*  Organ-specific cell division abnormalities caused by mutation in a general cell cycle regulator in C. elegans | Development
Cdks can also be negatively regulated by cyclin-dependent kinase inhibitors (CKIs); small polypeptides that bind to and inhibit ... One important gene family involved in such control is the p21/p27/p57 class of negative cell cycle regulators. Loss of function ... Koff, A. and Polyak, K. (1995). p27KIP1, an inhibitor of cyclin-dependent kinases. Prog. Cell Cycle Res. 1, 141-147. ... Hong, Y., Roy, R. and Ambros, V. (1998). Developmental regulation of a cyclin-dependent kinase inhibitor controls postembryonic ...
  http://dev.biologists.org/content/129/9/2155
*  WikiGenes - CDK1 - cyclin-dependent kinase 1
T-loop deletion of CDC2 from breast cancer tissues eliminates binding to cyclin B1 and cyclin-dependent kinase inhibitor p21. ... T-loop deletion of CDC2 from breast cancer tissues eliminates binding to cyclin B1 and cyclin-dependent kinase inhibitor p21 [2 ... Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1. Chin, Y.E., Kitagawa, M ... is accompanied by increased cyclin D1 expression and decreased cyclin-dependent kinase inhibitor association with cyclin E-Cdk2 ...
  http://www.wikigenes.org/e/gene/e/983.html
*  Flap structure-specific endonuclease 1 - Wikipedia
... and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21". J. Biol. Chem. ... and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21". J. Biol. Chem. ... Henneke G, Koundrioukoff S, Hübscher U (Jul 2003). "Phosphorylation of human Fen1 by cyclin-dependent kinase modulates its role ... Warbrick E, Lane DP, Glover DM, Cox LS (1997). "Homologous regions of Fen1 and p21Cip1 compete for binding to the same site on ...
  https://en.wikipedia.org/wiki/Flap_structure-specific_endonuclease_1
*  Proliferating cell nuclear antigen - Wikipedia
... and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21". J. Biol. Chem. ... Cyclin D1, Cyclin O, Cyclin-dependent kinase 4, Cyclin-dependent kinase inhibitor 1C, DNMT1, EP300, Flap structure-specific ... "Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57KIP2 requires binding to proliferating cell ... "A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor ...
  https://en.wikipedia.org/wiki/Proliferating_cell_nuclear_antigen
*  p21 - Wikipedia, wolna encyklopedia
Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57KIP2 requires binding to proliferating cell ... CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1).. *↑ a b Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ. The p21 ... Li Y, Jenkins CW, Nichols MA, Xiong Y. Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21. „ ... proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 ...
  https://pl.wikipedia.org/wiki/P21
*  P21 - Wikipedia
p21 is a potent cyclin-dependent kinase inhibitor (CKI). The p21 (CIP1/WAF1) protein binds to and inhibits the activity of ... also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) ... CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)". Gartel AL, Radhakrishnan SK (May 2005). "Lost in transcription: p21 ... Cyclin-Dependent Kinase Inhibitor p21 at the US National Library of Medicine Medical Subject Headings (MeSH) Drosophila dacapo ...
  https://en.wikipedia.org/wiki/P21
*  Cyclin-dependent kinase inhibitor 1C - Wikipedia
Cyclin-dependent kinase inhibitor 1C is a tight-binding inhibitor of several G1 cyclin/Cdk complexes and a negative regulator ... "New functional activities for the p21 family of CDK inhibitors". Genes & Development. 11 (7): 847-62. doi:10.1101/gad.11.7.847 ... "Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57KIP2 requires binding to proliferating cell ... "Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57KIP2 requires binding to proliferating cell ...
  https://en.wikipedia.org/wiki/Cyclin-dependent_kinase_inhibitor_1C
*  MRS 2578 - BET-bromodomain inhibition research
Ras promotes the build up from the cyclin-dependent kinase inhibitor p21Waf1/Cip1 (p21). which by competing for binding cyclin? ... p21 bound cyclin?D1 efficiently and bound C8α less efficiently but did not bind the Rabbit Polyclonal to IKK-gamma (phospho- ... Ras promotes the build up from the cyclin-dependent kinase inhibitor p21Waf1/Cip1. Posted on June 14, 2017. by ... 35S-labelled p21 or luciferase settings (L) were incubated with MRS 2578 His-tagged cyclin?D1 or C8α bound to nickel- agarose ...
  http://healthandwellnesssource.org/tag/mrs-2578/
*  CIP/KIP - Wikipedia
"Crystal structure of the p27Kip1 cyclin-dependent kinase inhibitor bound to the cyclin A-cdk2 complex". Nature. 382: 325-331. ... "p21 is a universal inhibitor of cyclin kinases". Nature. 366: 701-704. Toyoshima H, Hunter T (1994). "p27, a novel inhibitor of ... "Increased proteasome-dependent degredation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas". ... As cyclin-dependent kinase inhibitors, CIP/KIP proteins have been classically viewed as tumor suppressors; however, the exact ...
