*  SPTAN1 - Wikipedia
Elevated protein expression of alpha II-spectrin has been detected in cerebrospinal fluid in patients with Guillain-Barré ... Alpha II-spectrin has shown promising utility as a biomarker for brain necrosis and apoptosis in infants with congenital heart ... Secondly, another insert of 20 amino acids in the 10th spectrin repeat, termed SH3i+, contains protein kinase A and protein ... Herrmann H, Wiche G (1987). "Plectin and IFAP-300K are homologous proteins binding to microtubule-associated proteins 1 and 2 ...
  https://en.wikipedia.org/wiki/SPTAN1
*  Patent US8492107 - Neural proteins as biomarkers for nervous system injury and other neural ... - Google Patents
Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) ... The present invention identifies biomarkers that are diagnostic of nerve cell injury and/or neuronal disorders. ... Blennow, K. "Cerebrospinal Fluid Protein Biomarkers for Alzheimer's Disease", NeuroRx: The Journal of the American Society for ... myelin associated protein (MAG), Oligodendrocyte NS-1 protein; Glial Protein Biomarkers: GFAP (P47819), Protein disulfide ...
  http://www.google.ca/patents/US8492107
*  Heart-type fatty acid binding protein - Wikipedia
"Identification of post-mortem cerebrospinal fluid proteins as potential biomarkers of ischemia and neurodegeneration". ... "Serum heart-type fatty acid-binding protein and cerebrospinal fluid tau: marker candidates for dementia with Lewy bodies". ... Heart-type fatty acid binding protein (hFABP) also known as mammary-derived growth inhibitor is a protein that in humans is ... "Fatty acid-binding protein, heart". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). Kleine AH, Glatz JF, Van ...
  https://en.wikipedia.org/wiki/Heart-type_fatty_acid_binding_protein
*  Frontiers | Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases |...
... alterations in metal homeostasis and aggregation of proteins such as α-synuclein (α-syn), which is a key constituent of Lewy ... alterations in metal homeostasis and aggregation of proteins such as α-synuclein (α-syn), which is a key constituent of Lewy ... and the reduced activity/protein levels of Aβ degrading enzymes such as neprilysin or insulin degrading enzyme. In addition, ... and the reduced activity/protein levels of Aβ degrading enzymes such as neprilysin or insulin degrading enzyme. In addition, ...
  https://www.frontiersin.org/articles/10.3389/fncel.2015.00124/full
*  Cerebrospinal fluid tau and ptau181 increase with cortical amyloid deposition in cognitively normal individuals: Implications...
Snider B, Fagan A, Roe C, Shah A, Grant E, Xiong C, Morris J, Holtzman D. Cerebrospinal fluid biomarkers and rate of cognitive ... We explored the relationship between in vivo brain amyloid and CSF markers of proteins present in neurons and constituents of ... Cerebrospinal fluid beta-amyloid -42 and tau in control subjects at risk for Alzheimer's disease: the effect of APOE epsilon4 ... Fagan A, Head D, Shah A, Marcus D, Mintun M, Morris J, Holtzman D. Decreased cerebrospinal fluid Aβ42 correlates with brain ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2806678/
*  Frontiers | Bypassing hazard of housekeeping genes: their evaluation in rat granule neurons treated with cerebrospinal fluid of...
... aims to evaluate the expression stability of seven housekeeping genes in rat granule neurons treated with cerebrospinal fluid ... study aims to evaluate the expression stability of seven housekeeping genes in rat granule neurons treated with cerebrospinal ... fluid of MS patients. The selected reference genes were quantified by real time PCR and their expression stability was assessed ... It is a promising biofluid in the search for biomarkers and disease associated proteins in MS, both with respect to ...
  https://www.frontiersin.org/articles/10.3389/fncel.2015.00375/full
*  NFL (protein) - Wikipedia
"Cerebrospinal fluid biomarkers of white matter lesions - cross-sectional results from the LADIS study". European Journal of ... The Neurofilament light subunit can be measured with immunoassays in cerebrospinal fluid and plasma and reflects axonal damage ... Nomata Y, Watanabe T, Wada H (1983). "Highly acidic proteins from human brain: purification and properties of Glu-50 protein". ... Chin SS, Liem RK (1990). "Expression of rat neurofilament proteins NF-L and NF-M in transfected non-neuronal cells". Eur. J. ...
