*  Gadopentetic acid - Wikipedia
It is often used when viewing intracranial lesions with abnormal vascularity or abnormalities in the blood-brain barrier. It is ... when cation A is the protonated form of the amino sugar meglumine the salt goes under the name "gadopentetate dimeglumine". It ... Gadobenic acid Gadoxetic acid Murphy KJ, Brunberg JA, Cohan RH (1996). "Adverse reactions to gadolinium contrast media: a ... It is used to assist imaging of blood vessels and of inflamed or diseased tissue where the blood vessels become "leaky". ...
  https://en.wikipedia.org/wiki/Gadopentetic_acid
*  Glutamine - Wikipedia
... nonessential amino acid in the human body, and one of the few amino acids that can directly cross the blood-brain barrier. ... In human blood, glutamine is the most abundant free amino acid. The dietary sources of glutamine includes especially the ... is an α-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated −NH2+ ... as any other of the 20 proteinogenic amino acids Lipid synthesis, especially by cancer cells. Regulation of acid-base balance ...
  https://en.wikipedia.org/wiki/Glutamine
*  US4595697A - Treatment of seizure disorders and pharmaceutical compositions useful therein - Google Patents
GABA and its precursors do not readily cross the blood-brain barrier. However, one approach to increasing GABA concentrations ... A61K31/195-Carboxylic acids, e.g. valproic acid having an amino group ... a) non-toxic acid addition salts formed with inorganic acids, such as hydrochloric, hydrobromic, sulfuric, and phosphoric acid ... A61K31/185-Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids ...
  https://patents.google.com/patent/US4595697
*  Metabolic Regulation in Brain Cells | Springer for Research & Development
Recent studies of metabolic regulation in brain have focused on the complexity and fine-tuning involved in the control of ... Pardridge, W.M. (1983) Neuropeptides and the blood brain barrier. Annu. Rev. Physiol. 45:73-82.PubMedGoogle Scholar ... an astrocyte specific enzyme implicated in the replenishment of amino acid neurotransmitter pools. Brain Res. 329:364-367. ... Insulin increases glucose transfer across the blood-brain barrier in man. J. Clin. Invest. 67:597-604.PubMedGoogle Scholar ...
  https://rd.springer.com/chapter/10.1007/978-1-4613-2037-1_25
*  Glutamic acid - Wikipedia
Smith, Quentin R. (April 2000). "Transport of glutamate and other amino acids at the blood-brain barrier". The Journal of ... A key process in amino acid degradation is transamination, in which the amino group of an amino acid is transferred to an α- ... R1-amino acid + R2-α-ketoacid ⇌ R1-α-ketoacid + R2-amino acid A very common α-keto acid is α-ketoglutarate, an intermediate in ... Glutamic acid is an α-amino acid with formula C 5H 9O 4N. It is usually abbreviated as Glu or E in biochemistry. Its molecular ...
  https://en.wikipedia.org/wiki/Glutamic_acid
*  Gamma-Amino-beta-hydroxybutyric acid - Wikipedia
... perhaps due to its greater capacity to cross the blood-brain barrier. However, GABOB is of relatively low potency as an ... γ-Amino-β-hydroxybutyric acid (GABOB), also known as β-hydroxy-γ-aminobutyric acid (β-hydroxy-GABA), and sold under the brand ... De Maio, D.; Pasquariello, G. (1963). "Gamma-amino-beta-hydroxybutyric acid (GABOB) and brain serotonin". Psychopharmacologia. ... Effect of gamma-amino-beta-hydroxybutyric acid (GABHB) on experimentally-induced epileptic activity]" [Effect of γ-amino-β- ...
  https://en.wikipedia.org/wiki/Gamma-Amino-beta-hydroxybutyric_acid
*  Aprotinin - Wikipedia
One scientific study in rats reported that treatment with aprotinin prevents disruption of the blood-brain barrier during the C ... The amino acid sequence for bovine BPTI is RPDFC LEPPY TGPCK ARIIR YFYNA KAGLC QTFVY GGCRA KRNNF KSAED CMRTC GGA. There are 10 ... ISBN 978-0-7167-7027-5. Xu CY (Feb 2014). "permeability of blood-brain barrier is mediated by serine protease during ... It has a molecular weight of 6512 and consists of 16 different amino acid types arranged in a chain 58 residues long that folds ...
  https://en.wikipedia.org/wiki/Aprotinin
*  Postprandial somnolence - Wikipedia
... making tryptophan preferentially available to the large neutral amino acid transporter at the blood-brain barrier. Uptake of ... This lowers the ratio of these branched-chain amino acids in the bloodstream relative to tryptophan (an aromatic amino acid), ... The LNAA Transport at the Blood Brain Barrier". Retrieved 2008-06-12. Fernstrom JD, Wurtman RJ (1971). "Brain serotonin content ... Increased brain serotonin and melatonin levels result in sleepiness. Evidence suggests that the small rise in blood glucose ...
  https://en.wikipedia.org/wiki/Postprandial_somnolence
*  Metkefamide - Wikipedia
Despite its peptidic nature, upon systemic administration, metkefamide rapidly penetrates the blood-brain-barrier and disperses ... Met]Enkephalin Frakefamide J S Davies; Royal Soc of Chem (8 November 2000). Amino Acids, Peptides and Proteins. Royal Society ... enkephalin with the amino acid sequence Tyr-D-Ala-Gly-Phe-(N-Me)-Met-NH2. It behaves as a potent agonist of the δ- and μ-opioid ... Frederickson RC, Smithwick EL, Shuman R, Bemis KG (February 1981). "Metkephamid, a systemically active analog of methionine ...
  https://en.wikipedia.org/wiki/Metkefamide
*  Mediation of Highly Concentrative Uptake of Pregabalin by L-Type Amino Acid Transport in Chinese Hamster Ovary and Caco-2 Cells...