  https://en.wikipedia.org/wiki/CIP/KIP
*  Cyclin A2 - Wikipedia
"Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex". Nature. 382 (6589): 325 ... "Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage ... Wang Y, Prives C (Jul 1995). "Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases ... Cyclin A2 belongs to the cyclin family, whose members regulate cell cycle progression by interacting with CDK kinases. Cyclin ...
  https://en.wikipedia.org/wiki/Cyclin_A2
*  Impact of Air Pollution on Vitamin D Status and Related Health Consequences | IntechOpen
... increases expression of cyclin-dependant kinase (CDK) inhibitors - e.g.: proteins p21 and p27. It results in keeping the cell ... Vitamin D with the vitamin D receptor (VDR) binds to the regulatory sequences in the promoters of p21 and p27 genes activating ... Rb phosphorylation is catalyzed by the G1 cyclines and cyclin dependent kinases - CDKs. The CDKs activity can be inhibited by ... Rb phosphorylation is catalyzed by the G1 cyclines and cyclin dependent kinases - CDKs. The CDKs activity can be inhibited by ...
  https://www.intechopen.com/books/the-impact-of-air-pollution-on-health-economy-environment-and-agricultural-sources/impact-of-air-pollution-on-vitamin-d-status-and-related-health-consequences/
*  REPAIRtoire - a database of DNA repair pathways
... and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21. Gary R, Ludwig ... May bind an additional third magnesium ion after substrate binding. SUBUNIT: Interacts with PCNA. The C-terminal domain binds ... Can bind simultaneously to both PCNA and EP300. INTERACTION: P54132:BLM; NbExp=3; IntAct=EBI-707816, EBI-621372; P12004:PCNA; ... Essential amino acids for substrate binding and catalysis of human flap endonuclease 1. Shen B, Nolan JP, Sklar LA, Park MS J ...
  http://repairtoire.genesilico.pl/proteins/48/
*  Plus it
Sherr CJ and Roberts JM (1995) Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 9: 1149-1163. ... 6A, YC-1 significantly increased the binding of p21CIP1/WAF1, but not p27KIP1, to CDK2. The binding of p21CIP1/WAF1 or p27KIP1 ... Of note, YC-1 induced a dramatic increase in the expression of cyclin-dependent kinase (CDK)-inhibitory protein, p21CIP1/WAP1, ... Lee MH, Reynisdottir I, and Massague J (1995) Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain ...
  http://jpet.aspetjournals.org/content/312/3/917
*  Cyclin-Dependent Kinase Inhibitors as Anticancer Therapeutics | Molecular Pharmacology
These criteria include binding to a cyclin such as cyclin E; not having bound inhibitory proteins such as p21, p27, or p57; not ... Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. Nature 382:325-331. ... Cyclin-Dependent Kinase Inhibitors as Anticancer Therapeutics. Mary E. Law, Patrick E. Corsino, Satya Narayan and Brian K. Law ... Cyclin-Dependent Kinase Inhibitors as Anticancer Therapeutics Message Subject (Your Name) has forwarded a page to you from ...
  http://molpharm.aspetjournals.org/content/88/5/846
*  Cyclin A1 - Wikipedia
"Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to ... Cyclins function as activating subunits of enzymatic complex together with cyclin-dependent kinases (CDKs). Different cyclins ... and the Kip/Cip family of CDK-inhibitor proteins. Cyclin-A1 interacts with: CDC20, Cyclin-dependent kinase 2, E2F1, GNB2L1, ... This cyclin binds both Cdk1 and Cdk2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in ...
  https://en.wikipedia.org/wiki/Cyclin_A1
*  Cyclin-dependent kinase 4 - Wikipedia
"Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to ... See also CDK inhibitor for inhibitors of various CDKs. Cyclin-dependent kinase 4 has been shown to interact with: CDC37, CDKN1B ... 1995). "Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C". Proc. Natl. Acad. ... "Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase ...
  https://en.wikipedia.org/wiki/Cyclin-dependent_kinase_4
*  Blockade of the Ras-Extracellular Signal-Regulated Kinase 1/2 Pathway Is Involved in Smooth Muscle 22α-Mediated Suppression of...
