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*  SPTAN1 - Wikipedia
Elevated protein expression of alpha II-spectrin has been detected in cerebrospinal fluid in patients with Guillain-Barré ... Alpha II-spectrin has shown promising utility as a biomarker for brain necrosis and apoptosis in infants with congenital heart ... Secondly, another insert of 20 amino acids in the 10th spectrin repeat, termed SH3i+, contains protein kinase A and protein ... Herrmann H, Wiche G (1987). "Plectin and IFAP-300K are homologous proteins binding to microtubule-associated proteins 1 and 2 ...
  https://en.wikipedia.org/wiki/SPTAN1
*  Patent US8492107 - Neural proteins as biomarkers for nervous system injury and other neural ... - Google Patents
Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) ... The present invention identifies biomarkers that are diagnostic of nerve cell injury and/or neuronal disorders. ... Blennow, K. "Cerebrospinal Fluid Protein Biomarkers for Alzheimer's Disease", NeuroRx: The Journal of the American Society for ... myelin associated protein (MAG), Oligodendrocyte NS-1 protein; Glial Protein Biomarkers: GFAP (P47819), Protein disulfide ...
  http://www.google.ca/patents/US8492107
*  Heart-type fatty acid binding protein - Wikipedia
"Identification of post-mortem cerebrospinal fluid proteins as potential biomarkers of ischemia and neurodegeneration". ... "Serum heart-type fatty acid-binding protein and cerebrospinal fluid tau: marker candidates for dementia with Lewy bodies". ... Heart-type fatty acid binding protein (hFABP) also known as mammary-derived growth inhibitor is a protein that in humans is ... "Fatty acid-binding protein, heart". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). Kleine AH, Glatz JF, Van ...
  https://en.wikipedia.org/wiki/Heart-type_fatty_acid_binding_protein
*  Impact of legumes and plant proteins consumption on cognitive performances in the elderly | Journal of Translational Medicine |...
A dietary pattern including plant proteins was independently associated with an improved ADAS-cog after 1 year (B = 0.584, p = ... Longitudinal cerebrospinal fluid biomarker changes in preclinical Alzheimer disease during middle age. JAMA Neurol. 2015;72: ... Globally, plant-based protein sources represented 37.5% of the total protein consumed.. Table 1 Demographic and clinical ... may suggest a greater effect of plant-based proteins on cognitive performance than that of animal protein. Our study also ...
  https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-017-1209-5
*  Cerebrospinal fluid synaptosomal-associated protein 25 is a key player in synaptic degeneration in mild cognitive impairment...
... and indicate the promise of CSF SNAP-25 and SNAP-25/Aβ42 ratio as diagnostic and prognostic biomarkers for the earliest ... Cerebrospinal fluid (CSF) synaptosomal-associated protein 25 (SNAP-25) is a newly discovered marker indicating synaptic damage ... Spearman correlation was performed to test the relationships between biomarkers. Overall diagnostic accuracy (area under the ... Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects. Ann Neurol. 2009;65:403-13. ...
  https://alzres.biomedcentral.com/articles/10.1186/s13195-018-0407-6
*  Frontiers | Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases |...
... alterations in metal homeostasis and aggregation of proteins such as α-synuclein (α-syn), which is a key constituent of Lewy ... alterations in metal homeostasis and aggregation of proteins such as α-synuclein (α-syn), which is a key constituent of Lewy ... and the reduced activity/protein levels of Aβ degrading enzymes such as neprilysin or insulin degrading enzyme. In addition, ... and the reduced activity/protein levels of Aβ degrading enzymes such as neprilysin or insulin degrading enzyme. In addition, ...
  https://www.frontiersin.org/articles/10.3389/fncel.2015.00124/full
*  Normalisation of cerebrospinal fluid biomarkers parallels improvement of neurological symptoms following HAART in HIV dementia ...
Elevated cerebrospinal fluid (CSF) levels of markers of neural injury and immune activation have been found in HIV dementia, ... Blennow K, Wallin A, Agren H, Spenger C, Siegfried J, Vanmechelen E: Tau protein in cerebrospinal fluid: a biochemical marker ... Normalisation of cerebrospinal fluid biomarkers parallels improvement of neurological symptoms following HAART in HIV dementia ... Andersson L, Blennow K, Fuchs D, Svennerholm B, Gisslen M: Increased cerebrospinal fluid protein tau concentration in neuro- ...
  https://bmcinfectdis.biomedcentral.com.preview-live.oscarjournals.springer.com/articles/10.1186/1471-2334-6-141
*  Cerebrospinal fluid tau and ptau181 increase with cortical amyloid deposition in cognitively normal individuals: Implications...