Wang Y and Welty DF (1996) The simultaneous estimation of the influx and efflux blood-brain barrier permeabilities of ... L-type amino acid transport system is an ubiquitous Na+-independent transport system for large, neutral amino acids across ... 2003) Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid ... amino acid transport on substrate affinity of the heteromeric b(0,+) amino acid transporter. J Biol Chem 275: 14331-14335. ...
  http://jpet.aspetjournals.org/content/313/3/1406.long
*  Plus it
The concentrations of free amino acids and other electrolytes in cerebrospinal fluid, in vivo dialysate of brain, and blood ... 1988) The glucose transporter of the human brain and blood-brain barrier. Ann. Neurol. 24:757-764. ... 1984) Neutral amino acid transport by plasma membrane vesicles of rabbit choroid plexus. Brain Res. 295:155-160. ... The extracellular fluid of the central nervous system is physically isolated from the plasma by the blood-brain barrier (i.e., ...
  http://jpet.aspetjournals.org/content/282/2/1109
*  Piet Borst - Wikipedia
... in the blood-brain barrier (23) and in the gut (oral availability of drugs) (24) (25). Proof that the Mdr2/MDR3 (ABCB4) P- ... N-lactoyl-amino acids are ubiquitous metabolites that originate from CNDP2-mediated reverse proteolysis of lactate and amino ... Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity ... N-lactoyl-amino acids, a novel metabolites of mammals (42), and glutamate-conjugates (43). The first mouse tumor model suitable ...
  https://en.wikipedia.org/wiki/Piet_Borst
*  Levonantradol - Wikipedia
Synthetic cannabinoids like Levonantradol readily cross the blood-brain barrier because they are highly lipophilic and have low ... The amino group is protected by rxn with ethyl chloroformate, the ester group is saponified, and then cyclodehydration with ... polyphosphoric acid leads to the dihydroquinoline ring system (2). Deblocking with HBr is followed by etherification of the ... It can cause an increase in heart rate and decrease in blood pressure. Euphoric symptoms rarely occurred in subjects. Dane salt ...
  https://en.wikipedia.org/wiki/Levonantradol
*  Controlled release of dopamine from a polymeric brain implant In vivo characterization.
Neocortical transplants in the mammalian brain lack a blood-brain barrier to macromolecules. Science 1987; 235~772-774 29. ... Aromatic amino acids and modification of parkinsonism. N Engl J Med 1967; 276:374-379 4. Yahr MD, Duvoisin RC, Schear MJ, et al ... dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), was measured by in vivo dialysis 133-35) on the third, tenth, ... Brain Res 1979;177:555-560 27. Madrazo I, Leon V, Torres C, et al. Transplantation of fetal substantia nigra and adrenal m e d ...
  https://www.docme.ru/doc/1918334/controlled-release-of-dopamine-from-a-polymeric-brain-imp..
*  5-Hydroxytryptophan - Wikipedia
May 2008). "Augmented brain 5-HT crosses the blood-brain barrier through the 5-HT transporter in rat". Eur. J. Neurosci. 27: ... 5-Hydroxytryptophan (5-HTP), also known as oxitriptan, is a naturally occurring amino acid and chemical precursor as well as a ... 5-HTP crosses the blood-brain barrier, while 5-HT does not. Excess 5-HTP, especially when administered with vitamin B6, is ... 5-HTP is decarboxylated to serotonin (5-hydroxytryptamine or 5-HT) by the enzyme aromatic-L-amino-acid decarboxylase with the ...
  https://en.wikipedia.org/wiki/5-Hydroxytryptophan
*  Patent US5182107 - Transferrin receptor specific antibody-neuropharmaceutical or diagnostic ... - Google Patents
The present invention pertains to a method for delivering a neuropharmaceutical or diagnostic agent across the blood brain ... barrier to the brain of a host. The method comprises administering to the host a therapeutically effective amount of an ... The levels of various substances in the blood, such as hormones, amino acids and ions, undergo frequent, small fluctuations ... The capillaries that supply blood to the tissues of the brain constitute the blood brain barrier (Goldstein et al. (1986) ...
  http://www.google.com/patents/US5182107?dq=5,381,459
*  Racetams with NDRIs - BrainMeta.com Forum
Brain Sections, Brain Evolution, Brain Development, Brain Circuitry, Brain Functions, brain atlases, primate brain, brain, ... brain atlas, neuroscience, coronal, sagittal, brain pics, atlas and pics of brain, mind/brain, brain, neuroscience, mind, brain ... neuroscience, neuroinformatics, brain, monkey brain, macaque brain, macaca mulatta, brains, neuroanatomy, ... brain structure, primate brain, brain atlas, stereotaxic atlas, ... Must pass blood-brain barrier. - A. Under normal conditions. - ...
  http://brainmeta.com/forum/index.php?showtopic=24785&hl=
*  US5885976A - Methods useful for the treatment of neurological and mental disorders related to deficient serotonin...
