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*  HLA-DQ9 - Wikipedia
... is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ9 is a split antigen of the DQ3 broad antigen. ... "Analysis of MHC class II antigens in Japanese IDDM by a novel HLA-typing method, hybridization protection assay". Diabetes Res ... Törn C, Gupta M, Sanjeevi CB, Aberg A, Frid A, Landin-Olsson M (2004). "Different HLA-DR-DQ and MHC class I chain-related gene ... "Polymorphism between loci for human leukocyte antigens DR and DQ in patients with nasal polyps". Ann. Otol. Rhinol. Laryngol. ...
  https://en.wikipedia.org/wiki/HLA-DQ9
*  HLA-DQ1 - Wikipedia
HLA-DQ1 is a serotype that covers a broad range of HLA-DQ haplotypes. Historically it was identified as a DR-like alpha chain ... 1992). "Association of HLA-B51 and lack of association of class II alleles with Behçet's disease". Tissue Antigens. 40 (1): 22- ... 1992). "Human leukocyte antigen serologic and DNA typing of Behçet's disease and its primary association with B51". Invest. ... Olerup O, Olsson R, Hultcrantz R, Broome U (1995). "HLA-DR and HLA-DQ are not markers for rapid disease progression in primary ...
  https://en.wikipedia.org/wiki/HLA-DQ1
*  JUVENILE IDIOPATHIC ARTHRITIS AND HLA CLASS I AND CLASS II INTERACTION AND AGE OF ONSET EFFECTS
... free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI ... HLA class II. DR-DQ haplotypic associations Based on these observations of disease heterogeneity, the data were subdivided to ... The genetic risk factors are known to include genes in the Human Leukocyte Antigen (HLA) complex on chromosome 6, which carry ... Tissue Antigens. 2003;61(1):80-4. [PubMed]. 13. Murray KJ, Moroldo MB, Donnelly P, Prahalad S, Passo MH, Giannini EH, et al. ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2917207/?lang=en-ca
*  HLA-DQ7 - Wikipedia
... of the broad antigen group DQ3 which also contains DQ8 and DQ9. DQ7 is linked by haplotype to a number of DQA1 (DQ alpha chain ... high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans". Tissue Antigens. 62 (4): ... HLA-DQ7 (DQ7) is an HLA-DQ serotype that recognizes the common HLA DQB1*0301 and the less common HLA DQB1*0304 gene products. ... These DQ alpha chains are also known to form transhaplotype isomers with other HLA-DQ. DQ7 is linked to the following alpha ...
  https://en.wikipedia.org/wiki/HLA-DQ7
*  Tony Wyss-Coray, PhD's Profile | Stanford Profiles
In contrast, other surface antigens such as HLA-DR, -DP and -DQ, ICAM-1, LFA-3 and CD29, which are all known to participate in ... However, they are unable to capture the antigen and only antigens, which bind to T cell membranes such as the gp120 ... Intact and broad immune cell effector functions and specific individual cytokines have been linked to HIV disease outcome, but ... Activated T-cells expressing MHC class II surface antigens are able to present antigen and thus function as peptide-presenting ...
  https://profiles.stanford.edu/tony-wyss-coray
*  Efficient ex vivo induction of T cells with potent anti-tumor activity by protein antigen encapsulated in nanoparticles |...
... based immunotherapies have the advantage to induce T cells with a potentially broad repertoire of specificities. However, ... papilloma virus specific T cells infiltrating cervical cancer and draining lymph nodes show remarkably frequent use of HLA-DQ ... Waeckerle-Men Y, Gander B, Groettrup M (2005) Delivery of tumor antigens to dendritic cells using biodegradable microspheres. ... Protein antigen (Ag)-based immunotherapies have the advantage to induce T cells with a potentially broad repertoire of ...
  https://link.springer.com/article/10.1007%2Fs00262-013-1411-0
*  Dengue-2 and yellow fever 17DD viruses infect human dendritic cells, resulting in an induction of activation markers, cytokines...
