*  beta.3 adrenergic receptor agonists and uses thereof - Patent # 6706743 - PatentGenius
... adrenergic receptor-mediated diseases, conditions, or disorders in a mammal which methods comprise administering to the mammal ... beta..sub.3 adrenergic receptor agonists of structural Formula (I), ##STR1##the stereoisomers and prodrugs thereof, and the ... pharmaceutically acceptable salts of the compounds, stereoisomers and prodrugs, wherein Ar, R, R.sub.1, R.sub.2, R.sub.3, R.sub ... beta..sub.1 and .beta..sub.2 Receptor Selectivity. In vivo selectivity for .beta..sub.1 and .beta..sub.2 receptors may be ...
  http://www.patentgenius.com/patent/6706743.html
*  Adrenergic Receptors
... surface receptors for two major catecholamine hormones and neurotransmitters that regulate key physiological responses, ... 1996) The betaadrenergic receptor is a substrate for the insulin receptor tyrosine kinase. Journal of Biological Chemistry 271 ... Lefkowitz RJ (1998) G protein‐coupled receptors. III. New roles for receptor kinases and beta‐arrestins in receptor signalling ... regulation of betaadrenergic receptors: agonist‐induced reduction in receptor mRNA levels. Proceedings of the National Academy ...
  http://www.els.net/WileyCDA/ElsArticle/refId-a0000005.html
*  Beta-2 adrenergic receptor - Wikipedia
Other adrenergic receptors Alpha-1 adrenergic receptor Alpha-2 adrenergic receptor Beta-1 adrenergic receptor Beta-3 adrenergic ... The beta-2 adrenergic receptor (β2 adrenoreceptor), also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor ... "Insulin stimulates sequestration of beta-adrenergic receptors and enhanced association of beta-adrenergic receptors with Grb2 ... Frielle T, Caron MG, Lefkowitz RJ (May 1989). "Properties of the beta 1- and beta 2-adrenergic receptor subtypes revealed by ...
  https://en.wikipedia.org/wiki/Beta-2_adrenergic_receptor
*  Biochemical and Molecular Aspects of Vascular Adrenergic Regulation of Blood Pressure in the Elderly
R. P. Xiao, "Beta-adrenergic signaling in the heart: dual coupling of the beta2-adrenergic receptor to G(s) and G(i) proteins ... C. Lavoie, J. F. Mercier, A. Salahpour et al., "β1/β2-adrenergic receptor heterodimerization regulates β2-adrenergic receptor ... β-adrenergic receptor kinase and β1-adrenergic receptors in the failing human heart," Circulation, vol. 87, no. 2, pp. 454-463 ... and beta2-adrenergic receptor subtypes optimizes beta-adrenergic modulation of cardiac contractility," Circulation Research, ...
  https://www.hindawi.com/journals/ijhy/2012/915057/ref/
*  Thermogenin - Wikipedia
Schleiff E, Shore GC, Goping IS (Mar 1997). "Human mitochondrial import receptor, Tom20p. Use of glutathione to reveal specific ... Fatty acids cause the following signaling cascade: Sympathetic nervous system terminals release Norepinephrine onto a Beta-3 ... adrenergic receptor on the plasma membrane. This activates adenylyl cyclase, which catalyses the conversion of ATP to cyclic ... variant of the uncoupling protein gene and the Trp64Arg mutation of the beta 3-adrenergic receptor gene on weight gain in ...
  https://en.wikipedia.org/wiki/Thermogenin
*  WikiGenes - Diabetes Mellitus, Type 2
Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta 3-adrenergic-receptor gene. Walston ... Peroxisome proliferator-activated receptor gamma and metabolic disease. Willson, T.M., Lambert, M.H., Kliewer, S.A. Annu. Rev. ... A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection ... Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose- ...
  https://www.wikigenes.org/e/mesh/e/23228.html
*  ICI-118,551 - Wikipedia
"Human fat cell beta-adrenergic receptors: beta-agonist-dependent lipolytic responses and characterization of beta-adrenergic ... Hillman KL, Doze VA, Porter JE (August 2005). "Functional characterization of the beta-adrenergic receptor subtypes expressed ... ICI-118,551 is a selective β2 adrenergic receptor (adrenoreceptor) antagonist. ICI binds to the β2 subtype with at least 100 ... therapeutic use in humans although it has been used widely in research to understand the action of the β2 adrenergic receptor, ...