Snider B, Fagan A, Roe C, Shah A, Grant E, Xiong C, Morris J, Holtzman D. Cerebrospinal fluid biomarkers and rate of cognitive ... We explored the relationship between in vivo brain amyloid and CSF markers of proteins present in neurons and constituents of ... Cerebrospinal fluid beta-amyloid -42 and tau in control subjects at risk for Alzheimer's disease: the effect of APOE epsilon4 ... Fagan A, Head D, Shah A, Marcus D, Mintun M, Morris J, Holtzman D. Decreased cerebrospinal fluid Aβ42 correlates with brain ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2806678/
*  Frontiers | Bypassing hazard of housekeeping genes: their evaluation in rat granule neurons treated with cerebrospinal fluid of...
... aims to evaluate the expression stability of seven housekeeping genes in rat granule neurons treated with cerebrospinal fluid ... study aims to evaluate the expression stability of seven housekeeping genes in rat granule neurons treated with cerebrospinal ... fluid of MS patients. The selected reference genes were quantified by real time PCR and their expression stability was assessed ... It is a promising biofluid in the search for biomarkers and disease associated proteins in MS, both with respect to ...
  https://www.frontiersin.org/articles/10.3389/fncel.2015.00375/full
*  NFL (protein) - Wikipedia
"Cerebrospinal fluid biomarkers of white matter lesions - cross-sectional results from the LADIS study". European Journal of ... The Neurofilament light subunit can be measured with immunoassays in cerebrospinal fluid and plasma and reflects axonal damage ... Nomata Y, Watanabe T, Wada H (1983). "Highly acidic proteins from human brain: purification and properties of Glu-50 protein". ... Chin SS, Liem RK (1990). "Expression of rat neurofilament proteins NF-L and NF-M in transfected non-neuronal cells". Eur. J. ...
  https://en.wikipedia.org/wiki/NFL_(protein)
*  Frontiers | Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum | Frontiers in Neuroanatomy
Thus, sortilin fragments are a prominent constituent of the extracellularly deposited protein products at SPs in human cerebrum ... Thus, sortilin fragments are a prominent constituent of the extracellularly deposited protein products at SPs in human cerebrum ... Here we demonstrate deposition of fragments from the Vps10p protein sortilin at senile plaques (SPs) in aged and AD human ... Here we demonstrate deposition of fragments from the Vps10p protein sortilin at senile plaques (SPs) in aged and AD human ...
  https://www.frontiersin.org/articles/10.3389/fnana.2017.00045/full
*  Cerebrospinal fluid tau and ptau181 increase with cortical amyloid deposition in cognitively normal individuals: Implications...
Snider B, Fagan A, Roe C, Shah A, Grant E, Xiong C, Morris J, Holtzman D, (2009) Cerebrospinal fluid biomarkers and rate of ... Age but not diagnosis is the main predictor of plasma amyloid beta-protein levels. Arch Neurol 60: 958-964 *CrossRef, ... Fagan A, Head D, Shah A, Marcus D, Mintun M, Morris J, Holtzman D, (2009) Decreased cerebrospinal fluid Aβ42 correlates with ... Fagan A, Roe C, Xiong C, Mintun M, Morris J, Holtzman D, (2007) Cerebrospinal fluid tau/Aβ42 ratio as a prediction of cognitive ...
  http://onlinelibrary.wiley.com/doi/10.1002/emmm.200900048/references
*  Environmental Health Perspectives - Thyroid Hormones in Relation to Lead, Mercury, and Cadmium Exposure in the National...
