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*  Flucetorex - Wikipedia
Flucetorex (INN) is an amphetamine which was investigated as an anorectic but does not appear to have ever been marketed. It is ... related to fenfluramine. Benfluorex Fludorex Tiflorex C.R. Ganellin; David J. Triggle (21 November 1996). Dictionary of ...
  https://en.wikipedia.org/wiki/Flucetorex
*  Fenfluramine - Wikipedia
Fenfluramine is a substituted amphetamine and is also known as 3-trifluoromethyl-N-ethylamphetamine. It is a racemic mixture of ... Unlike various other amphetamine derivatives, fenfluramine is reported to be dysphoric, "unpleasantly lethargic", and non- ... In overdose, fenfluramine can cause serotonin syndrome and rapidly result in death. Fenfluramine acts primarily as a serotonin ... Fenfluramine was approved in the United States in 1973. The combination of fenfluramine and phentermine was proposed in 1984. ...
  https://en.wikipedia.org/wiki/Fenfluramine
*  Substances of Abuse and Hallucinogenic Activity: The Serotoninergic Pathway - Focus on Classical Hallucinogens and Entactogens ...
The substituted amphetamines 3, 4-methylenedioxymethamphetamine, methamphetamine, p-chloroamphetamine and fenfluramine induce 5 ... Toxicity of amphetamines: an update. Arch Toxicol. 2012;86:1167-231.PubMedCrossRefGoogle Scholar ... Mørland J. Toxicity of drug abuse-amphetamine designer drugs (ecstasy): mental effects and consequences of single dose use. ...
  https://link.springer.com/chapter/10.1007%2F978-3-319-75124-5_2
*  5-HT2C receptor agonist - Wikipedia
... such as amphetamines). Prior to the discovery of fenfluramine, amphetamines were the primary form of anorectic drugs available ... Fenfluramine was sold as a racemic mixture of two enantiomers, dexfenfluramine and levofenfluramine. In 1994, sales of the ... Fenfluramine's anorectic effect is achieved through an increase in serotonin levels, imparting a sensation of fullness, which ... The 5-HT2c receptor agonist Fenfluramine (market names Pondimin, Ponderax and Adifax) was discovered in 1972 as a result of ...
  https://en.wikipedia.org/wiki/5-HT2C_receptor_agonist
*  Anti-obesity medication - Wikipedia
Catecholamine releasing agents such as amphetamine, phentermine, and related substituted amphetamines (e.g., bupropion) which ... "FDA Announces Withdrawal Fenfluramine and Dexfenfluramine (Fen-Phen)". U.S. Food and Drug Administration. FDA. Retrieved 2014- ... Use of amphetamines increased over the subsequent decades, including Obetrol and culminating in the "rainbow pill" regime. This ... Amphetamines (marketed as Benzedrine) became popular for weight loss during the late 1930s. They worked primarily by ...
  https://en.wikipedia.org/wiki/Anti-obesity_medication
*  Pharmacological treatment of obesity
Feeney S, Goodall E, Silverstone T. The prolactin response to d- and l-fenfluramine and to d-amphetamine in human subjects. Int ... Goodall EM, Feeney S, McGuirk J, Silverstone T. A comparison of the effects of d- and l-fenfluramine and d-amphetamine on ... While amphetamine delays intake outset, fenfluramine does not, but rather anticipates food intake cessation (15). In animals, ... These studies were carried out in animals using amphetamine, and in humans using fenfluramine (in metabolic units) (13,14). The ...
  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302006000200024&tlng=es&lng=en&nrm=iso
*  Dexfenfluramine - Wikipedia
It is the d-enantiomer of fenfluramine and is structurally similar to amphetamine, but lacks any psychologically stimulating ... FDA Announces Withdrawal Fenfluramine and Dexfenfluramine (Fen-Phen) "Abbott Pulls Diet Drug Meridia Off US Shelves". Wall ... Fenfluramine Levofenfluramine Norfenfluramine Benfluorex Stuart Ira Fox. Human Physiology. Twelfth Edition. McGraw Hill. 2011. ... Drug description Dexfenfluramine hydrochloride Questions and Answers about Withdrawal of Fenfluramine (Pondimin) and ...
