*  Epigenetics of breast cancer: Polycyclic aromatic hydrocarbons as risk factors - Jeffy - 2002 - Environmental and Molecular...
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266: 66-71.. *CrossRef, ... Different response of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-sensitive genes in human breast cancer MCF-7 and MDA-MB-231 ... Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer. J Natl Cancer Inst 91: 943-949.. * ... BRCA1 and BRCA2 mutations in breast cancer families with multiple primary cancers. Clin Cancer Res 6: 4259-4264.. *PubMed, ...
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*  EASL - Clinical Practice Guidelines
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science. 1994; 266: 6671. CrossRef , PubMed ... 304]Farazi, P.A. and DePinho, R.A. Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer. 2006; 6: ... Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med ... 31]Marra, G. and Boland, C.R. Hereditary nonpolyposis colorectal cancer: the syndrome, the genes, and historical perspectives. ...
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*  1994 in science - Wikipedia
"A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1". Science. 266 (5182): 66-71. doi:10.1126/ ... The first gene linked to Alzheimer's disease is discovered. No new linked genes would be found until 2009. The BRCA1 gene is ... "7Q-linked breast and ovarian cancer susceptibility gene", issued 1998-05-05, assigned to Myriad Genetics, Inc., The United ... Gallagher, James (2011-04-04). "Five more Alzheimer's genes discovered, scientists say". BBC News. Retrieved 2018-01-12. US ...
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*  Association for Molecular Pathology v. Myriad Genetics, Inc. - Wikipedia
"A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1". Science. 266 (5182): 66-71. doi:10.1126/ ... which detects certain mutations in the BRCA1 and BRCA2 genes that put women at high risk for breast cancer and ovarian cancer. ... with specific variations from the norm that are indicative of susceptibility to breast cancer and ovarian cancer was not a " ... US5693473 US5709999 US5710001 US5753441 US6033857 Hamblett, Mark (March 30, 2010). "Genes Linked to Breast, Ovarian Cancers Are ...
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*  Myriad Genetics - Wikipedia
"A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1". Sciencemag.org. 1994-10-07. Retrieved 2014-03- ... filed a lawsuit charging that patents on two human genes associated with breast and ovarian cancer, BRCA1 and BRCA2, are ... "A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1". Science. 266 (5182): 66-71. doi:10.1126/ ... and patients sued Myriad Genetics to challenge seven United States patents on genes related to breast cancer and ovarian cancer ...
  https://en.wikipedia.org/wiki/Myriad_Genetics
*  60S ribosomal protein L27 - Wikipedia
"A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1". Science. 266 (5182): 66-71. doi:10.1126/ ... As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through ... 1995). "Comparison of the positional cloning methods used to isolate the BRCA1 gene". Hum. Mol. Genet. 4 (8): 1259-66. doi: ... Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the ...
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*  NBR1 - Wikipedia
"A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1". Science. 266 (5182): 66-71. doi:10.1126/ ... "Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes". Gene. 262 (1-2): 89-98. doi: ... Neighbor of BRCA1 gene 1 protein is a protein that in humans is encoded by the NBR1 gene. The protein encoded by this gene was ... This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three ...
  https://en.wikipedia.org/wiki/NBR1
*  VAT1 - Wikipedia
"A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1". Science. 266 (5182): 66-71. doi:10.1126/ ... Jul 1995). "22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families ... 1995). "The search for BRCA1". Cancer Res. 54 (24): 6374-82. PMID 7987831. Matoba R, Okubo K, Hori N, et al. (1994). "The ... 1995). "Comparison of the positional cloning methods used to isolate the BRCA1 gene". Hum. Mol. Genet. 4 (8): 1259-66. doi: ...
  https://en.wikipedia.org/wiki/VAT1
*  Activation of Estrogen Receptor-α by the Anion Nitrite | Cancer Research
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 1994; 266: 66-71. ... Similar to estradiol, the anions induced the growth and expression of estrogen-regulated genes in breast cancer cells and ... Phytoestrogens and breast cancer risk. Review of the epidemiological evidence. Breast Cancer Res Treat 2003; 77: 171-83. ... Proportion of breast cancer cases in the United States explained by well-established risk factors. J Natl Cancer Inst 1995; 87 ...
  http://cancerres.aacrjournals.org/content/68/10/3950
*  PSME3 - Wikipedia
"A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1". Science. 266 (5182): 66-71. Bibcode:1994Sci... ... "A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21". Nat Genet. 7 (4): 472-9. doi:10.1038/ng0894-472 ... PSME3 human gene location in the UCSC Genome Browser. PSME3 human gene details in the UCSC Genome Browser.. ... "Comparison of the positional cloning methods used to isolate the BRCA1 gene". Hum. Mol. Genet. 4 (8): 1259-66. doi:10.1093/hmg/ ...
  https://en.wikipedia.org/wiki/PSME3
*  Brca1 is required for embryonic development of the mouse cerebral cortex to normal size by preventing apoptosis of early neural...
