*  Morphine (band) - Wikipedia
"Vapors of Morphine makes it a point to keep the music fresh". Patriot Ledger. Retrieved 2012-12-02. Sean L. Maloney. "Vapors of ... Founding members have reformed into the band Vapors of Morphine, maintaining much of the original style and sound. Morphine ... The Other Side Morphine data at AllMusic Twinemen on Myspace Vapors of Morphine at Facebook. ... As of 2014, the group was renamed Vapors of Morphine and regularly performs in Boston and New Orleans, and holds a standing ...
  https://en.wikipedia.org/wiki/Morphine_(band)
*  Vapors of Morphine Honor Local Music Tradition With Atwood's Residency | BDCWire
Vapors unites old members and creates new magic. ... Keeping the music of Morphine alive more than a decade after a ... "We call ourselves Vapors of Morphine because we're not really here," saxophonist Dana Colley announces to a buzzing room on a ... Vapors of Morphine, a trio composed of Colley, Deupree and vocalist/guitarist/bassist Jeremy Lyons, is the current form of ... Vapors, maybe, but hardly absent; Colley, Deupree and Lyons pull off the rare feat of seamlessly honoring a legacy and ...
  http://www.bdcwire.com/vapors-of-morphine-honor-local-music-tradition-with-atwoods-residency/
*  Patent US7078018 - Delivery of opioids through an inhalation route - Google Patents
... allowing the vapor to cool, thereby forming a condensation aerosol comprising particles with less than 5% opioid degradation ... The method comprises: a) heating a composition, wherein the composition comprises an opioid, to form a vapor; and, b) ... "Morphine degradation product" refers to a compound resulting from a chemical modification of morphine. The modification, for ... "Vapor" refers to a gas, and "vapor phase" refers to a gas phase. The term "thermal vapor" refers to a vapor phase, aerosol, or ...
  http://www.google.com/patents/US7078018?dq=7,346,545
*  Dana Colley - Wikipedia
... a Morphine fan page Twinemen at MySpace.com Members of Morphine at MySpace.com Vapors of Morphine's Official Website. ... As of 2014, the trio renamed themselves Vapors of Morphine and regularly performs shows in Boston and New Orleans. Colley has ... Orchestra Morphine remained sporadically active thereafter, reassembling occasionally to perform Morphine material. Musical ... Vapors of Morphine at Facebook Three Colors at Gbmusic.com The Other Side - ...
  https://en.wikipedia.org/wiki/Dana_Colley
*  Ticlopidine hydrochloride solubility / Chloramphenicol brand name philippines
Burning will produce irritating vapors and.msds hcl msds clp 12722008 msds cloro clorox msds helianthus annuus seed oil msds ... PRODUCT: MORPHINE HYDROCHLORIDE. ITEMS. SPECIFICATIONS:. SOLUBILITY. Soluble in water, slightly soluble in ethanol (96%), ... 1978 Thiothixene; Vol 18: 527-566; 1989 Ticlopidine hydrochloride; Vol.Product list Pharma APls A. Tetracaine Hcl Thimerosal ...
  http://webmusicdownload.ga/mymiw/ticlopidine-hydrochloride-solubility-vyf.php
*  Patent US7524484 - Delivery of diphenhydramine through an inhalation route - Google Patents
... passing air through the heated vapor to produce aerosol particles having less than 5% degradation product and an aerosol having ... heating a thin layer of diphenhydramine on a solid support to form a vapor; and, b) ... 1997). "Morphine Pharmacokinetics after Pulmonary Administration from a Novel Aerosol Delivery System," Clinical Pharmacology ... "Vapor" refers to a gas, and "vapor phase" refers to a gas phase. The term "thermal vapor" refers to a vapor phase, aerosol, or ...
  http://www.google.ca/patents/US7524484
*  Patent US7601337 - Delivery of antipsychotics through an inhalation route - Google Patents
... allowing the vapor to cool, thereby forming a condensation aerosol comprising particles with less than 5% antipsychotic drug ... The method comprises: a) heating a composition, wherein the composition comprises an antipsychotic, to form a vapor; and, b) ... 1997). "Morphine Pharmacokinetics after Pulmonary Administration from a Novel Aerosol Delivery System," Clinical Pharmacology ... "Vapor" refers to a gas, and "vapor phase" refers to a gas phase. The term "thermal vapor" refers to a vapor phase, aerosol, or ...
