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*  15-Hydroxyeicosatetraenoic acid - Wikipedia
... leukotriene D4, and E4. Formation of the leukotrienes is initiated by 5-lipoxygenase metabolism of arachidonic acid to form a 5 ... a metabolite of arachidonic acid. Various cell types metabolize arachidonic acid to 15(S)-hydroperoxyeicosatetraenoic acid (15( ... 13E-eicosatetraenoic acid (15(R)-HpETE). Human cells release arachidonic acid (i.e. 5Z,8Z,11Z,14Z-eicosatetraenoic acid) from ... Maas, R. L.; Turk, J; Oates, J. A.; Brash, A. R. (1982). "Formation of a novel dihydroxy acid from arachidonic acid by ...
  https://en.wikipedia.org/wiki/15-Hydroxyeicosatetraenoic_acid
*  Similar articles for PubMed (Select 2995993) - PubMed - NCBI
Arachidonic acid metabolism in normal and hypereosinophilic syndrome human eosinophils: generation of leukotrienes B4, C4, D4 ... Arachidonic acid metabolism in bovine alveolar macrophages. Effect of calcium ionophore on lipoxygenase products. ... Metabolism of arachidonic acid through the 5-lipoxygenase pathway in normal human peritoneal macrophages. ... Generation of lipoxygenase metabolites of arachidonic acid by monolayer cultures of tracheal epithelial cells and intact ...
  https://www.ncbi.nlm.nih.gov/pubmed?db=pubmed&cmd=link&linkname=pubmed_pubmed&uid=2995993
*  Dexamethasone - BML-EI126 - Enzo Life Sciences
A2 and C activities and arachidonic acid release from endothelial cells in response to bradykinin and leukotriene D4: M.A. ...
  http://www.enzolifesciences.com/BML-EI126/dexamethasone/
*  Role of a nonsteroidal anti-inflammatory agent, ibuprofen, in coronary revascularization after acute myocardial infarction |...
Inhibition of cyclooxygenase resulted in increased accumulation of nonesterified fatty acids, particularly arachidonic acid, in ... Ezra D, Boyd LM, Feuerstein G, Goldstein RE (1983) Coronary constriction by leukotriene C4, D4, and E4 in the intact pig heart ... Fiedler VB, Abram TS (1987) Effects of intracoronary leukotriene D4 infusion on the coronary circulation, hemodynamics, and ... Accumulation of unesterified arachidonic acid in ischemic canine myocardium. Circ Res 54:313-322PubMedGoogle Scholar ...
  https://link.springer.com/article/10.1007/BF01907014
*  Multiple Bradykinin Receptors: Results of Studies Using a Novel Class of Receptor Antagonists | SpringerLink
A2 and C activities and arachidonic acid release from endothelial cells in response to bradykinin and leukotriene D4, ... Arachidonic Acid Release Tissue Kallikrein Bradykinin Receptor High Molecular Weight Kininogen Bradykinin Antagonist ... Murayama, T., and Ui, M., 1976, Receptor-mediated inhibition of adenylate cyclase and stimulation of arachidonic acid release ... Boschcov, P., Paiva, A.C.M., Paiva, T.B., and Shimuta, S.I., 1984, Further evidence for the existence of two receptor sites for ...
  https://link.springer.com/chapter/10.1007/978-1-4757-5971-6_9
*  The effect of leukotriene antagonists, lipoxygenase inhibitors and selected standards on leukotriene-mediated allergic...
D4, and E4are major contributors to the pathobiology of human bronchial asthma. Therefore, it is likely that compounds that ... I. Kennedy, M. Langley and C. J. Whelan,The release and metabolism of 3 H-arachidonic acid from guinea pig perfused lungs in ... A simple method for the study of the action of drugs on the release and metabolism of arachidonic acid. J. Pharmacol. Methods6 ... E. J. Goetzl,Mediators of immediate hypersensitivity derived from arachidonic acid. N. Eng. J. Med.303, 822-825 (1980).Google ...
