*  Plus it
... extracellular matrix metalloproteinase inducer matrix metalloproteinase expression by amphiregulin in transformed human breast ... Thirteen (15.9%) patients presented with stage Ib2 disease, whereas 50 (61.0%) had stage IIa, and 19 (23.2%) had stage IIb. ... Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to anoikis through inhibition ... positive feedback regulation of extracellular matrix metalloproteinase inducer (EMMPRIN) expression and matrix ...
  http://clincancerres.aacrjournals.org/content/14/2/494
*  Contribution of matrilysin (MMP-7) to the metastatic pathway of human colorectal cancers | Gut
1995) Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and ... matrix metalloproteinase. MT1-MMP. membrane type-1 matrix metalloproteinase. SDS. sodium dodecyl sulphate. ... Matrix metalloproteinase 2 (MMP-2) and matrix metalloproteinase 9 (MMP-9) type IV collagenases in colorectal cancer. Cancer Res ... 1995) Distinct pattern of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 mRNA expression in human ...
  http://gut.bmj.com/content/45/2/252
*  SMART: HX domain annotation
... is a matrix metalloproteinase involved in human breast cancer pathology and in arthritic processes. The crystal structure of ... members of the matrix metalloproteinase family that cleave extracellular matrix constituents [(PUBMED:14619953)]. These zinc ... C-TERMINAL DOMAIN (HAEMOPEXIN-LIKE DOMAIN) OF HUMAN MATRIX METALLOPROTEINASE-2. 1su3. X-ray structure of human proMMP-1: New ... Matrix metalloproteinases are thought to be key players in the remodelling activity of cells associated with both physiological ...
  http://smart.embl-heidelberg.de/smart/do_annotation.pl?DOMAIN=HX&BLAST=DUMMY
*  A randomised controlled phase II trial of pre-operative celecoxib treatment reveals anti-tumour transcriptional response in...
In transgenic breast cancer models, over-expression of COX-2 leads to tumour formation while COX-2... ... is frequently over-expressed in primary breast cancer. ... The majority of the matrix metalloproteinase (MMP) family ... Sato H, Kinoshita T, Takino T, Nakayama K, Seiki M: Activation of a recombinant membrane type 1-matrix metalloproteinase (MT1- ... Orlichenko L, Radisky D: Matrix metalloproteinases stimulate epithelial-mesenchymal transition during tumor development. Clin ...
  https://rd.springer.com/article/10.1186/bcr3409
*  Myoepithelial cells: good fences make good neighbors | Breast Cancer Research | Full Text
Simian M, Hirai Y, Navre M, Werb Z, Lochter A, Bissell MJ: The interplay of matrix metalloproteinases, morphogens and growth ... In this review we briefly address the characteristics of breast myoepithelial cells from human breast and mouse mammary gland, ... Bissell MJ, Bilder D: Polarity determination in breast tissue: desmosomal adhesion, myoepithelial cells, and laminin 1. Breast ... and facilitate the sculpting of new BM through the production of matrix metalloproteinases (MMPs), including MMP2 and MMP3 [45 ...
  https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr1286
*  Y-box factor YB-1 predicts drug resistance and patient outcome in breast cancer independent of clinically relevant tumor...
Matrix metalloproteinase-2 immunoreactive protein: a marker of aggressiveness in breast carcinoma. Cancer 1998;83: 1153-62.. * ... Tissue distribution of major matrix metalloproteinases and their transcripts in human breast carcinomas. Anticancer Res 1999;19 ... Expression of tumorigenesis-associated factors in normal tissue adjacent to breast cancer has been described for major matrix ... Enhancement of mdr1 gene expression in normal tissue adjacent to advanced breast cancer. Breast Cancer Res Treat 2000;61: 13-20 ...