  http://www.google.com/patents/US7601337?dq=5927278
*  Patent US6464688 - Osmotic pump delivery system with flexible drug compartment - Google Patents
Osmotic devices having vapor-permeable coatings. US5869096. Dec 9, 1994. Feb 9, 1999. Alza Corporation. Oral osmotic device ... According to further embodiments, the pharmaceutical agent may include one or more of the following drugs: morphine, ... Osmotic-delivery devices having vapor-permeable coatings. US5801188. Jan 8, 1997. Sep 1, 1998. Medtronic Inc.. Clonidine ... For example, the pharmaceutical agent may include one or more of the following drugs: morphine, hydromorphone, levorphanol, ...
  http://www.google.com/patents/US6464688?dq=6,712,702
*  Urban legends about drugs - Wikipedia
Like MDMA, MPPP is a designer drug, but its effects are more akin to morphine or other opiates. Despite the similarity in name ... of administration in which the user will heat/melt crystal methamphetamine and inhale the resulting methamphetamine vapor. The ... Thebaine was not detected in any of the tested powdered drugs (street heroin, morphine tablet, codeine tablet) or the urine of ... They also tested street heroin, 1 morphine tablet and 1 codeine tablet. Urine specimens were screened by EMIT and confirmed for ...
  https://en.wikipedia.org/wiki/Urban_legends_about_drugs
*  In situ chemical deposition of PPy/NDSA and PPy/DBSA layers on QCM electrodes: synthesis, structural, morphological and ammonia...
Aiming to detect ammonia vapor, polypyrrole (PPy) thin layers were in situ coated on AT-cut 10 MHz quartz crystal microbalance ... Ammonia vapor sensing tests were related to QCM frequency changes recorded upon vapor adsorption and desorption on PPy films, ... Electroactive polymers for the detection of morphine. J Polym Res 21:565-577CrossRefGoogle Scholar ... Aiming to detect ammonia vapor, polypyrrole (PPy) thin layers were in situ coated on AT-cut 10 MHz quartz crystal microbalance ...
  https://link.springer.com/article/10.1007/s10965-018-1500-z
*  Forgotten Disc Friday: FDF Volume 3 Issue 349 - Morphine - YES
"Members of Morphine". With new vocalist Jeremy Lyons the band changed their name to "Vapors of Morphine" and still preform live ... Following Sandmans death Colley and Conway set up "Orchestra Morphine" a band set up to tour and celebrate Marks life, as well ... Overview - This is the third studio album from the Boston band "Morphine". Formed in 1989 the trio blended jazz and alternative ...
  http://forgottendiscfriday.blogspot.com/2014/08/fdf-volume-3-issue-349-morphine-yes.html
*  Chapter 9. Pharmacogenetics | Pharmacotherapy: A Pathophysiologic Approach, 8e | AccessPharmacy | McGraw-Hill Medical
Codeine and tramadol are converted by CYP2D6 to morphine and O-desmethyltramadol, respectively, and thus poor CYP2D6 ... Codeine increases pain thresholds to copper vapor laser stimuli in extensive but not poor metabolizers of sparteine. Clin ... Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother. Lancet 2006;368:704.. [PubMed: ... codeine might exhibit symptoms of narcotic overdose associated with high morphine concentration. This toxicity potential had ...
  http://accesspharmacy.mhmedical.com/content.aspx?bookid=462§ionid=41100775&jumpsectionID=41104387
*  1 - Managed forex accounts in malaysia
2mg subarachnoid morphine to hyperbaric bupivacaine for cesarean delivery: a prospective study of 856 cases. ... so cold that water is found as vast deposits of ice and wisps of water vapor. 5 Polysaccharide-based biopolymers Comprising the ... 1989, 33, 259; Markovski. In most cases the skin is represented in the form of sequence of layers with various optical and ...
  http://oilforexprofits.com/managed-forex-accounts-in-malaysia.html
*  6-Monoacetylmorphine (6-MAM) Confirmation, Chain of Custody, Meconium - Mayo Medical Laboratories | Pediatric Catalog
6-MAM is further metabolized into morphine, the dominant metabolite of heroin, and morphine will typically be found in a ... or inhaling vapors. ... Heroin shares the core structure of morphine, with the addition ... It is no longer used clinically in the United States, though it is used elsewhere for rapid relief of pain.(1) Like morphine ... Heroin (diacetylmorphine) is a semisynthetic opiate that is closely related to morphine. ...
