Contribution of matrilysin (MMP-7) to the metastatic pathway of human colorectal cancers | Gut
1995) Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and ... matrix metalloproteinase. MT1-MMP. membrane type-1 matrix metalloproteinase. SDS. sodium dodecyl sulphate. ... Matrix metalloproteinase 2 (MMP-2) and matrix metalloproteinase 9 (MMP-9) type IV collagenases in colorectal cancer. Cancer Res ... 1995) Distinct pattern of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 mRNA expression in human ...http://gut.bmj.com/content/45/2/252
SMART: HX domain annotation
... is a matrix metalloproteinase involved in human breast cancer pathology and in arthritic processes. The crystal structure of ... members of the matrix metalloproteinase family that cleave extracellular matrix constituents [(PUBMED:14619953)]. These zinc ... C-TERMINAL DOMAIN (HAEMOPEXIN-LIKE DOMAIN) OF HUMAN MATRIX METALLOPROTEINASE-2. 1su3. X-ray structure of human proMMP-1: New ... Matrix metalloproteinases are thought to be key players in the remodelling activity of cells associated with both physiological ...http://smart.embl-heidelberg.de/smart/do_annotation.pl?DOMAIN=HX&BLAST=DUMMY
A randomised controlled phase II trial of pre-operative celecoxib treatment reveals anti-tumour transcriptional response in...
In transgenic breast cancer models, over-expression of COX-2 leads to tumour formation while COX-2... ... is frequently over-expressed in primary breast cancer. ... The majority of the matrix metalloproteinase (MMP) family ... Sato H, Kinoshita T, Takino T, Nakayama K, Seiki M: Activation of a recombinant membrane type 1-matrix metalloproteinase (MT1- ... Orlichenko L, Radisky D: Matrix metalloproteinases stimulate epithelial-mesenchymal transition during tumor development. Clin ...https://rd.springer.com/article/10.1186/bcr3409
Myoepithelial cells: good fences make good neighbors | Breast Cancer Research | Full Text
Simian M, Hirai Y, Navre M, Werb Z, Lochter A, Bissell MJ: The interplay of matrix metalloproteinases, morphogens and growth ... In this review we briefly address the characteristics of breast myoepithelial cells from human breast and mouse mammary gland, ... Bissell MJ, Bilder D: Polarity determination in breast tissue: desmosomal adhesion, myoepithelial cells, and laminin 1. Breast ... and facilitate the sculpting of new BM through the production of matrix metalloproteinases (MMPs), including MMP2 and MMP3 [45 ...https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr1286
p38 Gamma MAPK | Springer for Research & Development
p38γ MAPK cooperates with c-Jun in trans-activating matrix metalloproteinase 9. J Biol Chem. 2010;285:15149-58.PubMed ... Qi XM, Yin N, Ma S, Lepp A, Tang J, Jing W. p38γ MAPK is a therapeutic target for triple-negative breast cancer by stimulation ... p38γ promotes breast cancer motility and metastasis through regulation of RhoC GTPase, cytoskeletal architecture, and a novel ... Estrogen receptor-α phosphorylation at serine-118 and tamoxifen response in breast cancer. J Natl Cancer Inst. 2009;101:1725-9. ...https://rd.springer.com/referenceworkentry/10.1007/978-3-319-67199-4_101521
Y-box factor YB-1 predicts drug resistance and patient outcome in breast cancer independent of clinically relevant tumor...
Matrix metalloproteinase-2 immunoreactive protein: a marker of aggressiveness in breast carcinoma. Cancer 1998;83: 1153-62.. * ... Tissue distribution of major matrix metalloproteinases and their transcripts in human breast carcinomas. Anticancer Res 1999;19 ... Expression of tumorigenesis-associated factors in normal tissue adjacent to breast cancer has been described for major matrix ... Enhancement of mdr1 gene expression in normal tissue adjacent to advanced breast cancer. Breast Cancer Res Treat 2000;61: 13-20 ...http://onlinelibrary.wiley.com/doi/10.1002/ijc.1610/full
Anti-invasive and antiangiogenic effects of MMI-166 on malignant glioma cells | Springer for Research & Development
Background The constitutive overexpression of matrix metalloproteinases (MMPs) is frequently observed in malignant tumours. In ... Haas TL, Madri JA: Extracellular matrix-driven matrix metalloproteinase production in endothelial cells: implications for ... The increased expression of MMPs has been associated with cancers of the head and neck, breast, lung, stomach, and pancreas [12 ... Bramhall SR: The matrix metalloproteinases and their inhibitors in pancreatic cancer. Int J Pancreatol. 1997, 21: 1-12.PubMed ...https://rd.springer.com/article/10.1186/1471-2407-10-339
Optical Imaging of Cancer-Related Proteases Using Near-Infrared Fluorescence Matrix Metalloproteinase-Sensitive and Cathepsin B...
