*  Expression of Matrix Metalloproteinases and Their Inhibitor TIMP-1 in the Rat Carotid Artery After Balloon Injury |...
Matrix metalloproteinases and tissue inhibitor of metalloproteinases: a review of their role in tumorigenesis and tissue ... Galis ZS, Sukhova GK, Lark MW, Libby P. Increased expression of matrix metalloproteinases and matrix degrading activity in ... Matrix metalloproteinases of vascular wall cells are increased in balloon-injured rat carotid artery. J Vasc Surg. 1994;20:209- ... Expression of Matrix Metalloproteinases and Their Inhibitor TIMP-1 in the Rat Carotid Artery After Balloon Injury. Karen E. ...
  http://atvb.ahajournals.org/content/17/9/1837
*  Genetically Determined Resistance to Collagenase Action Augments Interstitial Collagen Accumulation in Atherosclerotic Plaques ...
Degradation of extracellular matrix by matrix metalloproteinases (MMPs) may play various critical roles in the progression and ... Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic ... Matrix metalloproteinases: a tail of a frog that became a prince. Nat Rev Mol Cell Biol. 2002; 3: 207-214. ... Effect of matrix metalloproteinase inhibition on progression of atherosclerosis and aneurysm in LDL receptor-deficient mice ...
  http://circ.ahajournals.org/content/110/14/1953
*  Matrix metalloproteinase - Wikipedia
MBInfo - Matrix metalloproteinases (MMPs) facilitate extracellular matrix disassembly The Matrix Metalloproteinase Protein ... "Cysteine array matrix metalloproteinase (CA-MMP)/MMP-23 is a type II transmembrane matrix metalloproteinase regulated by a ... a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase ... Matrix Metalloproteinases: Its implications in cardiovascular disorders Van Lint P, Libert C (December 2007). "Chemokine and ...
  https://en.wikipedia.org/wiki/Matrix_metalloproteinase
*  Relation of Plaque Lipid Composition and Morphology to the Stability of Human Aortic Plaques | Arteriosclerosis, Thrombosis,...
Galis ZS, Sukhova GK, Lark MW, Libby P. Increased expression of matrix metalloproteinases and matrix degrading activity in ... potential role of matrix-degrading metalloproteinases and implications for plaque rupture. Circulation. 1995;92:1565-1569. ... 18 Further dissolution of structural proteins may occur because of the release of matrix metalloproteinases from macrophage- ... may further contribute to connective tissue degradation by activating macrophages and stimulating matrix metalloproteinase ...
  http://atvb.ahajournals.org/content/17/7/1337.long
*  Use of an antibody against the matrix metalloproteinasegenerated aggrecan neoepitope fvdipen-cooh to assess the effects...
Stromelysin is a matrix metalloproteinase (MMP) that has been implicated in the turnover of aggrecan from articular cartilage. ... Inhibition of matrix metalloproteinases by N-carboxyalkyl peptides. J Med Chem 36:42934301, 1993 McLean IW, Nakane PK: ... Quantification of a matrix metalloproteinase-generated aggrecan GI fragment using monospecific anti-peptide serum. Biochem J ... and to determine whether the stromelysin-generated neoepitope can be used as a marker of matrix metalloproteinase (MMP) ...
  https://www.docme.ru/doc/2182765/use-of-an-antibody-against-the-matrix-metalloproteinasege..
*  Anti-invasive and antiangiogenic effects of MMI-166 on malignant glioma cells | Springer for Research & Development
Background The constitutive overexpression of matrix metalloproteinases (MMPs) is frequently observed in malignant tumours. In ... Haas TL, Madri JA: Extracellular matrix-driven matrix metalloproteinase production in endothelial cells: implications for ... Bramhall SR: The matrix metalloproteinases and their inhibitors in pancreatic cancer. Int J Pancreatol. 1997, 21: 1-12.PubMed ... Tonn JC, Kerkau S, Hanke A, Bouterfa H, Mueller JG, Wagner S, Vince GH, Roosen K: Effect of synthetic matrix-metalloproteinase ...
  https://rd.springer.com/article/10.1186/1471-2407-10-339
*  Increased Secretion of Tissue Inhibitors of Metalloproteinases 1 and 2 From the Aortas of Cholesterol Fed Rabbits Partially...