  https://en.wikipedia.org/wiki/ICI-118,551
*  Thermogenin - Wikipedia
Human mitochondrial import receptor, Tom20p. Use of glutathione to reveal specific interactions between Tom20-glutathione S- ... Additive effect of A→G (-3826) variant of the uncoupling protein gene and the Trp64Arg mutation of the beta 3-adrenergic ... 3, 2001, S. 373-6. doi:10.1007/s001250051629. PMID 11317671.. *Nibbelink M, Moulin K, Arnaud E, et al.: Brown fat UCP1 is ... 3, 1990, S. 255-64. doi:10.1002/jcb.240430306. PMID 2380264.. *Bouillaud F, Villarroya F, Hentz E, et al.: Detection of brown ...
  https://de.wikipedia.org/wiki/Thermogenin
*  beta-1 Adrenergic Receptors - beta 1 Adrenergic Receptor Summary Report | CureHunter
A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The adrenergic beta-1 receptors are equally sensitive to ... beta-1; Adrenergic Receptor, beta-1; Receptor, Adrenergic, beta-1; Adrenergic Receptor, beta 1; Adrenergic Receptors, beta-1; ... Adrenergic beta 1 Receptors; Receptor, beta-1 Adrenergic; Receptors, Adrenergic beta-1; Receptors, beta 1 Adrenergic; beta 1 ... Adrenergic Receptors; beta-1 Adrenergic Receptor; beta-1 Receptors, Adrenergic; Adrenergic beta-1 Receptors; Receptors, beta-1 ...
  http://www.curehunter.com/public/keywordSummaryD018342-beta-1-Adrenergic-Receptors-beta-1-Adrenergic-Receptor.do
*  Beta-1 adrenergic receptor - Wikipedia
Other adrenergic receptors Alpha-1 adrenergic receptor Alpha-2 adrenergic receptor Beta-2 adrenergic receptor Beta-3 adrenergic ... The beta-1 adrenergic receptor (β1 adrenoreceptor), also known as ADRB1, is a beta-adrenergic receptor, and also denotes the ... "The cardiac beta-adrenergic receptor. Structural similarities of beta 1 and beta 2 receptor subtypes demonstrated by ... "Human beta 1- and beta 2-adrenergic receptors: structurally and functionally related receptors derived from distinct genes". ...
  https://en.wikipedia.org/wiki/Beta-1_adrenergic_receptor
*  YOHIMBE: Uses, Side Effects, Interactions and Warnings - WebMD
Implications for the beta-adrenergic receptor hypothesis of antidepressant action. Arch.Gen.Psychiatry 1986;43(12):1155-1161. ... Brodde, O. E., Anlauf, M., Arroyo, J., Wagner, R., Weber, F., and Buck, K. D. Hypersensitivity of adrenergic receptors and ... Motulsky, H. J., Shattil, S. J., and Insel, P. A. Characterization of alpha 2-adrenergic receptors on human platelets using [ ... The alpha 2-adrenergic receptor antagonist yohimbine inhibits epinephrine-induced platelet aggregation in healthy subjects. ...
  https://www.webmd.com/vitamins-supplements/ingredientmono-759-yohimbe.aspx
*  GNAI2 - Wikipedia
McClue SJ, Milligan G (Sep 1990). "The alpha 2B adrenergic receptor of undifferentiated neuroblastoma x glioma hybrid NG108-15 ... "G alpha i-G alpha s chimeras define the function of alpha chain domains in control of G protein activation and beta gamma ... "Characterization and distribution of alpha 2-adrenergic receptors in the human intestinal mucosa". The Journal of Clinical ... Offermanns S, Schultz G, Rosenthal W (Feb 1991). "Evidence for opioid receptor-mediated activation of the G-proteins, Go and ...
  https://en.wikipedia.org/wiki/GNAI2
*  ABHD2 - Wikipedia
"Primary structure of a human protein which bears structural similarities to members of the rhodopsin/beta-adrenergic receptor ... This gene encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a very wide range of ... Edgar AJ, Polak JM (Apr 2002). "Cloning and tissue distribution of three murine alpha/beta hydrolase fold protein cDNAs". ... "Age-related pulmonary emphysema in mice lacking alpha/beta hydrolase domain containing 2 gene". Biochemical and Biophysical ...