Overexpression of matrix-metalloproteinase-9 in human breast cancer: a potential favourable indicator in node-negative patients ... Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3. ... Tumor-derived matrix metalloproteinase-13 (MMP-13) correlates with poor prognoses of invasive breast cancer. BMC Cancer. 2008;8 ... Matrix metalloproteinase expression is related to angiogenesis and histologic grade in spindle cell soft tissue neoplasms of ...http://thno.org/v02p0179.htm
Tumor-Associated Macrophages Press the Angiogenic Switch in Breast Cancer | Cancer Research
... matrix metalloproteinase-9, and uPA ( 7). Alternatively, they may recruit and interact with other cells in the tumor ... Using an autochthonous mouse model of breast cancer to study their function in breast cancer, we showed that they are required ... Tumor-Associated Macrophages Press the Angiogenic Switch in Breast Cancer. Elaine Y. Lin and Jeffrey W. Pollard ... Tumor-Associated Macrophages Press the Angiogenic Switch in Breast Cancer Message Subject (Your Name) has forwarded a page to ...http://cancerres.aacrjournals.org/content/67/11/5064
Cell Adhesion Molecules in Carcinoma Invasion and Metastasis | SpringerLink
... matrix metalloproteinase-2, and membrane type-1-matrix/metalloproteinase are required for mimicry of embryonic vasculogenesis ... Nishimura Y, Itoh K, Yoshioka K, Tokuda K, Himeno M (2003) Overexpression of ROCK in human breast cancer cells: evidence that ... Veitch DP, Nokelainen P et al (2003) Mammalian tolloid metalloproteinase, and not matrix metalloprotease 2 or membrane type 1 ... Increased expression of membrane type 1-matrix metalloproteinase in head and neck carcinoma. Cancer 79:139-144PubMedCrossRef ...https://link.springer.com/chapter/10.1007/978-1-4419-7203-3_1
Assessment of acute, 14-day, and 13-week repeated oral dose toxicity of Tiglium seed extract in rats | BMC Complementary and...
In 13-week toxicity study, TS extract exhibited no dose-related changes (mortality, body weight, food/water consumption, ... and 13-week repeated-dose toxicity (31.25, 62.5, 125, 250, and 500 mg/kg) in Sprague-Dawley rats and F344 rats. Hematological, ... J Breast Cancer. 2017;20:234-9.View ArticlePubMedPubMed CentralGoogle Scholar. ... Beijing: Science Press; 1996.Google Scholar. *. Wang X, Lan M, Wu HP, Shi YQ, Lu J, Ding J, Wu KC, Jin JP, Fan DM. Direct ...https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-018-2315-5
Dentin Matrix Protein 1 Enhances Invasion Potential of Colon Cancer Cells by Bridging Matrix Metalloproteinase-9 to Integrins ... Li G., Fridman R., Kim H. R. Tissue inhibitor of metalloproteinase-1 inhibits apoptosis of human breast epithelial cells. ... Edwards D. R. The tissue inhibitors of metalloproteinases (TIMPs) Clendeninn N. J. Appelt K. eds. . Matrix Metalloproteinase ... Expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases in head and neck squamous cell carcinoma. ...http://cancerres.aacrjournals.org/content/64/3/952
Overview of MMP Biology and Gene Associations in Human Diseases | IntechOpen
The matrix metalloproteinase inhibitor batimastat (BB-94) retards human breast cancer solid tumor growth but not ascites ... activation of pro-matrix metalloproteinase-2 by leukolysin/membrane-type 6 matrix metalloproteinase/matrix metalloproteinase 25 ... Matrix metalloproteinase-9 and matrix metalloproteinase-2 gene polymorphisms in multiple sclerosis. Journal of Neuroimmunology ... matrix metalloproteinase-2, and tissue inhibitor of matrix metalloproteinase-1 in human abdominal aortic vascular smooth muscle ...https://www.intechopen.com/books/the-role-of-matrix-metalloproteinase-in-human-body-pathologies/overview-of-mmp-biology-and-gene-associations-in-human-diseases/
Human keratinocyte cell lines differ in the expression of the collagenolytic matrix metalloproteinases-1,-8, and-13 and of TIMP...