Galis ZS, Sukhova GK, Lark MW, Libby P. Increased expression of matrix metalloproteinases and matrix degrading activity in ... Involvement of extracellular-matrix-degrading metalloproteinases in rabbit aortic smooth muscle cell proliferation. Biochem J. ... Expression of matrix metalloproteinases and their inhibitor TIMP-1 in the rat carotid artery after balloon injury. Arterioscler ... Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix associated protein with a distinctive pattern of ...
  http://atvb.ahajournals.org/content/19/7/1700
*  Adiponectin Specifically Increased Tissue Inhibitor of Metalloproteinase-1 Through Interleukin-10 Expression in Human...
The present study was designed to elucidate the effects of adiponectin on matrix metalloproteinases (MMPs) and tissue inhibitor ... potential role of matrix degrading metalloproteinases and implication for plaque rupture. Circulation. 1995; 92: 1565-1569. ... 1 The balance between MMPs and TIMPs determines the actual metalloproteinase activities and controls the extracellular matrix ... which are controlled by the balance between matrix metalloproteinases (MMPs) and their inhibitors (tissue inhibitor of ...
  http://circ.ahajournals.org/content/109/17/2046
*  Treating Wrinkles with Dimethylaminoethanol, Retinol and Mineral Salts
16. J Varani et al, Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and ... 25. B Dreno, Oligoéléments et peau, Cosmétologie 8 44-47 (1995). 26. G Brooks, The importance of zinc in the ageing process and ... The effects of the DRMC treatment lasted until the end of the study: reductions in wrinkle grades were recorded at 17% in the ... 17. C Bertin et al, Retinol + Melibiose: An innovative anti-aging combination, 20th IFSCC Congress (1998) ...
  http://www.cosmeticsandtoiletries.com/formulating/function/active/219659391.html
*  Handling Metalloproteinases - Current Protocols
Substrate cleavage by metalloproteinases involves nucleophilic attack on the scissile peptide bond by a water molecule that is ... Control of matrix metalloproteinase catalytic activity. Matrix Biol. 26:587‐596. doi: 10.1016/j.matbio.2007.07.001. ... Matrix metalloproteinases and tissue inhibitors of metalloproteinases: Structure, function, and biochemistry. Circulation Res. ... A principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase ...
  http://www.currentprotocols.com/WileyCDA/CPUnit/refId-ps2116.html
*  Matrix Metalloproteinase-2 Production and Its Binding to the Matrix Are Increased in Abdominal Aortic Aneurysms |...
Matrix Metalloproteinase-2 Production and Its Binding to the Matrix Are Increased in Abdominal Aortic Aneurysms. Valerie Davis ... Matrix Metalloproteinase-2 Production and Its Binding to the Matrix Are Increased in Abdominal Aortic Aneurysms ... Matrix Metalloproteinase-2 Production and Its Binding to the Matrix Are Increased in Abdominal Aortic Aneurysms ... Matrix Metalloproteinase-2 Production and Its Binding to the Matrix Are Increased in Abdominal Aortic Aneurysms ...
  http://atvb.ahajournals.org/content/18/10/1625
*  The Novartis-ILAR Rheumatology Prize 2001 Osteoarthritis: from molecule to man | Springer for Research & Development
Coordinate regulation of matrix metallopro-teases and tissue inhibitors of metalloproteinase expression in human synovial ... Dean DD, Martel-Pelletier J, Pelletier JP, Howell DS, Woessner JF: Evidence for metalloproteinase and metalloproteinase ... Elevated metalloproteinase and tissue inhibitor of metalloproteinase mRNA in human osteoarthritic synovia. J Rheumatol. 1993, ... Caron JP, Tardif G, Martel-Pelletier J, Di Battista JA, Geng C, Pelletier JP: Modulation of matrix metalloproteases 13 ( ...
  https://rd.springer.com/article/10.1186/ar378
*  Effects of inflammatory cytokine IL-27 on the activation of fibroblast-like synoviocytes in rheumatoid arthritis
Bradley K, Scatizzi JC, Shamiyeh E. Retinoblastoma suppression of matrix metalloproteinase-1, but not interleukin-6, though a p ... CXCL10 and matrix metalloproteinase-1 of RA-FLS than that of control FLS (all P , 0.05). Moreover, an additive or synergistic ... and matrix metalloproteinase production by fibroblast-like synoviocytes from rheumatoid arthritis patients. Arthritis Rheum. ... FLS can mediate cartilage and bone destruction in RA mainly via the elucidation of matrix metalloproteinases (MMPs) such as MMP ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2945019/
*  Y-box factor YB-1 predicts drug resistance and patient outcome in breast cancer independent of clinically relevant tumor...
