*  Switch recombination and somatic hypermutation are controlled by the heavy chain 3′ enhancer region | JEM
Quantitation of immunoglobulin mu-gamma 1 heavy chain switch region recombination by a digestion-circularization polymerase ... Expression of I mu-C gamma hybrid germline transcripts subsequent to immunoglobulin heavy chain class switching. Int. Immunol. ... Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching. ... A class switch control region at the 3′ end of the immunoglobulin heavy chain locus. Cell. 77:737-747. doi:10.1016/0092-8674(94 ...
  http://jem.rupress.org/content/206/12/2613
*  IGHM - Wikipedia
"Human immunoglobulin heavy chain genes: evolutionary comparisons of C mu, C delta and C gamma genes and associated switch ... 1988). "Molecular basis of the cell-surface expression of immunoglobulin mu chain without light chain in human B lymphocytes". ... Tsubata T, Reth M (1990). "The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form ... Dolby TW, Devuono J, Croce CM (1981). "Cloning and partial nucleotide sequence of human immunoglobulin mu chain cDNA from B ...
  https://en.wikipedia.org/wiki/IGHM
*  Application # 2012/0093829. NEW METHODS FOR TREATMENT OF INFLAMMATORY DISEASES - Patents.com
and .gamma.) and .kappa. light chain immunoglobulin sequences, together with targeted mutations that inactivate the endogenous ... Each heavy chain is comprised of a heavy chain variable region (abbreviated herein as V.sub.H) and a heavy chain constant ... Each light chain is comprised of a light chain variable region (abbreviated herein as V.sub.L) and a light chain constant ... DNA encoding the heavy and light chain immunoglobulins can be obtained from the non-human hybridoma of interest and engineered ...
  http://patents.com/us-20120093829.html
*  Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells
DiSanto JP, Guy-Grand D, Fisher A, Tarakhovsky A. Critical role for the common cytokine receptor gamma chain in intrathymic and ... Role of NK1.1+ T cells in a TH2 response and in immunoglobulin E production. Science. 1995 Dec 15;270(5243):1845-1847. [PubMed] ... A unique feature of their T cell receptor (TCR) repertoire is the expression of an invariant TCR alpha chain, V alpha 14-J ... TCR-associated zeta-Fc epsilon RI gamma heterodimers on CD4-CD8- NK1.1+ T cells selected by specific class I MHC antigen. ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2192838/?lang=en-ca
*  Nanosensors - LIEBER CHARLES M.
Heavy chains are classified as gamma, mu, alpha, delta, or epsilon, which in turn define the immunoglobulin classes, IgG, IgM, ... gamma, delta, epsilon and mu constant region genes, as well as myriad immunoglobulin variable region genes. Light chains are ... The terms variable light chain (VL) and variable heavy chain (VH) refer to these light and heavy chains respectively. ... The article as in claim 83, wherein the functional moieties comprise grafted polymer chains with chain length less than the ...
  http://www.freepatentsonline.com/y2002/0117659.html
*  FCAR - Wikipedia
"Functional association between the human myeloid immunoglobulin A Fc receptor (CD89) and FcR gamma chain. Molecular basis for ... while outside-in signaling caused by ligand binding depends on FcαRI association with the Fc receptor gamma chain (FcR γ-chain ... with Fc epsilon RI gamma 2 subunits in U937 cells. Aggregation induces the tyrosine phosphorylation of gamma 2". Journal of ... However, this chain alone cannot perform signaling in response to IgA binding, and FcαRI must associate with a dimeric form of ...
  https://en.wikipedia.org/wiki/FCAR
*  Frontiers | Chimeric Antigen Receptor-Engineered NK-92 Cells: An Off-the-Shelf Cellular Therapeutic for Targeted Elimination of...
... through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and ... Analysis of Fc gamma RIII (CD16) membrane expression and association with CD3 zeta and Fc epsilon RI-gamma by site-directed ... Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol (2004) 75(2):163-89. doi:10.1189/jlb.0603252 ... Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming. Nat Immunol (2004) 5(12):1260-5. doi: ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.00533/full
*  Transgenic non-human animals capable of producing heterologous antibodies of various isotypes - GenPharm International Inc.
... capable of producing heterologous antibodies and transgenic non-human animals having inactivated endogenous immunoglobulin ... immunoglobulin heavy-chain genes, Nature 306:809-812 (1983). Mowatt et. al., DNA sequence of the murine .gamma.1 switch segment ... Copies of Immunoglobulin κ Light Chain Genes This example describes the cloning of immunoglobulin κ light chain genes from ... Immunoglobulin Heavy Chain μ Genes This example describes the cloning of immunoglobulin heavy chain μ genes from cultured cells ...
