Methylation Regulates Alpha-Synuclein Expression and Is Decreased in Parkinson's Disease Patients' Brains | Journal of...
Alpha-synuclein (SNCA) is a key component of Lewy bodies found in Parkinson's disease (PD) patients (Spillantini et al., 1997; ... Alpha-synuclein (SNCA) is a major risk gene for Parkinson's disease (PD), and increased SNCA gene dosage results in a ... Methylation Regulates Alpha-Synuclein Expression and Is Decreased in Parkinson's Disease Patients' Brains. Ahmad Jowaed, Ina ... 2008) GATA transcription factors directly regulate the Parkinson's disease-linked gene alpha-synuclein. Proc Natl Acad Sci U S ...http://www.jneurosci.org/content/30/18/6355
Alpha-synuclein alters differently gene expression of Sirts, PARPs and other stress response proteins: implications for...
Alpha-synuclein (ASN) is a presynaptic protein that can easily change its conformation under different types of stress. It's ... Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc Natl Acad Sci ... Luk KC, Song C, O'Brien P et al (2009) Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular ... Mattila PM, Rinne JO, Helenius H et al (2000) Alpha-synuclein-immunoreactive cortical Lewy bodies are associated with cognitive ...https://link.springer.com/article/10.1007/s12035-016-0317-1
Conditional Expression of Parkinson's Disease-Related Mutant α-Synuclein in the Midbrain Dopaminergic Neurons Causes...
2001) Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model. Am J ... neurons and the presence of α-synuclein (α-syn)-positive intracytoplasmic inclusions named Lewy bodies (LBs) and Lewy neurites ... 2006) Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science 313:324-328. ... 2010) Alpha-synuclein: membrane interactions and toxicity in Parkinson's disease. Annu Rev Cell Dev Biol 26:211-233. ...http://www.jneurosci.org/content/32/27/9248
Maria Grazia Spillantini - Wikipedia
She is most noted for identifying the protein alpha-synuclein as the major component of Lewy bodies, the characteristic protein ... "Alpha-synuclein in Lewy bodies". Nature. 388 (6645): 839-40. doi:10.1038/42166. PMID 9278044. Ghetti, MG; Goedert, M; Crowther ... In particular her work studies the role of microtubule-associated protein tau and alpha-synuclein aggregation in the ... deposit found in the brain in Parkinson's disease and dementia with Lewy bodies. She has also identified mutations in the MAPT ...https://en.wikipedia.org/wiki/Maria_Grazia_Spillantini
Frontiers | S-nitrosylation of the thioredoxin-like domains of protein disulfide isomerase and its role in neurodegenerative...
1998). Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. Am. J. ... Alpha-synuclein in Lewy bodies. Nature 388, 839-840. doi: 10.1038/42166 ... Here, cytoplasmic Lewy bodies, which stain for aggregated α-synuclein in the substantia nigra, results in the clinical ... it was also seen to provoke co-localization and in parallel the formation of α-synuclein:synphilin-1-containing Lewy-body-like ...https://www.frontiersin.org/articles/10.3389/fchem.2015.00027/full
Deferiprone Rescues Behavioral Deficits Induced by Mild Iron Exposure in a Mouse Model of Alpha-Synuclein Aggregation |...
Alpha-synuclein in Lewy bodies. Nature, 388(6645), 839-840. doi: 10.1038/42166.CrossRefPubMedGoogle Scholar ... Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein. Neuron, 34(4), 521- ... 2012). Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo. PLoS ONE, 7(6), e39465. doi: ... Alpha-synuclein Iron Deferiprone Parkinson's disease Rotarod Novel object recognition test Electronic supplementary material. ...https://link.springer.com/article/10.1007/s12017-017-8447-9
Frontiers | Molecular Events Underlying Parkinson's Disease - An Interwoven Tapestry | Neurology
In particular, the recent identification and functional characterization of several genes, including α-synuclein, parkin, DJ-1 ... In particular, the recent identification and functional characterization of several genes, including α-synuclein, parkin, DJ-1 ... Alpha-synuclein in Lewy bodies. Nature 388, 839-840. ... Chaperone suppression of alpha-synuclein toxicity in a ... 2008). Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy. J. Clin. Invest. 118, 777-788. ...https://www.frontiersin.org/articles/10.3389/fneur.2013.00033/full
Frontiers | Live imaging of synaptic vesicle release and retrieval in dopaminergic neurons | Frontiers in Neural Circuits
Alpha-synuclein in Lewy bodies. Nature 388, 839-840. ... Alpha-synuclein locus triplication causes Parkinson's disease. ... Finally these approaches should also be well suited for studying mutations in genes such as α-synuclein that are known to both ... Maroteaux, L., Campanelli, J. T., and Scheller, R. H. (1988). Synuclein: a neuron-specific protein localized to the nucleus and ... Spillantini, M. G., Schmidt, M. L., Lee, V. M., Trojanowski, J. Q., Jakes, R., and Goedert, M. (1997). ...https://www.frontiersin.org/articles/10.3389/neuro.04.003.2009/full