HLA-DR,DP,DQ-FITC (Dako Cytomation), CD80-FITC (Iotest Immunotech), CD38-FITC (Caltag, Invitrogen) or OX40L-PE (BD Biosciences ... Detection of viral antigen and specific co-stimulatory markers by flow cytometry in human MoDCs - Cells were harvested by ... A broad range (1.95-8,000 pg/mL) of concentrated human recombinant cytokines, provided by the vendor, was used to establish ... reduced expression of viral antigens within DCs at all time points tested when compared to DENV. Similar results were described ...
  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000500012&lng=en&nrm=iso&tlng=en
*  Viruses | Free Full-Text | Molecular Signatures of Hepatitis C Virus (HCV)-Induced Type II Mixed Cryoglobulinemia (MCII) | HTML
Hla dr-dq combination associated with the increased risk of developing human hcv positive non-hodgkin's lymphoma is related to ... Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia. ... Tissue Antigens 2010, 75, 127-135. [Google Scholar] [CrossRef]. *Cacoub, P.; Renou, C.; Kerr, G.; Hue, S.; Rosenthal, E.; Cohen ... Monoclonal antibodies isolated from human b cells neutralize a broad range of h1 subtype influenza a viruses including swine- ...
  http://www.mdpi.com/1999-4915/4/11/2924/htm
*  Frontiers | Definition of CD4 Immunosignatures Associated with MTB | Immunology
The results identified hundreds of novel epitopes and antigens, and documented the novel observation that T cells in latent MTB ... DP and DQ alleles representative of those most commonly expressed in the general population, coupled with high throughput ... The results identified hundreds of novel epitopes and antigens, and documented the novel observation that T cells in latent MTB ... DP and DQ alleles representative of those most commonly expressed in the general population, coupled with high throughput ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2014.00124/full
*  Recent advances in coeliac disease | Gut
... with partial HLA-DQ2 (DQB1*02 without DQA1*05), 2% with partial HLA-DQ2 (DQA1*05 without DQB1*02), and 6% HLA-DQ8 without DQ-2 ... Another gluten peptide (p57-73) is deamidated by tissue transglutaminase and is presented to T cells by HLA-DQ2 on antigen ... Therefore, a much broader spectrum of individuals are being investigated for coeliac disease and consequently being diagnosed ( ... 22 It is plausible that these factors may help induce oral tolerance to dietary antigens in susceptible individuals. However, a ...
  http://gut.bmj.com/content/55/7/1037
*  lupus.html
it is further divided into smaller regions called HLA-A, HLA-B, HLA-C, HLA-DR, HLA-DQ. In lupus patients there is an increased ... Another important area on the short arm of chromosome #6 is the human leukocyte antigen (HLA) region. It is located next to the ... Lupus is used as a broad term to describe several forms of the disease, but is most often used to refer to systemic lupus ... The disease is characterized by constant IgG production directed at self antigens in all nucleated cells (Janeway, 1999). This ...
  http://www.bio.davidson.edu/courses/Immunology/Students/spring2000/wilson/restricted/lupus.html
*  Trans-dominant cellular inhibition of DC-SIGN-mediated HIV-1 transmission
... free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI ... and HLA-DP (clone B7/21, Leinco Technologies). MAbs to HLA-1 identify MHC class I expression, and MAbs to HLA-DP, -DQ, and -DR ... LFA-1 and MHC class II antigens. To investigate the role of MHC class II antigens in the DC-SIGN transmission of infectious HIV ... Extracellular antigen processing and presentation by immature dendritic cells. Proc Natl Acad Sci U S A. 1999;96:15056-15061. ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC446230/?lang=en-ca
*  CHAPTER 73 MORPHOLOGY OF MONOCYTES AND MACROPHAGES | Free Medical Textbook
MONOCYTE-MACROPHAGE SURFACE ANTIGENS. HLA CLASS II RECEPTORS. Monocytes and macrophages serve an important function as antigen- ... DQ. There is a wide variation in expression of MHC class II antigens on macrophages from different tissues. While spleen ... These receptors have broad ranges of expression on different cells. The first, FcRI (CD64), is a receptor found on monocytes, ... HLA, human leukocyte antigens; IL-4, interleukin-4; IMP, intramembrane particles; LFA-1, lymphocyte function-associated antigen ...
  https://medtextfree.wordpress.com/2012/01/10/chapter-73-morphology-of-monocytes-and-macrophages/
*  HLA Genes, Islet Autoantibodies and Residual C-Peptide at the Clinical Onset of Type 1 Diabetes Mellitus...
