... extracellular matrix metalloproteinase inducer matrix metalloproteinase expression by amphiregulin in transformed human breast ... Thirteen (15.9%) patients presented with stage Ib2 disease, whereas 50 (61.0%) had stage IIa, and 19 (23.2%) had stage IIb. ... Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to anoikis through inhibition ... positive feedback regulation of extracellular matrix metalloproteinase inducer (EMMPRIN) expression and matrix ...http://clincancerres.aacrjournals.org/content/14/2/494
Contribution of matrilysin (MMP-7) to the metastatic pathway of human colorectal cancers | Gut
1995) Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and ... matrix metalloproteinase. MT1-MMP. membrane type-1 matrix metalloproteinase. SDS. sodium dodecyl sulphate. ... Matrix metalloproteinase 2 (MMP-2) and matrix metalloproteinase 9 (MMP-9) type IV collagenases in colorectal cancer. Cancer Res ... 1995) Distinct pattern of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 mRNA expression in human ...http://gut.bmj.com/content/45/2/252
Molecular Cytogenetic Identification of Subgroups of Grade III Invasive Ductal Breast Carcinomas with Different Clinical...
Coexpression of Matrix Metalloproteinase-7 (MMP-7) and Epidermal Growth Factor (EGF) Receptor in Colorectal Cancer ... Elston CW, Ellis IO Pathological prognostic factors in breast cancer.: I. The value of histological grade in breast cancer: ... integrating a new model of breast differentiation into cytogenetic pathways of breast carcinogenesis. Lab Invest 2002;82:1525- ... Hackett A Immunolocalization of a human basal epithelium specific keratin in benign and malignant breast disease. Breast Cancer ...http://clincancerres.aacrjournals.org/content/10/18/5988.long
Tumour matrilysin expression predicts metastatic potential of stage I (pT1) colon and rectal cancers | Gut
Matrix metalloproteinase family. In Parks WC, Mecham RP, eds. Matrix metalloproteinases. California: Academic Press, 1998:219- ... overexpressing breast cancer cells in vitro and in vivo. Cancer Res2001;61:8887-95. ... Yamamoto H, Itoh F, Adachi Y, et al. Relation of enhanced secretion of active matrix metalloproteinases with tumor spread in ... Matrix metalloproteinases (MMP) are promising targets for cancer therapy based on their massive upregulation in malignant ...http://gut.bmj.com/content/54/12/1751
Tumor-derived matrix metalloproteinase-13 (MMP-13) correlates with poor prognosis of invasive breast cancer | BMC Cancer | Full...
... protein may promote breast tumor progression, however, its role is yet to be fully established. Furthermore, it is not clear ... was performed on paraffin-embedded tissue microarray specimens from 263 breast carcinomas. The intensity and the extent of IHC ... and inversely correlated with overall survival of breast cancer patients. MMP-13 may serve as an independent prognostic factor ... MMP-13 also correlated with the expression of Her-2/neu (p = 0.015) and TIMP-1 (p < 0.010), respectively in tumor cells. Tumor- ...https://0-bmccancer-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/1471-2407-8-83
SMART: HX domain annotation
... is a matrix metalloproteinase involved in human breast cancer pathology and in arthritic processes. The crystal structure of ... members of the matrix metalloproteinase family that cleave extracellular matrix constituents [(PUBMED:14619953)]. These zinc ... C-TERMINAL DOMAIN (HAEMOPEXIN-LIKE DOMAIN) OF HUMAN MATRIX METALLOPROTEINASE-2. 1su3. X-ray structure of human proMMP-1: New ... Matrix metalloproteinases are thought to be key players in the remodelling activity of cells associated with both physiological ...http://smart.embl-heidelberg.de/smart/do_annotation.pl?DOMAIN=HX&BLAST=DUMMY
Poria Uses, Benefits & Dosage - Drugs.com Herbal Database
Pachymic acid impairs breast cancer cell invasion by suppressing nuclear factor-ΚB-dependent matrix metalloproteinase-9 ... Breast Cancer Res Treat. 2011;126(3):609-620.20521099 29. Ling H, Zhou L, Jia X, Gapter LA, Agarwal R, Ng KY. Polyporenic acid ... Growth-inhibitory effects of a beta-glucan from the mycelium of Poria cocos on human breast carcinoma MCF-7 cells: cell-cycle ... Jpn Kokai Tokkyo Koho: 1996.. 48. Wang WK, Hsu TL, Wang YY. Liu-wei-dihuang: a study by pulse analysis. Am J Chin Med. 1998;26( ...https://www.drugs.com/npp/poria.html
A randomised controlled phase II trial of pre-operative celecoxib treatment reveals anti-tumour transcriptional response in...
