J. ... "Regulation of Fas-associated death domain interactions by the death effector domain identified by a modified reverse two-hybrid ... protein complex binding. • scaffold protein binding. • protein binding. • identical protein binding. • cysteine-type ...
  https://en.wikipedia.org/wiki/CASP8
*  DAXX antibody | acris-antibodies.com
Death-associated protein 6) or BING2, was first discovered through its cytoplasmic… ... death-domain associated protein) also known as DAP6( ... to the Fas death domain and enhances Fas-mediated apoptosis. ... BING2, DAP6, EAP1, Death domain-associated protein 6, Fas death domain-associated protein, ETS1-associated protein 1 ... DAXX(death-domain associated protein) also known as DAP6(Death-associated protein 6) or BING2, was first discovered through its ...
  https://www.acris-antibodies.com/target/daxx-antibody.htm
*  CFLAR Gene - GeneCards | CFLAR Protein | CFLAR Antibody
Protein Coding), CASP8 And FADD Like Apoptosis Regulator, including: function, proteins, disorders, pathways, orthologs, and ... CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis. (PMID: 9380701) Inohara N ... Cell cycle-dependent regulation of FLIP levels and susceptibility to Fas-mediated apoptosis. (PMID: 10227994) Algeciras- ... Domains & Families for CFLAR Gene Gene Families for CFLAR Gene. HGNC:. *1019 : Death effector domain containing ...
  https://www.genecards.org/cgi-bin/carddisp.pl?gene=CFLAR
*  Apoptosis: cell 'death' reveals creation - creation.com
Programmed cell death is an intricately controlled and irreducibly complex process, without which no multicellular life could ... a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis, Cell 81:505-512, 1995 ... A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain, J. ... The first line proteins are those containing a so-called 'death domain' (DD). Some of these are trans-membrane proteins with a ...
  https://creation.com/apoptosis-cell-death-reveals-creation
*  Betulinic Acid-Induced Apoptosis in Glioma Cells: A Sequential Requirement for New Protein Synthesis, Formation of Reactive...
CD95 associates via its death domain with the Fas-associating protein with death domain (FADD/MORT1), which binds FADD-like ICE ... 1C). Next, we asked whether BA-induced apoptosis was an active type of cell death, that is, requires new mRNA and protein ... BA-induced apoptosis requires new protein, but not RNA, synthesis, is independent of p53, and results in p21 protein ... Bcl-2 family protein expression during BA-induced apoptosis. LN-18 (left) or LN-229 (right) cells were untreated or treated ...
  http://jpet.aspetjournals.org/content/289/3/1306.long
*  TRADD - Wikipedia
"Regulation of Fas-associated death domain interactions by the death effector domain identified by a modified reverse two-hybrid ... This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus ... Tumor necrosis factor receptor type 1-associated DEATH domain protein is a protein that in humans is encoded by the TRADD gene ... TRADD is an adaptor protein. The protein encoded by this gene is a death domain containing adaptor molecule that interacts with ...
  https://en.wikipedia.org/wiki/TRADD
*  Death-associated protein 6 - Wikipedia
It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor ... Death-associated protein 6 also known as Daxx is a protein that in humans is encoded by the DAXX gene. Daxx, a Death domain- ... and cell death. Daxx interacts with the TGF-β type II receptor by binding of C-terminal domain of the protein. When the cell is ... a novel Fas-binding protein that activates JNK and apoptosis". Cell. 89 (7): 1067-76. doi:10.1016/S0092-8674(00)80294-9. PMC ...
  https://en.wikipedia.org/wiki/Death-associated_protein_6
*  Caspase 10 - Wikipedia
"Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally ... and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II ... "Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally ... Zheng, L; Schickling O; Peter M E; Lenardo M J (August 2001). "The death effector domain-associated factor plays distinct ...
  https://en.wikipedia.org/wiki/Caspase_10
*  Caspase 8 - Wikipedia
The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD ... death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis". J. ... "Regulation of Fas-associated death domain interactions by the death effector domain identified by a modified reverse two-hybrid ... a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death". Proc. Natl. Acad ...
