*  Hydroxyprogesterone acetate - Wikipedia
The first product was 17alpha-acetoxyprogesterone4 (Figure 1) marketed under the trade name of Prodox.® Prodox was introduced ... 17a-hydroxyprogesterone caproate and 17a-hydroxyprogesterone acetate, introduced in 1953, and the most potent of all new ... Hydroxyprogesterone acetate is the generic name of the drug and its INN. OHPA is or was marketed under the brand name Prodox ... of hydroxyprogesterone a c e t a te, in bottles of 25 tablets. GREENBLATT RB (1959). "Hormonal control of functional uterine ...
*  20alpha-hydroxysteroid dehydrogenase - Wikipedia
17alpha-hydroxyprogesterone + NAD(P)H + H+ The 3 substrates of this enzyme are 17alpha,20alpha-dihydroxypregn-4-en-3-one, NAD+ ... Wiest WG (December 1968). "On the function of 20 alpha-hydroxypregn-4-en-3-one during parturition in the rat". Endocrinology. ... In enzymology, a 20-α-hydroxysteroid dehydrogenase (EC is an enzyme that catalyzes the chemical reaction 17alpha, ... 3β(or 20α)-hydroxysteroid dehydrogenase AKR1C1 Shikita M, Inano H, Tamaoki B (1967). "Further studies on 20-alpha- ...
*  Medroxyprogesterone acetate - Wikipedia
"6-methyl-17alpha-hydroxyprogesterone, the lower fatty acid 17-acylates and methods for producing the same", published 1968-04- ... Penning TM, Sharp RB, Krieger NR (December 1985). "Purification and properties of 3 alpha-hydroxysteroid dehydrogenase from rat ... selective inhibition of 3 alpha-hydroxysteroid oxidoreductase activity". Journal of Steroid Biochemistry. 17 (2): 197-203. doi: ... On November 17, 2004, the United States Food and Drug Administration put a black box warning on the label, indicating that ...
*  Gestonorone caproate - Wikipedia
In animals, it is approximately 25 times more potent than progesterone or hydroxyprogesterone caproate. In humans, 100 or 200 ... or 17alpha-hydroxy-19-nor-progesterone-caproate (DepostatB, Schering), 200 mg daily. These doses can be considered as ... The preparations used were Proluton Depot (17a-hydroxy-progesterone caproate) and in 3 patients SH 5132 (17a-hydroxy-19- ... Like the closely related progestins hydroxyprogesterone caproate and 19-norprogesterone, gestonorone caproate shows poor ...
*  Congenital Adrenal Hyperplasia - Symptoms, Treatments and Resources for Congenital Adrenal Hyperplasia
Congenital Adrenal Hyperplasia - MedHelp's Congenital Adrenal Hyperplasia Center for Information, Symptoms, Resources, Treatments and Tools for Congenital Adrenal Hyperplasia. Find Congenital Adrenal Hyperplasia information, treatments for Congenital Adrenal Hyperplasia and Congenital Adrenal Hyperplasia symptoms.
*  Congenital adrenal hyperplasia type 1 - definition of Congenital adrenal hyperplasia type 1 by The Free Dictionary
Define Congenital adrenal hyperplasia type 1. Congenital adrenal hyperplasia type 1 synonyms, Congenital adrenal hyperplasia type 1 pronunciation, Congenital adrenal hyperplasia type 1 translation, English dictionary definition of Congenital adrenal hyperplasia type 1. n. Any of a group of genetic disorders characterized by an enzyme deficiency that leads to insufficient production of cortisol and often aldosterone by the...
*  Congenital adrenal hyperplasia due to 21-hydroxylase deficiency - Wikipedia
Congenital adrenal hyperplasia due to 21-hydroxylase deficiency (21-OH CAH), in all its forms, accounts for over 95% of diagnosed cases of congenital adrenal hyperplasia, and "CAH" in most contexts refers to 21-hydroxylase deficiency. An overview of the other types of CAH is presented in the main article. The condition can be classified into "salt-wasting", "simple virilizing", and "non-classical" forms. The salt-wasting and simple virilizing types are sometimes grouped together as "classical". The CYP21A2 gene for the P450c21 enzyme (also known as 21-hydroxylase) is at 6p21.3, amid genes HLA B and HLA DR coding for the major human histocompatibility loci (HLA). CYP21A2 is paired with a nonfunctional pseudogene CYP21A1P. Scores of abnormal alleles of CYP21A2 have been documented, most arising from recombinations of homologous regions of CYP21A2 and CYP21A1P. Differences in residual enzyme activity of the various alleles account for the various degrees of severity of the disease. Inheritance of ...