  http://pediatric.testcatalog.org/show/MAMMX
*  Read Paper Republic: The Northern Border
Even the coal fire and ashes in that stove had been endowed with spirit through long exposure to the vapors of cooking herbs. ... not the metallic tang of morphine. Your classmates were flummoxed. As accustomed as they were to death from hours spent ... 1989." You spent all night flipping through the notebook. The first half was a record of the progression of your uncle's ...
  https://paper-republic.org/pubs/read/the-northern-border/
*  Oxycodone - Wikipedia
... with fewer side effects than morphine. The author concluded that the controlled release form is a valid alternative to morphine ... Diverted oxycodone may be taken orally or ingested through insufflation; used intravenously, or the heated vapors inhaled. In ... In 1997, a group of Australian researchers proposed (based on a study in rats) that oxycodone acts on KORs, unlike morphine, ... It was hoped that a thebaine-derived drug would retain the analgesic effects of morphine and heroin with less dependence. ...
  https://en.wikipedia.org/wiki/Oxycodone
*  Inflammatory | GreenMedInfo | Adverse Pharmacological Action
E-cig vapor extract caused toxicity and reduced the antiviral response to polycytidylic acid.Dec 31, 2017. ... Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation.May 30, 2016. ...
  http://www.greenmedinfo.com/content/inflammatory
*  History of general anesthesia - Wikipedia
Friedrich Sertürner (1783-1841) first isolated morphine from opium in 1804; he named it morphine after Morpheus, the Greek god ... Wells, H (1847). A History of the Discovery of the Application of Nitrous Oxide Gas, Ether, and Other Vapors to Surgical ... Victor H. Mair wrote that mafei "appears to be a transcription of some Indo-European word related to "morphine"." Some authors ... After treatment and/or storage, the sponge could be heated and the vapors inhaled with anasthetic effect.[citation needed] ...
  https://en.wikipedia.org/wiki/History_of_general_anesthesia
*  IBOGAiN.SE :: View topic - Ibogain Faktatr d.
Glick, S. D., Rosman, K., Rao, N. C., Maisonneuve, I. M. och Carlson, J. N., 'Effects of Ibogaine on Acute Signe of Morphine ... A popular method of heroin administration among Dutch addicts is to heat the heroin on a sheet of tinfoil and inhale the vapors ... Chronic morphine or cocaine exposure decreases levels of phosphoRet, the protein kinase that mediates GDNF signaling, in the ... Glick, S., Rossman, K., Rao, N., Maisonneuve, I., and Carlson, J. (1992). Effects of ibogaine on acute signs of morphine ...
  http://forum.ibogain.se/viewtopic.php?p=1631
*  the IVSP ramipril ibuprofen wechselwirkungen
Unexpectedly high amounts of morphine, 6-monoacetyl-morphine. T.Fei, Y. And Franklin, R. Biol Pharm Bull 2008;312163в2181. A. ... PH2O is the water vapor pressure usually 40 is the partial pressure of carbon dioxide in arterial blood (mmHg), and RQ is ... in the rat mesolimbic dopamine system by chronic exposure to morphine or cocaine. ... In 1989, Siegel and colleagues presented their experience with 14 patients with primary intraocular lymphoma (the term, ...
  http://design-citi.ru/latest-drugs-in-india/ramipril-ibuprofen-wechselwirkungen.html
*  Social transfer of pain in mice | Science Advances
Morphine base (300 mg/kg) was delivered subcutaneously in an emulsion that consisted of 50 mg of morphine base suspended in 0.1 ... Anxiety-like behavior in mice in two apparatuses during withdrawal from chronic ethanol vapor inhalation. Alcohol. Clin. Exp. ... Morphine withdrawal.. To determine whether withdrawal from a drug of abuse would lead to the social transfer of pain, mice were ... 1 Social transfer of CFA and morphine withdrawal-induced pain.. (A) Experimental timeline of experiments presented in (B) and ( ...
  http://advances.sciencemag.org/content/2/10/e1600855.full
*  Patent US7128067 - Method and apparatus for generating an aerosol - Google Patents
Ion vapor source for mass spectrometry of liquids. US4735217. 21 Aug 1986. 5 Apr 1988. The Procter & Gamble Company. Dosing ... Aerosol formulations and aerosol delivery of butalbital, lorazepam, ipratropium, baclofen, morphine and scopolamine. ... It was further desired to heat the vapor sufficiently to prevent condensation at the exit of the flow passage. There were ... Fingerprinting system incorporating a spray container and a portable vapor tank. US4730111. 24 Feb 1986. 8 Mar 1988. Research ...
