*  Fibrinogen alpha chain - Wikipedia
Alternative splicing results in two isoforms that vary in the carboxy-terminus. Fibrinogen alpha chain has been shown to ... Fibrinogen Fibrinogen gamma chain GRCh38: Ensembl release 89: ENSG00000171560 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... "Carboxy-terminal-extended variant of the human fibrinogen alpha subunit: a novel exon conferring marked homology to beta and ... Fibrinogen alpha chain is a protein that in humans is encoded by the FGA gene. The protein encoded by this gene is the alpha ...
  https://en.wikipedia.org/wiki/Fibrinogen_alpha_chain
*  ICAM-1 - Wikipedia
... and a carboxy-terminus cytoplasmic domain. The structure of ICAM-1 is characterized by heavy glycosylation, and the protein's ... and fibrinogen. These three proteins are generally expressed on endothelial cells and leukocytes, and they bind to ICAM-1 to ... ICAM-1 is a transmembrane protein possessing an amino-terminus extracellular domain, a single transmembrane domain, ... Abraham G, Colonno RJ (Aug 1984). "Many rhinovirus serotypes share the same cellular receptor". Journal of Virology. 51 (2): ...
  https://en.wikipedia.org/wiki/ICAM-1
*  US6103888A - Mammalian cationic proteins having lipopolysaccharide binding and anti-coagulant activity - Google Patents
... fragment found at the carboxy-terminus of CAP18. Polypeptides are capable of binding to LPS and inhibiting LPS-mediated ... The sequence derived from Edman degradation is found at the carboxy-terminus of the protein beginning at amino acid position ... Prothrombinase converts prothrombin (factor II) to thrombin (IIa). Thrombin generates fibrin monomers from fibrinogen. Because ... CAP18 includes a short peptide, usually present at its carboxy-terminus, referred to as the reactive nitrogen inhibitory ...
  https://patents.google.com/patent/US6103888
*  Patent US6887473 - Inhibition of angiogenesis in disease states with an anti-αvβ3 monoclonal ... - Google Patents
COOH refers to the free carboxy group present at the carboxy terminus of a polypeptide. In keeping with standard polypeptide ... wherein said antibody preferentially inhibits fibrinogen binding to αvβ3 compared to fibrinogen binding to αIIbβ3. ... The unprotected linear peptide with free amino and carboxy termini so obtained is converted to its corresponding cyclic peptide ... herein by formulae whose left and right orientation is in the conventional direction of amino-terminus to carboxy-terminus. ...
  http://www.google.com.au/patents/US6887473
*  US5719041A - DNA encoding ecotin homologs - Google Patents
USA 82:5132 1985!). Solid phase synthesis begins at the carboxy-terminus of the putative peptide by coupling a protected amino ... Factor Xa activates prothrombin to thrombin which cleaves fibrinogen to fibrin and ultimately results in the formation of a ... ID NO:8) and corresponded to the amino terminus of ecotin.. FIG. 6. Determination of the molecular weight of the ecotin •FXa ... For insoluble carriers, those which react with the carboxy group of the C-terminal amino acid to form a bond which is readily ...
  https://patents.google.com/patent/US5719041?oq=patent%3A5992892
*  Patente US5906975 - Conformationally stabilized cell adhesion peptides - Google Patentes
... the presence of a negatively charged group at the amino terminus and a positively charged group at the carboxy terminus creates ... Haverstick et al., Inhibition of Platelet Adhesion to Fibronectin, Fibrinogen and von Willebrand Factor Substrates by a ... The N-terminus of Gly 1 was cyclized to the side chain carboxyl group of Asp 7. The cyclization was accomplished by adding 10 ... Additional amino acids can be present at the NH2 and COOH termini, as represented by X and Y, respectively. ...
  http://www.google.es/patents/US5906975?hl=es&dq=flatulence
*  The ubiquitous gp63-like metalloprotease from lower trypanosomatids: in the search for a function
Exopeptidases cleave the peptide bond proximal to the amino (NH2)or carboxy (COOH) termini of the proteinaceous substrate, ... fibrinogen, hemoglobin and immunoglobulins (Bouvier et al. 1990), as well as extracellular matrix components such as type IV ... Aminopeptidases act at a free NH2 terminus of the polypeptide chain and liberate a single amino acid residue, a dipeptide or a ... Based on their site of action at the NH2 or COOH terminus, the exopeptidases are classified as amino- or carboxipeptidases, ...
