*  Expression of the Multiple Sclerosis-Associated MHC Class II Allele HLA-DRB1*1501 Is Regulated by Vitamin D | Sigma-Aldrich
HLA-DRB1*15 haplotypes. For example, nearly all (98% of 57 sequenced individuals) of HLADRB1* 04, HLA-DRB1*07 and HLA-DRB1*09 ... HLA-DRB1, HLA-DQA1 and HLA-DQB1 and identified a consensus binding site for VDR next to the HLA-DRB1 gene. This was the only ... A region at or near the HLA-DRB1 locus in the MHC influences the risk of MS. HLA-DRB1 has over 400 different alleles. The ... Figure 1. HLA-DRB1 promoter.. Sequence shown is that for HLA-DRB1*15. Important regulatory elements (S, X and Y Boxes) are ...
  https://www.sigmaaldrich.com/technical-documents/articles/biofiles/expression-of-the.html
*  multiple sclerosis - BioMedLib™ search engine
HLA-DRB (human leukocyte antigen-DR beta) alleles, particularly HLA-DRB1*1501, may be of significance in the pathogenesis of MS ... The alleles were determined by the Polymerase Chain Reaction (PCR) method in 259 MS patients and 312 healthy control ... The two-locus analysis of the interaction between the MBP VNTR polymorphism and the HLA-DRB1 allele showed that the HLADRB1* ... Nejati P, Attar M, Rahimian M, Fathi D, Shahbazi M: Combination of Myelin Basic Protein Gene Polymorphisms with HLA-DRB1*1501 ...
  http://bmlreview.com/?kwr=multiple+sclerosis&smntc=gene+or+genome&kwr=&ck=&cxts=10&fntszff=100&hghlght=maroon&srtrdr=relevance&annttn=none&pdthm=2010&hqryhstry=5062b3f288e4d101&pgwdth=100&mld=&wft=wims&b4s=362657833
*  HLA class II histocompatibility antigen, DRB1-8 beta chain
HLA-DRB1 alleles are associated with dermatitis herpetiformis in Chinese population.. 26953725. alleles DRB1*01:01, DQ4, DQ7 ... HLA-DRB1*04 alleles are associated with pulmonary tuberculosis;the subtype HLA-DRB1*04:11:01 (p = 0.0019; OR = 2.23; 95% CI = ... HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) ... HLA-DRB1*03 is associated with microalbuminuria in type 1 diabetes. HLA-DRB1*04 had no association.. ...
  https://pharos.nih.gov/idg/targets/Q30134
*  Product Overview anti-HLA-DRB1 Antibodies
Selected quality suppliers for anti-HLA-DRB1 antibodies. ... Order monoclonal and polyclonal HLA-DRB1 antibodies for many ... HLA-DRB1 Antigen Profile Antigen Summary HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a ... Human HLA Class II DR beta 1 (HLA-DRB1) interaction partners * HLA susceptibility alleles in Norwegian juvenile MG where HLA- ... Browse our anti-HLA-DRB1 (HLA-DRB1) Antibodies. Full name:. anti-HLA Class II DR beta 1 Antibodies (HLA-DRB1). On www. ...
  http://www.antibodies-online.com/tcr-signaling-pathway-12/hla-drb1-antibody-3702/
*  Protocols and Video Articles Authored by Wei Tian
HLA-G*01:01:01, the most common HLA-G allele, formed a separate lineage from other alleles. Our results shed new lights into ... 01-MICA*Del-MICB*009N-DRB1*04:06 and HLA-B*35:01-MICA*Del-MICB*009N-DRB1*15:01, in addition to HLA-B*48-MICA*Del. Unexpectedly ... Compared with carbon atomic chains, the boron nitride atomic chains have an alternative arrangement of polar covalent B-N bonds ... Three HLA-G alleles in the coding region, 4 polymorphic sites in the 3'UTR, 3 3'UTR haplotypes and 4 HLA-G EHs differed ...
  https://www.jove.com/author/Wei_Tian
*  HLA B7-DR15-DQ6 - Wikipedia
The gene-allele representation of the haplotype is: HLA A*0301Cw*0702 : B*0702 : DRB1*1501 : DQA1*0102 : DQB1*0602 This is ... The other B7-DR2-DQ1 stems from the fact that DQ1 is an alpha chain serotype that is now covered by the beta chain type DQ5 and ... ISBN 0-19-262390-7. Middleton D, Williams F, Hamill M, Meenagh A (2000). "Frequency of HLA-B alleles in a Caucasoid population ... HLA B7-DR15-DQ6 is a representation(by serotype) of a common HLA haplotype found in Western Eurasia. The haplotype can be ...
  https://en.wikipedia.org/wiki/HLA_B7-DR15-DQ6
*  Increased Frequencies of Myelin Oligodendrocyte Glycoprotein/MHC Class II-Binding CD4 Cells in Patients with Multiple Sclerosis...