  https://link.springer.com/article/10.1007/BF01967398
*  Lipoxygenase Inhibitors as Potential Cancer Chemopreventives | Cancer Epidemiology, Biomarkers & Prevention
Arachidonic acid metabolism of cytosolic fractions of Lewis lung carcinoma cells. Adv. Prostaglandin Thromboxane Leukotriene ... Miller A. M., Weiner R. S., Ziboh V. A. Evidence for the role of leukotrienes C4 and D4 as essential intermediates in CSF- ... which metabolizes arachidonic acid into 12(S)-HETE (54) ; the leukocyte type, or L-12-LO, which converts arachidonic acid or ... or 15-carbon atoms of arachidonic acid (17, 18, 19) . In cells, arachidonic acid is esterified to membrane phospholipids in the ...
  http://cebp.aacrjournals.org/content/8/5/467.long
*  Leukotriene - Wikipedia
Leukotrienes are a family of eicosanoid inflammatory mediators produced in leukocytes by the oxidation of arachidonic acid (AA ... leukotriene D4) is to trigger contractions in the smooth muscles lining the bronchioles; their overproduction is a major cause ... Leukotrienes are synthesized in the cell from arachidonic acid by arachidonate 5-lipoxygenase. The catalytic mechanism involves ... and the essential fatty acid eicosapentaenoic acid (EPA) by the enzyme arachidonate 5-lipoxygenase. Leukotrienes use lipid ...
  https://en.wikipedia.org/wiki/Leukotriene
*  flare ups in endodontics -1 etiological factors | Inflammation | Immune System
... the arachidonic acid is metabolized largely by a 5-lipooxygenase to a series of products called leukotrienes (43). One of these ... Loss of glutamic acid converts LT C4 into LT D4, which, in turn, forms LT E4 by the loss of glycine. This last group of ... They are derived from arachidonic acid, a 20-carbon polyunsaturated fatty acid in the cell membrane. The enzyme phospholipase ... It is the principal metabolite of arachidonic acid in mast cells. When these cells are activated by IgE, PGD2 participates in ...
  https://www.scribd.com/document/29924342/flare-ups-in-endodontics-1-etiological-factors
*  Thomas V. McCaffrey | Moffitt Cancer Center
The effect of arachidonic acid metabolites on the ciliary beat frequency of human nasal mucosa in vitro. Acta Otolaryngol. 1992 ... Cyrus C, Yang B, McCaffrey T. Leukotrienes C4 and D4 increase the ciliary beat frequency in human upper airway mucosa in vitro ... 1984 Jun;92(3):308-311. Pubmedid: 6431371. *Mertz JS, McCaffrey TV, Kern EB. Role of the nasal airway in regulation of airway ... 1984 Oct;92(5):546-550. Pubmedid: 6438585. *Mertz JS, McCaffrey TV, Kern EB. Objective evaluation of anterior septal surgical ...
  https://moffitt.org/providers/thomas-mccaffrey/
*  Effects of the Arachidonate Lipoxygenase Inhibitor BW755C on Traumatic and Peritumoural Brain Oedema | Springer for Research &...
It inhibits synthesis of prostaglandins and leukotrienes by inhibition in the cyclooxygenase and lipoxygenase pathways of... ... synthesis of prostaglandins and leukotrienes by inhibition in the cyclooxygenase and lipoxygenase pathways of arachidonic acid ... Species difference in increased vascular permeability by synthetic leukotriene C4 and D4. Prostaglandins 21: 637-648PubMed ... Aritake K, Wakai S, Asano T, Takakura K (1983) Peroxidation of arachidonic acid and brainoedema. Brain Nerve 35: 965-973PubMed ...
  https://rd.springer.com/chapter/10.1007/978-3-7091-9115-6_23
*  Coconut Oil: Miracle Medicine or Quack Treatment?
Lear about saturated fat, unsaturated fat, pufa, MCT oil, Medium chain triglycerides, lauric acid and monolaurin. ... Bellamkonda K, Chandrashekar NK, Osman J, Selvanesan BC, Savari S, Sjölander A. The eicosanoids leukotriene D4 and ... arachidonic acid. Prostaglandins Leukot Med. 1982;8(3):219-37.. https://www.ncbi.nlm.nih.gov/pubmed/6952288 ... Lauric Acid. While only 2-5% of the fatty acids in cow's milk are lauric acid, coconut oil is comprised of almost 50% lauric ...
  https://endalldisease.com/coconut-oil-miracle-medicine-quack/
*  Antioxidants | Free Full-Text | Evening Primrose (Oenothera biennis) Biological Activity Dependent on Chemical Composition |...