IJMS | Free Full-Text | Novel Strategies for Drug Discovery Based on Intrinsically Disordered Proteins (IDPs) | HTML
... α-synuclein, an intrinsically disordered protein involved in Parkinson diseases, is also a hub of the protein network. The ... Spillantini, MG; Schmidt, ML; Lee, VM; Trojanowski, JQ; Jakes, R; Goedert, M. Alpha-synuclein in Lewy bodies. Nature 1997, 388 ... Characterization of inhibitor-bound alpha-synuclein dimer: Role of alpha-synuclein N-terminal region in dimerization and ... A broken alpha-helix in folded alpha-Synuclein. J. Biol. Chem 2003, 278, 15313-15318. [Google Scholar] ...http://www.mdpi.com/1422-0067/12/5/3205/htm
Contursi Terme - Wikipedia
The NIH team and a team led by Maria Spillantini reported on alpha-synuclein deposits in Lewy bodies as well as alpha-synuclein ... "Alpha-synuclein in Lewy bodies". Nature. 388 (6645): 839-40. doi:10.1038/42166. PMID 9278044. ... Mezey E, Dehejia A, Harta G, Papp MI, Polymeropoulos MH, Brownstein MJ (1998). "Alpha synuclein in neurodegenerative disorders ... the same team identified a point mutation in the alpha-synuclein gene in the Contursi kindred as well as Greek pedigrees with ...https://en.wikipedia.org/wiki/Contursi_Terme
History of Parkinson's disease - Wikipedia
Within days of the publication of the PARK1 findings, alpha-synuclein was discovered to be the major component of Lewy bodies ... Schulz-Schaeffer WJ (August 2010). "The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, ... "Alpha-synuclein in Lewy bodies". Nature. 388 (6645): 839-40. doi:10.1038/42166. PMID 9278044. ... In 1912 Frederic Lewy described a pathologic finding in affected brains, later named "Lewy bodies". In 1919 Konstantin ...https://en.wikipedia.org/wiki/History_of_Parkinson's_disease
JCI - α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells
Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells. Proc Natl ... The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Ann Neurol. 2004;55(2):164-173.. View this ... Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M. Alpha-synuclein in Lewy bodies. Nature. 1997;388(6645): ... Lewy bodies (LB) and Lewy neurites (LN), are intracytoplasmic inclusions that develop in the cell body and neurites of affected ...https://www.jci.org/articles/view/43366
Alpha-synuclein - Wikipedia
Alpha-synuclein is the primary structural component of Lewy body fibrils. Occasionally, Lewy bodies contain tau protein; ... and NACP/alpha-synuclein-epitopes in lewy bodies in sporadic Parkinson's disease and in dementia with Lewy bodies". Brain ... Lewy bodies. A single molecule study in 2008 suggests alpha-synuclein exists as a mix of unstructured, alpha-helix, and beta- ... Therefore, NACP is now referred to as human alpha-synuclein. Alpha-synuclein is a synuclein protein of unknown function ...https://en.wikipedia.org/wiki/Alpha-synuclein
Parkinson's disease - Wikipedia
Other forms of alpha-synuclein (e.g., oligomers) that are not aggregated in Lewy bodies and Lewy neurites may actually be the ... Schulz-Schaeffer WJ (August 2010). "The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, ... alpha-synuclein, is the main component of the Lewy bodies that accumulate in the brains of people with PD. Mutations in some ... alpha-synuclein was found to be the main component of Lewy bodies by Spillantini, Trojanowski, Goedert and others. ...https://en.wikipedia.org/wiki/Parkinson's_disease
Alice Lazzarini - Wikipedia
... alpha-synuclein was discovered to be the major component of Lewy bodies within brain cells of PD patients; according to the ... that fragments of alpha-synuclein bind to other proteins to form the Lewy body, an insoluble proteinaceous material ... "Alpha-synuclein in Lewy bodies". Nature. 388 (6645): 839-40. doi:10.1038/42166. PMID 9278044. Lazzarini's blog on her ... alpha-synuclein. Lazzarini worked with the Italian Instituto de Scienze Neurologiche to get blood samples from the family ...https://en.wikipedia.org/wiki/Alice_Lazzarini
Dr Michel Goedert :: Cambridge Neuroscience
... "alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies." Proc Natl ... "Alpha-synuclein in Lewy bodies." Nature 388(6645):839-40 Details. Tolnay M, Spillantini MG, Goedert M, Ulrich J, Langui D, ... "Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies." ... whereas mutations in the alpha-synuclein gene cause familial forms of Parkinson's disease and dementia with Lewy bodies. ...http://www.neuroscience.cam.ac.uk/directory/profile.php?migo
Familial Parkinson's point mutation abolishes multiple system atrophy prion replication | PNAS
Alpha-synuclein in Lewy bodies. Nature 388:839-840.. .. OpenUrlCrossRefPubMed ... and dementia with Lewy bodies (DLB). In PD, PDD, and DLB patients, α-synuclein accumulates in neurons as Lewy bodies and Lewy ... 2014) Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys ... 2004) The new mutation, E46K, of α-synuclein causes Parkinson and Lewy body dementia. Ann Neurol 55:164-173. ...http://www.pnas.org/content/115/2/409.full
Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of...