  http://www.google.com.au/patents/US7128067
*  Patent US9272074 - Surgical fasteners and methods for sealing wounds - Google Patents
... morphine and the like; non-narcotics such as salicylates, aspirin, acetaminophen, d-propoxyphene and the like; opioid receptor ... chemical vapor deposition, plasma polymerization, plasma treatments, coupling treatments, such as silane coupling treatments ... the reactive members are attached to the surgical fastener by surface modification techniques such as physical vapor deposition ... chemical vapor deposition, plasma treatments, coupling treatments, acid hydrolysis and base hydrolysis. ...
  http://www.google.ca/patents/US9272074
*  Patente US5725884 - Pharmaceutical excipient having improved compressibility - Google Patentes
Colloidal silicon dioxide is a submicron fumed silica prepared by the vapor-phase hydrolysis (e.g., at 1110 C.) of a silicon ... morphine, dihydromorphone, oxycodone, etc.), non-steroidal anti-inflammatory agents (e.g., naproxyn, diclofenac, indomethacin, ... 6 Abr 1989. 8 May 1990. Sbp, Inc.. Use of parenchymal cell cellulose to improve comestibles. ... 7 Mar 1989. The Procter & Gamble Company. Reduced calorie and reduced fat chocolate confectionery compositions. ...
  http://www.google.es/patents/US5725884?hl=es&dq=flatulence
*  DailyMed - MORPHINE SULFATE- morphine sulfate tablet, extended release
Morphine sulfate extended-release tablets should be prescribed only by healthcare professionals who are knowledgeable in the use of potent opioids for the management of chronic pain. Initiate the dosing regimen for each patient individually, taking into account the patient's prior analgesic treatment experience and risk factors for addiction, abuse, and misuse [see Warnings and Precautions (5.1)]. Monitor patients closely for respiratory depression, especially within the first 24 to 72 hours of initiating therapy with morphine sulfate extended-release tablets [see Warnings and Precautions (5.2)]. Morphine sulfate extended-release tablets must be taken whole. Crushing, chewing, or dissolving morphine sulfate extended-release tablets will result in uncontrolled delivery of morphine and can lead to overdose or death [see Warnings and ...
  https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a07378f9-607a-49c6-bdb8-5c8b4ce91a49
*  Resveratrol May Preserve Pain-Relieving Effects of Morphine | International Anesthesia Research Society
After inducing morphine tolerance in rats, the researchers tested the animals' spinal cord responses to morphine, with or without resveratrol. The results showed significant enhancement of morphine's effects in animals receiving resveratrol. In morphine-tolerant rats, the pain-relieving response to morphine was about 20 percent of normal. In rats receiving resveratrol, morphine responses were restored to about 60 percent of normal.. In preserving the pain-relieving effects of morphine, resveratrol appeared to work in two ways. It reversed the increase in expression of a type of neurotransmitter (N-methyl D-aspartate, or NMDA) receptors associated with morphine tolerance. Resveratrol also blocked the increase of inflammation-promoting ...
  http://www.iars.org/resveratrol_may_preserve_pain-relieving_effects_of_morphine/?Archive=y%3Fprint%3Dy&pg=9&F_All=y?print=y
*  Phosphoproteomics and Bioinformatics Analyses of Spinal Cord Proteins in Rats with Morphine Tolerance
Introduction Morphine is the most effective pain-relieving drug, but it can cause unwanted side effects. Direct neuraxial administration of morphine to spinal cord not only can provide effective, reliable pain relief but also can prevent the development of supraspinal side effects. However, repeated neuraxial administration of morphine may still lead to morphine tolerance. Methods To better understand the mechanism that causes morphine tolerance, we induced tolerance in rats at the spinal cord level by giving them twice-daily injections of morphine (20 µg/10 µL) for 4 days. We confirmed tolerance by measuring paw withdrawal latencies and maximal possible analgesic effect of morphine on day 5. We then carried out phosphoproteomic analysis to investigate the global ...