*  Congenital adrenal hyperplasia due to 11β-hydroxylase deficiency - Wikipedia
Congenital adrenal hyperplasia due to 11β-hydroxylase deficiency is a form of congenital adrenal hyperplasia (CAH) which produces a higher than normal amount of androgen, resulting from a defect in the gene encoding the enzyme steroid 11β-hydroxylase which mediates the final step of cortisol synthesis in the adrenal. 11β-OH CAH results in hypertension due to excessive mineralocorticoid effects. It also causes excessive androgen production both before and after birth and can virilize a genetically female fetus or a child of either sex. Mineralocorticoid manifestations of severe 11β-hydroxylase deficient CAH can be biphasic, changing from deficiency (salt-wasting) in early infancy to excess (hypertension) in childhood and adult life. Salt-wasting in early infancy does not occur in most cases of 11β-OH CAH but can occur because of impaired production of aldosterone aggravated by inefficiency of salt conservation in early infancy. When it occurs it resembles the salt-wasting of severe ...
*  What does 17-alpha-hydroxyprogesterone mean?
Definition of 17-alpha-hydroxyprogesterone in the Definitions.net dictionary. Meaning of 17-alpha-hydroxyprogesterone. What does 17-alpha-hydroxyprogesterone mean? Information and translations of 17-alpha-hydroxyprogesterone in the most comprehensive dictionary definitions resource on the web.
*  hydroxyprogesterone - Symptoms, Treatments and Resources for hydroxyprogesterone
hydroxyprogesterone - MedHelp's hydroxyprogesterone Center for Information, Symptoms, Resources, Treatments and Tools for hydroxyprogesterone. Find hydroxyprogesterone information, treatments for hydroxyprogesterone and hydroxyprogesterone symptoms.
*  Genetics and clinical presentation of classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
Defective conversion of 17-hydroxyprogesterone to 11-deoxycortisol accounts for more than 90 percent of cases of congenital adrenal hyperplasia (CAH). This conversion is mediated by 21-hydroxylase, the enzyme encoded by theCYP21A2gene.Patients with c
*  Treatment of classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency in infants and children
Defective conversion of 17-hydroxyprogesterone to 11-deoxycortisol accounts for more than 95 percent of cases of congenital adrenal hyperplasia. This conversion is mediated by 21-hydroxylase, deficiency of which is caused by mutations in the CYP21A2
*  11β-Hydroxyprogesterone - Wikipedia
11β-Hydroxyprogesterone (11β-OHP), also known as 21-deoxycorticosterone, as well as 11β-hydroxypregn-4-ene-3,20-dione, is a naturally occurring, endogenous steroid and derivative of progesterone. It is a potent mineralocorticoid. Increased levels of 11β-OHP occur in 21-hydroxylase deficiency. Along with its epimer 11α-hydroxyprogesterone (11α-OHP), 11β-OHP has been identified as a very potent competitive inhibitor of both isoforms (1 and 2) of 11β-hydroxysteroid dehydrogenase (11β-HSD). 21-Deoxycortisol (11β,17α-dihydroxyprogesterone) 11-Deoxycorticosterone (21-hydroxyprogesterone) Corticosterone (11β,21-dihydroxyprogesterone) Cortisol (11β,17α,21-trihydroxyprogesterone) 11-Deoxycortisol (17α,21-dihydroxyprogesterone) 9α-Bromo-11-ketoprogesterone "Human Metabolome Database: Showing metabocard for 11b-Hydroxyprogesterone (HMDB04031)". hmdb.ca. Retrieved 2016-12-16. Souness ...
*  Congenital Adrenal Hyperplasia in Males : Symptoms & Causes - Parenting Nation India
Congenital Adrenal Hyperplasia in males (CAH), symptoms, causes and treatment of Congenital Adrenal Hyperplasia, parents should always get themselves treated in all manner of conditions before going ahead to bear children.