High levels of tissue inhibitor of metalloproteinase-1 predict poor outcome in patients with breast cancer.. McCarthy K, ... Matrix metalloproteinases -8 and -9 and tissue inhibitor of metalloproteinase-1 in burn patients. A prospective observational ... Effect of phorbol ester and cytokines on matrix metalloproteinase and tissue inhibitor of metalloproteinase expression in tumor ... Expression pattern of matrix metalloproteinases in human liver.. Lichtinghagen R, Helmbrecht T, Arndt B, Boker KH., Eur J Clin ...https://pub.uni-bielefeld.de/publication/1619452
Matrix metallopeptidase 13 - Wikipedia
... a novel human matrix metalloproteinase produced by breast carcinomas". J Biol Chem. 269 (24): 16766-73. PMID 8207000. "Entrez ... "Matrix metalloproteinases collagenase-2, macrophage elastase, collagenase-3, and membrane type 1-matrix metalloproteinase ... Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal ... "A matrix metalloproteinase gene expressed in human T lymphocytes is identical with collagenase 3 from breast carcinomas". ...https://en.wikipedia.org/wiki/Matrix_metallopeptidase_13
WikiGenes - MMP1 - matrix metallopeptidase 1 (interstitial...
Matrix metalloproteinase single-nucleotide polymorphisms and haplotypes predict breast cancer progression. Hughes, S., Agbaje, ... Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9. Ogata, Y., Enghild, ... Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9 . ... Membrane type I matrix metalloproteinase usurps tumor growth control imposed by the three-dimensional extracellular matrix. ...http://www.wikigenes.org/e/gene/e/4312.html
In vitro evaluation of functional interaction of integrin αvβ3 and matrix metalloprotease-2
Matrix Metalloproteinases: They're Not Just for Matrix Anymore! Curr. Opin. Cell Biol. 2001;13(5):534-540. [PubMed] ... Mt1-Mmp Initiates Activation of Pro-Mmp-2 and Integrin Alpha V Beta 3 Promotes Maturation of Mmp-2 in Breast Carcinoma Cells. ... Matrix Metalloproteinases: A Tail of a Frog That Became a Prince. Nat. Rev. Mol. Cell Biol. 2002;3(3):207-214. [PubMed] ... Matrix Metalloproteinase Is Activated During Migration of Human Endothelial Cells and Modulates Endothelial Motility and Matrix ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2790922/
Pharmacologic and Genetic Manipulation of MMP-2 and -9 Affects Retinal Neovascularization in Rodent Models of OIR | IOVS | ARVO...
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol. 2000;2:737-744. [CrossRef] [ ... 72 KD and 92 KD type IV collagenase, type IV collagen, and laminin mRNAs in breast cancer: a study by in situ hybridization. J ... Matrix metalloproteinases (MMPs) comprise a family of proteolytic enzymes of more than 20 members that are zinc and calcium ... Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1. Proc Natl Acad Sci USA. ...https://iovs.arvojournals.org/article.aspx?articleid=2124958
Comparison the Prognostic Value of Galectin-3 and Serum Markers of Cardiac Extracellular Matrix Turnover in Patients with...