In transgenic breast cancer models, over-expression of COX-2 leads to tumour formation while COX-2... ... is frequently over-expressed in primary breast cancer. ... The majority of the matrix metalloproteinase (MMP) family ... Sato H, Kinoshita T, Takino T, Nakayama K, Seiki M: Activation of a recombinant membrane type 1-matrix metalloproteinase (MT1- ... Orlichenko L, Radisky D: Matrix metalloproteinases stimulate epithelial-mesenchymal transition during tumor development. Clin ...https://rd.springer.com/article/10.1186/bcr3409
Key stages in mammary gland development: The cues that regulate ductal branching morphogenesis | Breast Cancer Research | Full...
... matrix metalloproteinase; TEB, terminal end bud; TIMP, tissue inhibitor of metalloproteinases. ... Sternlicht MD, Werb Z: How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol. 2001, 17: 463-516. 10.1146 ... Notably, EGFR activation stimulates the expression of matrix metalloproteinase (MMP)-2 (gelatinase-A) and the MMP-2 activator ... Notably, the transmembrane metalloproteinase ADAM (a disintegrin and metallo-proteinase)17 (TNF-α-converting enzyme; TACE) can ...https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr1368
Myoepithelial cells: good fences make good neighbors | Breast Cancer Research | Full Text
Simian M, Hirai Y, Navre M, Werb Z, Lochter A, Bissell MJ: The interplay of matrix metalloproteinases, morphogens and growth ... In this review we briefly address the characteristics of breast myoepithelial cells from human breast and mouse mammary gland, ... Bissell MJ, Bilder D: Polarity determination in breast tissue: desmosomal adhesion, myoepithelial cells, and laminin 1. Breast ... and facilitate the sculpting of new BM through the production of matrix metalloproteinases (MMPs), including MMP2 and MMP3 [45 ...https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr1286
p38 Gamma MAPK | Springer for Research & Development
p38γ MAPK cooperates with c-Jun in trans-activating matrix metalloproteinase 9. J Biol Chem. 2010;285:15149-58.PubMed ... Qi XM, Yin N, Ma S, Lepp A, Tang J, Jing W. p38γ MAPK is a therapeutic target for triple-negative breast cancer by stimulation ... p38γ promotes breast cancer motility and metastasis through regulation of RhoC GTPase, cytoskeletal architecture, and a novel ... Estrogen receptor-α phosphorylation at serine-118 and tamoxifen response in breast cancer. J Natl Cancer Inst. 2009;101:1725-9. ...https://rd.springer.com/referenceworkentry/10.1007/978-3-319-67199-4_101521
G Protein Alpha 12 and 13 | Springer for Research & Development
Breast cancer cell invasion mediated by Gα12 signaling involves expression of interleukins-6 and -8, and matrix ... metalloproteinase-2. J Mol Signal. 2014;9:6.PubMedPubMedCentralCrossRefGoogle Scholar ... G12 signaling through c-Jun NH2-terminal kinase promotes breast cancer cell invasion. PLoS ONE. 2011;6(11):e26085.PubMed ... Lin F, Chen S, Sepich DS, Panizzi JR, Clendenon SG, Marrs JA, Hamm HE, Solnica-Krezel L. Gα12/13 regulate epiboly by inhibiting ...https://rd.springer.com/referenceworkentry/10.1007%2F978-3-319-67199-4_586
Production and characterization of a human single-chain Fv to collagenase IV | SpringerLink
Vaisanen, A., Tuominen, H., Kallioinen, M. et al., Matrix metalloproteinase-2(72 KD type IV collagenase) expression occurs in ... Association of MMP-2 activation potential with metastatic progression in human breast cancer cell lines independent of MMP-2 ... the early stage of human melanocytic tumor progression and may have prognostic value,J. Pathol., 1996, 180: 283.PubMedCrossRef ...https://link.springer.com/article/10.1007/BF02882738
Y-box factor YB-1 predicts drug resistance and patient outcome in breast cancer independent of clinically relevant tumor...