  http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083817
*  Morphine is an opioid analgesic drug commonly used for pain relief - Aurora Kinases as Druggable Targets in Cancer Therapy
Morphine is an opioid analgesic drug commonly used for pain relief in cancer patients. demonstrate that morphine contributes to chemoresistance via expanding the population of cancer stem cells and promotes tumor growth thereby revealing Specnuezhenide a novel role of morphine and providing some new guides in clinical use of morphine. = 5) nalmefene (= 5) morphine (= 5) or nalmefene plus morphine (= 5) right after tumor cell implantation. Due to the potential desensitization of opioid receptors the dose of morphine and nalmefene were increased stepwise (5 10 and 15 mg/kg s.c. for every two weeks). For drug combination the nalmefene dose was one-tenth of the morphine dose because this ratio is generally considered to result in a complete ...
  http://www.exposed-skin-care.net/2016/08/19/morphine-is-an-opioid-analgesic-drug-commonly-used-for-pain-relief/
*  Multiple effects of long-term morphine treatment on postsynaptic [beta]-adrenergic receptor function in hippocampus: an...
Abstract: We previously reported that [beta]-adrenergic receptors are increased in cerebral cortex and hippocampus in rats treated chronically with morphine and subsequently down-regulated after morphine withdrawal [22,23]. The changes in receptor density in hippocampus were accompanied by a corresponding super- and subsensitivity, respectively, in [beta]-adrenergic responsiveness, as assessed electrophysiologically by measuring the ability of isoproterenol to augment population spike responses in the slice. In this study, we compared the ability of isoproterenol to reduce the Ca2+-activated K+ slow afterhyperpolarization (slow AHP) in pyramidal neurons in hippocampal slices from opiate-naive and chronic morphine-treated rats to determine whether such changes in [beta]-adrenergic receptor function are localized postsynaptically. Chronic treatment of rats with morphine ...
  https://deepblue.lib.umich.edu/handle/2027.42/31332
*  The effect of alloxan-induced diabetes on anti-nociception and on the development of morphine tolerance and dependence in rats
Diabetes is one of the most common diseases in all societies including Iran. One of its important complications is the neuropathic pain, which can be relieved by opioid drugs such as morphine. Opioid therapy is restricted due to development of tolerance and physical or mental dependence. In this study, the effect of diabetes on morphine analgesia and development of morphine tolerance and dependence was investigated. Experimental diabetes was induced by alloxan (120 mg/kg, s.c.) in rats. Morphine sulfate (7 mg/kg, i.p.) application for 5 days developed tolerance in animals. On 5th day, 30 min after the injection of morphine, the acute and chronic pain was evaluated in diabetic and non-diabetic animals using hot plate and formalin test. In addition, withdrawal signs (jumping, chewing, urine and feces) were recorded for ten minutes using ...
  http://ijpr.sbmu.ac.ir/article_155.html
*  Fan, X., Zhang, J., Zhang, X., Yue, W. and Ma, L. (2002) Acute and chronic morphine treatments and morphine withdrawal...
Fan, X., Zhang, J., Zhang, X., Yue, W. and Ma, L. (2002) Acute and chronic morphine treatments and morphine withdrawal differentially regulate GRK2 and GRK5 gene expression in rat brain. Neuro-pharmacology, 43, 809-816.
  http://www.scirp.org/reference/ReferencesPapers.aspx?ReferenceID=1022670
*  The Devious Side of Morphine Addiction in Canada - Drug Facts
Morphine is an extremely strong opiate analgesic drug and is the most important active agent in opium and the prototypical opioid.. It is also a natural endocrine product in humans and other animals. Like other opioids, diacetylmorphine or commonly know as heroin, morphine targets directly the central nervous system (CNS) to alleviate pain, and at synapses of the nucleus accumbens in particular.. Morphine is extremely addictive when compared to other substances; physical, tolerance and psychological dependences build up very rapidly. Withdrawal from morphine causes nausea, tearing, yawning, chills, and sweating lasting up to three days. Morphine crosses the placental barrier, and babies born to morphine-using mothers go through withdrawal.. Addictive drugs, for instance ...
  http://www.drugfacts.ca/prescription-drugs/the-devious-side-of-morphine-addiction-in-canada/
*  COMPARATIVE STUDY BETWEEN THE EFFICACY OF TRANSDERMAL FENTANYL PATCHES INTRATHECAL MORPHINE AND INTRAMUSCULAR MORPHINE IN THE...