  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652006000400006&lng=en&tlng=en
*  Regulation by Fibrinogen and Its Products of Intercellular Adhesion Molecule-1 Expression in Human Saphenous Vein Endothelial...
... sequences at the carboxy terminus and the middle section of the 2 Aα chains of fibrinogen17 are able to bind to endothelial ... at 1 μmol/L fibrinogen, to 171±18% at 2 μmol/L fibrinogen, and to 210±20% at 4 μmol/L fibrinogen (ANOVA, P,0.05; n=4). After ... of basal levels at 0.3 μmol/L fibrinogen, to 112±8% at 1 μmol/L fibrinogen, to 109±10% at 2 μmol/L fibrinogen, and to 94±4% at ... The role of fibrinogen as a bridging ligand was attributed to binding of the γ117-133 sequence of the fibrinogen D domain to ...
  http://atvb.ahajournals.org/content/20/3/652
*  Clinical value of serum transferrin measurements - IFCC
... a 28-residue transmembrane region and a 671-residue extracellular carboxyl-terminus (McClelland et al 1984, Schneider et al ... The structure of the ectodomain has striking similarities to the membranebound carboxy peptidase II (Lawrence et al 1999), ... to recombinant human erythropoietin in patients with the anemia of renal failure by serum transferrin receptor and fibrinogen. ... 1984 Oct 18-24;311(5987):675-8.. Shih YJ, Baynes RD, Hudson BG, Flowers CH, Skikne BS, Cook JD. Serum transferrin receptor is a ...
  http://www.ifcc.org/ifcc-communications-publications-division-cpd/ifcc-publications/ejifcc-journal/e-journal-volumes/ejifcc-2002-vol-13/vol-13-no-2/clinical-value-of-serum-transferrin-measurements/
*  Compositions for the Detection and Treatment of Colorectal Cancer - Patent application
... terminus or carboxy terminus of a polypeptide of the invention. An amino acid spacer is a sequence of amino acids that are not ... TABLE-US-00086 Fibrinogen alpha chain (FGA) (e.g., GenBank Accession Number NP 000499 (SEQ ID NO: 86)): 1 mfsmrivclv lsvvgtawta ... immediately contiguous with one or both of the amino and carboxy termini of the polypeptide. [0076] Polypeptides of the ... TABLE-US-00102 Fibrinogen Beta Chain Precursor (e.g., GenBank Accession Number NP 005132 (SEQ ID NO: 102)): 1 mkrmvswsfh ...
  http://www.patentsencyclopedia.com/app/20110151490
*  Clotting Factor-Fc Chimeric Proteins to Treat Hemophilia - Patent application
The portion of an immunoglobulin constant region will have both an N, or an amino terminus, and a C, or carboxy terminus. In ... Factor Xa is required to convert prothrombin to thrombin, which converts fibrinogen to fibrin as a final stage in forming a ... wherein X is linked at its C terminus to the N terminus of L, and L is linked at its C terminus to the N terminus of F and ... When a is zero X is directly linked at its C terminus to the N terminus of F. For example, but not as a limitation, a may be 0 ...
  http://www.patentsencyclopedia.com/app/20130273047
*  COMBINATION THERAPY USING RECEPTOR TYROSINE KINASE INHIBITORS AND ANGIOGENESIS INHIBITORS - Patent application
Fab' " fragments differ from Fab fragments by the addition of a few residues at the carboxy terminus of the heavy chain CH1 ... αvβ3 binds a large variety of ligands, including fibrin, fibrinogen, laminin, thrombospondin, vitronectin and von Willebrand's ... fibrinogen, von Willebrand's factor, thrombospondin, laminin; for αvβ5: vitronectin; for αvβ1: fibronectin and vitronectin; for ... 1984) J. EXP. Med. 160, 1686; Liu et a. (1985) Proc. Natl. Acad. Sci. USA 82, 8648). Other methods include those described by ...