  https://en.wikipedia.org/wiki/ABHD2
*  The Immature Heart and Anesthesia | Anesthesiology | ASA Publications
beta-adrenergic receptors and the adenylyl cyclase system are well developed by late fetal life (Figure 5). [93,169,170 ] beta ... 93,178 ] The number of muscarinic receptors peaks 1-2 weeks earlier than beta-adrenergic receptors. ... alpha1and beta1= adrenergic receptors; AC = adenylyl cyclase; AT II = angiotensin II; DAG = diacyl glycerol; G1= inhibitory G ... alpha1and beta1= adrenergic receptors; AC = adenylyl cyclase; AT II = angiotensin II; DAG = diacyl glycerol; G1= inhibitory G ...
  http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1948387
*  Bitolterol - Wikipedia
Bitolterol mesylate (Tornalate) is a short-acting β2 adrenergic receptor agonist used for the relief of bronchospasm in ... Walker, Susannah B.; Kradjan, Wayne A.; Bierman, C. Warren (6 May 1985). "Bitolterol Mesylate: A Beta-adrenergic Agent; ... 5 (3): 127-137. doi:10.1002/j.1875-9114.1985.tb03410.x. PMID 3895171. "ChEBI: Bitolterol". Chemical Entities of Biological ... Friedel HA; Brogden RN (1988). "Bitolterol. A preliminary review of its pharmacological properties and therapeutic efficacy in ...
  https://en.wikipedia.org/wiki/Bitolterol
*  G beta-gamma complex - Wikipedia
"Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors". ... April 2004). "Targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer in failing human hearts". ... June 1998). "Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene ... Heart failure can be characterized by a loss of β adrenergic receptor (βAR) signalling in heart cells. When the βAR is ...
  https://en.wikipedia.org/wiki/G_beta-gamma_complex
*  Age-Related Impairment in Insulin Release | Diabetes
Alterations in leukocyte beta-receptor affinity with aging. A potential explanation for altered beta-adrenergic sensitivity in ... Reduced beta-adrenergic receptor concentrations in ageing man. Nature 1977;267:856-858pmid:197415. ... Transgenic overexpression of beta(2)-adrenergic receptors in airway epithelial cells decreases bronchoconstriction. Am J ... Age-associated decrease in beta-adrenergic receptors and adenylate cyclase activity in rat brown adipose tissue. J Gerontol ...
  http://diabetes.diabetesjournals.org/content/61/3/692.full.print
*  Differential Responses to Salt Intake-Stress Interactions | Springer for Research & Development
Koepke, J. P., & DiBona, G. F. (1985a). Central beta-adrenergic receptors mediate renal nerve activity during stress in ... Koepke, J. P., & DiBona, G. F. (1986). Central adrenergic receptor control of renal function in conscious hypertensive rats. ... Koepke, J. P., Grignolo, A., Light, K. C., & Obrist, P. A. (1983a). Central beta-adrenoceptor mediation of the antinatriuretic ... Sodium responsiveness of central alphaadrenergic receptors in spontaneously hypertensive rats. Hypertension, 11, 326-333.PubMed ...
  https://rd.springer.com/chapter/10.1007/978-1-4899-0697-7_13
*  Gabriella Campadelli-Fiume - Wikipedia
"Assessment of compliance in children using inhaled beta adrenergic agonists". Ann Allergy. 62 (5): 406-9. PMID 2566291. Herpes ... The Herpes Simplex Virus JMP Mutant Enters Receptor-Negative J Cells through a Novel Pathway Independent of the Known Receptors ... AlphaV-beta3-Integrin Relocalizes nectin1 and Routes Herpes Simplex Virus to Lipid Rafts Chong YH, Soh CC (1966). "The protein ... Herpes Simplex Virus Glycoproteins gH/gL and gB Bind Toll-Like Receptor 2, and Soluble gH/gL Is Sufficient To Activate NF-κB ...
  https://en.wikipedia.org/wiki/Gabriella_Campadelli-Fiume
*  Effects of Angiotensin II Type 1 Receptor Blockade and Angiotensin-Converting Enzyme Inhibition on Cardiac β-Adrenergic Signal...