Furthermore, 15-HETrE blocks the conversion of arachidonic acid (AA) to leukotriene A4 (LTA4) by direct inhibition of 5-LOX. In ... Evening primrose oil (EPO) is extremely high in linoleic acid (LA) (70-74%) and γ-linolenic acid (GLA) (8-10%), which may ... EPO supplementation results in an increase in plasma levels of γ-linolenic acid and its metabolite dihomo-γ-linolenic acid ( ... This oil contains mainly aliphatic alcohols, fatty acids, sterols, and polyphenols. ...
  https://www.mdpi.com/2076-3921/7/8/108/htm
*  Hyperalgesic and edematogenic effects of peptides isolated from the venoms of honeybee ( Apis mellifera) and neotropical social...
Rackham A, Ford-Hutchinson AW (1983) Inflammation and pain sensitivity: effects of leukotrienes D4, B4 and prostaglandin E1 in ... a novel dual 5-lipoxygenase/cyclooxygenase inhibitor with potent anti-inflammatory activity in an arachidonic acid-induced ear ... Martin HA (1990) Leukotriene B4 induced decrease in mechanical and thermal thresholds of C-fiber mechanonociceptors in rat ... Martin HA, Basbaum AI, Goetzl EJ, Levine JD (1988) Leukotriene B4 decreases the mechanical and thermal thresholds of C-fiber ...
  https://link.springer.com/article/10.1007/s00726-010-0512-8
*  JCI - The organization and consequences of eicosanoid signaling
The role of leukotrienes C4 and D4 in disease. LTs are the products of the 5-LO pathway of arachidonic acid metabolism (Figure ... Organization of leukotriene and prostaglandin synthesis * The role of leukotrienes C4 and D4 in disease ... FLAP facilitates arachidonic acid presentation to 5-LO and subsequent conversion of arachidonic acid to LTA4. LTA4 interacts ... It has been postulated that FLAP presents arachidonic acid to 5-LO (36) but may also restrict the diffusion of arachidonic acid ...
  https://www.jci.org/articles/view/18338
*  Arachidonic acid - Wikipedia
... leukotriene B4, leukotriene C4, leukotriene D4, and leukotriene E4 as well as to 5-hydroxyicosatetraenoic acid (5-HETE) which ... Health effects of arachidonic acid supplementation[edit]. Arachidonic acid supplementation in daily doses of 1,000-1,500 mg for ... Arachidonic acid is not one of the essential fatty acids. However, it does become essential if a deficiency in linoleic acid ... Arachidonic acid is also used in the biosynthesis of anandamide.[17]. *Some arachidonic acid is converted into ...
  https://en.wikipedia.org/wiki/Arachidonic_acid
*  Leukotriene D4 Summary Report | CureHunter
It is generated from LEUKOTRIENE C4 after partial hydrolysis of the peptide chain, i.e., cleavage of the gamma-glutamyl portion ... Leukotriene D4: One of the biologically active principles of SRS-A. ... Unsaturated Fatty Acids: 3881*Eicosanoids: 1470*Arachidonic Acids: 92*Leukotrienes: 2325*SRS-A: 144*Leukotriene D4: 437*14- ... Leukotriene D; Leukotriene D-4; Leukotrienes D; Leukotriene D 4; LTD4; Glycine, N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9- ...
  http://www.curehunter.com/public/keywordSummaryD017998-Leukotriene-D4.do
*  Arachidonic acid - Wikipedia
... leukotriene B4, leukotriene C4, leukotriene D4, and leukotriene E4 as well as to 5-hydroxyicosatetraenoic acid (5-HETE) which ... Arachidonic acid is also used in the biosynthesis of anandamide.[17]. *Some arachidonic acid is converted into ... Health effects of arachidonic acid supplementationEdit. Arachidonic acid supplementation in daily dosages of 1,000-1,500 mg for ... Dietary arachidonic acid and inflammationEdit. Increased consumption of arachidonic acid will not cause inflammation during ...