... of a composition which increases serotonin transmission to the human to be treated followed by the application to the brain of ... AC pulsed magnetic field alone or in conjunction with a DC magnetic field and a sufficient amount of random noise to the brain ... it receives one of the richest blood supplies of any organ; (3) it lies outside the blood brain barrier, but has direct access ... "Control of brain monoamine synthesis by diet and plasma amino acids." The American Journal of Clinical Nutrition, 28, 638-647). ...
  https://patents.google.com/patent/US5885976?oq=flatulence
*  SLC3A2 - Wikipedia
... amino acids. LAT is highly expressed in brain capillaries (which form the blood brain barrier) relative to other tissues. A ... "Selective expression of the large neutral amino acid transporter at the blood-brain barrier". Proc. Natl. Acad. Sci. U.S.A. 96 ... Large Neutral Amino Acid-Transporter 1 at the US National Library of Medicine Medical Subject Headings (MeSH) Amino Acid ... "Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid ...
  https://en.wikipedia.org/wiki/SLC3A2
*  腦 - 維基百科,自由的百科全書
Pardridge, W. The Blood-Brain Barrier: Bottleneck in Brain Drug Development. NeuroRx. 2005, 2 (1): 3-14. PMC 539316. PMID ... Chapter 15, Amino acid neurotransmitters. (編) G. Siegel; 等. Basic Neurochemistry. Raven Press. 1989: 311-332. ISBN 978-0-88167- ... 另一個研究腦功能的手段,是檢查特定區域腦損傷(英語:Brain damage)的後果。雖然腦有顱骨和腦膜保護,由腦脊液包圍,並且由血腦屏障將其與
  https://zh.wikipedia.org/zh-hk/%E8%85%A6
*  Aspartame Sweet
Excess of these amino acids can cross the "blood brain barrier" (BBB), especially in children. Problems include MS, ALS, memory ... Phenylalanine is another amino acid and is normally found in the body (including the brain). Persons with the genetic disorder ... Aspartame is made up of aspartic acid (40%), phenylalanine (50%), and methanol (10%). Aspartic acid and glutamate are ... Too much of either one can kill certain brain neurons by allowing too much calcium to enter cells, which leads to an influx of ...
  http://agclinic.com/aspartame-sweet/
*  Pyridoxal - DrugBank
The 4-carboxyaldehyde form of vitamin B 6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino ... acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. [PubChem] ... Blood Brain Barrier. +. 0.6605. Caco-2 permeable. -. 0.6034. P-glycoprotein substrate. Non-substrate. 0.6664. ... including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other ...
  https://www.drugbank.ca/drugs/DB00147
*  Immunoregulation in the Central Nervous System: Detection of Cytokines in Cerebrospinal Fluid | SpringerLink
W. W. Tourtellotte, and B.I. Ma, Multiple sclerosis - the blood-brain-barrier and the measurement of de novo central nervous ... Purification and NH2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell ... Penetration of recombinant interleukin-2 across the blood-cerebrospinal fluid barrier, J.Neurosurg., 69:29-34 (1988).CrossRef ... M. S. Ahmed, J. Leanos-Q, C.A. Cinarello and C.M. Blatteis, Interleukin-1 reduces opiod binding in guinea pig brain, Peptides 6 ...
  https://link.springer.com/chapter/10.1007/978-1-4613-0607-8_10
*  Methyldopate hydrochloride Monograph for Professionals - Drugs.com
Crosses the blood-brain barrier.h j. Methyldopa crosses the placenta in humans101 102 and is distributed into milk.101 103 ... Test for urinary uric acid. May interfere with measurement of uric acid by the phosphotungstate method at concentrations of the ... National High Blood Pressure Education Program Working Group report on high blood pressure in pregnancy. Am J Obstet Gynecol. ... National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Report of the National High ...
  https://www.drugs.com/monograph/methyldopate-hydrochloride.html
*  S100B - Wikipedia
Czeisler BM, Janigro D (June 2006). "Reading and writing the blood-brain barrier: relevance to therapeutics". Recent patents on ... amino acid sequence of S100 beta". J. Neurochem. 45 (3): 700-5. doi:10.1111/j.1471-4159.1985.tb04048.x. PMID 4031854.. ... Over the last decade, S100B has emerged as a candidate peripheral biomarker of blood-brain barrier (BBB) permeability and CNS ... Marchi N, Cavaglia M, Fazio V, Bhudia S, Hallene K, Janigro D (April 2004). "Peripheral markers of blood-brain barrier damage ...
  https://en.wikipedia.org/wiki/S100B