CAMK2A - Wikipedia
Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification ... The product of this gene belongs to the Serine/Threonine protein kinases family, and to the Ca2+/calmodulin-dependent protein ... "Entrez Gene: CAMK2A calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha". Walikonis RS, Oguni A, Khorosheva EM, ... cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II ...https://en.wikipedia.org/wiki/CAMK2A
Isoforms (Conformations?) of Turkey Gizzard Myosin Light Chain Kinase: Separation by Anion Exchange High Performance Liquid...
Myosin light chain kinase illustrates well how an enzyme simultaneously affects and is affected by interlocking pieces in the ... Corbin, J. D. and Reimann, E. M., 1974, Assay of cyclic AMP-dependent protein kinase, Methods Enzymol., 38: 287.PubMedCrossRef ... Walsh, M. P., Cavadore, J.-C., Vallet, B., and Demaille, J., 1980, Calmodulin-dependent myosin light chain kinases from cardiac ... Phosphorylation of smooth muscle myosin light chain kinase by Ca2+/calmodulin-dependent protein kinase II: Comparative study of ...https://link.springer.com/chapter/10.1007/978-1-4684-6003-2_30
Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification ... is activated and becomes calcium independent upon phosphorylation by cyclic nucleotide-dependent protein kinases. J Biol Chem ... 1998) Cyclic-GMP-dependent protein kinase inhibits the Ras/mitogen-activated protein kinase pathway. Mol Cell Biol 18:6983-6994 ... 1994) High-affinity binding and localization of the cyclic GMP-dependent protein kinase with the intermediate filament protein ...http://www.jneurosci.org/content/21/11/3871
Synapsin I - Wikipedia
Cyclic AMP-dependent protein kinase is unique in its mechanism of activation. The protein kinase is composed of two regulatory ... It is phosphorylated by four known classes of protein kinases including those activated by cAMP, calcium/calmodulin, mitogen, ... Cyclic AMP binds to the regulatory subunits of cAMP-dependent protein kinase and causes the dissociation of its regulatory ... binds to calmodulin to form a calcium/calmodulin complex which then activates the calcium/calmodulin-dependent protein kinase, ...https://en.wikipedia.org/wiki/Synapsin_I
Mitogen-Activated Protein Kinases (Erk1,2) Phosphorylate Lys-Ser-Pro (KSP) Repeats in Neurofilament Proteins NF-H and NF-M |...
Cyclic AMP-dependent protein kinase (PKA) and protein kinase C (PKC) are the principal kinases targeting the head domain of NF- ... its regulation by calmodulin. J Biol Chem 261:13023-13030. ... 1992) Association of cyclic-AMP-dependent protein kinase with ... Effect of phosphorylation on 68 kDa neurofilament subunit protein assembly by the cyclic AMP dependent protein kinase in vitro. ... 1993) Tau protein kinase II has similar characteristics to cdc2 kinases for phosphorylating neurofilament proteins. J Biol Chem ...http://www.jneurosci.org/content/18/11/4008
Role of urokinase and its receptor in basal and stimulated colonic epithelial cell migration in vitro | Gut
Evidence for cyclic AMP-dependent and protein kinase C-dependent pathways. Circ Res 72:330-340. ... such as focal adhesion kinase,11 protein kinase C (PKC),8extracellular signal regulated kinase,11 12 Janus associated kinases, ... 1994) Role of actin and calmodulin in migration and proliferation of rabbit gastric mucosal cells in culture. J Gastroenterol ... protein kinase C. ON. oligonucleotide. PMA. phorbol-12-myristate-13-acetate. u-PA. urokinase-type plasminogen activator. u-PAR ...http://gut.bmj.com/content/47/1/105
Angus Clark Nairn, PhD > Psychiatry | Yale School of...