Adenovirus-mediated over-expression of the cyclin/cyclin-dependent kinase inhibitor, p21 inhibits vascular smooth muscle cell ... SM22α is an actin-binding protein, and the SM22α(1-151) mutant with truncation of the actin-binding domain has no actin-binding ... dependent kinase (CDK) inhibitors, such as p21waf1 (p21) and particularly p27kip1 (p27), thereby eliminating their growth- ... Cyclin D1 is required for cells to exit the G1 phase and enter the S phase. Mitogen-induced downregulation of p21 and p27 ...
  http://atvb.ahajournals.org/content/30/4/683
*  Interactive Fly, Drosophila
These regions share key hydrophobic residues with the PCNA-binding domain of the cyclin-dependent kinase inhibitor p21(Waf1/ ... Gadd45 competes with p21 for binding to PCNA and conversely, p21 blocks the ability of Gadd45 to bind PCNA. p21 appears to ... Phosphorylation of Cdt1 by cyclin-dependent kinases promotes its binding to SCF-Skp2 E3 ubiquitin ligase, but the Cdk2/Skp2- ... Like another p53-regulated gene, p21WAF1/CIP1, whose product binds to cyclin-dependent kinases (Cdk's) and proliferating cell ...
  http://www.sdbonline.org/sites/fly/polycomb/pcna2a.htm
*  Patent US8017749 - Compositions and methods to treat cancer with cupredoxins and CpG rich DNA - Google Patents
... a cyclin-dependent kinase inhibitor, such as p16, p21 or p27; a suicide protein such as thymidine kinase or nitroreductase; a ... Cupredoxin peptides may or may not bind copper.. In some embodiments, the cupredoxin peptide has some of the functional ... Aminothiazole inhibitors of cyclin dependent kinases. WO1999027890A2. Nov 30, 1998. Jun 10, 1999. Bristol-Myers Squibb Company ... cyclin dependent kinase inhibitors as found in WO 99/24416 (see also U.S. Pat. No. 6,040,321); and prenyl-protein transferase ...
  http://www.google.com/patents/US8017749?dq=5311516
*  Milk Thistle (PDQ®): Integrative, alternative, and complementary therapies - Health Professional Information [NCI] | HealthLink...
... an increase in Cip1/p21 concomitant with a decrease in kinase activity of cyclin-dependent kinases and associated cyclins. Clin ... inhibits activation of erbB1 signaling and induces cyclin-dependent kinase inhibitors, G1 arrest, and anticarcinogenic effects ... Zi X, Zhang J, Agarwal R, et al.: Silibinin up-regulates insulin-like growth factor-binding protein 3 expression and inhibits ... Manna SK, Mukhopadhyay A, Van NT, et al.: Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, ...
  https://www.healthlinkbc.ca/health-topics/ncicdr0000347008
*  Bharat Aggarwal - Wikipedia
... degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 ... "Retraction: The Dietary Polyphenols trans-Resveratrol and Curcumin Selectively Bind Human CB1 Cannabinoid Receptors with ... Aggarwal patented curcumin as an inhibitor of NF-κB activation, and he co-founded a company in 2004 called Curry ... September 26, 1996. Retrieved October 6, 2016. Singh, Seema (September 7, 2007). "From Exotic Spice to Modern Drug?". Cell. 130 ...
  https://en.wikipedia.org/wiki/Bharat_Aggarwal
*  ORBi: Browsing ORBi
It is also able to increase the amount of the p21 cyclin-dependent kinase inhibitor. The human p21 promoter harbors p53 ... [ ... The human p21 promoter harbors p53-responsive elements and an NF-kappaB binding site. [less ▲] ... It is also able to increase the amount of the p21 cyclin-dependent kinase inhibitor. ... Activation of ATP-dependant K+ channels and inhibition of insulin release: effect of BPDZ 62. Lebrun, P.; Antoine, M.-H.; ...
  http://orbi.ulg.ac.be/browse?type=journal&value=Journal+of+Pharmacology+and+Experimental+Therapeutics+
*  Two-Hybrid Paper
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of g1 cyclin-dependent kinases. Cell 75, 805-816.. Kranz, J. E., ... In addition, systems that use Gal4 as the DNA binding domain cannot be used with yeast strains that have a wild-type GAL4 gene ... Wild type p16 interacts with two human Cyclin-dependent kinases, Cdk4 and Cdk6 to inhibit their activity. As expected, ... we used interaction mating to characterize a set of seven Drosophila Cyclin-dependent kinases (Cdk) interactors, or Cdis ( ...
  http://proteome.wayne.edu/YTHnetworks.html
*  1ycq - Proteopedia, life in 3D
One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by ... Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in ... The MDM2 oncoprotein is a cellular inhibitor of the p53 tumor suppressor in that it can bind the transactivation domain of p53 ... Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. ...
  http://proteopedia.org/wiki/index.php/1ycq
*  Sox15 and Fhl3 transcriptionally coactivate Foxk1 and regulate myogenic progenitor cells | The EMBO Journal
... dysregulation of the cyclindependent kinase inhibitor, p21, and perturbed cell cycle progression of the MPC population (Garry ... Turner J, Nicholas H, Bishop D, Matthews J, Crossley M (2003) The LIM protein FHL3 binds basic kruppel‐like factor/kruppel‐like ... dysregulation of the cyclindependent kinase inhibitor, p21 (Cdkn1a), and perturbed cell cycle progression of the MPC ... Hawke TJ, Meeson A, Jiang N, Graham S, Hutcheson K, DiMaio M, Garry DJ (2003b) p21 is essential for normal myogenic progenitor ...
  http://emboj.embopress.org/content/26/7/1902