... a short-term culture of PMBCs obtained from patients with MS and healthy control subjects carrying the HLA DRB1*0401 allele. We ... We analyzed the Vβ-chain of a panel of CD4 clones by flow cytometry and found that each clone expressed a single Vβ-chain type ... T cell target in MS patients with epitopes identified that are restricted in the context of HLA DRB1*0401 and HLA DRB1*1501 (18 ... MOG97-109 has been identified as a major target of T cells in subjects with the DRB1*0401 allele (18-21). We used the higher ...
  http://www.jimmunol.org/content/187/2/1039
*  HLA-A3 - Wikipedia
For A3, the alpha, "A", chain are encoded by the HLA-A*03 allele group and the β-chain are encoded by B2M locus. This group ... A*0301 : C*0702 : B*0702 : DRB1*1501 : DQA1*0102 : DQB1*0602 Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF ( ... Allele Query Form IMGT/HLA - European Bioinformatics Institute Machens A, Löliger C, Pichlmeier U, Emskötter T, Busch C, ... HLA-A3 (A3) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody ...
  https://en.wikipedia.org/wiki/HLA-A3
*  Histopathology of PLP-induced EAE in HLA DQB1*0602 Tg m | Open-i
Histopathology of PLP-induced EAE in HLA DQB1*0602 Tg mouse. Samples were taken on day19 after immunization. Panel (A) shows ... HLA-DQ beta-Chains/genetics/metabolism*. *HLA-DRB1 Chains/genetics/metabolism*. *Multiple Sclerosis/chemically induced*/ ... functional role for DQB1*0602 as a predisposing allele in MS.This, together with previously demonstrated disease-susceptibility ... Methods: The HLA-DRB1*1501- and HLA-DQB1*0602-Tg mice (MHC-II(-/-)), and control non-HLA-DR15-relevant-Tg mice were immunized ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC3344688_1742-2094-9-29-6&req=4
*  Role of Cytokines in Systemic Lupus Erythematosus: Recent Progress from GWAS and Sequencing
HLA Class II genes including HLA-DRB1 are also a major component of T-Cell signaling networks, and they present relevant ... lower expression levels than T allele homozygotes. Both the A allele of rs13277113 and the T allele of rs2248932 were confirmed ... β2 chain (ITGB2) protein, ITGAM forms a leukocyte integrin, complement receptor 3 (CC3), that facilitates adhesion of ... More specifically, the DR beta 1 gene (HLA-DRB1) has been shown to associate with SLE across a range of ethnic populations, ...
  https://www.hindawi.com/journals/bmri/2012/798924/
*  Regression of Low-Grade Cervical Intraepithelial Neoplasia i... : Obstetrics & Gynecology
DRB1*13 allele frequency is lower in women with cervica ... Decreased frequency of HLA-DRB1 13 alleles in Frenchwomen with ... The typing of DQA1, DQB1, and DRB1 was performed by polymerase chain reaction specific sequence oligonucleotide (SSO) reverse ... The probability of regression was also analyzed according to HPV and HLA-DRB1*13 status. In the group of HLA-DRB1*13 patients ... The HLA-DRB1*13 genotype was found in 20 (23%) cases (Table 1), of which 9 cases corresponded to DRB1*1301, 9 cases to DRB1* ...
  http://journals.lww.com/greenjournal/Fulltext/2004/10000/Regression_of_Low_Grade_Cervical_Intraepithelial.18.aspx
*  Positive and Negative Associations of Human Leukocyte Antigen Variants with the Onset and Prognosis of Adult Glioblastoma...
Other HLA variants at loci on either side of the HLA-B to HLA-C segment, i.e., A*03, DRB1*15 and MICA exon 5 allele A5.1, which ... and of another STR in exon 5 of the MHC class I-like chain A (MICA) gene were resolved through PCR amplification and automated ... These markers lie centromeric to the HLA-A locus and telomeric to the HLA-DRB1 locus, suggesting that HLA-B, HLA-C and perhaps ... resolved individual alleles from the classical HLA genes HLA-A, -B, -C, and -DRB1 at chromosome 6p21.3 (44, 45). Alleles of the ...
  http://cebp.aacrjournals.org/content/14/8/2040.long
*  Frontiers | T Cell-Mediated Chronic Inflammatory Diseases Are Candidates for Therapeutic Tolerance Induction with Heat Shock...