  http://www.patentsencyclopedia.com/app/20110223167
*  Patente US6025194 - Nucleic acid sequence of senescence asssociated gene - Google Patentes
The amino acid sequence of the pGS-GC6 fusion protein of the invention is shown below in the amino to carboxy terminus ... AA442793 758863 fibrinogen receptor (glycoprotein IIb) AA444171 759500 ALK-3 AA424414 760179 peripherin (RDS) AA418421 767295 ... Useful pGC6 proteins of the invention may include heterologous sequences linked at the amino- or carboxy-terminus, wherein the ... amino acid sequences are shown in the amino to carboxy terminus direction; an * designates a stop codon). ...
  http://www.google.es/patents/US6025194
*  LEUKOCYTE-BINDING POLYPEPTIDES AND USES THEREOF - Patent application
Additions and deletions to a peptide may be at the amino terminus, the carboxy terminus, and/or internal, can be produced by ... fibrinogen, but in contrast to the fibrinogen mutant mice, cell adhesion to immobilized fibrinogen is still possible and the ... invention can be expressed as fusion proteins fused at the N-terminus or C-terminus, or at both termini, to one or more of ... fibrinogen. In contrast to soluble fibrinogen, immobilized fibrinogen can mediate cell adhesion by binding to non-activated Mac ...
  http://www.patentsencyclopedia.com/app/20090291048
*  COMPOSITIONS AND METHODS FOR TREATING PATHOLOGIC ANGIOGENESIS AND VASCULAR PERMEABILITY - Patent application
The paxillin binding sequence (PBS) on GIT1 is found at the carboxy-terminus of the protein and has been shown to prevent ... Additionally, cells expressing αIIb:β3 or αIIb-Robo4:β3 were plated on fibronectin and fibrinogen, and Rac-GTP levels were ... To clarify which Lim domain is required for binding to Robo4, serial deletions were made from the carboxy terminus of paxillin ... As described previously, cells expressing αIIb-Robo4:β3 displayed a decrease in cell area when plated on fibrinogen, but this ...
  http://www.patentsencyclopedia.com/app/20100222401
*  Patent US7468458 - Accelerants for the modification of non-natural amino acids and non-natural ... - Google Patents
Similarly, a "carboxy terminus modification group" refers to any molecule that can be attached to the carboxy terminus of a ... fibrinogen, fibronectin, four-helical bundle protein, G-CSF, glp-1, GM-CSF, glucocerebrosidase, gonadotropin, growth factor, ... An "amino terminus modification group" refers to any molecule that can be attached to the amino terminus of a polypeptide. ... Multifunctional polymer derivatives include, but are not limited to, linear polymers having two termini, each terminus being ...
  http://www.google.com/patents/US7468458
*  Production of glycosylated polypeptides in micro algae - Institut Francais de Recherche pour l'Exploitation de la Mer (IFREMER)
... and/or truncations of the amino acid sequence at either or both the amino or carboxy termini. A mutein may have the same but ... fibrinogen and others. While transgenic goats and other transgenic animals (mice, sheep, cows, etc.) can be genetically ... which are typically found at the C-terminus of proteins that induced a retrograde transport into the ER or Golgi. ... 1984). The released sialic acids were passed through a Microcon® YM-10 (Fisher Scientific) prior to DMB derivatization. The DMB ...
  http://www.freepatentsonline.com/8728761.html
*  US5437864A - Method of inhibiting blood coagulation in extracorporeal circulation by inhibiting human tissue factor -...
1 from about residue 1 at its amino terminus to about residue 209 through about residue 224 at its carboxy terminus. Thus, ... Jacek Musial, et al.; Loss of Fibrinogen Receptors from the Platelet . . . The Journal of Laboratory and Clinical Medicine; vol ... 1 from about residue 32 at its amino terminus to about residue 209 through about residue 224 at its carboxy terminus. Thus, ... shown from left to right and in the direction from amino-terminus to carboxy-terminus using the single letter amino acid ...
  https://patents.google.com/patent/US5437864?oq=flatulence
*  MONOCLONAL ANTIBODIES AGAINST ANGPTL4 - Patent application
The VH domain is at the amino-terminus of the heavy chain, and the CH3 domain is at the carboxy-terminus. In a native antibody ... 6G11 specifically bound to the C-terminal fibrinogen-like domain of mouse ANGPTL4. O. Epitope Binning [0311]To determine if ... From N-terminus to C-terminus, both light and heavy chain variable regions typically comprise the domains FR1, CDR1, FR2, CDR2 ... The variable region of the light chain is at the amino-terminus of the light chain. In a native antibody, the variable regions ...