Decreased catecholamine sensitivity and beta-adrenergic receptor density in failing human hearts. N Engl J Med. 1982;307:205- ... β-Adrenergic Signal Transduction. β-Adrenergic Receptors. To address the question of whether the local sympathetic activation ... After the stimulation of β-adrenergic receptors with agonists, the number of receptors declines.48 When rats are treated with ... cAMP after stimulation of cardiac β-adrenergic receptors is due to a decline in the number of β-adrenergic receptors,11 12 13 ...
  http://hyper.ahajournals.org/content/31/3/747
*  Use of milrinone in cardiac surgical patients | SpringerLink
Homologous desensitization of beta adrenergic receptor coupled adenylate cyclase.J Biol Chem 1985;260:4561-4564.Google Scholar ... Agonist induced desensitization of the beta receptor linked adenylate cyclase.Pharmacol Rev 1983;35:5-31.Google Scholar ... The β-adrenergic pathway in the failing heart: Implications for inotropic therapy.Cardiology 1990;77(Suppl 1):1-32.Google ... One patient who had suffered an acute myocardial infarction with heart failure resistant to vasodilators, beta-agonists, and ...
  https://link.springer.com/article/10.1007/BF00877820
*  Patent US6476046 - Diazabicyclo[4.3.0]nonanes, and methods of use thereof - Google Patents
... including opiate receptors. An additional aspect of the present invention relates to the use of the diazabicyclo[4.3.0]nonanes ... the angiotensin receptor, the alpha- and beta-adrenergic receptors and the serotonin receptors. G protein-coupled receptors ... adrenergic receptors, sigma receptors, serotonin receptors, dopamine receptors, angiotensin receptors, adenosine receptors, ... beta subunits and alpha and beta subunits; GABA receptors (e.g., the bovine alpha 1 and beta 1 subunits (Schofield et al. (1987 ...
  http://www.google.com/patents/US6476046?dq=6,757,710
*  Labetalol - Wikipedia
Labetalol is highly selective for postsynaptic alpha1- adrenergic, and non-selective for beta-adrenergic receptors. It is about ... Labetalol is a dual alpha (α1) and beta (β1/β2) adrenergic receptor blocker and competes with other Catecholamines for binding ... Labetalol was the first drug created that combined both alpha- and beta- adrenergic receptor blocking properties. It was ... Labetalol acts by blocking alpha and beta adrenergic receptors, resulting in decreased peripheral vascular resistance without ...
  https://en.wikipedia.org/wiki/Labetalol
*  Current Recommendation for First Line Therapy of Uncomplicated Hypertension | SpringerLink
Prichard BNC: Beta-adrenergic receptor blockade in hypertension, past, present, and future. Br J Clin Pharmacol, 5: 379-390, ... Hansson L: Beta-adrenergic blockade in essential hypertension. Acta Med Scand, 550(Suppl 3): 7-40, 1973.Google Scholar ... The role of beta-blockers, calcium antagonists, and ACE-inhibitors. Med Clin N Am, 71: 947-957,1987.Google Scholar ... Beta-Blocker Heart Attack Trial Research Group: A randomized trial of propanolol in patients with acute myocardial infarction. ...
  https://link.springer.com/chapter/10.1007/978-1-4615-3946-9_7
*  Rhodopsin-like receptors - Wikipedia
Beta3 (ADRB3, B3AR) Dopamine receptor InterPro: IPR000929 D1 (DRD1, DADR) D2 (DRD2, D2DR) D3 (DRD3, D3DR) D4 (DRD4, D4DR) D5 ( ... IPR002232 Adrenergic receptor InterPro: IPR002233 Alpha1A (ADRA1A, A1AA) Alpha1B (ADRA1B, A1AB) Alpha1D (ADRA1D, A1AD) Alpha2A ... chemokine receptor (DARC, DUFF) G Protein-coupled Receptor 30 (GPER, CML2, GPCR estrogen receptor) Angiotensin II receptor ... Opioid receptor InterPro: IPR001418 delta Opioid receptor (OPRD1, OPRD) kappa Opioid receptor (OPRK1, OPRK) mu Opioid receptor ...
  https://en.wikipedia.org/wiki/Rhodopsin-like_receptors