*  A Cohort Study of Metformin Exposure and Survival in Patients with Stage I-III Colorectal Cancer | Cancer Epidemiology,...
Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase. Mol ... MicroRNA-21-mediated regulation of Sprouty2 protein expression enhances the cytotoxic effect of 5-fluorouracil and metformin in ... The use for research of anonymized data held by the NCRI is covered by the Health (Provision of Information) Act 1997. ...
  http://cebp.aacrjournals.org/content/22/8/1364?rss=1
*  Protein kinase, AMP-activated, alpha 1 - Wikipedia
"Stimulation of glucose transport by AMP-activated protein kinase via activation of p38 mitogen-activated protein kinase". J. ... 1996). "Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the ... Bolster DR, Crozier SJ, Kimball SR, Jefferson LS (2002). "AMP-activated protein kinase suppresses protein synthesis in rat ... AMP-activated protein kinase catalytic subunit alpha-1 is an enzyme that in humans is encoded by the PRKAA1 gene. The protein ...
  https://en.wikipedia.org/wiki/Protein_kinase,_AMP-activated,_alpha_1
*  PRKAB1 - Wikipedia
5'-AMP-activated protein kinase subunit beta-1 is an enzyme that in humans is encoded by the PRKAB1 gene. The protein encoded ... 2000). "Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding". Biochem. J. 346 ... 2004). "The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy ... "Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding". Biochem. J. ENGLAND. ...
  https://en.wikipedia.org/wiki/PRKAB1
*  PRKAB2 - Wikipedia
5'-AMP-activated protein kinase subunit beta-2 is an enzyme that in humans is encoded by the PRKAB2 gene. The protein encoded ... 2000). "Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding". Biochem. J. 346 ... "Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding". Biochem. J. ENGLAND. ... "Entrez Gene: PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit". Cheung, P C; Salt I P; Davies S P; Hardie D G ...
  https://en.wikipedia.org/wiki/PRKAB2
*  Plus it
... activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. Am. J. Physiol.; 273:E1107-E1112. ... 2010 Regulation of NT‐PGC‐1alpha subcellular localization and function by protein kinase A‐dependent modulation of nuclear ... The expression of trunc‐PGC‐1α and non‐trunc‐PGC‐1α are important given that differences in protein domains influence which ... An additional aim in this study was to test whether different stimuli activate the two characterized PGC‐1α promoter regions ...
  http://physreports.physiology.org/content/1/6/e00140
*  AMP-Activated Protein Kinase-Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol | Diabetes
Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. Biochem J 2000; 3: 659- ... SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. J Biol Chem 2008; 283: 20015- ... Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 2002; 8 ... AMP-activated protein kinase (AMPK) (5,12,13). AMPK is a heterotrimeric protein consisting of an α-catalytic subunit and two ...
  http://diabetes.diabetesjournals.org/content/59/3/554
*  Metformin Increases AMP-Activated Protein Kinase Activity in Skeletal Muscle of Subjects With Type 2 Diabetes | Diabetes
Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied ... AMP-activated protein kinase (AMPK) is activated in muscle of subjects with type 2 diabetes during exercise. Diabetes 50:921- ... Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal ... Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major ...
  http://diabetes.diabetesjournals.org/content/51/7/2074
*  Frontiers | AMP-Activated Protein Kinase and O-GlcNAcylation, Two Partners Tightly Connected to Regulate Key Cellular Processes...
Its activation under energetic stress is known to activate energy-producing pathways and to inactivate energy-consuming ... Its activation under energetic stress is known to activate energy-producing pathways and to inactivate energy-consuming ... The AMP-activated protein kinase (AMPK) is an important cellular energy sensor. ... The AMP-activated protein kinase (AMPK) is an important cellular energy sensor. ...
  https://www.frontiersin.org/articles/10.3389/fendo.2018.00519/full
*  Activation and Signaling by the AMP-Activated Protein Kinase in Endothelial Cells | Circulation Research
Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab. ... AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling [2007;100:328-341]. AMP-Activated Protein Kinase in the ... Mammalian TAK1 activates Snf1 protein kinase in yeast and phosphorylates AMP-activated protein kinase in vitro. J Biol Chem. ... The AMP-activated protein kinase (AMPK) is a heterotrimeric serine/threonine protein kinase consisting of the catalytic subunit ...
  http://circres.ahajournals.org/content/105/2/114.long
*  Berberine, a Natural Plant Product, Activates AMP-Activated Protein Kinase With Beneficial Metabolic Effects in Diabetic and...