Alpha-synuclein in Lewy bodies. Nature 388, 839-840.. OpenUrlCrossRefPubMedWeb of Science ... UAS α-Synuclein/+;THGal4,UAS α-Synuclein/+; 'UAS-αSyn/UAS-CncC', THGal4, UAS α-Synuclein/+;THGal4, UAS α-Synuclein/UAS cncC; ' ... α-synuclein is the major structural component of the Lewy body in both sporadic and familial PD (Spillantini et al., 1997). The ... 2010). Inhibiting alpha-synuclein oligomerization by stable cell-penetrating beta-synuclein fragments recovers phenotype of ...http://dmm.biologists.org/content/4/5/701
S-nitrosylation of UCHL1 induces its structural instability and promotes α-synuclein aggregation
Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. The American ... Alpha-synuclein in Lewy bodies. Nature 388, 839-840, doi: (1997).10.1038/42166 [PubMed] [Cross Ref] ... α-synuclein is a major component of cytoplasmic inclusions called Lewy body (LB) in sporadic PD patient brain. It indicates ... Lewy body component DJ1, which is a redox dependent molecular chaperone, prevents α-synuclein aggregation and protects neurons ...http://pubmedcentralcanada.ca/pmcc/articles/PMC5353675/
Unbiased Proteomics of Early Lewy Body Formation Model Implicates Active Microtubule Affinity-Regulating Kinases (MARKs) in...
1998b) alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc ... 1998) Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. J Pathol 152 ... alpha-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous alpha-synuclein to Lewy body ... 2013) Lewy body-like alpha-synuclein aggregates resist degradation and impair macroautophagy. J Biol Chem 288:15194-15210. doi: ...http://www.jneurosci.org/content/37/24/5870
Parkinson's disease Wikipedia
Other forms of alpha-synuclein (e.g., oligomers) that are not aggregated in Lewy bodies and Lewy neurites may actually be the ... alpha-synuclein, is the main component of the Lewy bodies that accumulate in the brains of people with PD. Mutations in ... alpha-synuclein was found to be the main component of Lewy bodies by Spillantini, Trojanowski, Goedert and others. ... and the presence of Lewy bodies (accumulations of the protein alpha-synuclein) in many of the remaining neurons. This loss of ...http://en.wikibedia.ru/wiki/Parkinson%27s_disease
The inhibitory effect of pyrroloquinoline quinone on the amyloid formation and cytotoxicity of truncated alpha-synuclein |...
... as well as Lewy bodies, which are cytoplasmic inclusions in PD. It is known that truncated alpha-synuclein has a much higher ... Alpha-synuclein119 aggregated more rapidly and enhanced significantly the fibril formation of alpha-synuclein. Although both of ... alpha-synuclein133 showed a similar aggregation with full-length alpha-synuclein and no acceleration effect. We showed that PQQ ... Recently, it has been shown that not only full-length alpha-synuclein, but also C-terminal truncated forms exist in the normal ...https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/1750-1326-5-20
Dynamic transport and localization of alpha-synuclein in primary hippocampal neurons | Molecular Neurodegeneration | Full Text
Tagged α-synuclein migrated at a rate of 1.85 ± 0.09 μm/s, consistent with previous reports, and single exon deletion mutants ... Single exon deletions within the lipid-binding N-terminal domain of α-synuclein (exons 2, 3, and 4) partially disrupted its ... To investigate the role of the helical domain in transport and localization of α-synuclein, eGFP-tagged constructs were ... Abnormal accumulation of α-synuclein aggregates in dopaminergic neurons of the substantia nigra is diagnostic of sporadic ...https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/1750-1326-5-9
Subregional 6-[18F]fluoro-ʟ-m-tyrosine Uptake in the Striatum in Parkinson's Disease | BMC Neurology | Full Text
Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M: Alpha-synuclein in Lewy bodies. Nature. 1997, 388: 839- ... Idiopathic PD is defined as a synucleinopathy in which Lewy bodies, pathological aggregations of the synaptic protein α- ... Hughes AJ, Daniel SE, Lees AJ: Improved accuracy of clinical diagnosis of Lewy body Parkinson's disease. Neurology. 2001, 57: ... synuclein, are found in the dopaminergic neurons in the substantia nigra [14, 15]. A reduction of dopamine in the striatum is a ...https://bmcneurol.biomedcentral.com/articles/10.1186/1471-2377-11-35
Seeding and transgenic overexpression of alpha‐synuclein triggers dendritic spine pathology in the neocortex | EMBO Molecular...
... synuclein aggregates, not lewy bodies, cause neurodegeneration in dementia with Lewy bodies. J Neurosci 27: 1405-1410. ... Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc Natl Acad Sci ... Masliah E (2000) Dopaminergic loss and inclusion body formation in alpha‐synuclein mice: implications for neurodegenerative ... synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death. Neuron 72: 57-71. ...http://d3gz45kfcn01zz.cloudfront.net/content/early/2017/03/28/emmm.201607305