Transthyretin, thyroxine, and retinol-binding protein in human cerebrospinal fluid:effect of lead exposure. Toxicol Sci 61(1): ... In addition, many studies have measured blood Cd, which is a good biomarker for recent exposure, but urinary Cd is a better ... was negatively correlated with transthyretin levels in cerebrospinal fluid samples from human patients (Zheng et al. 2001). ... Thyroid-disrupting chemicals: interpreting upstream biomarkers of adverse outcomes. Environ Health Perspect 117:1033-1041. ...
  https://ehp.niehs.nih.gov/1205239/
*  Is There Any Relationship between Apolipoprotein E Polymorphism and Idiopathic Parkinsonâ s Disease? | OMICS International
Apolipoprotein E is a plasma protein that has an important role in transport and metabolism of lipids in serum as well as in ... he human apolipoprotein E (apoE) protein is an important protein in plasma, cerebrospinal fluid, and interstitial fluid of ... the level of cerebrospinal biomarkers such as Amyloid-beta and Tau protein is changed in both degenerative diseases and the ... and cerebrospinal fluid biomarkers. Studies searching possible correlation between the age at onset of Parkinson's disease and ...
  https://www.omicsonline.org/open-access/is-there-any-relationship-between-apolipoprotein-e-polymorphism-andidiopathic-parkinsons-disease-2161-0460-1000296.php?aid=84495
*  Oligoclonal band - Wikipedia
... or cerebrospinal fluid (CSF) is analyzed. Two methods of analysis are possible: (a) protein electrophoresis, a method of ... Nevertheless, OCBs remain useful as a biomarker. Oligoclonal bands are an important indicator in the diagnosis of multiple ... Cerebrospinal fluid humoral immunity in the differential diagnosis of multiple sclerosis. PLoS One. 2017 Jul 20;12(7):e0181431 ... For the analysis of cerebrospinal fluid, a patient has a lumbar puncture performed, which collects some of his or her ...
  https://en.wikipedia.org/wiki/Oligoclonal_band
*  Biochemistry and cell biology of tau protein in neurofibrillary degeneration. - Semantic Scholar
... but also other cytoskeletal proteins, kinases, and phosphatases, motor proteins, chaperones, and membrane proteins). The ... Many of the unusual properties of Tau can be explained by its nature as a natively unfolded protein. Examples are the large ... Tau represents the subunit protein of one of the major hallmarks of Alzheimer disease (AD), the neurofibrillary tangles, and is ... Cerebrospinal Fluid Biomarkers in Alzheimer's Disease-From Brain Starch to Bench and Bedside. *Matthias Pawlowski, Sven G. ...
  https://www.semanticscholar.org/paper/Biochemistry-and-cell-biology-of-tau-protein-in-Mandelkow-Mandelkow/9c287c7a126bbe580110a731e508b90fd56ee8c4
*  Cerebrospinal fluid Presenilin-1 increases at asymptomatic stage in genetically determined Alzheimer's disease | Molecular...
Our data suggest that CSF-PS1 complexes may be useful as an early biomarker for AD, reflecting the pathology at asymptomatic ... can be detected as soluble heteromeric aggregates in cerebrospinal fluid (CSF). The aim of this study was to examine the ... in order to evaluate their potential as early biomarkers. Western blotting, differential centrifugation and co- ... Amyloid precursor protein trafficking, processing, and function. J Biol Chem. 2008;283:29615-9.View ArticlePubMedPubMed Central ...
  https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-016-0131-2
*  Contactin-2, a synaptic and axonal protein, is reduced in cerebrospinal fluid and brain tissue in Alzheimer's disease |...
... and biomarkers reflecting changes in these cellular processes are needed for early diagnosis and monitoring the progression of ... Contactin-2 is a synaptic and axonal membrane protein that interacts with proteins involved in the pathology of AD such as ... We hypothesized that AD might be characterized by changes in contactin-2 levels in the cerebrospinal fluid (CSF) and brain ... and other CSF biomarkers reflecting AD pathology were analyzed. We further characterized the expression of contactin-2 in ...
  https://alzres.biomedcentral.com/articles/10.1186/s13195-018-0383-x
*  Role of Interleukin-6 Correlated to C. pneumoniae Infection as a Biomarker for Prediction of Stroke Severity in Young Patients...