... by activating the stress-activated kinase AMP-activated protein kinase (AMPK) (5,6). AMPK is activated under a variety of ... Stimulation of glucose transport by AMP-activated protein kinase via activation of p38 mitogen-activated protein kinase. J Biol ... Leff T: AMP-activated protein kinase regulates gene expression by direct phosphorylation of nuclear proteins. Biochem Soc Trans ... Hawley SA, Gadalla AE, Olsen GS, Hardie DG: The antidiabetic drug metformin activates the AMP-activated protein kinase cascade ...
  http://diabetes.diabetesjournals.org/content/55/8/2256.full
*  The Rab GTPase-Activating Protein AS160 Integrates Akt, Protein Kinase C, and AMP-Activated Protein Kinase Signals Regulating...
The Rab GTPase-Activating Protein AS160 Integrates Akt, Protein Kinase C, and AMP-Activated Protein Kinase Signals Regulating ... The Rab GTPase-Activating Protein AS160 Integrates Akt, Protein Kinase C, and AMP-Activated Protein Kinase Signals Regulating ... The Rab GTPase-Activating Protein AS160 Integrates Akt, Protein Kinase C, and AMP-Activated Protein Kinase Signals Regulating ... The Rab GTPase-Activating Protein AS160 Integrates Akt, Protein Kinase C, and AMP-Activated Protein Kinase Signals Regulating ...
  http://diabetes.diabetesjournals.org/content/56/2/414
*  Isoform-Specific Regulation of 5′ AMP-Activated Protein Kinase in Skeletal Muscle From Obese Zucker (fa/fa) Rats in Response to...
AMP-activated protein kinase (AMPK) is activated in muscle of subjects with type 2 diabetes during exercise. Diabetes50 :921 - ... AMP-activated protein kinase (AMPK). We determined the effects of insulin and muscle contraction/hypoxia on PI 3-kinase, AMPK, ... AMP-activated protein kinase (AMPK) has emerged as one potential therapeutic molecular target that plays a role in mediating ... Involvement of AMP-Activated Protein Kinase in Glucose Uptake Stimulated by the Globular Domain of Adiponectin in Primary Rat ...
  http://diabetes.diabetesjournals.org/content/51/9/2703
*  AMP-activated protein kinase - Wikipedia
"AMP-activated protein kinase kinase activity and phosphorylation of AMP-activated protein kinase in contracting muscle of ... 5' AMP-activated protein kinase or AMPK or 5' adenosine monophosphate-activated protein kinase is an enzyme (EC 2.7.11.31) that ... It should not be confused with cyclic AMP-activated protein kinase (protein kinase A). AMPK is a heterotrimeric protein complex ... "Endurance training increases LKB1 and MO25 protein but not AMP-activated protein kinase kinase activity in skeletal muscle". Am ...
  https://en.wikipedia.org/wiki/AMP-activated_protein_kinase
*  α-Lipoic Acid Prevents Endothelial Dysfunction in Obese Rats via Activation of AMP-Activated Protein Kinase | Arteriosclerosis,...
We showed previously that α-lipoic acid (ALA) activates AMP-activated protein kinase (AMPK) and reduces lipid accumulation in ... α-Lipoic Acid Prevents Endothelial Dysfunction in Obese Rats via Activation of AMP-Activated Protein Kinase. Woo Je Lee, In Kyu ... Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Nat Med. 2004; ... Energy-sensing and signaling by AMP-activated protein kinase in skeletal muscle. J Appl Physiol. 2001; 91: 1017-1028. ...
  http://atvb.ahajournals.org/content/25/12/2488
*  The AMP-activated protein kinase pathway - new players upstream and downstream | Journal of Cell Science
Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases ... A homologue of AMP-activated protein kinase in Drosophila melanogaster is sensitive to AMP and is activated by ATP depletion. ... Salt, I. P., Johnson, G., Ashcroft, S. J. H. and Hardie, D. G. (1998). AMP-activated protein kinase is activated by low glucose ... Bolster, D. R., Crozier, S. J., Kimball, S. R. and Jefferson, L. S. (2002). AMP-activated protein kinase suppresses protein ...
  http://jcs.biologists.org/content/117/23/5479
*  Deficiency of Phosphoinositide 3-Kinase Enhancer Protects Mice From Diet-Induced Obesity and Insulin Resistance | Diabetes
In this regard, AMP-activated protein kinase (AMPK) is one of the targets. AMPK is the master sensor for energy status and is ... AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. Am J Physiol 1997 ... Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders. J ... 5′-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4- ...
  http://diabetes.diabetesjournals.org/content/59/4/883?with-ds=yes
*  AMP-kinase α2 subunit gene PRKAA2 variants are associated with total cholesterol, low-density lipoprotein-cholesterol and high...