... free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI ... HLA antigens and other risk factors in the development of retinopathy in type 1 diabetes. Br J Ophthalmol. 1982;66:280-285. [ ... HLA-DR antigen association with proliferative diabetic retinopathy. Int Ophthalmol. 1985;8:33-35. [PubMed] ... and DQ-based probes to establish haplotypes [24]. In addition, allele specific PCR amplification of DRB1 alleles was also used ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3055880/?lang=en-ca
*  Frontiers | Milestones of Hematopoietic Stem Cell Transplantation - From First Human Studies to Current Developments |...
HLA) system allowed improved donor selection , including HLA-identical related and unrelated donors. Besides bone marrow (BM) ... HLA) system allowed improved donor selection , including HLA-identical related and unrelated donors. Besides bone marrow (BM) ... Exciting insights into the genetics of the human leukocyte antigen ( ... Exciting insights into the genetics of the human leukocyte antigen ( ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2016.00470/full
*  Plus it
In vivo evidence for the contribution of human histocompatibility leukocyte antigen (HLA)-DQ molecules to the development of ... The role of thymic expression of viral antigens in the mouse has further been shown to control both the frequency of specific T ... The role of infectious agents in triggering autoimmunity through molecular mimicry or broad activation of T-cells by ... T-cell recognition of human pre-proinsulin peptides depends on the polymorphism at HLA DQ locus: a study using HLA DQ8 and DQ6 ...
  http://diabetes.diabetesjournals.org/content/54/suppl_2/S87
*  MOUSE MODELS FOR ASSESSING PROTEIN IMMUNOGENICITY: LESSONS AND CHALLENGES
... free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI ... HLA-DQ Determines the Response to Exogenous Wheat Proteins: A Model of Gluten Sensitivity in Transgenic Knockout Mice. J ... 51 These mice could also facilitate the identification of peptides presented by HLA-DR molecules from an antigen in question, ... It has long been known that low or high doses of antigens may induce "low zone" or "high zone" tolerance, respectively.74 These ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC4846475/
*  US Patent # 7,993,869. Method for detecting gluten - Patents.com
... or the HLA-DQ (alpha 1*03, beta 1*0302) heterodimers. Tissue Antigens 1997; 49:29-34. 20. Spurkland A, Sollid, LM, Ronningen, K ... This broad cross reactivity of the mAb is a major advantage compared to already existing gluten detection methods since the mAb ... For the mAb assay the amount of antigen detected is represented relative to the maximum amount (.mu.g/ml) detected in a given ... In a preferred embodiment the T-cell epitope is an MHC-class II epitope presented to the T cells by HLA-DQ-2 or HLA-DQ-8, as ...
  http://patents.com/us-7993869.html
*  Association of chronic fatigue syndrome with human leucocyte antigen class II alleles | Journal of Clinical Pathology
Levinson RD, Park MS, Rikkers SM, et al. Strong associations between specific HLA-DQ and HLA-DR alleles and the ... and a possible association between human leucocyte antigen (HLA) class II antigens and chronic fatigue immune dysfunction has ... Keller et al found a possible association of HLA-DQ3 with chronic fatigue syndrome,7 but HLA-DQ3 is a broad definition based on ... HLA typing. Patients and controls were typed for HLA class II alleles: HLA-DRB1, HLA-DQA1, and HLA-DQB1 by polymerase chain ...