  http://www.freepatentsonline.com/5877397.html
*  IGKV1D-33 Gene - GeneCards | KVD33 Protein | KVD33 Antibody
Immunoglobulin Kappa Variable 1D-33, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards ... Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked. ... Complete amino acid sequence of the variable domains of two human IgM anti-gamma globulins (Lay/Pom) with shared idiotypic ... The primary structure of a human immunoglobulin L-chain of kappa-type (Bence-Jones protein Scw.), II: The chymotryptic peptides ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=IGKV1D-33
*  Frontiers | A Temporal Model of Human IgE and IgG Antibody Function | Immunology
Gamma globulin antigenic types defined by heavy chain determinants. Science (1964) 145(3628):168-70. doi:10.1126/science. ... Serum immunoglobulin G subclass responses in different phases of hepatitis E virus infection. J Med Virol (2013) 85(5):828-32. ... switching to gamma 1, gamma 3, and gamma 4, but not gamma 2. Mian Yi Xue Za Zhi (1995) 155(5):2318-28. ... Immunoglobulin G subclass deficiency: fact or fancy? Curr Allergy Asthma Rep (2002) 2(5):356-60. doi:10.1007/s11882-002-0067-1 ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2013.00235/full
*  FCGR1A - Wikipedia
"Functional association between the human myeloid immunoglobulin A Fc receptor (CD89) and FcR gamma chain. Molecular basis for ... and FcR gamma chain. Molecular basis for CD89/FcR gamma chain association". The Journal of Biological Chemistry. 270 (50): ... the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI". Experimental Hematology. 22 (7): 599-606. PMID ... High affinity immunoglobulin gamma Fc receptor I is a protein that in humans is encoded by the FCGR1A gene. FCGR1A has been ...
  https://en.wikipedia.org/wiki/FCGR1A
*  Application # 2016/0194396. Bi-Specific Monovalent Fc Diabodies That Are Capable of Binding CD32B and CD79b and Uses...
... and are composed of three polypeptide chains an ... monovalent diabodies that comprise an immunoglobulin Fc Domain ... Fc.gamma.RII has only two immunoglobulin-like regions in its immunoglobulin binding chain and hence a much lower affinity for ... or eliminate binding to Fc.gamma.RIA (CD64), Fc.gamma.RIIA (CD32A), Fc.gamma.RIIB (CD32B), Fc.gamma.RIIIA (CD16a) or Fc.gamma. ... reduced binding to Fc.gamma.RIA (CD64), Fc.gamma.RIIA (CD32A), Fc.gamma.RIIB (CD32B), Fc.gamma.RIIIA (CD16a) or Fc.gamma.RIIIB ...
  http://patents.com/us-20160194396.html
*  SALIVARY PROTEIN BIOMARKERS FOR HUMAN ORAL CANCER - The Regents of the University of California
Heavy chains are classified as gamma, mu, alpha, delta, or epsilon, which in turn define the immunoglobulin classes, IgG, IgM, ... The terms variable light chain (VL) and variable heavy chain (VH) refer to these light and heavy chains respectively. ... gamma, delta, epsilon, and mu constant region genes, as well as the myriad immunoglobulin variable region genes. Light chains ... chain (about 50-70 kD). The N-terminus of each chain defines a variable region of about 100 to 110 or more amino acids ...
  http://www.freepatentsonline.com/y2011/0021370.html
*  RECOMBINANT RENEWABLE POLYCLONAL ANTIBODIES - Patent application
Heavy chains are classified as gamma, mu, alpha, delta, or epsilon, which in turn define the immunoglobulin classes, IgG, IgM, ... The terms "variable light chain" (VL) and "variable heavy chain" (VH) refer, respectively, to these light and heavy chains. ... of immunoglobulin genes. The recognized immunoglobulin genes include the kappa, lambda, alpha, gamma, delta, epsilon, and mu ... chain expressed as two chains; and (6) scFv, single chain antibody, a genetically engineered molecule containing the variable ...
  http://www.patentsencyclopedia.com/app/20130085072
*  Application # 2002/0137106. Detection of biological pathway components - Patents.com
The recognized immunoglobulin genes include the kappa and lambda light chain constant region genes, the alpha, gamma, delta, ... "Fc" portion of an antibody refers to that portion of an immunoglobulin heavy chain that comprises one or more heavy chain ... single chain Fv). Single chain antibodies are also useful to construct detection moieties. Methods for producing single chain ... 0035] "Antibody" refers to a polypeptide ligand substantially encoded by an immunoglobulin gene or immunoglobulin genes, or ...
  http://patents.com/us-20020137106.html
*  Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks
FcR gamma chain deletion results in pleiotrophic effector cell defects. Cell. 1994;76(3):519-529. doi: 10.1016/0092-8674(94) ... Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis. Immunity. ... A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature. 1991;350(6317 ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2912199/?lang=en-ca
*  Application # 2011/0123542. CCL20-SPECIFIC ANTIBODIES FOR CANCER THERAPY - Patents.com
0058] The isotype of the heavy chain (gamma, alpha, delta, epsilon or mu) determines immunoglobulin class (IgG, IgA, IgD, IgE ... 0053] Antibodies, or immunoglobulins, comprise two heavy chains linked together by disulfide bonds and two light chains, each ... 0059] Single chain antibodies fall within the scope of the present invention. Single chain antibodies can be single chain ... immunoglobulin light and heavy chain (linked V.sub.H-V.sub.L or single chain Fv (ScFv)). Both V.sub.H and V.sub.L may copy ...