  https://en.wikipedia.org/wiki/NFL_(protein)
*  Frontiers | Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum | Frontiers in Neuroanatomy
Thus, sortilin fragments are a prominent constituent of the extracellularly deposited protein products at SPs in human cerebrum ... Thus, sortilin fragments are a prominent constituent of the extracellularly deposited protein products at SPs in human cerebrum ... Here we demonstrate deposition of fragments from the Vps10p protein sortilin at senile plaques (SPs) in aged and AD human ... Here we demonstrate deposition of fragments from the Vps10p protein sortilin at senile plaques (SPs) in aged and AD human ...
  https://www.frontiersin.org/articles/10.3389/fnana.2017.00045/full
*  Cerebrospinal fluid tau and ptau181 increase with cortical amyloid deposition in cognitively normal individuals: Implications...
Snider B, Fagan A, Roe C, Shah A, Grant E, Xiong C, Morris J, Holtzman D, (2009) Cerebrospinal fluid biomarkers and rate of ... Age but not diagnosis is the main predictor of plasma amyloid beta-protein levels. Arch Neurol 60: 958-964 *CrossRef, ... Fagan A, Head D, Shah A, Marcus D, Mintun M, Morris J, Holtzman D, (2009) Decreased cerebrospinal fluid Aβ42 correlates with ... Fagan A, Roe C, Xiong C, Mintun M, Morris J, Holtzman D, (2007) Cerebrospinal fluid tau/Aβ42 ratio as a prediction of cognitive ...
  http://onlinelibrary.wiley.com/doi/10.1002/emmm.200900048/references
*  Is There Any Relationship between Apolipoprotein E Polymorphism and Idiopathic Parkinsonâ s Disease? | OMICS International
Apolipoprotein E is a plasma protein that has an important role in transport and metabolism of lipids in serum as well as in ... he human apolipoprotein E (apoE) protein is an important protein in plasma, cerebrospinal fluid, and interstitial fluid of ... the level of cerebrospinal biomarkers such as Amyloid-beta and Tau protein is changed in both degenerative diseases and the ... and cerebrospinal fluid biomarkers. Studies searching possible correlation between the age at onset of Parkinson's disease and ...
  https://www.omicsonline.org/open-access/is-there-any-relationship-between-apolipoprotein-e-polymorphism-andidiopathic-parkinsons-disease-2161-0460-1000296.php?aid=84495
*  Environmental Health Perspectives - Thyroid Hormones in Relation to Lead, Mercury, and Cadmium Exposure in the National...
Transthyretin, thyroxine, and retinol-binding protein in human cerebrospinal fluid:effect of lead exposure. Toxicol Sci 61(1): ... In addition, many studies have measured blood Cd, which is a good biomarker for recent exposure, but urinary Cd is a better ... was negatively correlated with transthyretin levels in cerebrospinal fluid samples from human patients (Zheng et al. 2001). ... Thyroid-disrupting chemicals: interpreting upstream biomarkers of adverse outcomes. Environ Health Perspect 117:1033-1041. ...
  https://ehp.niehs.nih.gov/1205239/
*  Oligoclonal band - Wikipedia
... or cerebrospinal fluid (CSF) is analyzed. Two methods of analysis are possible: (a) protein electrophoresis, a method of ... Nevertheless, OCBs remain useful as a biomarker. Oligoclonal bands are an important indicator in the diagnosis of multiple ... Cerebrospinal fluid humoral immunity in the differential diagnosis of multiple sclerosis. PLoS One. 2017 Jul 20;12(7):e0181431 ... For the analysis of cerebrospinal fluid, a patient has a lumbar puncture performed, which collects some of his or her ...
  https://en.wikipedia.org/wiki/Oligoclonal_band
*  Role of Interleukin-6 Correlated to C. pneumoniae Infection as a Biomarker for Prediction of Stroke Severity in Young Patients...