Thesis, English, COMPARATIVE STUDY BETWEEN THE EFFICACY OF TRANSDERMAL FENTANYL PATCHES INTRATHECAL MORPHINE AND INTRAMUSCULAR MORPHINE IN THE RELIEF OF ACUTE POSTOPERATIVE PAIN AFTER MAJOR ONCOLOGICAL SURGERY for Othman Ahmed Hassan
  http://www.philadelphia.edu.jo/newlibrary/eng/english-books/671-english-books/93749-engb-93749
*  Involvement of the p53 tumor-suppressor protein in the development of antinociceptive tolerance to morphine
The present study was designed to determine whether the p53 tumor-suppressor protein is involved in the development of antinociceptive tolerance to morphine. When the doses of morphine (mg/kg per injection) were subcutaneously given into mice as pretreatment twice daily for 2 days (first day (30) and second day (60)), intrathecal (i.t.) administration of morphine (0.1nmol) was inactive due to antinociceptive tolerance in the 0.5% formalin test on the third day. Tolerance to i.t. morphine was significantly suppressed by i.t. injection of pifithrin-alpha (1 and 10nmol), an inhibitor of p53 activation, benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone (Z-VAD-fmk) (1 and 10nmol), a non-selective caspase inhibitor, or N(G)-nitro-l-arginine methyl ester (l-NAME) (2 and 20nmol), a non-selective inhibitor of nitric oxide synthase, 5min before each ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:302486
*  The effect of GABAB receptor activation within the ventral tegmental area on morphine-induced incentive sensitization in female...
Repeated administration of morphine sensitizes animals to the stimulant and rewarding properties of the drug. It may also alter the expression and function of GABA receptors within the ventral tegmental area (VTA), a midbrain region that is implicated in morphine action. In the present study, the effect of activation of GABAB receptor subtypes within the VTA on morphine-induced incentive sensitization in female Wistar rats (250-300 g) was investigated. Female rats (n = 8) were chronically implanted with a 21-gauge cannula in the VTA (V = 8.5, L = 0.9, and A = -4.8 mm from bregma). One week after the surgery, the animals received morphine (5 mg/kg, s.c.) in their home cage for three consecutive days. Five days later, the animals were conditioned with an ineffective dose of morphine in a two compartment un-biased apparatus. Different doses of ...
  http://ijpr.sbmu.ac.ir/article_121.html
*  DailyMed - MORPHINE SULFATE - morphine sulfate solution
Several literature reports indicate that morphine administered subcutaneously during the early gestational period in mice and hamsters produced neurological, soft tissue and skeletal abnormalities. With one exception, the effects that have been reported were following doses that were maternally toxic and the abnormalities noted were characteristic of those observed when maternal toxicity is present. In one study, following subcutaneous infusion of doses greater than or equal to 0.15 mg/kg to mice, exencephaly, hydronephrosis, intestinal hemorrhage, split supraoccipital, malformed sternebrae, and malformed xiphoid were noted in the absence of maternal toxicity. In the hamster, morphine sulfate given subcutaneously on gestation day 8 produced exencephaly and cranioschisis. In rats treated with subcutaneous infusions of morphine during the period of organogenesis, no teratogenicity was observed. No maternal ...
  https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d5e29ebe-0e74-4ba7-a16c-e3199cc70c11
*  JCI - Alternatively spliced mu opioid receptor C termini impact the diverse actions of morphine
exon 3 (mE3M mice), while the other two selectively truncated C-terminal tails encoded by either exon 4 (mE4M mice) or exon 7 (mE7M mice). Studies of these mice revealed divergent roles for the C termini in morphine-induced behaviors, highlighting the importance of C-terminal variants in complex morphine actions. In mE7M-B6 mice, the exon 7-associated truncation diminished morphine tolerance and reward without altering physical dependence, whereas the exon 4-associated truncation in mE4M-B6 mice facilitated morphine tolerance and reduced morphine dependence without affecting morphine reward. mE7M-B6 mutant mice lost morphine-induced receptor desensitization in the brain stem and hypothalamus, consistent with exon 7 involvement in morphine ...
  https://m.jci.org/articles/view/88760/pdf
*  JCI - Alternatively spliced mu opioid receptor C termini impact the diverse actions of morphine
exon 3 (mE3M mice), while the other two selectively truncated C-terminal tails encoded by either exon 4 (mE4M mice) or exon 7 (mE7M mice). Studies of these mice revealed divergent roles for the C termini in morphine-induced behaviors, highlighting the importance of C-terminal variants in complex morphine actions. In mE7M-B6 mice, the exon 7-associated truncation diminished morphine tolerance and reward without altering physical dependence, whereas the exon 4-associated truncation in mE4M-B6 mice facilitated morphine tolerance and reduced morphine dependence without affecting morphine reward. mE7M-B6 mutant mice lost morphine-induced receptor desensitization in the brain stem and hypothalamus, consistent with exon 7 involvement in morphine ...