  https://en.wikipedia.org/wiki/Caspase_8
*  Pathogenic Mechanisms in Type 1 Diabetes: The Islet is Both Target and Driver of Disease
... expression of dominant-negative Fas-associated death domain protein in beta cells protects against Fas ligand-induced apoptosis ... BH3-interacting domain death agonist, CTL - cytotoxic T lymphocyte, dnFADD - dominant-negative Fas-associated death domain, ... Fas-associated death domain; GAD65 - glutamic acid decarboxylase 65; GFAP - glial fibrillary acidic protein; HLA - human ... 5.3 The Fas/FasL pathway is a minor effector of beta-cell destruction. Ligation of the Fas (CD95) death receptor by FasL on ...
  http://www.soc-bdr.org/content/rds/archive/9/4_winter/chapter_i_pathogenesis/pathogenic_mechanisms_in_t1d/?showfulltext=1
*  Activation-induced cell death - Wikipedia
... whose cytoplasmic domain is then able to bind the death domain of the adaptor protein FADD (Fas-associated protein with death ... However, overexpression of the protein CFLAR (caspase and FADD-like apoptosis regulator) inhibits Fas-mediated apoptosis. ... AICD (activation-induced cell death) is programmed cell death caused by the interaction of Fas receptors (Fas, CD95) and Fas ... domain). Procaspase 8 binds to FADD's death effector domain (DED) and proteolytically self-activates as caspase 8. Fas, FADD, ...
  https://en.wikipedia.org/wiki/Activation-induced_cell_death
*  Patent US20030211108 - Monoclonal antibody inducing apoptosis - Google Patents
... and the antigens that induce apoptosis of nucleated blood cells having human Integrin Associated Protein. Accordingly, they are ... while also having an action of inducing apoptosis of nucleated blood cells; these properties can be utilized to prepare useful ... useful as antibodies that recognize human Integrin Associated Protein for its distinction and identification, ... The monoclonal antibodies of this invention are antibodies that specifically recognize human Integrin Associated Protein, ...
  http://www.google.com/patents/US20030211108?dq=oakley+D523,461
*  Apoptosis and Its Relevance to Autoimmunity by Keith B. Elkon - ANNE ALMASY Book Archive
A novel protein containing a death domain that interacts with fas/APO-1(CD95) in yeast and causes cell death. Cell 1995;81:513- ... Chu K, Niu X, Williams LT: A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis. Proc Natl Acad Sci USA ... Signaling protein oligomeric transduction structures are early mediators of death receptor-induced apoptosis at the plasma ... The initial explanation was that Fas-deficient cells accumulate because of apoptosis resistance. However, if it fits with a ...
  http://annealmasy.com/pdf/apoptosis-and-its-relevance-to-autoimmunity
*  Histone Deacetylase Inhibitors Modulate the Sensitivity of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Resistant...
FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 1995; 81: ... Fas, TNFR-1, TRAIL-R1, and TRAIL-R2) share a homophilic protein/protein intracellular domain, the death domain ( 41, 42), which ... the death domain of FADD binds to the death domain of TRAIL-R1 or TRAIL-R2. The death effector domain of FADD, in turn, ... Itoh N, Nagata S. A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen. J Biol Chem 1993; ...
  http://cancerres.aacrjournals.org/content/66/1/499
*  Telomerase reverse transcriptase - Wikipedia
Fas-Associated protein with Death Domain) can be used to force cells expressing hTERT to undergo apoptosis. Viral proteins like ... This led to apoptosis and cell death in cells with short telomere lengths, a promising result for cancer treatment. Although ... The protein can be a toxin, an apoptotic factor, or a viral protein. Toxins such as diphtheria toxin interfere with cellular ... "Regulation of telomerase activity and anti-apoptotic function by protein-protein interaction and phosphorylation". FEBS Lett. ...
  https://en.wikipedia.org/wiki/Telomerase_reverse_transcriptase