  https://en.wikipedia.org/wiki/Dexfenfluramine
*  Anorectic - Wikipedia
Following the war, amphetamines were redirected for use on the civilian market. Indeed, amphetamine itself was sold ... This was the case with aminorex in the 1960s, and again in the 1990s with fenfluramine (see: Fen-phen). Likewise, association ... Amphetamine sulfate (also known as amfetamine) - USFDA-approved for the treatment of exogenous obesity under the brand name " ... Many amphetamines produce side effects, including addiction, tachycardia and hypertension, making prolonged unsupervised use ...
  https://en.wikipedia.org/wiki/Anorectic
*  Plus it
1992) The substituted amphetamines 3,4-methylenedioxymethamphetamine, methamphetamine, p-chloroamphetamine and fenfluramine ... 1994) Amphetamine-like effect of l-deprenyl in drug-discrimination studies. Clin Pharmacol Ther 56:768-773. ... 1995) DOI, a 5-HT2A/2C receptor agonist, potentiates amphetamine-induced dopamine release in rat striatum. Brain Res 698:204- ... 1992) The effect of 5-HT3 receptor antagonists on the discriminative stimulus effects of amphetamine. Eur J Pharmacol 212:271- ...
  http://jpet.aspetjournals.org/content/291/1/239
*  David Levitsky | Cornell College of Human Ecology
Effect of dl-fenfluramine on thermic effect of food in humans. Internat J Obesity 1990;14:647-55. ... Strupp BJ, Bunsey M, Levitsky DA, Kesler M. Time-dependent effects of post-trial amphetamine treatment in rats: Evidence for ... Levitsky DA, Troiano R. Metabolic consequences of fenfluramine for the control of body weight. Am J Clin Nutr 1992;55:167S-72S ... The effects of D-fenfluramine on the development of aflatoxin-B1 induced GGT+. Internat J Obesity Relat Metab Disord 1993;17: ...
  https://www.human.cornell.edu/people/dal4?netid=dal4
*  Levofenfluramine - Wikipedia
... fenfluramine, is a drug of the amphetamine family that, itself (i.e., in enantiopure form), was never marketed. It is the ... Both fenfluramine and dexfenfluramine are anorectic agents that have been used clinically in the treatment of obesity (and ... Fenfluramine Dexfenfluramine Norfenfluramine Chapman and Hall (1996). Dictionary of Organic Compounds. CRC Press. p. 3141. ISBN ... Ni W, Li MW, Thakali K, Fink GD, Watts SW (May 2004). "The fenfluramine metabolite (+)-norfenfluramine is vasoactive". The ...
  https://en.wikipedia.org/wiki/Levofenfluramine
*  Distinctive effects of modafinil and d-amphetamine on the homeostatic and circadian modulation of the human waking EEG |...
... of fenfluramine and its comparison with chlorpromazine and d-amphetamine: blood levels, EEG mapping and safety evaluation. Meth ... Nicholson AN, Stone BM (1980) Heterocyclic amphetamine and caffeine on sleep in man. Br J Clin Pharmacol 9:195-203PubMedGoogle ... While d-amphetamine inhibits the expression of a sleep-related process, probably through a direct cortical activation masking ... Pigeau RA, Naitoh P, Buguet A, McCann C, Baranski J, Taylor M, Thompson M, Mack I (1995) Modafinil, d-amphetamine and placebo ...
  https://link.springer.com/article/10.1007%2Fs00213-002-1315-8
*  Small Changes in Ambient Temperature Cause Large Changes in 3,4-Methylenedioxymethamphetamine (MDMA)-Induced Serotonin...
MDMA and other amphetamines have been shown to disrupt thermoregulation in both rats and humans (Gordon et al., 1991; Dafters, ... Experiments with methamphetamine, p-chloroamphetamine, fenfluramine, dizocilpine and dextromethorphan. J Pharmacol Exp Ther 272 ... The amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA) is a drug of abuse and has been shown to be neurotoxic to 5 ... Temperature has an affect on amphetamine-induced 5-HT and DA release, which may be important to neurotoxicity. Clausing et al ...