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266, 66-71. ... Moreover, the apparent link between BRCA1 and the primary microcephaly genes ASPM (Bond et al., 2002; Zhong et al., 2005) and ... Mouse embryos lacking Brca1, the ortholog of the human breast cancer susceptibility gene BRCA1, show apoptosis in the neural ... Wang, R. H., Yu, H. and Deng, C. X. (2004). A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpoint ...
  http://dev.biologists.org/content/136/11/1859
*  Cancers | Free Full-Text | BRCA1 and Oxidative Stress | HTML
Finally, we consider its significance in prevention and/or treatment of BRCA1-related cancers. ... Thus, it is essential to understand the function of BRCA1 in oxidative stress regulation. In this review, we briefly summarize ... Increasing evidence suggests that BRCA1 regulates oxidative stress and this may be another mechanism in preventing ... BRCA1's many binding partners and mechanisms, and discuss data supporting the function of BRCA1 in oxidative stress regulation ...
  http://www.mdpi.com/2072-6694/6/2/771/htm
*  PALB2 Functionally Connects the Breast Cancer Susceptibility Proteins BRCA1 and BRCA2 | Molecular Cancer Research
BRCA1 and BRCA2 are the major genes associated with inherited susceptibility to breast and ovarian cancer (1-4). Cells that are ... A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science (New York NY) 1994;266:66-71. ... BRCA1 and BRCA2 are the most frequently mutated genes that have been identified in inherited breast and ovarian cancer (1-4). ... PALB2 Functionally Connects the Breast Cancer Susceptibility Proteins BRCA1 and BRCA2. Fan Zhang, Qiang Fan, Keqin Ren and Paul ...
  http://mcr.aacrjournals.org/content/7/7/1110
*  Are We Ready to Screen for Inherited Susceptibility to Cancer? | Cancer Network | The Oncology Journal
In families with hereditary forms of cancer, the use of genetic tests to determine whether family members have inherited ... The discovery of inherited gene mutations that increase the risk of certain cancers could greatly expand the use of predictive ... for the breast and ovarian cancer susceptibility gene BRCA1. Science. 266:66-71, 1994. ... somatic cell mutations in three classes of genes have been found:. tumor-suppressor genes, DNA mutation repair genes, and ...
  http://www.cancernetwork.com/review-article/are-we-ready-screen-inherited-susceptibility-cancer
*  High XIST and Low 53BP1 Expression Predict Poor Outcome after High-Dose Alkylating Chemotherapy in Patients with a BRCA1-like...
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 1994;266:66-71. ... Genomic signature of BRCA1 deficiency in sporadic basal-like breast tumors. Genes Chromosomes Cancer 2011;50:71-81. ... Skewed X chromosome inactivation and breast and ovarian cancer status: evidence for X-linked modifiers of BRCA1. J Natl Cancer ... Prediction of BRCA1-association in hereditary non-BRCA1/2 breast carcinomas with array-CGH. Breast Cancer Res Treat 2009;116: ...
  http://mct.aacrjournals.org/content/15/1/190
*  The BRCA1 Breast Cancer Suppressor: Regulation of Transport, Dynamics, and Function at Multiple Subcellular Locations
... gene in breast and breast/ovarian families negative for BRCA1 and BRCA2 alterations," Genes Chromosomes and Cancer, vol. 33, no ... Y. Miki, J. Swensen, D. Shattuck-Eidens et al., "A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1 ... The interplay between BRCA1 and RHAMM is linked to breast cancer, both through BRCA1 gene mutations in familial breast cancer ... Inherited mutations in the BRCA1 gene predispose to a higher risk of breast/ovarian cancer. The BRCA1 tumor suppressor is a ...
  https://www.hindawi.com/journals/scientifica/2012/796808/
*  Evidence for a heritable predisposition to Chronic Fatigue Syndrome | BMC Neurology | Full Text
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science. 1994, 266 (5182): 66-71. 10.1126/ ... high-risk pedigrees identified in the UPDB have lead to the discovery of multiple cancer predisposition genes including BRCA1, ... A candidate prostate cancer susceptibility gene at chromosome 17p. Nat Genet. 2001, 27 (2): 172-180. 10.1038/84808.View Article ... Hill JR: A survey of cancer sites by kinship in the Utah Mormon population. Banbury Report No 4; Cancer Incidence in Defined ...
  https://bmcneurol.biomedcentral.com/articles/10.1186/1471-2377-11-62
*  References | LaraSig
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science. 1994; 266: 66-71. ... Mutations in BRCA1 and BRCA2 in breast cancer families: are there more breast cancer-susceptibility genes? . Am J Hum Genet. ... Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of BRCA1, BRCA2, BRCA1/BRCA2, BRCA1 ... Probability of carrying a mutation of breast-ovarian cancer gene BRCA1 based on family history. J Natl Cancer Inst. 1997; 89: ...