  http://www.patentsencyclopedia.com/app/20110008359
*  Patent US5837672 - Methods and compositions for the detection of soluble β-amyloid peptide - Google Patents
Likewise, an antibody to the last 20 amino acids at the carboxyl terminus of APP (60 amino acids beyond the βAP region) also ... 167:1094-1101). The detection of fragments of the carboxy-terminal portion of APP in plasma has also been reported (Rumble et ... 1-1000 0.2Fibrinogen Type I 1-1000 0Fibrinogen Type II 1-1000 0Fibrinogen Type III 1-1000 0 ... Seubert, et al., "Secretion of Beta-amyloid precursor protein cleaved at the amino terminus of the Beta-amyloid peptide", ...
  http://www.google.com/patents/US5837672?dq=6519629
*  US5001230A - T cell activation markers - Google Patents
Internal segments, unlike the amino and carboxy termini, will differ significantly at the "unattached end" from the same ... fibrinogen, or the like. ... and then attaching the peptide by way of its carboxy terminus. ... Amino acids of Formula III are numbered with respect to the N-terminus of the mature H400 polypeptide. Thus, Ser5 is serine at ... 1984. Molecular cloning of a cDNA encoding human antihaemophilic factor. Miner et al. 1992. The basic region of AP-1 specifies ...
  https://patents.google.com/patent/US5001230
*  LOW PARTICULATE LUBRICIOUS COATING WITH VINYL PYRROLIDONE AND ACIDIC POLYMER-CONTAINING LAYERS - Patent application
Laminins are heterotrimers of three non-identical chains: one α, β, and γ chain that associate at the carboxy-termini into a ... Fibrinogen adsorption was significantly less on the coating with the poly (acrylic acid) top coat compared to the photo-PVP and ... on the C-terminus, N-terminus, or both) the core sequence. The one or more additional amino acids that flank the core sequence ... 15 is a graph showing results of an in vitro fibrinogen immunoassay measuring absorption from human platelet poor plasma to ...
  http://www.patentsencyclopedia.com/app/20140193474
*  Patent US5856090 - DNA-methylase linking reaction - Google Patents
In the next step, a glutathione S-transferase gene is generated so that it can be attached to the carboxy-terminus (3'-end) of ... a fibrinogen type III domain or a protein including a fibrinogen type III domain, a DNA binding domain or a protein including a ... A first terminus of the vector is complementary to a first terminus of the insert, and the second terminus of the vector is ... The construct also includes a factor X protease cleavage site near the carboxy-terminus of the Msp I methylase gene. ...
  http://www.google.com/patents/US5856090?dq=6861155
*  Assay of procarboxypeptidase U, a novel determinant of the fibrinolytic cascade, in human plasma. - Free Online Library
20.) Fleury V, Angles-Cano E. Characterization of the binding of plasminogen to fibrin surfaces: the role of carboxy-terminal ... Combined use of markers of muscle necrosis and fibrinogen conversion in the early differentiation of myocardial infarction and ... from the COOH terminus of peptides and proteins. In the plasma compartment, this family of enzymes is represented by ...
  https://www.thefreelibrary.com/Assay+of+procarboxypeptidase+U%2C+a+novel+determinant+of+the+...-a0209404235
*  Primed to Understand Fibrinogen in Cardiovascular Disease | Arteriosclerosis, Thrombosis, and Vascular Biology
Fibrinogen gamma′ chain carboxy terminal peptide selectively inhibits the intrinsic coagulation pathway. Br J Haematol. 2007; ... chain containing a unique 20-amino acid sequence at the C terminus. Between 8% and 15% of circulating fibrinogen in healthy ... to-total fibrinogen ratio7-11 suggests that γA/γ′ fibrinogen is not simply a biomarker for increased total fibrinogen. Together ... fibrinogen versus γA/γA fibrinogen.30 Accordingly, γA/γ′ fibrinogen may be increased to downregulate inflammation-induced ...
  http://atvb.ahajournals.org/content/36/1/4