The HLA dictionary 2008: a summary of HLA-A,-B,-C,-DRB1/3/4/5, and-DQB1 alleles and their association with serologically ... The SE is a five amino-acid sequence motif found in residues 70-74 of the HLA-DRβ chain that encodes a conserved positively ... HLA-DRB1*0401-DQB1*0302 and HLA-DRB1*0301-DQB1*0201 have been associated with T1D susceptibility whereas the haplotypes HLA- ... HLA-B27 encompasses around 105 known subtypes (HLA-B*27:01 to HLA-B*27:106 thus far identified) that are encoded by 132 alleles ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.01408/full
*  Multiple sclerosis as a polygenic disease: An update, Russian Journal of Genetics | 10.1134/S1022795410030026 | DeepDyve
Combined Effect of HLA-DRB1*1501 and Interleukin-1 Receptor Antagonist Gene Allele 2 in Susceptibility to Relapsing/Remitting ... Vitamin D Receptor Gene Polymorphism in Multiple Sclerosis and the Association with HLA Class II Alleles ... by Inheritance of a 175-kb Region of the TcR V Beta Chain Locus and HLA Class II Genes ... A Markov Chain Monte Carlo Technique for Identification of Combinations of Allelic Variants Underlying Complex Diseases in ...
  https://www.deepdyve.com/lp/springer_journal/multiple-sclerosis-as-a-polygenic-disease-an-update-dx2Y010u4D
*  Gary Peltz | Stanford Medicine Profiles
HLA-DRB1 and -DQB1 genotypes were previously determined for these samples, allowing data stratification based on HLA-associated ... Most of the T cell clones recognized a given spirochetal Ag exclusively within the context of one HLA class II allele. However ... Nine bound to the 210-kD heavy chain and one (My8) bound to the 18-kD light chain. They defined six topographically distinct ... These data show that distinct HLA class II alleles confer both predisposition and resistance to PBC and provide insight into ...
  https://med.stanford.edu/profiles/gary-peltz
*  ASMscience | Human Leukocyte Antigen
However, no significant difference in HLA class II antigens and the frequencies of haplotypes HLA A-B and HLA A-B-DR was found ... Differences in HLA A-B haplotypes and HLA A-B-DR haplotypes were not statistically significant between healthy individuals and ... Differences were found in HLA-A antigen frequencies and HLA-B antigen frequencies between Legionella-positive patients and a ... frequency and HLA haplotype frequency in Legionella-positive patients with frequencies in healthy individuals from a local ...
  http://www.asmscience.org/content/book/10.1128/9781555817985.chap35
*  Actigraphy | Leaders in Pharmaceutical Business Intelligence (LPBI) Group
A connection between an immune gene, the human leukocyte antigen (HLA) allele HLA-DR2, and narcolepsy in humans had already ... DRB1*1503, and DRB1*1602 are DR2subtypes.DRB1*1101 and DRB1*12022 are DR5 subtypes. ... HLA) DQB1*0602 and DQA1*0102 (DQ1) genes using a specific polymerase chain reaction (PCR)-oligotyping technique. A similar ... Mignot's lab found that it was not the initial HLA-DR2allele that predisposed humans to narcolepsy, but another, nearby HLA ...
  https://pharmaceuticalintelligence.com/tag/actigraphy/
*  HLA-DRB1 gene - Genetics Home Reference
The protein produced from the HLA-DRB1 gene, called the beta chain, attaches (binds) to another protein called the alpha chain ... Researchers have identified hundreds of different versions (alleles) of the HLA-DRB1 gene, each of which is given a particular ... The HLA-DRB1 gene provides instructions for making a protein that plays a critical role in the immune system. The HLA-DRB1 gene ... A particular HLA-DRB1 gene variant called HLA-DRB1*04:04 is the most well-known risk factor for autoimmune Addison disease. ...
  https://ghr.nlm.nih.gov/gene/HLA-DRB1
*  Plus it
HLA DR3 was defined as DRB1*03:01 - DQA1*05:01 - DQB1*02:01, and HLA DR4-DQ8 was defined as DQA1*03:01 - DQB1*03:02 with DRB1* ... zero minor alleles) and also homozygous for the minor allele (two minor alleles) versus not (zero or one minor alleles). All ... Recent studies suggest a possible regulatory role of a TCF7L2 variant on acyl-CoA synthetase long-chain family member 5 (ACSL5 ... The protective HLA DRB1*15:01-DQB1*0602 haplotype was found in four noncarriers and in three carriers of the type 2 diabetes- ...