  http://www.jneurosci.org/content/18/13/5086.long
*  US6207699B1 - Pharmaceutical combinations for treating obesity and food craving - Google Patents
Yu, Y. L.; Fisher, H.; Sekowski, A.; Wagner, G. C. Amphetamine and fenfluramine suppress ethanol intake in ethanol-dependent ... 1. Brauer, L. H.; Johanson, C. E.; Schuster, C. R.; Rothman, R. B.; de Wit, H. Evaluation of phentermine and fenfluramine, ... Rothman, R. B.; Elmer, G. I.; Shippenberg, T. S.; Rea, W.; Baumann, M. H. Phentermine and fenfluramine: preclinical studies in ... Rothman, R. B.; Gendron, T. M.; Hitzig, P. Combined use of fenfluramine and phenternine in the treatment of cocaine addiction: ...
  https://patents.google.com/patent/US6207699
*  10 HAZARDOUS Metermine Side Effects VS Duromine - F*CK FAT
Phentermine/fenfluramine decreases cocaine self-administration in rhesus monkeys. Neuroreport. 1997 Apr 14;8(6):1347-51. ... Metermine includes side effects from the amphetamine effects of the medication.. Because of the potential for addiction, ... A comparison of tyrosine against placebo, phentermine, caffeine, and D-amphetamine during sleep deprivation. Nutr Neurosci. ... Valvular heart disease and primary pulmonary hypertension associated with fenfluramine-phentermine]. Harefuah. 1998 Dec 1;135( ...
  https://fckfat.com/metermine-side-effects/
*  Iprindole - Wikipedia
... amphetamine, methamphetamine, fenfluramine, phenelzine, tranylcypromine, trimipramine, and fluoxetine, likely via inactivating ... Fuller RW, Hemrick-Luecke S (July 1980). "Long-lasting depletion of striatal dopamine by a single injection of amphetamine in ... Hegadoren KM, Baker GB, Coutts RT, Dewhurst WG (March 1991). "Interactions of iprindole with fenfluramine metabolism in rat ... Fuller RW, Baker JC, Molloy BB (February 1977). "Biological disposition of rigid analogs of amphetamine". Journal of ...
  https://en.wikipedia.org/wiki/Iprindole
*  Plus it
2000) Amphetamine-induced DA-effluxes: a voltage-sensitive and intracellular Na+-dependent mechanism. Soc Neurosci Abstr 26: ... 1993) Evidence of an exocytotic-like release of [3H]5-hydroxytryptamine induced by D-fenfluramine in rat hippocampal ... 1998) Protein kinase C inhibitors block amphetamine-mediated dopamine release in rat striatal slices. J Pharmacol Exp Ther 284: ... 2000) who demonstrated in HEK 293 cells expressing the hDAT that 1) amphetamine causes an inward current depolarizing the ...
  http://molpharm.aspetjournals.org/content/59/5/1129
*  Tramadol - Wikipedia
John's wort, passiflora, etc.), amphetamines, substituted amphetamines, phenethylamine and substituted phenethylamines, ... Reimann W, Schneider F (May 1998). "Induction of 5-hydroxytryptamine release by tramadol, fenfluramine and reserpine". European ... A pressor response similar to the so-called "cheese effect" was noted in combinations of amphetamine and tramadol, which ... differ from neurotoxic amphetamine derivatives in their mode of action at 5-HT nerve endings in vitro". Journal of ...
  https://en.wikipedia.org/wiki/Tramadol
*  Indian Patents. 242722:A COMPOSITION AND METHOD FOR BODY WEIGHT LOSS
... fenfluramine and d-fenfluramine, which suppress appetite by both releasing serotonin and then inhibiting its re-uptake; and ... Generic Name and Mechanism Brand Name Comments Amphetamine + Adderall Not commonly used Dextroamphetamine therapeutically for ... Consequently, after a number of confirmed "Fen-Phen"-related patient deaths, most of the drugs containing fenfluramine have ... For example, the once popular appetite suppressant drug "Fen-Phen" (the combination of fenfluramine and phentermine), which ...
  http://www.allindianpatents.com/patents/242722-a-composition-and-method-for-body-weight-loss
*  Serotonin-norepinephrine-dopamine reuptake inhibitor - Wikipedia
Amphetamine, which releases NA from vesicles and prevents re-uptake was also used in the treatment of depression at the time ... Rothman, RB; Elmer, GI; Shippenberg, TS; Rea, W; Baumann, MH (1998). "Phentermine and fenfluramine. Preclinical studies in ... The above finding has been found for amphetamine and some of its variously substituted analogs including PAL-287 etc. RTI-112 ... Baumann, MH; Clark, RD; Woolverton, WL; Wee, S; Blough, BE; Rothman, RB (2011). "In vivo effects of amphetamine analogs reveal ...