  http://patents.com/us-20110123542.html
*  WO2003025137A2 - Sweet taste receptors - Google Patents
Heavy chains are classified as gamma, mu, alpha, delta, or epsilon, which in turn define the immunoglobulin classes, IgG, IgM, ... gamma, delta, epsilon and mu constant region genes, as well as myriad immunoglobulin variable region genes. Light chains are ... The terms variable light chain (VL) and variable heavy chain (VH) refer to these light and heavy chains respectively. ... Single chain antibodies are formed by linking the heavy and light chain fragments of the Fv region via an amino acid bridge, ...
  https://patents.google.com/patent/WO2003025137A2/en
*  MS4A2 - Wikipedia
The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast ... 1992). "The gene and cDNA for the human high affinity immunoglobulin E receptor beta chain and expression of the complete human ... 1995). "Different roles for the Fc epsilon RI gamma chain as a function of the receptor context". J. Exp. Med. 181 (1): 247-55 ... "The human genes for the alpha and gamma subunits of the mast cell receptor for immunoglobulin E are located on human chromosome ...
  https://en.wikipedia.org/wiki/MS4A2
*  Frontiers | FCγ Chimeric Receptor-Engineered T Cells: Methodology, Advantages, Limitations, and Clinical Relevance | Immunology
... chain. In contrast, the extracellular CAR single chain variable fragment (scFv), which recognizes the targeted TAA, has been ... chain. In contrast, the extracellular CAR single chai... ... Thus, we and others have developed the Fc gamma chimeric ... Thus, we and others have developed the Fc gamma chimeric receptors (FcCRs)-based strategy. Like CARs, FcCRs are composed of ... interferon gamma; IgG, immunoglobulin G; IL-12, interleukin-12; IL-15, interleukin-15; mAb, monoclonal antibody; MHC, major ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.00457/full
*  Susumu Tonegawa - Wikipedia
A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene ... Haas, W., Pereira, P., & Tonegawa, S. (1993). Gamma/delta cells. Annual review of immunology, 11(1), 637-685. Tsien, J. Z., ... and somatic rearrangement of T cell gamma genes". Cell. 40 (2): 259-269. doi:10.1016/0092-8674(85)90140-0. "The MIT 150: 150 ... In 1994, he was appointed as the first Director of the MIT Center for Learning and Memory, which developed under his guidance ...
  https://en.wikipedia.org/wiki/Susumu_Tonegawa
*  Patent US6613581 - Microfluidic analytic detection assays, devices, and integrated systems - Google Patents
Heavy chains are classified as gamma, mu, alpha, delta, or epsilon, which define the immunoglobulin classes, IgG, IgM, IgA, IgD ... gamma, delta, epsilon, and mu constant region genes as well as the various immunoglobulin variable genes. Light chains are ... Each tetramer is composed of two identical pairs of polypeptide chains, each pair having one light and one heavy chain. The N- ... Typically, an antibody comprises a framework from an immunoglobulin gene or fragment that specifically binds and recognizes an ...
  http://www.google.ca/patents/US6613581
*  Does larch arabinogalactan enhance immune function? A review of mechanistic and clinical trials | Nutrition & Metabolism | Full...
interferon-gamma. Ig: immunoglobulin. IL: interleukin. lcFOS: long-chain fructooligosaccharides. MCP-1: macrophage ... shows that a mixture of oligosaccharides, consisting of short-chain galactooligosaccharides (scGOS) and long-chain ... Regulation of short-chain fatty acid production. Proc Nutr Soc. 2003;62(1):67-72. doi:10.1079/PNS2002207.View ArticleGoogle ... Blottiere HM, Buecher B, Galmiche J-P, Cherbut C. Molecular analysis of the effect of short-chain fatty acids on intestinal ...
  https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-016-0086-x
*  CD3G - Wikipedia
CD3G (gamma chain) is one of the four peptides (gamma, delta, epsilon and zeta) that form CD3. Defects in CD3G are associated ... 1987). "Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family ... T-cell surface glycoprotein CD3 gamma chain is a protein that in humans is encoded by the CD3G gene. T cell antigen receptor ( ... 1987). "The human T3 gamma chain is phosphorylated at serine 126 in response to T lymphocyte activation". J. Biol. Chem. 262 ( ...
  https://en.wikipedia.org/wiki/CD3G
*  Patent US7078492 - Human antipneumococcal antibodies from non-human animals - Google Patents
Human light chains are classified as kappa and lambda light chains. Heavy chains are classified as mu, delta, gamma, alpha, or ... "Human immunoglobulin molecules" refer to immunoglobulin proteins that are encoded by human immunoglobulin gene sequences. ... the light chain or the antigen-binding portion thereof, or both the light chain and heavy chain or antigen-binding portions ... The invention also relates to isolated heavy and light chain immunoglobulin molecules of the human antibodies to S. pneumoniae ...
  http://www.google.com/patents/US7078492?dq=5910382