*  Comparison of Cortisol Pump With Standard Treatment for Congenital Adrenal Hyperplasia - Full Text View - ClinicalTrials.gov
Congenital adrenal hyperplasia (CAH) is a common genetic endocrine disorder, with 21-hydroxylase enzyme deficiency accounting for 95% of the cases. 21-hydroxylase deficiency presents with a spectrum of clinical manifestations ranging from salt-wasting and virilization of female neonates (classic CAH) to symptomatic (precocious puberty, short stature, acne) or asymptomatic hyperandrogenemia (non-classic CAH). Classic CAH is characterized by impaired cortisol and mineralocorticoid biosynthesis, which triggers adrenocorticotropic hormone (ACTH) hyper-secretion and accumulation of adrenal androgens. Glucocorticoid treatment of patients with classic CAH focuses on cortisol replacement and prevention of the ACTH-driven androgen excess. Current conventional glucocorticoid treatment regimens (short or long-acting agents dosed once, twice or thrice daily) have failed to simulate physiological cortisol secretion and suppress adrenal androgen overproduction, without supraphysiologic replacement. Short-term ...
*  Congenital Adrenal Hyperplasia Dubai UAE
21-hydroxylase deficiency (also known as congenital adrenal hyperplasia) is an inherited disorder that affects the adrenal glands. These glands are located on top of the kidneys and produce a variety of hormones that regulate many essential functions in the body. Two of these hormones, cortisol and aldosterone, are produced from cholesterol through the activity of an enzyme called 21-hydroxylase. Cortisol has numerous functions such as maintaining blood sugar levels, protecting the body from stress, and suppressing inflammation. Aldosterone, sometimes called the salt-retaining hormone, acts on the kidneys to regulate the levels of salt and water in the body, which affects blood pressure. People with 21-hydroxylase deficiency have a shortage of the 21-hydroxylase enzyme, which impairs the conversion of cholesterol to cortisol and aldosterone. When the precursors of cortisol and aldosterone build up in the adrenal glands, they are converted to male sex hormones called androgens. Androgens are ...
*  At the end of my rope, doctors are stumped... Addison's with high cortisol? - Endocrine conditions - Condition | Our Health
This thread is over a year old but I thought I would check in on you. How are you now? Here is something that may help with what your dealing with. I'm 43 years old and a female in 1993 I was diagnosed with Congenital Adrenal Hyperplasia 21 OH deficiency I had a stress dose of cortisol for adrenal crisis and was sent home with no other instructions. Being a young mother and ignorant of this condition I thought it was a one time event and tried to move on with my life. Needless to say for twenty some odd years I had no idea I was in trouble. I had an ACTH stimulation test that showed a morning cortisol of 16 the 17 hydroxyprogesterone level was 10,900 at thirty minutes. I asked for an adrenal washout CT scan and it showed a .09 x 1.3 cm growth on my left adrenal gland. These can produce excess cortisol but is you are CAH 21 OH deficient you can't use it and full physiologic replacement should be given. I recommend Dr Maria New at Mount Sanai hospital in New York she is an expert in ...
*  11α-Hydroxyprogesterone - Wikipedia
11α-Hydroxyprogesterone (11α-OHP), or 11α-hydroxypregn-4-ene-3,20-dione is an endogenous steroid and metabolite of progesterone. It is a weak antiandrogen, and is devoid of androgenic, estrogenic, and progestogenic activity. It was investigated as a topical antiandrogen for the treatment of androgen-dependent skin conditions in the early 1950s, and was found to produce some benefit. In 1995, 11α-OHP, along with its epimer 11β-hydroxyprogesterone, was identified as a very potent competitive inhibitor of both isoforms (1 and 2) of 11β-hydroxysteroid dehydrogenase (11β-HSD). It is notably not metabolized by 11β-HSD2. 11α-OHP is a more potent inhibitor of 11β-HSD than enoxolone (glycyrrhetinic acid) or carbenoxolone in vitro (IC50 = 0.9 nM; IC50 = 5 nM in transfected cells). The compound has been found to be highly active in conferring mineralocorticoid sodium-retaining activity of corticosterone in vivo in rat bioassays and in increasing blood pressure, effects that it mediates ...