Matrix metalloproteinase-2 immunoreactive protein: a marker of aggressiveness in breast carcinoma. Cancer 1998;83: 1153-62.. * ... Tissue distribution of major matrix metalloproteinases and their transcripts in human breast carcinomas. Anticancer Res 1999;19 ... YB-1 regulates transcription of the matrix metalloproteinase 2 (MMP-2)/gelatinase A gene, which encodes a protease facilitating ... Expression of tumorigenesis-associated factors in normal tissue adjacent to breast cancer has been described for major matrix ...
  http://onlinelibrary.wiley.com/doi/10.1002/ijc.1610/full
*  Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) Is Induced Upon Monocyte Differentiation and Is Expressed in Human...
Stimulation of matrix metalloproteinase production by recombinant extracellular matrix metalloproteinase inducer from ... Galis ZS, Sukhova GK, Lark MW, Libby P. Increased expression of matrix metalloproteinases and matrix degrading activity in ... Objective- Because extracellular matrix metalloproteinase inducer (EMMPRIN), a tumor cell-derived protein, induces matrix ... Potential role of matrix-degrading metalloproteinases and implications for plaque rupture. Circulation. 1995; 92: 1565-1569. ...
  http://atvb.ahajournals.org/content/22/7/1200
*  Frontiers | Extracellular environment contribution to astrogliosis-lessons learned from a tissue engineered 3D model of the...
Besides presenting the extracellular matrix as a key modulator of astrogliosis, this simple, controlled and reproducible 3D ... can diminish astrogliosis.Besides presenting the extracellular matrix as a key modulator of astrogliosis, this simple, ... shown that chemical inhibition of RhoA with ibuprofen or indirectly targeting RhoA by the induction of extracellular matrix ... shown that chemical inhibition of RhoA with ibuprofen or indirectly targeting RhoA by the induction of extracellular matrix ...
  https://www.frontiersin.org/articles/10.3389/fncel.2015.00377/full
*  Transcriptional Suppression of Matrix Metalloproteinase-2 Gene Expression in Human Astroglioma Cells by TNF-α and IFN-γ | The...
Production of matrix metalloproteinases and tissue inhibitor of metalloproteinases-1 by human brain tumors. J. Neurosurg. 81: ... Matrix metalloproteinases and tissue inhibitors of metalloproteinases in human gliomas. J. Neurosurg. 83: 298. ... Metalloproteinases in multiple myeloma: production of matrix metalloproteinase-9 (MMP-9), activation of proMMP-2, and induction ... Effect of phorbol ester and cytokines on matrix metalloproteinase and tissue inhibitor of metalloproteinase expression in tumor ...
  http://www.jimmunol.org/content/161/12/6664.long
*  Plus it
Increased expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of metalloproteinases 1 and 2 correlate with ... Measurement of matrix metalloproteinases and tissue inhibitors of metalloproteinases in blood and tissues. Clinical and ... Matrix metalloproteinase-1 is associated with poor prognosis in colorectal cancer. Nat Med 1996;2:461-2. ... Matrix metalloproteinase-1 is associated with poor prognosis in oesophageal cancer. J Pathol 1998;185:256-61. ...
  http://clincancerres.aacrjournals.org/content/11/12/4437
*  Plus it
Dentin Matrix Protein 1 Enhances Invasion Potential of Colon Cancer Cells by Bridging Matrix Metalloproteinase-9 to Integrins ... Edwards D. R. The tissue inhibitors of metalloproteinases (TIMPs) Clendeninn N. J. Appelt K. eds. . Matrix Metalloproteinase ... Expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases in head and neck squamous cell carcinoma. ... Brinckerhoff C. E., Matrisian L. Matrix metalloproteinases: a tail of a frog that became a prince. Nat. Rev., 3: 207-214, 2002. ...
  http://cancerres.aacrjournals.org/content/64/3/952
*  Method and composition for inhibition of angiogenesis using antagonists based on MMP-9 and β1 integrins - University of...