Circulating matrix metalloproteinase-2 but not matrix metalloproteinase-3, matrix metalloproteinase-9, or tissue inhibitor of ... Galectin-3 enhances cyclin D(1) promoter activity through SP1 and a cAMP-responsive element in human breast epithelial cells. ... Interplay of matrix metalloproteinases, tissue inhibitors of metalloproteinases and their regulators in cardiac matrix ... Comparison of matrix metalloproteinase 9 and brain natriuretic peptide as clinical biomarkers in chronic heart failure. Am ...http://www.medsci.org/v11p1098.htm
Biobehavioral Influences on Matrix Metalloproteinase Expression in Ovarian Carcinoma | Clinical Cancer Research
... invasiveness of breast cancer cell lines upon co-cultivation with macrophages is due to TNF-α dependent up-regulation of matrix ... Biobehavioral Influences on Matrix Metalloproteinase Expression in Ovarian Carcinoma. Susan K. Lutgendorf, Donald M. Lamkin, ... Biobehavioral Influences on Matrix Metalloproteinase Expression in Ovarian Carcinoma. Susan K. Lutgendorf, Donald M. Lamkin, ... Biobehavioral Influences on Matrix Metalloproteinase Expression in Ovarian Carcinoma. Susan K. Lutgendorf, Donald M. Lamkin, ...http://clincancerres.aacrjournals.org/content/14/21/6839.long
Cancers | Free Full-Text | STAT3 in Cancer-Friend or Foe? | HTML
Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C. Proc. Natl. Acad ... The JAK2/STAT3 signaling pathway is required for growth of CD44(+)CD24(−) stem cell-like breast cancer cells in human tumors. J ... STAT3 is known to increase the expression of various matrix metalloproteinases (MMPs), including MMP-1, MMP-2, MMP-7 and MMP-9 ... STAT3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis. Oncogene 2004, 23, ...http://www.mdpi.com/2072-6694/6/3/1408/htm
Matrix Metalloproteinase-8 and Tissue Inhibitor of Metalloproteinase-1 in Serum Do Not Reflect the Analytes Circulating in...
Gelatinase concentrations and zymographic profiles in human breast cancer: matrix metalloproteinases circulating in plasma are ... Plasma matrix metalloproteinase-9 level is better than serum matrix metalloproteinase-9 level to predict gastric cancer ... Matrix Metalloproteinase-8 and Tissue Inhibitor of Metalloproteinase-1 in Serum Do Not Reflect the Analytes Circulating in ... Matrix Metalloproteinase-8 and Tissue Inhibitor of Metalloproteinase-1 in Serum Do Not Reflect the Analytes Circulating in ...http://atvb.ahajournals.org/content/28/3/e15
Calciphylaxis (Calcific Uremic Arteriolopathy) | Springer for Research & Development
Weight loss-induced calciphylaxis: potential role of matrix metalloproteinases. J Dermatol 2003;30:915-919.PubMedGoogle Scholar ... Calciphylaxis associated with metastatic breast carcinoma. J Am Acad Dermatol 1999;41:295-298.PubMedCrossRefGoogle Scholar ... 13.. Munavalli F, Reisenauer A, Moses M, Kilroy S, Arbiser JL. ...https://rd.springer.com/chapter/10.1007/978-0-387-68858-9_35
Detection of ovarian cancer using antibody arrays - Raybiotech,Inc. Guangzhou
Ripley et al., Expression of matrix metalloproteinase-26 and tissue inhibitors of metalloproteinase-3 and -4 in normal ovary ... Tissue inhibitor of metalloproteinase-4 is elevated in early-stage breast cancers with accelerated progression and poor ... TIMP-4 belongs to the matrix metalloproteinase (MMP) superfamily. MMPs are essential elements in extra-cellular matrix (ECM) ... Expression of matrix metalloproteinase-26 and tissue inhibitors of metalloproteinase-3 and -4 in normal ovary and ovarian ...http://www.freepatentsonline.com/9897608.html
RAC1 - Wikipedia
Jul 11, 2012). "Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression". Science translational ... Dokmanovic M, Hirsch DS, Shen Y, Wu WJ (Jun 2009). "Rac1 contributes to trastuzumab resistance of breast cancer cells: Rac1 as ... "Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression". Science Translational Medicine. 4 (142 ... suggesting Rac1 as a predictive marker and therapeutic target for trastuzumab-resistant breast cancer. However, given Rac1's ...https://en.wikipedia.org/wiki/RAC1