  https://www.jci.org/articles/view/88760/sd/1
*  Neuropathic Pain Aided by Morphine + Epilepsy Medication
Scientists studying induced nerve injury in rodents have found that the analgesic effects of morphine can decline over time. When morphine is used in combination with carbamazepine, which prevents epileptic seizures, this loss of drug efficacy may be reversed.. There has been mixed efficacy in general using opioids to treat neuropathic pain. The pain relief brought about by morphine can diminish over time. In this study, when carbamazepine was added to the morphine regimen, opioid induced hyperalgesia was reversed. As reported in PLOS ONE, the combination of drugs administered to rodents showed that "the dampening of the analgesic effects of morphine on neuropathic pain behavior in vivo can be countered with the addition of CBZ.". To read the article, click here.. To read the journal article, click here.. Posted on September 16, 2014. ...
  https://www.painweek.org/news_posts/neuropathic-pain-aided-by-morphine-epilepsy-medication.html
*  Plus it
Unbound heroin and 6-MAM concentrations could not be directly measured in plasma because rapid degradation complicated their measurement. However, estimates of unbound morphine concentrations in plasma based on in vitro protein binding data suggest that M-KLH rats had much lower unbound morphine concentrations than controls despite an overall increase in total plasma morphine concentrations. If this were also true for 6-MAM, it would account for the lower 6-MAM levels in brain in vaccinated rats.. Further support for the importance of 6-MAM binding is provided by a heroin vaccine composed of hapten conjugated to protein through the bridge nitrogen. This vaccine generated antibodies with a higher affinity for 6-MAM than heroin yet blunted heroin analgesia in rats (Stowe et al., 2011). Another immunogen, which had a lower affinity for 6-MAM than heroin, was not as effective (Stowe et al., 2011).. Higher plasma ...
  http://jpet.aspetjournals.org/content/344/2/397
*  KEGG PATHWAY: Morphine addiction - Homo sapiens (human)
Morphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most important brain-reward circuit involves dopamine (DA) -containing neurons in the ventral tegmental area (VTA) of the midbrain and their target areas in the limbic forebrain, in particular, the nucleus accumbens (NAc) and frontal regions of cerebral cortex. Morphine can cause indirect excitation of VTA dopamine neurons by reducing inhibitory synaptic transmission mediated by GABAergic neurons. The chronic use of morphine is characterized by adaptive changes in neurons and neuronal communication; such adaptations (e.g., 'superactivation' of adenylyl cyclase) must underlie altered behaviour associated with morphine dependence and withdrawal ...
  http://www.genome.jp/kegg-bin/show_pathway?hsa05032+5139
*  Brain Sciences | Free Full-Text | The Neurodevelopmental Impact of Neonatal Morphine Administration | HTML
Medical management of newborn infants often necessitates recurrent painful procedures, which may alter nociceptive pathways during a critical developmental period and adversely effect neuropsychological outcomes. To mitigate the effects of repeated painful stimuli, opioid administration for peri-procedural analgesia and ICU (intensive care unit) sedation is common in the NICU (neonatal intensive care unit). A growing body of basic and animal evidence suggests potential long-term harm associated with neonatal opioid therapy. Morphine increases apoptosis in human microglial cells, and animal studies demonstrate long-term changes in behavior, brain function, and spatial recognition memory following morphine exposure. This comprehensive review examines existing preclinical and clinical evidence on the long-term impacts of neonatal pain and opioid therapy.
  http://www.mdpi.com/2076-3425/4/2/321/htm
*  American-Eurasian Network for Scientific Information
The Modulatory Role of GABA-B Receptors within the Shell Part of Nucleus Accumbens on the Expression of Morphine-Induced Conditioned Place Preference in Morphine-Tolerant ...