4. The antagonist of claim 1 wherein the protein-protein interactions cause co-localization of matrix metalloproteinase 9 (MMP- ... 1. An antagonist that inhibits angiogenesis by modifying protein-protein interactions between matrix metalloproteinase 9 (MMP-9 ... Controlling tumor angiogenesis and metastasis of C26 murine colon adenocarcinoma by a new matrix metalloproteinase inhibitor, ... matrix degrading enzymes and extracellular matrix components (Varner et al. 1995; Blood and Zetter 1990; Weidner et al. 1992). ...
  http://www.freepatentsonline.com/7101975.html
*  Multiple regulatory inputs converge on cortactin to control invadopodia biogenesis and extracellular matrix degradation |...
Cortactin is an essential regulator of matrix metalloproteinase secretion and extracellular matrix degradation in invadopodia. ... Rasmussen, H. S. and McCann, P. P. (1997). Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with ... Matrix metalloproteinase inhibitors: a novel class of anticancer agents. Adv. Enzyme Regul. 35, 293-301. ... Matrix metalloproteinase inhibition: a review of anti-tumour activity. Ann. Oncol. 6, 967-974. ...
  http://jcs.biologists.org/content/121/3/369
*  Heat Shock Protein 47 Is Expressed in Fibrous Regions of Human Atheroma and Is Regulated by Growth Factors and Oxidized Low...
... matrix metalloproteinases, and tissue inhibitors of matrix metalloproteinases by human vascular smooth muscle cells. ... Seventeen samples contained atherosclerotic plaque, which was subclassified as fibrous (n=12) or lipid-rich (n=5). ... Hsp47 was readily detectable in 11 of the 17 atherosclerotic artery samples (Figure 1⇓, C and D). The strongest and most ...
  http://circ.ahajournals.org/content/101/11/1229
*  Plus it
... matrix metalloproteinase 3; NF-κB, nuclear factor-κB; PAI-1, plasminogen activator inhibitor 1; pMIG, pMSCV-IRES-GFP; pIκBα-DN ... matrix metalloproteinase 3 (MMP3), interleukin 6 (IL-6), inducible IKK, Fas antigen, NF-κB p105, engrailed-1, Fos-related ... The average of P-calls for all arrays used in this study was 40.1 ± 1.4% (means ± SE; n = 17). Analysis of differential gene ... Because the tyrosine kinase activity of the IR is critical for insulin action (17), the effects of TNF-α on insulin-induced ...
  http://diabetes.diabetesjournals.org/content/51/5/1319
*  The plasma concentration of VEGF, HE4 and CA125 as a new biomarkers panel in different stages and sub-types of epithelial...
Relationship between the expression of VEGF signal components and matrix metalloproteinases in ovarian tumors. Bull Exp Biol ... Folkman J: Angiogenesis in cancer, vascular, rheumatoid, and other disease. Nat Med 1995, 1: 27-31. 10.1038/nm0195-27PubMed ... 17.. Kamińska J, Kowalska M: Clinical significance of serum tumor markers measurements in patients with ovarian cancer. Voice ... 17].. Angiogenesis has been established as an important factor in human carcinogenesis influencing tumor growth and invasion [ ...
  https://link.springer.com/article/10.1186/1757-2215-6-45
*  Lack of Tissue Inhibitor of Metalloproteinases 2 Leads to Exacerbated Left Ventricular Dysfunction and Adverse Extracellular...
Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function. Physiol Rev. 2007;87: ... Tissue inhibitor of metalloproteinases 2 is the only TIMP with the unique property of activating matrix metalloproteinases 2 ( ... Inhibition of membrane-type 1 matrix metalloproteinase at cell-matrix adhesions. Cancer Res. 2007;67:11621-11629. ... tissue inhibitor of metalloproteinases 2 deficient; MMPi, matrix metalloproteinase inhibitor; EF, ejection fraction; VcFC, ...
  http://circ.ahajournals.org/content/124/19/2094