  http://onlinelibrary.wiley.com/doi/10.1002/ijc.1610/full
*  Anti-invasive and antiangiogenic effects of MMI-166 on malignant glioma cells | Springer for Research & Development
Background The constitutive overexpression of matrix metalloproteinases (MMPs) is frequently observed in malignant tumours. In ... Haas TL, Madri JA: Extracellular matrix-driven matrix metalloproteinase production in endothelial cells: implications for ... The increased expression of MMPs has been associated with cancers of the head and neck, breast, lung, stomach, and pancreas [12 ... Bramhall SR: The matrix metalloproteinases and their inhibitors in pancreatic cancer. Int J Pancreatol. 1997, 21: 1-12.PubMed ...
  https://rd.springer.com/article/10.1186/1471-2407-10-339
*  Tumor-Associated Macrophages Press the Angiogenic Switch in Breast Cancer | Cancer Research
... matrix metalloproteinase-9, and uPA ( 7). Alternatively, they may recruit and interact with other cells in the tumor ... Using an autochthonous mouse model of breast cancer to study their function in breast cancer, we showed that they are required ... Tumor-Associated Macrophages Press the Angiogenic Switch in Breast Cancer. Elaine Y. Lin and Jeffrey W. Pollard ... Tumor-Associated Macrophages Press the Angiogenic Switch in Breast Cancer Message Subject (Your Name) has forwarded a page to ...
  http://cancerres.aacrjournals.org/content/67/11/5064
*  Plus it
Dentin Matrix Protein 1 Enhances Invasion Potential of Colon Cancer Cells by Bridging Matrix Metalloproteinase-9 to Integrins ... Li G., Fridman R., Kim H. R. Tissue inhibitor of metalloproteinase-1 inhibits apoptosis of human breast epithelial cells. ... Edwards D. R. The tissue inhibitors of metalloproteinases (TIMPs) Clendeninn N. J. Appelt K. eds. . Matrix Metalloproteinase ... Expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases in head and neck squamous cell carcinoma. ...
  http://cancerres.aacrjournals.org/content/64/3/952
*  Overview of MMP Biology and Gene Associations in Human Diseases | IntechOpen
The matrix metalloproteinase inhibitor batimastat (BB-94) retards human breast cancer solid tumor growth but not ascites ... activation of pro-matrix metalloproteinase-2 by leukolysin/membrane-type 6 matrix metalloproteinase/matrix metalloproteinase 25 ... Matrix metalloproteinase-9 and matrix metalloproteinase-2 gene polymorphisms in multiple sclerosis. Journal of Neuroimmunology ... matrix metalloproteinase-2, and tissue inhibitor of matrix metalloproteinase-1 in human abdominal aortic vascular smooth muscle ...
  https://www.intechopen.com/books/the-role-of-matrix-metalloproteinase-in-human-body-pathologies/overview-of-mmp-biology-and-gene-associations-in-human-diseases/
*  Matrix metallopeptidase 13 - Wikipedia
... a novel human matrix metalloproteinase produced by breast carcinomas". J Biol Chem. 269 (24): 16766-73. PMID 8207000. "Entrez ... "Matrix metalloproteinases collagenase-2, macrophage elastase, collagenase-3, and membrane type 1-matrix metalloproteinase ... Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal ... "A matrix metalloproteinase gene expressed in human T lymphocytes is identical with collagenase 3 from breast carcinomas". ...
  https://en.wikipedia.org/wiki/Matrix_metallopeptidase_13
*  In vitro evaluation of functional interaction of integrin αvβ3 and matrix metalloprotease-2
Matrix Metalloproteinases: They're Not Just for Matrix Anymore! Curr. Opin. Cell Biol. 2001;13(5):534-540. [PubMed] ... Mt1-Mmp Initiates Activation of Pro-Mmp-2 and Integrin Alpha V Beta 3 Promotes Maturation of Mmp-2 in Breast Carcinoma Cells. ... Matrix Metalloproteinases: A Tail of a Frog That Became a Prince. Nat. Rev. Mol. Cell Biol. 2002;3(3):207-214. [PubMed] ... Matrix Metalloproteinase Is Activated During Migration of Human Endothelial Cells and Modulates Endothelial Motility and Matrix ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2790922/
*  Comparison the Prognostic Value of Galectin-3 and Serum Markers of Cardiac Extracellular Matrix Turnover in Patients with...