  http://aensiweb.com/old/aeb_Jan_2014.html
*  Mr. Morphine - Erik Ringmar's web pages
I was surprised by all the heavy-duty drugs I was given this week. This is the kind of stuff you read about in newspapers - morphine and cocaine! My previous history as a drug user is easily told. I never tried any heavy recreational drugs and the few times - twice perhaps - that I smoked marijuana, I really hated it. Since those bad experiences some 25 years ago, it's been clear to me that drugs are scary and that my mind doesn't need additional excitement. My mind creates sufficient excitement on its own.. Now let me tell you about Mr. Morphine. Mr. Morphine is a guy who suddenly appears after I've had 12.5 milliliters of that clear, opium-based, liquid my doctor gave me. Mr. Morphine is a super hero like what you would find in an old Marvel Comic. He has a purple dress and a red cape, and he can fly through the air with his fist clenched. Mr ...
  http://ringmar.net/index.php/2008/10/03/mr-morphine/
*  Plus it
The effects of morphine on the incorporation of [14C]serine into phospholipid via the base-exchange reaction were examined using washed brain microsomal membranes as the enzyme source. The addition of morphine in vitro increased the basal rate (no added Ca++) of [14C]serine exchange, with the maximum increase occurring at 10 µM. This concentration of morphine also increased the Ca++-stimulated exchange at Ca++ concentrations of 10, 15, and 20 mM but not 5, 25, or 30 mM. These morphine effects in vitro were blocked by naloxone. Both acute and chronic prior treatment with morphine decreased the basal rate of [14C]serine exchange. However, chronic but not acute morphine treatment significantly increased the Ca++-stimulated exchange of [14C]serine at all Ca++ concentrations tested (2.5-30 mM). In contrast, ...
  http://molpharm.aspetjournals.org/content/14/3/448
*  The effect of food intake on the pharmacokinetics of sustained-release morphine sulfate capsules.
The effect of food intake on the pharmacokinetics of sustained-release (SR) morphine sulfate capsules was assessed in 24 healthy male volunteers. Subjects were randomized to receive a single, 20-mg SR morphine sulfate capsule while fasting and immedi
  http://www.biomedsearch.com/nih/effect-food-intake-pharmacokinetics-sustained/9152568.html
*  Biphasic Effects of Naloxone in the Rats Receiving Morphine Overdose A Place Preference Study
Downward phase of dose-response morphine converted U shape curve was chosen as a base for investigating the effects of different doses of naloxone (0.05-0.4 mg/Kg) on morphine reward/aversion properties using place preference method. First, male Wistar rats (200-220 g) were received morphine (1-7.5 mg/Kg) for place conditioning and marginal dose of morphine (5 mg/Kg) calculated by GraphPad software. In the next part, the animals received different naloxone challenge doses (0.05-0.4 mg/Kg; IP) on the test day. Animals' behavior was monitored using a video camera during the test session. Time spent in each compartment was calculated as the main sign of drug seeking behavior. In addition, numbers of rearing and sniffing as well as locomotion activity for each animal were counted as important dopamine-dependent behavioral signs. More over, the total compartment crossing by each ...
  http://ijpr.sbmu.ac.ir/article_998.html
*  Spinal Nitric Oxide Mediates Antinociception from Intravenous Morphine | Anesthesiology | ASA Publications
Next, the spinal pharmacology of intravenously administered morphine antinociception was examined. Animals received 2.5 mg/kg morphine administered intravenously, followed in 20 min by intrathecal injection of saline or a drug, and followed in 15 min by a second intrathecal injection of saline or a greater dose of the same drug. By this method, two doses of drug were studied in each experiment. Drugs studied were the [Greek small letter alpha]2-adrenergicantagonist idazoxan (2.5-45.0 [micro sign]g), the muscarinic antagonist atropine (5 - 40 [micro sign]g), the nonspecific NOS inhibitor NG-monomethyl-L-arginine(NMMA; 2-36 [micro sign]g), the neuronal NOS specific inhibitor 1-(2-trifluoromethylphenyl) imidazole (TRIM; 2.5 - 45.0 [micro sign]g), and the NO scavenger 2-(4-Carboxyphenyl)-4,4,5,5-tetramethyl-imidazoline-1-oxyl-3-oxide potassium (PTIO; 2.5 - 45.0 [micro sign]g). To study the interaction between intravenously administered ...
  http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1946998
*  Pharmaniaga Morphine Sulphate - Drugs.com
Pharmaniaga Morphine Sulphate is a medicine available in a number of countries worldwide. A list of US medications equivalent to Pharmaniaga Morphine Sulphate is available on the Drugs.com website.
  https://www.drugs.com/international/pharmaniaga-morphine-sulphate.html