Matrix metalloproteinase-2 immunoreactive protein: a marker of aggressiveness in breast carcinoma. Cancer 1998;83: 1153-62.. * ... Tissue distribution of major matrix metalloproteinases and their transcripts in human breast carcinomas. Anticancer Res 1999;19 ... Expression of tumorigenesis-associated factors in normal tissue adjacent to breast cancer has been described for major matrix ... Enhancement of mdr1 gene expression in normal tissue adjacent to advanced breast cancer. Breast Cancer Res Treat 2000;61: 13-20 ...http://onlinelibrary.wiley.com/doi/10.1002/ijc.1610/full
Anti-invasive and antiangiogenic effects of MMI-166 on malignant glioma cells | Springer for Research & Development
Background The constitutive overexpression of matrix metalloproteinases (MMPs) is frequently observed in malignant tumours. In ... Haas TL, Madri JA: Extracellular matrix-driven matrix metalloproteinase production in endothelial cells: implications for ... The increased expression of MMPs has been associated with cancers of the head and neck, breast, lung, stomach, and pancreas [12 ... Bramhall SR: The matrix metalloproteinases and their inhibitors in pancreatic cancer. Int J Pancreatol. 1997, 21: 1-12.PubMed ...https://rd.springer.com/article/10.1186/1471-2407-10-339
The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer? | Clinical Proteomics | Full Text
At least one of these inhibitors is now undergoing clinical trials in patients with breast cancer. ... Zucker S, Cao J, Chen W-T: Critical appraisal of the use of matrix metalloproteinases inhibitors in cancer treatment. Oncogene ... Lendeckel U, Kohl J, Arndt M: Increased expression of ADAM family members in human breast cancer and breast cancer cell lines. ... Fingleton B: Matrix metalloproteinases as valid clinical targets. Current Pharm Design. 2007, 13: 333-46. 10.2174/ ...https://clinicalproteomicsjournal.biomedcentral.com/articles/10.1186/1559-0275-8-9
Optical Imaging of Cancer-Related Proteases Using Near-Infrared Fluorescence Matrix Metalloproteinase-Sensitive and Cathepsin B...
Overexpression of matrix-metalloproteinase-9 in human breast cancer: a potential favourable indicator in node-negative patients ... Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3. ... Tumor-derived matrix metalloproteinase-13 (MMP-13) correlates with poor prognoses of invasive breast cancer. BMC Cancer. 2008;8 ... Matrix metalloproteinase expression is related to angiogenesis and histologic grade in spindle cell soft tissue neoplasms of ...http://thno.org/v02p0179.htm
Tumor-Associated Macrophages Press the Angiogenic Switch in Breast Cancer | Cancer Research
... matrix metalloproteinase-9, and uPA ( 7). Alternatively, they may recruit and interact with other cells in the tumor ... Using an autochthonous mouse model of breast cancer to study their function in breast cancer, we showed that they are required ... Tumor-Associated Macrophages Press the Angiogenic Switch in Breast Cancer. Elaine Y. Lin and Jeffrey W. Pollard ... Tumor-Associated Macrophages Press the Angiogenic Switch in Breast Cancer Message Subject (Your Name) has forwarded a page to ...http://cancerres.aacrjournals.org/content/67/11/5064
Maitake Mushroom: Uses, Side Effects, Interactions, Dosage, and Warning
Production of exopolysaccharide from mycelial culture of Grifola frondosa and its inhibitory effect on matrix metalloproteinase ... Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking maitake mushroom if you are ... in breast cancer patients: immunological effects. J.Cancer Res.Clin.Oncol. 2009;135(9):1215-1221. View abstract. ... Nutr Rev 1996;54(11 Pt 2):S91-S93. View abstract.. *Cui, F. J., Li, Y., Xu, Y. Y., Liu, Z. Q., Huang, D. M., Zhang, Z. C., and ...https://www.webmd.com/vitamins/ai/ingredientmono-560/maitake-mushroom