1 receptor antagonist in plasma and cerebrospinal fluid of patients following subarachnoid hemorrhage," British Journal of ... S. Suzuki, K. Tanaka, S. Nogawa et al., "Temporal profile and cellular localization of interleukin-6 protein after focal ... Role of Interleukin-6 Correlated to C. pneumoniae Infection as a Biomarker for Prediction of Stroke Severity in Young Patients ... and S-100 protein in patients with acute stroke," Stroke, vol. 27, no. 9, pp. 1553-1557, 1996. View at Publisher · View at ...
  https://www.hindawi.com/journals/ajn/2014/649106/ref/
*  Soluble CD14 in cerebrospinal fluid is associated with markers of inflammation and axonal damage in untreated HIV-infected...
... biomarkers of inflammation in the cerebrospinal fluid (CSF) have been associated with cognitive impairment. One such biomarker ... Gisslen M, Hagberg L, Brew BJ, Cinque P, Price RW, Rosengren L. Elevated cerebrospinal fluid neurofilament light protein ... Cerebrospinal fluid biomarkers of white matter lesions - cross-sectional results from the LADIS study. Eur J Neurol. 2010;17: ... Cerebrospinal fluid neopterin: an informative biomarker of central nervous system immune activation in HIV-1 infection. AIDS ...
  https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-016-1510-6
*  L-methylfolate, Methylcobalamin, and N-acetylcysteine in the Treatment of Alzheimer's Disease-Related Cognitive Decline «...
Folate and methylation status in relation to phosphorylated tau protein(181P) and {beta}-amyloid(1-42) in cerebrospinal fluid. ... Blennow K, Zetterberg H. Cerebrospinal fluid biomarkers for Alzheimer's disease. J Alzheimers Dis. 2009;18:413-417.. 66. Lanari ... Cerebrospinal fluid biomarkers and prediction of conversion in patients with mild cognitive impairment: 4-year follow-up in a ... and cerebrospinal fluid biomarkers. The review also considers the rationale for a combined B-vitamin and antioxidant supplement ...
  http://primarypsychiatry.com/l-methylfolate-methylcobalamin-and-n-acetylcysteine-in-the-treatment-of-alzheimeras-diseasearelated-cognitive-decline/
*  Delta sleep-inducing peptide - Wikipedia
... levels of DSIP in the plasma and cerebrospinal fluid are significantly deviated from the norm in patients with MDD, though ... It has been suggested that in the body it complexes with carrier proteins to prevent degradation, or exists as a component of a ... "Effect of delta-sleep inducing peptide-containing preparation Deltaran on biomarkers of aging, life span and spontaneous tumor ... "Decreased concentrations of delta-sleep inducing peptide in plasma and cerebrospinal fluid from depressed patients". Nordic ...
  https://en.wikipedia.org/wiki/Delta_sleep-inducing_peptide
*  Neurofilament - Wikipedia
"Cerebrospinal fluid biomarkers of white matter lesions - cross-sectional results from the LADIS study". European Journal of ... The fifth protein belonging to class IV, Nestin, is found in developing neurons and glia, and the presence of this protein is ... This protein is lost as development proceeds. The class III intermediate filament protein subunit peripherin is found in ... Class III contains the proteins vimentin, desmin, peripherin and glial fibrillary acidic protein (GFAP). The major ...
  https://en.wikipedia.org/wiki/Neurofilament
*  Elevated Levels of Innate Immune Modulators in Lymph Nodes and Blood Are Associated with More-Rapid Disease Progression in...