  http://jcp.bmj.com/content/58/8/860
*  Patent WO1989004875A2 - Characterization and detection of sequences associated with autoimmune diseases - Google Patents
... which detect either directly or indirectly the identity of the codon encoding for the amino acid at position 57 of the DQ-beta ... DNA sequences and corresponding amino acid sequences from the HLA class II beta region of the human genome that are associated ... Human leukocyte antigen typing. EP0472399A2 *. 20 Aug 1991. 26 Feb 1992. Mitsui Petrochemical Industries, Ltd.. HLA-DR antigen ... DQ-beta-3.2 and DQ-blank types Erlich et al., The Molecular Analysis of Histocompatibility Antigens, pp. 93-109 (Schacter et al ...
  http://www.google.com.au/patents/WO1989004875A2?cl=en
*  Clinical and laboratory aspects of common variable immunodeficiency
A genome-wide genetic linkage analysis to study IGAD1 in a large number of IgAD/CVID patients implicated the HLA-DQ/DR as a ... equipped with their surface antigen receptors and are capable of recognizing antigen in a first encounter. However, B cells ... The clinical spectrum of CVID is broad, and it may present at any age, from childhood through late adult life. Most of the ... The generation of memory cells to several antigens seems compromised, for example, memory cells for purified protein derivative ...
  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652004000400007&tlng=es&lng=en&nrm=iso
*  Genetic and Immunologic Biomarkers in Type 1 Diabetes
... these are HLA DP, HLA DQ, and HLA DR. Genes encoding the HLA DP apha and beta chains may have as m any as 23 and 120 alleles ... I t is believed th at an inciting event in the pancreatic islet leads to a release of self antigen [ 9 ] These antigens are ... 14 releasing additional epitopes and driving a broader attack by cells with diverse antigen specificities. A utoantibodies to ... was coined due to the study of the HLA region [ 40 41] The HLA DR/DQ haplotypes that account for 30 50% of genetic risk of type ...
  http://ufdc.ufl.edu/UFE0045760/00001
*  Protocols and Video Articles Authored by Eddie A. James
Human Leukocyte Antigen (HLA)-DRB1*15:01 and HLA-DRB5*01:01 Present Complementary Peptide Repertoires Frontiers in Immunology. ... Seventeen of these T cell lines and clones reacted to a broad range of studied native islet antigens and to post- ... Since all Class II HLA molecules share the same intracellular compartments during biosynthesis, it is possible that DQ and DR ... HLA-DR-restricted, S-Ag-specific CD4(+) T cells could be detected in blood and draining lymph nodes of uveitic mice with HLA ...
  https://www.jove.com/author/Eddie++A._James
*  Gary Schoolnik | Stanford Medicine Profiles
The predominant antigens reactive with IgG in serum were pili, protein II, a broad 23-33-kDa band of antigen, and presumptive ... The response to p64-75 is blocked by an anti-HLA-DQ mAb, while that to p151-161 is blocked by an anti-HLA-DR mAb. These ... Peptides can inhibit lysis by binding to the T cell or sensitize to lysis by binding an HLA-A2-related class-I molecule (HLA- ... T-CELL ACTIVATION BY PEPTIDE ANTIGEN - EFFECT OF PEPTIDE SEQUENCE AND METHOD OF ANTIGEN PRESENTATION PROCEEDINGS OF THE ...
  https://med.stanford.edu/profiles/gary-schoolnik
*  Analysis of TACI mutations in CVID & RESPI patients who have inherited HLA B*44 or HLA*B8 | BMC Medical Genetics | Full Text
One of the two original reports of the association between TACI and CVID also reported Human Leukocyte Antigen (HLA) haplotypes ... Of these, HLA*B44 was present in almost half of the patients and was thus the most common susceptibility allele. HLA *B44 was ... Of 13 affected subjects, nine had inherited HLA *B8 and six had inherited HLA B44. This raised the possibility that TACI ... We identified 63 CVID patients irrespective of HLA status and 13 RESPI patients who had inherited HLA*B44. To evaluate for ...
  https://0-bmcmedgenet-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/1471-2350-10-100