... down-regulation of calmodulin-dependent protein kinase III in PC12 cells involves cyclic AMP-dependent protein kinase. J ... Matovcik LM, Nairn AC, Gorelick FS: Cellular localization of calmodulin-dependent protein kinases I and II to A-cells and D- ... calmodulin-dependent protein kinase I by calmodulin and by Ca2+/calmodulin-dependent protein kinase kinase. J Biol Chem. 1998 ... by cAMP-dependent protein kinase, protein kinase C and Ca2+/calmodulin-dependent protein kinase II. Eur J Biochem. 1990 Sep 11 ...http://medicine.yale.edu/psychiatry/people/angus_nairn-2.profile
Control of GluR1 AMPA Receptor Function by cAMP-Dependent Protein Kinase | Journal of Neuroscience
Inhibition of cyclic AMP-dependent kinase by expression of a protein kinase inhibitor/enhanced green fluorescent fusion protein ... 1997) Identification of the Ca2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in the α-amino-3- ... 5 C) or indirect effects of other kinases that act on Ser831. These results are consistent with biochemical studies that show ... 1996) Transient activation of cyclic AMP-dependent protein kinase during hippocampal long-term potentiation. J Biol Chem 271: ...http://www.jneurosci.org/content/20/1/89?ijkey=6516d0f6e54ae4839e5d63ec1a2689b2c1d8909e&keytype2=tf_ipsecsha
Tyrosine hydroxylase - Wikipedia
"Direct phosphorylation of brain tyrosine hydroxylase by cyclic AMP-dependent protein kinase: mechanism of enzyme activation". ... is phosphorylated by the calcium-calmodulin-dependent protein kinase. MAPKAPK2 (mitogen-activated-protein kinase-activating ... that are phosphorylated by a variety of protein kinases. Ser40 is phosphorylated by the cAMP-dependent protein kinase. Ser19 ( ... "Molecular cloning of cDNA coding for brain-specific 14-3-3 protein, a protein kinase-dependent activator of tyrosine and ...https://en.wikipedia.org/wiki/Tyrosine_hydroxylase
Tyrosine hydroxylase - Wikipedia
"Direct phosphorylation of brain tyrosine hydroxylase by cyclic AMP-dependent protein kinase: mechanism of enzyme activation". ... is phosphorylated by the calcium-calmodulin-dependent protein kinase. MAPKAPK2 (mitogen-activated-protein kinase-activating ... that are phosphorylated by a variety of protein kinases. Ser40 is phosphorylated by the cAMP-dependent protein kinase.[ ... Roskoski R, Roskoski LM (Jan 1987). "Activation of tyrosine hydroxylase in PC12 cells by the cyclic GMP and cyclic AMP second ...https://en.wikipedia.org/wiki/Tyrosine_3-monooxygenase
Memory in the enteric nervous system | Gut
23 Induction and maintenance of LTP involves several kinases, at least PKC,24 calcium/calmodulin dependent protein kinase (CaM ... cyclic AMP and its analogues, and phorbol esters (protein kinase C (PKC) activators) can mimic slow EPSPs in AH neurones.16-18 ... 1997) Postsynaptic inhibitors of calcium/calmodulin-dependent protein kinase type II block induction but not maintenance of ... 1997) Mediation by protein kinases C and A of Go-linked slow responses of enteric neurons to 5-HT. J Neurosci 17:1011-1024. ...http://gut.bmj.com/content/47/suppl_4/iv60
CREB1 - Wikipedia
Shimomura A, Ogawa Y, Kitani T, Fujisawa H, Hagiwara M (Jul 1996). "Calmodulin-dependent protein kinase II potentiates ... "Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires ... The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal ... Pandey SC (Oct 2004). "The gene transcription factor cyclic AMP-responsive element binding protein: role in positive and ...https://en.wikipedia.org/wiki/CREB1
ATF1 - Wikipedia
... cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and ... Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene. This gene encodes an ... of activating transcription factor-1 and the cAMP response element-binding protein by Ca2+/calmodulin-dependent protein kinases ... 1996). "Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 ...https://en.wikipedia.org/wiki/ATF1
A Key Role for Cyclic AMP-Responsive Element Binding Protein in Hypoxia-Mediated Activation of the Angiogenesis Factor CCN1 ...
... calmodulin-dependent protein kinase IV activity and CREB protein phosphorylation during post-hypoxic reoxygenation in neuronal ... was found to be suppressed by cAMP due to inhibition of the activity of mitogen-activated protein kinases (46). These results ... Cyclic AMP-dependent protein kinase: pivotal role in regulation of enzyme induction and growth. Science 1975;190:896-8. ... is enhanced upon hypoxia stress primarily in a protein kinase A and cyclic AMP-responsive element binding protein (CREB) and ...http://mcr.aacrjournals.org/content/6/9/1397
Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof - Patent # 6410294 ...
... paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides. ... the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid ... cyclic-ADPribose, arachidonic acid,diacylglycerol and calcium-calmodulin. The cyclic-AMP dependent protein kinases (PKA) are ... The second messenger dependent protein kinases primarily mediate the effects of second messengers such as cyclic AMP (cAMP), ...http://www.patentgenius.com/patent/6410294.html
AMP-activated protein kinase - Wikipedia
... liver kinase B1 (LKB1) which works in a complex with STRAD and MO25, calcium-/calmodulin-dependent kinase kinase 2 (]]CAMKK2, ... It should not be confused with cyclic AMP-activated protein kinase (protein kinase A). AMPK is a heterotrimeric protein complex ... STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade". J. Biol. 2 (4): 28. doi ... "AMP-activated protein kinase kinase activity and phosphorylation of AMP-activated protein kinase in contracting muscle of ...https://en.wikipedia.org/wiki/AMP-activated_protein_kinase
Isolation and characterization of the highly phosphorylated repeat domain of distinct heavy neurofilament subunit (NF-H)...