Cerebrospinal fluid interferon-gamma-inducible protein 10 (IP-10, CXCL10) in HIV-1 infection. J. Neuroimmunol. 168:154-163. [ ... Inflammatory and coagulation biomarkers and mortality in patients with HIV infection. PLoS Med. 5:e203. [PMC free article] [ ... other researchers have suggested using high levels of CXCL10 in cerebrospinal fluid for the diagnosis of AIDS dementia complex ... IFN-inducible protein of 10 kDa, IP-10); the proinflammatory cytokines IFN-γ, IL-12, and TNF-α; and the anti-inflammatory ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2786739/
*  A Rare Case of Unilateral Progressive Vision Loss and Pachymeningitis
Cerebrospinal fluid (CSF) constituents revealed 4 white blood cells per microliter with lymphocytic predominance; glucose and ... There are no serologic biomarkers available to confirm the diagnosis. In the past, melanocyte-specific proteins have been ... B) Macula OCT shows massive submacular fluid with resolution of submacular fluid during treatment. (C) Fundus fluorescein ... Neuroimaging may demonstrate meningitis, and can detect subretinal fluid. Spinal fluid typically demonstrates lymphocytic ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC5123095/
*  Plus it
Cerebrospinal fluid interleukin-10 is a potentially useful biomarker in immunocompetent primary central nervous system lymphoma ... Protein biomarker identification in the CSF of patients with CNS lymphoma. J Clin Oncol 2008;26:96-105 doi:10.1200/JCO.2007.12. ... Diagnostic value of interleukin-10 in cerebrospinal fluid for diffuse large B-cell lymphoma of the central nervous system. J ... CSF analysis for protein biomarker identification in patients with leptomeningeal metastases from CNS lymphoma ...
  http://www.ajnr.org/content/37/1/74
*  Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke | Journal of Neuroinflammation |...
Cerebrospinal fluid pentraxin 3 early after subarachnoid hemorrhage is associated with vasospasm. Intensive Care Med. 2011;37: ... Mannose-binding lectin serine proteases and associated proteins of the lectin pathway of complement: two genes, five proteins ... Blood biomarkers in stroke: research and clinical practice. Int J Stroke Off J Int Stroke Soc. 2012;7:435-9.View ArticleGoogle ... High-sensitivity C-reactive protein and risk of sepsis. PloS One. 2013;8, e69232.PubMedPubMed CentralView ArticleGoogle Scholar ...
  https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-016-0481-2
*  ASMscience | Protein Analysis for Dia
... to achieve higher-resolution separations of immunoglobulins for evaluation of oligoclonal bands in cerebrospinal fluid. ... The simplest is the qualitative question of whether a protein serving as a physiological marker is present or absent in a ... Blood represents the most common specimen collected for protein analysis. There are a variety of different types of diagnostic ... The electrophoretic method provides higher resolution than the typical methods for serum protein analysis, and it is applied in ...
  http://www.asmscience.org/content/book/10.1128/9781555815905.ch03
*  ASMscience | Protein Analysis in the
... especially with the explosion of clinically relevant biomarker analysis. Of particular import are the tremendous advances that ... protein based or not, are still applicable. This chapter covers the basic principles of protein testing in the clinical ... However, regulatory processes have not kept up with the burgeoning research in the area of protein analysis, and new diagnostic ... tests for protein analytes are approved for clinical testing at a glacial pace. Nonetheless, it is critical for the clinical ...
  http://www.asmscience.org/content/book/10.1128/9781555818722.ch4
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... and intraneuronal accumulation of hyperphosphorylated tau protein. Because cerebrospinal fluid (CSF) is in direct contact with ... imaging biomarkers, functional brain imaging, multivariate spatial covariance analysis, global normalization, differential ... Neuroscience, Issue 21, Cerebrospinal fluid, Alzheimer's disease, Transgenic mouse, β-amyloid, tau ... A Technique for Serial Collection of Cerebrospinal Fluid from the Cisterna Magna in Mouse ...
  https://www.jove.com/visualize/abstract/24722237/age-related-incidence-family-history-frontotemporal-dementia-data
*  Frontiers | Visual Dysfunction in Posterior Cortical Atrophy | Neurology
Cerebrospinal Fluid (CSF) Analysis with Measurement of AD Pathology Biomarkers. Cerebrospinal fluid examination is not required ... Markers of neuronal injury, the tau, and neurofilament light (NFL) proteins are elevated in the sera of AD patients, but levels ... as well as in vivo pathological biomarkers for AD. In the particular case of LBD, to which no disease-specific biomarker is ... Serum Biomarkers of AD. Decrement of peripheral β-amyloid does occur in AD, but later than CSF levels, so that an important ...
  https://www.frontiersin.org/articles/10.3389/fneur.2017.00389/full