Cell Adhesion Molecules in Carcinoma Invasion and Metastasis | SpringerLink
... matrix metalloproteinase-2, and membrane type-1-matrix/metalloproteinase are required for mimicry of embryonic vasculogenesis ... Nishimura Y, Itoh K, Yoshioka K, Tokuda K, Himeno M (2003) Overexpression of ROCK in human breast cancer cells: evidence that ... Veitch DP, Nokelainen P et al (2003) Mammalian tolloid metalloproteinase, and not matrix metalloprotease 2 or membrane type 1 ... Increased expression of membrane type 1-matrix metalloproteinase in head and neck carcinoma. Cancer 79:139-144PubMedCrossRef ...https://link.springer.com/chapter/10.1007/978-1-4419-7203-3_1
Metalloproteinases: role in breast carcinogenesis, invasion and metastasis | Breast Cancer Research | Full Text
Their primary function is degradation of proteins in the extracellular matrix. Currently, at least 19 members of this family ... have been found to correlate with poor prognosis in patients with breast cancer. Because MMPs are apparently involved in breast ... Consistent with their role in breast cancer progression, high levels of at least two MMPs (MMP-2 and stromelysin-3) ... Recent data from model systems suggest that MMPs are involved in breast cancer initiation, invasion and metastasis. ...https://0-breast--cancer--research-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/bcr65
Assessment of acute, 14-day, and 13-week repeated oral dose toxicity of Tiglium seed extract in rats | BMC Complementary and...
In 13-week toxicity study, TS extract exhibited no dose-related changes (mortality, body weight, food/water consumption, ... and 13-week repeated-dose toxicity (31.25, 62.5, 125, 250, and 500 mg/kg) in Sprague-Dawley rats and F344 rats. Hematological, ... J Breast Cancer. 2017;20:234-9.View ArticlePubMedPubMed CentralGoogle Scholar. ... Beijing: Science Press; 1996.Google Scholar. *. Wang X, Lan M, Wu HP, Shi YQ, Lu J, Ding J, Wu KC, Jin JP, Fan DM. Direct ...https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-018-2315-5
Dentin Matrix Protein 1 Enhances Invasion Potential of Colon Cancer Cells by Bridging Matrix Metalloproteinase-9 to Integrins ... Li G., Fridman R., Kim H. R. Tissue inhibitor of metalloproteinase-1 inhibits apoptosis of human breast epithelial cells. ... Edwards D. R. The tissue inhibitors of metalloproteinases (TIMPs) Clendeninn N. J. Appelt K. eds. . Matrix Metalloproteinase ... Expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases in head and neck squamous cell carcinoma. ...http://cancerres.aacrjournals.org/content/64/3/952
Overview of MMP Biology and Gene Associations in Human Diseases | IntechOpen
The matrix metalloproteinase inhibitor batimastat (BB-94) retards human breast cancer solid tumor growth but not ascites ... activation of pro-matrix metalloproteinase-2 by leukolysin/membrane-type 6 matrix metalloproteinase/matrix metalloproteinase 25 ... Matrix metalloproteinase-9 and matrix metalloproteinase-2 gene polymorphisms in multiple sclerosis. Journal of Neuroimmunology ... matrix metalloproteinase-2, and tissue inhibitor of matrix metalloproteinase-1 in human abdominal aortic vascular smooth muscle ...https://www.intechopen.com/books/the-role-of-matrix-metalloproteinase-in-human-body-pathologies/overview-of-mmp-biology-and-gene-associations-in-human-diseases/
Matrix metallopeptidase 13 - Wikipedia
... a novel human matrix metalloproteinase produced by breast carcinomas". J Biol Chem. 269 (24): 16766-73. PMID 8207000. "Entrez ... "Matrix metalloproteinases collagenase-2, macrophage elastase, collagenase-3, and membrane type 1-matrix metalloproteinase ... Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal ... "A matrix metalloproteinase gene expressed in human T lymphocytes is identical with collagenase 3 from breast carcinomas". ...https://en.wikipedia.org/wiki/Matrix_metallopeptidase_13