Known as the "fuel gauge of the cell",1 5′-AMP-activated protein kinase (AMPK), is activated by an increase in the cellular AMP ... Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature2002;415:339-43. ... AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab2005;1:15-25 ... AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells. J ...
  http://jmg.bmj.com/content/43/12/936
*  Frontiers | Chrysophanic Acid Suppresses Adipogenesis and Induces Thermogenesis by Activating AMP-activated Protein Kinase...
Furthermore, when co-treated with Compound C, the AMP-activated protein kinase (AMPK) inhibitor, CA was able to restore the ... Furthermore, when co-treated with Compound C, the AMP-activated protein kinase (AMPK) inhibitor, CA was able to restore the ... In addition, uncoupling protein 1 (UCP1) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α), the ... In addition, uncoupling protein 1 (UCP1) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α), the ...
  https://www.frontiersin.org/articles/10.3389/fphar.2016.00476/full
*  JCI - High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation
Phosphorylation of rat muscle acetyl-CoA carboxylase by AMP-activated protein kinase and protein kinase A. J Appl Physiol. 1997 ... Purification and characterization of the AMP-activated protein kinase. Copurification of acetyl-CoA carboxylase kinase and 3- ... Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. Biochem J. 2000;346 Pt 3 ... AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. Am J Physiol. ...
  https://www.jci.org/articles/view/88532
*  JCI - The blooming of the French lilac
An activating mutation in the gamma-1 subunit of the AMP-activated protein kinase. FEBS Lett 2001. 500:163-168. View this ... A specific method for activating AMP-activated protein kinase in intact cells? Eur J Biochem 1995. 229:558-565. View this ... AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate ... Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. Biochem J 2000. 346:659- ...
  https://www.jci.org/articles/view/14178
*  Coenzyme Q10 Attenuates High Glucose-Induced Endothelial Progenitor Cell Dysfunction through AMP-Activated Protein Kinase...
F. Y. L. Li, K. S. L. Lam, H.-F. Tse et al., "Endothelium-selective activation of AMP-activated protein kinase prevents ... D. Kukidome, T. Nishikawa, K. Sonoda et al., "Activation of AMP-activated protein kinase reduces hyperglycemia-induced ... Coenzyme Q10 Attenuates High Glucose-Induced Endothelial Progenitor Cell Dysfunction through AMP-Activated Protein Kinase ... inhibition by the AMP-activated protein kinase activation," Diabetes, vol. 51, no. 1, pp. 159-167, 2002. View at Publisher · ...
  https://www.hindawi.com/journals/jdr/2016/6384759/ref/
*  Caffeine Enhances Endothelial Repair by an AMPK-Dependent Mechanism | Arteriosclerosis, Thrombosis, and Vascular Biology
AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 ... The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. ... increasing levels of AMP lead to activation of AMP-activated protein kinases (AMPK, for review see10), which have been ... Hardie DG, Carling D. The AMP-activated protein kinase-fuel gauge of the mammalian cell? Eur J Biochem. 1997; 246: 259-273. ...
  http://atvb.ahajournals.org/content/28/11/1967
*  Activation of the Mitogen-Activated Protein Kinase (ERK1/2) Signaling Pathway by Cyclic AMP Potentiates the Neuroprotective...
mitogen-activated protein kinase kinase. MAPK. mitogen-activated protein kinase. *The American Society for Pharmacology and ... 1994) Cyclic AMP activates the mitogen-activated protein kinase cascade in PC12 cells. J Biol Chem 269:6207-6214. ... protects cerebellar granule neurons from apoptosis by activating the mitogen-activated protein kinase (MAP kinase) pathway. J ... mitogen-activated protein. TH. tyrosine hydroxylase. MAP-2. microtubule associated protein-2. CREB. cyclic AMP response element ...
  http://molpharm.aspetjournals.org/content/62/5/1043
*  Regulation of bile canalicular network formation and maintenance by AMP-activated protein kinase and LKB1 | Journal of Cell...
2005). The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases. J. Biol. Chem. 280, 29060 ... AMP-activated protein kinase (AMPK), a serine threonine kinase containing a catalytic α-subunit and regulatory β- and γ- ... AMPK can be activated by upstream kinases LKB1 and CaMKK (calmodulin-dependent protein kinase kinase). LKB1 is active in the ... LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase ...
  http://jcs.biologists.org/content/123/19/3294
*  Plus it
Although CFTR is a cyclic AMP-activated Cl− channel, it is also activated by protein kinase C (Jia et al., 1997) and by cyclic ... by protein kinase C is required for acute activation of cystic fibrosis transmembrane conductance regulator by protein kinase A ... Ca2+-mobilizing receptors are known to activate protein kinase C, to promote prostanoid release secondary to phospholipase A2 ... PotentialN-glycosylation sites are indicated by ∗, and putative protein kinase C phosphorylation sites are indicated by •. ...
  http://jpet.aspetjournals.org/content/297/1/43