  http://care.diabetesjournals.org/content/41/2/311
*  SMART: MHC II beta domain annotation
Crystallographic structure of a rheumatoid arthritis MHC susceptibility allele, HLA-DR1 (DRB1*0101), complexed with the ... andexplain the peptide specificity of HLA-DR1. Twelve hydrogen bonds betweenconserved HLA-DR1 residues and the main chain of ... HLA-DO in complex with HLA-DM. 4i5b. Structure of human MHC class II protein HLA-DR1 carrying an influenza hemagglutinin ... CRYSTAL STRUCTURE OF HLA-DR2 (DRA*0101,DRB1*1501) COMPLEXED WITH A PEPTIDE FROM HUMAN MYELIN BASIC PROTEIN. ...
  http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00921
*  Associate Professor Robert Heard - The University of Sydney
A genome-wide screen for linkage disequilibrium in Australian HLA-DRB1*1501 positive multiple sclerosis patients. Journal of ... Hoe, E., McKay, F., Schibeci, S., Heard, R., Stewart, G., Booth, D. (2010). Interleukin 7 Receptor Alpha Chain (IL-7Ralpha) ... Partially methylated alleles, microdeletion, and tissue mosaicism in a fragile X male with tremor and ataxia at 30 years of age ... A genome-wide screen for linkage disequilibrium in Australian HLA-DRB1*1501 positive multiple sclerosis patients. Journal of ...
  http://sydney.edu.au/medicine/people/academics/profiles/robert.heard.php
*  The role of vitamin D3 and vitamin B9 (Folic acid) in immune system
In genetics, several human leukocyte antigen alleles (more particularly HLA-DRB1*1501) could favor the disease whereas others ... 76 BGP-15 is a calcipotriol-based analog where the 24-OH has been substituted by a chloride atom on the side chain of the ... 5-butyloxazole unit analog and additional analogs containing a structurally modified side chain.77-79 The dominant side effects ... human DCs in vitro results in reduced expression of the cost imulatory molecules CD80 and CD86 and decreased expression of HLA- ...
  http://ijer.skums.ac.ir/article_15823.html
*  Simulated structures of trimer-HLA system.HLA-DRB1*01:0 | Open-i
HLA-DRB1*01:01-Frame 3 (d-f), HLA-DRB1*07:01 (g-i) and HLA-DRB1*15:01 (j-l). (a), (d), ( ... Simulated structures of trimer-HLA system.HLA-DRB1*01:01-Frame 2 (a-c), ... Furthermore in silico molecular dynamics analysis revealed that lapatinib could change the β chain helix in the HLA-DRB1*07:01 ... Fig 6c shows that the RMSDs stabilize at different rates, depending on the allele and frame. This variability is expected ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4476721_pone.0130928.g007&req=4
*  Next-Generation Sequencing Reveals That HLA-DRB3, -DRB4, and -DRB5 May Be Associated With Islet Autoantibodies and Risk for...
First, among the 25 HLA-DRB1 alleles, only 4 (DRB1*03:01:01, DRB1*04:01:01, DRB1*04:04:01, and DRB1*04:05:01) were positively ... Therefore, determining to what extent the DRB3, DRB4, and DRB5 β-chains are able to form heterodimers with the DRA α-chains is ... In the HLA-DR locus, alleles of HLA-DRB1 are in linkage disequilibrium with alleles of either HLA-DRB3 or -DRB4 or -DRB5. Hence ... DRB1*01:02:01, DRB1*08:01:01, and DRB1*10:01:01, respectively. The methods for NGS of HLA alleles vary between approaches and ...
  http://diabetes.diabetesjournals.org/content/65/3/710
*  Plus it
1999) Associations of HLA-DRB1, DQB1 and DPB1 alleles with pulmonary tuberculosis in south India. Tuber Lung Dis 79:309-317. ... A complete genetic deficiency of IFNgR2 (the IFNgR signaling chain) has been found in one patient with severe disseminated ... 1996) Arginine at positions 13 or 70-71 in pocket 4 of HLA-DRB1 alleles is associated with susceptibility to tuberculoid ... 1993) Study of HLA class II alleles by PCR oligotyping in leprosy patients from north India. Tissue Antigens 42:133-137. ...
  http://dmd.aspetjournals.org/content/29/4/479