Dosemeci, A., and Pont, H. C. (1992). Association of cyclic AMP dependent protein kinase with neurofilaments.Biochem. J. 282: ... Ca2+-calmodulin-dependent protein kinase II phosphorylates various types of non-epithelial intermediate filament proteins. ... Roder, H. M., and Ingram, V. M. (1991). Two novel kinases phosphorylate tau and the KSP site of heavy neurofilament subunits in ... Julien, J.-P., Smoluk, G. D., and Muspynski, W. E. (1983). Characteristics of protein kinase activity associated with rat ...https://link.springer.com/article/10.1007/BF02150227
CK2-An Emerging Target for Neurological and Psychiatric Disorders
Second messenger-dependent protein kinases, such as protein kinase A and protein kinase C, or CK1α, are also involved in GPCR ... One example of an in vivo CK2 substrate that links cyclic AMP (cAMP) signaling to nuclear responses, changes histone ... Primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and ... It was shown that the Ca2+/calmodulin-dependent protein kinase II (CaMKII), activated through activity-induced calcium influx, ...http://pubmedcentralcanada.ca/pmcc/articles/PMC5374411/
Article) - Biology Online
Calmodulin-dependentprotein kinase II promotes smooth muscle relaxation by decreasingthe sensitivity of MLC kinase for Ca2+. ... ß-adrenergicreceptors and cyclic AMP) or agonist bioavailability (endotheliumdysfunction, reduced nitric oxide and cyclic GMP ... Pharmacomechanical coupling: the role of calcium, G-proteins, kinases and phosphatases. Rev Physiol Biochem Pharmacol 134: 201- ... DG, along with Ca2+, activatesprotein kinase C (PKC), which phosphorylates specific targetproteins. There are several isozymes ...http://www.biology-online.org/articles/smooth_muscle_contraction_relaxation/article.html
Sperm Motility: Patterns and Regulation | SpringerLink
Pariset C.C., Feinberg J.M.F., Dacheux J.L., Weinman, S.J. Changes in calmodulin level and cAMP-dependent protein kinase ... Yeung C.H. Effects of cyclic AMP on the motility of mature and immature hamster epididymal spermatozoa studied by reactivation ... Porter M.E., Sale W.S. The 9+2 axoneme anchors multiple inter-arm dyneins and a network of kinases and phosphatases that ... Hoskins D., Stephens D., Hall M. Cyclic adenosine 3':5'-monophosphate and protein kinase levels in developing bovine ...https://link.springer.com/chapter/10.1007/978-1-4615-0273-9_5
Direct Evidence for Biphasic cAMP Responsive Element-Binding Protein Phosphorylation during Long-Term Potentiation in the Rat...
A number of protein kinases, including cAMP-dependent protein kinase A (PKA) and Ca2+/calmodulin-dependent kinase II (CaMKII), ... stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A. ... 1994) Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and IV involves phosphorylation of a ... 1991) Effects of KN-62, a specific inhibitor of calcium/calmodulin-dependent protein kinase II, on long-term potentiation in ...http://www.jneurosci.org/content/19/13/5683
Dr Michel Goedert :: Cambridge Neuroscience
"Tau protein is phosphorylated by cyclic AMP-dependent protein kinase and calcium/calmodulin-dependent protein kinase II within ... that dephosphorylates tau protein phosphorylated by proline-directed protein kinases or cyclic AMP-dependent protein kinase." J ... "Phosphorylation of tau by cyclic-AMP-dependent protein kinase." Dementia 4(5):256-63 Details ... Yoshida H, Goedert M (2006), "Sequential phosphorylation of tau protein by cAMP-dependent protein kinase and SAPK4/p38delta or ...http://www.neuroscience.cam.ac.uk/directory/profile.php?migo
G protein-coupled receptor - Wikipedia
... receptor domain by protein kinases. Cyclic AMP-dependent protein kinases (protein kinase A) are activated by the signal chain ... which in turn go on to bind and allosterically activate enzymes such as Ca2+/calmodulin-dependent kinases (CAMKs). The ... The G protein-coupled receptor kinases (GRKs) are protein kinases that phosphorylate only active GPCRs. G-protein-coupled ... stimulative regulative G-protein (Gs) or inhibitory regulative G-protein (Gi); adenylyl cyclase; protein kinase A (PKA); and ...https://en.wikipedia.org/wiki/G_protein%E2%80%93coupled_receptor
Substrate specificity of protein kinases - Patent # 5532167 - PatentGenius
The invention also provides peptide substrates for protein kinase A, cell cycle control kinases, src family kinases, the EGF ... motif for a phosphorylation site of a protein kinase. In the method of the invention, a protein kinase is contacted with an ... receptor and p92.sup.c-fps/fes based upon amino acid sequence motifs for the phosphorylation sites of these kinases. ... oriented degenerate peptide library, peptides within the library which are substrates for the kinase are converted to ...http://www.patentgenius.com/patent/5532167.html
LIM Kinase, a Newly Identified Regulator of Presynaptic Remodeling by Rod Photoreceptors After Injury | IOVS | ARVO Journals
Regulatory cascades involving calmodulin-dependent protein kinases. Mol Endocrinol. 2000; 14: 4-13. ... Tojima T, Takahashi M, Ito E. Dual regulation of LIM kinase 1 expression by cyclic AMP and calcium determines cofilin ... Ca2+/calmodulin-dependent protein kinase IV-mediated LIM kinase activation is critical for calcium signal-induced neurite ... Braun AP, Schulman H. The multifunctional calcium/calmodulin-dependent protein kinase: from form to function. Annu Rev Physiol ...http://iovs.arvojournals.org/article.aspx?articleid=2476141