Circulating matrix metalloproteinase-2 but not matrix metalloproteinase-3, matrix metalloproteinase-9, or tissue inhibitor of ... Galectin-3 enhances cyclin D(1) promoter activity through SP1 and a cAMP-responsive element in human breast epithelial cells. ... Interplay of matrix metalloproteinases, tissue inhibitors of metalloproteinases and their regulators in cardiac matrix ... Comparison of matrix metalloproteinase 9 and brain natriuretic peptide as clinical biomarkers in chronic heart failure. Am ...
  http://www.medsci.org/v11p1098.htm
*  Biobehavioral Influences on Matrix Metalloproteinase Expression in Ovarian Carcinoma | Clinical Cancer Research
... invasiveness of breast cancer cell lines upon co-cultivation with macrophages is due to TNF-α dependent up-regulation of matrix ... Biobehavioral Influences on Matrix Metalloproteinase Expression in Ovarian Carcinoma. Susan K. Lutgendorf, Donald M. Lamkin, ... Biobehavioral Influences on Matrix Metalloproteinase Expression in Ovarian Carcinoma. Susan K. Lutgendorf, Donald M. Lamkin, ... Biobehavioral Influences on Matrix Metalloproteinase Expression in Ovarian Carcinoma. Susan K. Lutgendorf, Donald M. Lamkin, ...
  http://clincancerres.aacrjournals.org/content/14/21/6839.long
*  Cancers | Free Full-Text | STAT3 in Cancer-Friend or Foe? | HTML
Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C. Proc. Natl. Acad ... The JAK2/STAT3 signaling pathway is required for growth of CD44(+)CD24(−) stem cell-like breast cancer cells in human tumors. J ... STAT3 is known to increase the expression of various matrix metalloproteinases (MMPs), including MMP-1, MMP-2, MMP-7 and MMP-9 ... STAT3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis. Oncogene 2004, 23, ...
  http://www.mdpi.com/2072-6694/6/3/1408/htm
*  Matrix Metalloproteinase-8 and Tissue Inhibitor of Metalloproteinase-1 in Serum Do Not Reflect the Analytes Circulating in...
Gelatinase concentrations and zymographic profiles in human breast cancer: matrix metalloproteinases circulating in plasma are ... Plasma matrix metalloproteinase-9 level is better than serum matrix metalloproteinase-9 level to predict gastric cancer ... Matrix Metalloproteinase-8 and Tissue Inhibitor of Metalloproteinase-1 in Serum Do Not Reflect the Analytes Circulating in ... Matrix Metalloproteinase-8 and Tissue Inhibitor of Metalloproteinase-1 in Serum Do Not Reflect the Analytes Circulating in ...
  http://atvb.ahajournals.org/content/28/3/e15
*  Calciphylaxis (Calcific Uremic Arteriolopathy) | Springer for Research & Development
Weight loss-induced calciphylaxis: potential role of matrix metalloproteinases. J Dermatol 2003;30:915-919.PubMedGoogle Scholar ... Calciphylaxis associated with metastatic breast carcinoma. J Am Acad Dermatol 1999;41:295-298.PubMedCrossRefGoogle Scholar ... 13.. Munavalli F, Reisenauer A, Moses M, Kilroy S, Arbiser JL. ...
  https://rd.springer.com/chapter/10.1007/978-0-387-68858-9_35
*  RAC1 - Wikipedia
Jul 11, 2012). "Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression". Science translational ... Dokmanovic M, Hirsch DS, Shen Y, Wu WJ (Jun 2009). "Rac1 contributes to trastuzumab resistance of breast cancer cells: Rac1 as ... "Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression". Science Translational Medicine. 4 (142 ... suggesting Rac1 as a predictive marker and therapeutic target for trastuzumab-resistant breast cancer. However, given Rac1's ...
  https://en.wikipedia.org/wiki/RAC1
*  GINSENG, SIBERIAN: Uses, Side Effects, Interactions and Warnings - WebMD
Yamazaki, T. and Tokiwa, T. Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits matrix metalloproteinase-7 ... Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: ... Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking Siberian ginseng if you are ... Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11. ...