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*  BRCA1/2 Mutations and Risk of Breast and Ovarian Cancer | Breast Cancer | JAMA | The JAMA Network
This genetic epidemiology study reports that risk of breast and ovarian cancer among women with BRCA1 and BRCA2 mutations ... A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science. 1994;266(5182):66-71.PubMedGoogle ... segments across the intronic and exonic regions of the BRCA1 or BRCA2 genes associated with different breast vs ovarian cancer ... with ovarian cancer, 272 (2%) with breast and ovarian cancer, and 4766 (40%) without cancer. In BRCA1, we identified 3 breast ...
  https://jamanetwork.com/journals/jama/fullarticle/2214084
*  Breast Cancer Susceptibility Genes
... genes, which constitute the most important of the known breast cancer susceptibility genes in terms of high penetrance and ... Hereditary breast cancer is mainly attributed toloss‐of‐function mutations in and ... A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266: 66-71. ... Figure 1. Distribution of breast cancer susceptibility genes. The majority of breast cancer cases are sporadic. Interestingly, ...
  http://www.els.net/WileyCDA/ElsArticle/refId-a0025847.html
*  https://www.cancer.gov/types/breast/hp/breast-prevention-pdq
... breast density, obesity, alcohol consumption, and exposure to ionizing radiation. Interventions to prevent breast cancer ... Review the evidence on risk factors and interventions to prevent breast cancer in this expert-reviewed summary. ... Risk factors for breast cancer are female sex and advancing age, inherited risk, ... Miki Y, Swensen J, Shattuck-Eidens D, et al.: A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. ...
  https://www.cancer.gov/types/breast/hp/breast-prevention-pdq
*  American Cancer Society Guidelines for Breast Cancer Screening: Update 2003 - Smith - 2008 - CA: A Cancer Journal for...
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 1994; 266: 66-71. *CrossRef, ... Determining carrier probabilities for breast cancer-susceptibility genes BRCA1 and BRCA2. Am J Hum Genet 1998; 62:145-158. * ... Probability of carrying a mutation of breast-ovarian cancer gene BRCA1 based on family history. J Natl Cancer Inst 1997; 89:227 ... Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium. Am J Hum Genet 1995; 56:265- ...
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*  Negative Regulation of AKT Activation by BRCA1 | Cancer Research
The role of the breast cancer susceptibility gene 1 (BRCA1) in sporadic epithelial ovarian cancer. Reprod Biol Endocrinol 2003 ... siRNAs corresponding to the genes for the indicated proteins were transferred into MCF-7 breast cancer cells. After 2 d, ... The breast cancer susceptibility gene 1 (Brca1) has been shown to play a key role in both hereditary and sporadic mammary ... The breast cancer susceptibility gene 1 (BRCA1) plays a key role in mammary tumorigenesis. However, the reasons why silencing ...
  http://cancerres.aacrjournals.org/content/68/24/10040
*  ATM mutations in Finnish breast cancer patients | Journal of Medical Genetics
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science1994;266:66-71. ... In Finland, mutations in the two major breast cancer susceptibility genes BRCA11 and BRCA22 appear to account for a ... Low proportion of BRCA1 and BRCA2 mutations in Finnish breast cancer families: evidence for additional susceptibility genes. ... one quarter of the hereditary predisposition to breast cancer.6 Inherited breast cancer susceptibility may also be the result ...
  http://jmg.bmj.com/content/39/3/192
*  Breast Cancer Prevention (PDQ®): Prevention - Health Professional Information [NCI] - North Kansas City Hospital, Kansas City,...
... advancing age is the biggest risk factor for breast cancer. Reproductive factors that increase exposure to endogenous estrogen ... Miki Y, Swensen J, Shattuck-Eidens D, et al.: A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. ... Refer to the PDQ summary on Genetics of Breast and Gynecologic Cancers for more information.) Mutations in BRCA genes are ... Note: Separate PDQ summaries on Breast Cancer Screening; Breast Cancer Treatment; Male Breast Cancer Treatment; Breast Cancer ...
  https://www.nkch.org/patients-visitors/health-library/healthwise-document-viewer/?id=ncicdr0000062779