*  NIH Clinical Center: NIH Clinical Center Senior Staff
Award in Recognition of Work with CAH Patients, Contributions to CAH Research and Quality Patient Care, 2011; USPHS Outstanding Service Medal for Conducting Outstanding Clinical Research and Building an Internationally Renowned Research Program to Further Understanding of Congenital Adrenal Hyperplasia, 2010; Congenital Adrenal Hyperplasia Research, Education and Support Foundation, Inc. grant in support of research in the area of congenital adrenal hyperplasia, 2005 - 2009; NIH Fellows Award for Research Excellence, 1997; NIH Clinical Research Loan Repayment and Scholarship Award, 1996; Dr. Louis Sklarow Memorial Award for outstanding graduate in medicine, SUNY at Buffalo, 1991; Alpha Omega Alpha Society. Selected Publications. BOOKS AND BOOK CHAPTERS. Charmandari E, Chrousos GP, Merke DP. Classic congenital adrenal hyperplasia. In: Adrenal Glands: diagnostic aspects and surgical therapy, Chapter 10, pp 101-114. Linos DA, VanHeerden JA, ...
*  17-Hydroxyprogesterone: The Test
Describes how the 17-hydroxyprogesterone (17-OHP) test is used, when a 17-OHP test is ordered, and what the results of a 17-hydroxyprogesterone test might mean
*  Running 100km in the home of Sound of Music for Congenital Adrenal Hyperplasia | Ryan Peden's Fundraiser
I will be competing in the Mozart 100 race in Salzburg on June 20th. 100km in the mountains where they filmed the Sound of Music! I am raising money for the CARES Foundation, an organisation that helps those living with Congenital Adrenal Hyperplasia (CAH). CAH is a family of inherited disorders affecting the adrenal glands. Classical CAH must be detected at birth to avoid an adrenal crisis, which can lead to death. Once detected, CAH can fortunately be managed with medication and, with adequate care, affected individuals go on to live normal lives. My family has been personally affected by CAH, with my daughter having been born in a country where screening at birth is not done. Through my running I aim to build crucial awareness, and fundraise for a fantastic organisation doing CAH research and support worldwide. All donations through this site go directly to the CARES Foundation.
*  Congenital Adrenal Hyperplasia | Health Encyclopedia | Dartmouth-Hitchcock
Congenital adrenal hyperplasia (CAH) is a group of rare inherited autosomal recessive disorders characterized by a deficiency of one of the enzymes needed to make specific hormones. CAH effects the adrenal glands located at the top of each kidney. Normally, the adrenal glands are responsible for producing three...
*  17-hydroxyprogesterone Blood Test Information
17-hydroxyprogesterone blood tests are part of an infant's routine screening, but it is also performed for a number of other reasons. Read on to learn what this test is, how it is used, when it is ordered, preparation and procedure, and to understand the results.
*  Gentaur Molecular :Assaypro \ 6β-Hydroxyprogesterone antibdoy \ 10251-05015
Gentaur molecular products has all kinds of products like :search , Assaypro \ 6β-Hydroxyprogesterone antibdoy \ 10251-05015 for more molecular products just contact us
*  17alpha-Hydroxyprogesterone Caproate (IARC Summary & Evaluation, Volume 21, 1979)
The available experimental and human data are inadequate to evaluate the carcinogenicity of 17a-hydroxyprogesterone caproate. For definition of the italicized terms, see Preamble Evaluation.. Subsequent evaluation: Suppl. 7 (1987) (Progestins) ...
*  JoVE Author Search: Blankenstein MA
Disease, Amyloid, Biomarkers, Growth, Role, Cerebrospinal Fluid, Threonine, Fibroblast Growth Factor, Hormone, Methods, Measure, 17-hydroxyprogesterone, Congenital Adrenal Hyperplasia, Development And Growth, Hormones, Hyperplasia, Meningiomas, Progesterone, Progesterone Receptors, Quality Control
*  Patrick Arnold » General
By Patrick Arnold I was recently asked a question about a very strange new prohormone product. What makes it strange is that is actually based on a female hormone - specifically it is based upon a hormone called 17alpha-hydroxyprogesterone. 17a-hydroxyprogesterone (or 17-HP) is a hormone intermediate in the steroidogenic pathway between progesterone and androstenedione. 17-HP is present […]. ...
*  Makena Side Effects in Detail - Drugs.com
Learn about the potential side effects of Makena (hydroxyprogesterone). Includes common and rare side effects information for consumers and healthcare professionals.