  https://en.m.wikipedia.org/wiki/Arachidonic_acid
*  PGI2 as a Regulator of Inflammatory Diseases
... leukotrienes, PAF, biological response modifiers and the family of cell adhesion-promoting molecules. ... Consistently, arachidonic acid induced platelet aggregation was inhibited by 13-cis-RA. Treatment with the inflammatory ... D4, and E4," Proceedings of the National Academy of Sciences of the United States of America, vol. 80, no. 6, pp. 1712-1716, ... "Allergen challenge of lung tissue from asthmatic elicits bronchial contraction that correlates with the release of leukotrienes ...
  https://www.hindawi.com/journals/mi/2012/926968/
*  White Rose Etheses Online
Prostaglandins, Leukotrienes and Essential Fatty Acids, 59(6), 415-422. Khera, M., Somogyi, G. T., Kiss, S., Boone, T. B., & ... Cetinel, S., Canillioglu, Y. E., Cikler, E., Sener, G., & Ercan, F. (2010). Leukotriene D4 receptor antagonist montelukast ... Evidence for the involvement of arachidonic acid metabolites in spontaneous and drug-induced contractions of rat urinary ... Frontiers in Neuroscience, 5(62). Sadananda, P., Kao, F. C. L., Liu, L., Mansfield, K. J., & Burcher, E. (2012). Acid and ...
  https://studylib.net/doc/6844313/--white-rose-etheses-online
*  Patent US20050192356 - Synergistic anti-inflammatory pharmaceutical compositions and methods of use - Google Patenten
The invention also provides a method of reducing inflammation by administering a composition comprising a reduced isoalpha acid ... RIAA) and isoalpha acid (IAA) isolated from hops, wherein the RIAA and IAA are in a ratio of about 3:1 to about 1:10. ... and isoalpha acid (IAA) isolated from hops, wherein the RIAA and IAA are in a ratio of about 3:1 to about 1:10. ... The invention provides a composition comprising a reduced isoalpha acid (RIAA) ...
  https://www.google.be/patents/US20050192356
*  Specialized pro-resolving mediators - Wikipedia
SPM are metabolites of arachidonic acid (AA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), or n-3 DPA (i.e. 7,10Z, ... and PUFA metabolites including in particular leukotrienes (e.g. LTB4), hydroxyeicosatetraenoic acids (e.g., 5-HETE, 12-HETE), ... Winkler JW, Orr SK, Dalli J, Cheng CY, Sanger JM, Chiang N, Petasis NA, Serhan CN (2016). "Resolvin D4 stereoassignment and its ... 16Z-docosapentaenoic acid or osbond acid) is an isomer of n-3 DPA (clupanodonic acid) differing form the latter fatty acid only ...
  https://en.wikipedia.org/wiki/Specialized_pro-resolving_mediators
*  Kounis syndrome: an update on epidemiology, pathogenesis, diagnosis and therapeutic management : Clinical Chemistry and...
Arachidonic acid products including thromboxane and leukotrienes were found to be significantly higher in nonallergic patients ... Cui S, Shibamoto T, Liu W, Takano H, Kurata Y. Effects of platelet-activating factor, thromboxane A2 and leukotriene D4 on ... growth factors and arachidonic acid products such as leukotrienes, thromboxane, prostacyclin, PAF and tumor necrosis factor-α ( ... Arachidonic acid metabolites in acute myocardial infarction. Angiology 1996;47:649-61. Google Scholar ...
  https://www.degruyter.com/view/j/cclm.2016.54.issue-10/cclm-2016-0010/cclm-2016-0010.xml
*  Matricaria Flower - Matricariae flos (Matricaria recutita L.) - Herbal Reference
... tested constituents of topical matricaria preparations in inflammations of the mouse ear induced by arachidonic acid, phorbol ... He was positive tested with roman matricaria extract 1%pet in D2 and D4 and with german matricaria tea D4 and with the ... 1994). At 15 µM chamazulene inhibited the synthesis of leukotriene B4 in stimulated rat peritoneal neutrophilic granulocytes by ... In a cell-free system 2 µM chamazulene blocked the chemical peroxidation of arachidonic acid. ...
  https://herbalref.com/matricaria-flower-matricariae-flos-matricaria-recutita-l/