1 receptor antagonist in plasma and cerebrospinal fluid of patients following subarachnoid hemorrhage," British Journal of ... S. Suzuki, K. Tanaka, S. Nogawa et al., "Temporal profile and cellular localization of interleukin-6 protein after focal ... Role of Interleukin-6 Correlated to C. pneumoniae Infection as a Biomarker for Prediction of Stroke Severity in Young Patients ... and S-100 protein in patients with acute stroke," Stroke, vol. 27, no. 9, pp. 1553-1557, 1996. View at Publisher · View at ...
  https://www.hindawi.com/journals/ajn/2014/649106/ref/
*  Toward onset prevention of cognitive decline in adults with Down syndrome (the TOP-COG study): study protocol for a randomized...
... whether Aβ42/Aβ40 is a cognitive decline biomarker. We will describe percentages recruited from each source, the number of ... The amyloid precursor protein gene is on chromosome 21, and so is over-expressed in Down syndrome, leading to amyloid β (Aβ) ... Amyloid precursor protein. ApoE: Apolipoprotein E. CI: Confidence interval. CSF: Cerebrospinal fluid ... Effects of simvastatin on cerebrospinal fluid biomarkers and cognition in middle-aged adults at risk for Alzheimer's disease. J ...
  https://trialsjournal.biomedcentral.com/articles/10.1186/1745-6215-15-202
*  Soluble CD14 in cerebrospinal fluid is associated with markers of inflammation and axonal damage in untreated HIV-infected...
... biomarkers of inflammation in the cerebrospinal fluid (CSF) have been associated with cognitive impairment. One such biomarker ... Gisslen M, Hagberg L, Brew BJ, Cinque P, Price RW, Rosengren L. Elevated cerebrospinal fluid neurofilament light protein ... Cerebrospinal fluid biomarkers of white matter lesions - cross-sectional results from the LADIS study. Eur J Neurol. 2010;17: ... Cerebrospinal fluid neopterin: an informative biomarker of central nervous system immune activation in HIV-1 infection. AIDS ...
  https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-016-1510-6
*  L-methylfolate, Methylcobalamin, and N-acetylcysteine in the Treatment of Alzheimer's Disease-Related Cognitive Decline «...
Folate and methylation status in relation to phosphorylated tau protein(181P) and {beta}-amyloid(1-42) in cerebrospinal fluid. ... Blennow K, Zetterberg H. Cerebrospinal fluid biomarkers for Alzheimer's disease. J Alzheimers Dis. 2009;18:413-417.. 66. Lanari ... Cerebrospinal fluid biomarkers and prediction of conversion in patients with mild cognitive impairment: 4-year follow-up in a ... and cerebrospinal fluid biomarkers. The review also considers the rationale for a combined B-vitamin and antioxidant supplement ...
  http://primarypsychiatry.com/l-methylfolate-methylcobalamin-and-n-acetylcysteine-in-the-treatment-of-alzheimeras-diseasearelated-cognitive-decline/
*  Mercury Toxicity Medication: Chelating Agents, Gastrointestinal Decontaminants
Sallsten G, Barregard L, Wikkelso C, Schutz A. Mercury and proteins in cerebrospinal fluid in subjects exposed to mercury vapor ... Scalp hair as a biomarker in environmental and occupational mercury exposed populations: suitable or not?. Environ Res. 2008 ... modifying effects of metallothionein single-nucleotide polymorphisms on the association between mercury exposure and biomarker ...
  https://emedicine.medscape.com/article/1175560-medication
*  Delta sleep-inducing peptide - Wikipedia
... levels of DSIP in the plasma and cerebrospinal fluid are significantly deviated from the norm in patients with MDD, though ... It has been suggested that in the body it complexes with carrier proteins to prevent degradation, or exists as a component of a ... "Effect of delta-sleep inducing peptide-containing preparation Deltaran on biomarkers of aging, life span and spontaneous tumor ... "Decreased concentrations of delta-sleep inducing peptide in plasma and cerebrospinal fluid from depressed patients". Nordic ...
  https://en.wikipedia.org/wiki/Delta_sleep-inducing_peptide
*  Neurofilament - Wikipedia
"Cerebrospinal fluid biomarkers of white matter lesions - cross-sectional results from the LADIS study". European Journal of ... The fifth protein belonging to class IV, Nestin, is found in developing neurons and glia, and the presence of this protein is ... This protein is lost as development proceeds. The class III intermediate filament protein subunit peripherin is found in ... Class III contains the proteins vimentin, desmin, peripherin and glial fibrillary acidic protein (GFAP). The major ...
  https://en.wikipedia.org/wiki/Neurofilament