  https://www.webmd.com/vitamins-supplements/ingredientmono-985-ginseng,%20siberian.aspx?activeingredientid=985&activeingredientname=ginseng,%20siberian
*  Shop Vitamark Products
... including expression of matrix metalloproteinase gelatinase B. J Biol Chem. 2000; 275:10405-10412. ... Zi X, Feyes DK, Agarwai R. Anticarcinogenic effect of a flavonoid antioxidant, silymarin, in human breast cancer cells MDA-MB ... Antiproliferative Effect of Curcumin (Diferuloylmethane) against Human Breast Tumor Cell Line. Anticancer Drugs. Jun1997;8(5): ... peptide that is found interlocked within the complex matrix hidden in the natural immune structure of the shark. VitaMune's ...
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*  Plus it
Yokoo T, Kitamura M. Dual regulation of IL-1β-mediated matrix metalloproteinase-9 expression in mesangial cells by NF-κB and AP ... NF-κB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4. J Biol ... matrix metalloproteinase-9; PDGF, platelet-derived growth factors; PTK, protein tyrosine kinase; RANKL, receptor activator for ... Other genes such as matrix metalloproteinase-9 (64), vascular endothelial growth factor (65), CXCR4 (66), and TWIST (67), which ...
  http://clincancerres.aacrjournals.org/content/15/2/425
*  Bone metastasis-related signaling pathways in breast cancers stratified by estrogen receptor status
Matrix metalloproteinase (MMP)-13 regulates mammary tumor-induced osteolysis by activating MMP9 and transforming growth factor- ... Duivenvoorden WC, Hirte HW, Singh G. Transforming growth factor beta1 acts as an inducer of matrix metalloproteinase expression ... Breast cancer metastasis to the bone: mechanisms of bone loss. Breast Cancer Res. 2010;12:215 ... Different gene expressions are associated with the different molecular subtypes of inflammatory breast cancer. Breast Cancer ...
  http://www.jcancer.org/v08p1045.htm
*  Cranberry (Vaccinium macrocarpon) | Plant Profiler | China-Mainland | Sigma-Aldrich
Two in vitro studies found that cranberry fractions dose-dependently inhibited matrix metalloproteinases and intracellular ... Sun, J. and Hai, Liu R. Cranberry phytochemical extracts induce cell cycle arrest and apoptosis in human MCF-7 breast cancer ... decreased expression of matrix metalloproteinases associated with prostate tumor metastasis, and anti-inflammatory activities ... Bodet, C., Chandad, F., and Grenier, D. Inhibition of host extracellular matrix destructive enzyme production and activity by a ...
  https://www.sigmaaldrich.com/china-mainland/zh/life-science/nutrition-research/learning-center/plant-profiler/vaccinium-macrocarpon.html
*  Twist transcription factor - Wikipedia
... but it has been implicated in the upregulation of matrix metalloproteinases and inhibition of TIMP. Recently, targeting Twist ... Mutations in the TWIST1 gene are associated with Saethre-Chotzen syndrome, breast cancer, and Sézary Syndrome. Twist plays an ... "Promotion of hepatocellular carcinoma metastasis through matrix metalloproteinase activation by epithelial-mesenchymal ... and thus inhibits cancer metastasis in cancer cell lines and xenograft model of breast cancer in mouse Twist transcription ...
  https://en.wikipedia.org/wiki/Twist_transcription_factor
*  Association of Genetic Variants of Small Non-Coding RNAs with Survival in Colorectal Cancer
Genetic polymorphisms of matrix metalloproteinases and clinical outcomes in colorectal cancer patients. Int J Med Sci. 2013;10: ... Common genetic variants in pre-microRNAs were associated with increased risk of breast cancer in Chinese women. Hum Mutat. 2009 ... Genotyping was performed at the National Center for Genome Medicine, Taiwan, using the Agena Bioscience iPLEX matrix-assisted ... breast [23], gastric [24], head and neck [25], liver [26], and colorectal cancer [27], suggesting its important general role in ...
  http://www.medsci.org/v15p0217.htm