  https://en.wikipedia.org/wiki/Serotonin%E2%80%93norepinephrine%E2%80%93dopamine_reuptake_inhibitor
*  MDAI - Wikipedia
Indan analogs of fenfluramine and norfenfluramine have reduced neurotoxic potential. Pharmacology, Biochemistry and Behaviour. ... Oberlender, R; Nichols, D. E. (1988). "Drug discrimination studies with MDMA and amphetamine". Psychopharmacology. 95 (1): 71-6 ... Oberlender, R; Nichols, D. E. (1991). "Structural variation and (+)-amphetamine-like discriminative stimulus properties". ... but the alpha-methyl group of the alkyl amino amphetamine side chain has been bound back to the benzene nucleus to form an ...
  https://en.wikipedia.org/wiki/MDAI
*  Anorexic Agents Aminorex, Fenfluramine, and Dexfenfluramine Inhibit Potassium Current in Rat Pulmonary Vascular Smooth Muscle...
Will J, Bisgard G. Haemodynamic effects of oral aminorex and amphetamine in unanaesthetized beagle dogs. Thorax. 1972;27:120- ... and by fenfluramine (Fig 1B⇓). Fenfluramine (2.0 mmol/L) reduced IK as much as an equimolar dose of the classic K+ channel ... ingestion of fenfluramine for 3 months increased pulmonary vascular resistance.35 In the present study, aminorex, fenfluramine ... Aminorex and fenfluramine inhibit whole-cell IK. A, Aminorex (10 mmol/L) and 4-AP (2 mmol/L) inhibit whole-cell IK in five rat ...
  http://circ.ahajournals.org/content/94/9/2216
*  Fenfluramine/phentermine - Wikipedia
Yu, Y. L.; Fisher, H.; Sekowski, A.; Wagner, G. C. (1997). "Amphetamine and fenfluramine suppress ethanol intake in ethanol- ... fenfluramine alone, a combination of phentermine and fenfluramine, and placebo, for weight loss in humans. Weight loss in those ... fenfluramine alone or dexfenfluramine alone. The FDA requested that the manufacturers of fenfluramine and dexfenfluramine ... Fenfluramine as a single drug was first introduced in the 1970s, but was not popular because it only temporarily reduced weight ...
  https://en.wikipedia.org/wiki/Fenfluramine/phentermine
*  Habilitace V. Hampla
Brenot F, Herve P, Petitpretz P, Parent F, Duroux P, Simonneau G: Primary pulmonary hypertension and fenfluramine use. Br Heart ... Byrne-Wuinn E, Grover R: Aminorex (Menocil) and amphetamine: acute and chronic effects on pulmonary and systemic haemodynamics ... Douglas J, Munro J, Kitchin A, Muir A, Proudfoot A: Pulmonary hypertension and fenfluramine. Brit Med J 1981; 283: 881-883. ... Gaul G, Blazek G, Deutsch E, Heeger H: Ein Fall von chronischer pulmonar Hypertonie nach Fenfluramine inname. Wiener Klinische ...
  http://fyziologie.lf2.cuni.cz/hampl/habilit/habil5.htm
*  Current and Potential Drugs for Treatment of Obesity-Endocrine Reviews : LC Research/Media Forum : Active Low-Carber Forums
d,l-Fenfluramine and d-amphetamine have been compared in eight postaddict volunteers. Fenfluramine overall was unpleasant and ... This included 1) continuous fenfluramine (60 mg/day); 2) intermittent fenfluramine; 3) alternating fenfluramine and phentermine ... Combining d-amphetamine with d-fenfluramine was not more effective in reducing food intake than d-amphetamine alone (417), but ... l-fenfluramine 60 mg/day; d,l-fenfluramine 40 mg/day; d,l-fenfluramine 20 mg/day; or placebo and diet. The groups lost between ...
  https://forum.lowcarber.org/showthread.php?t=50788