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*  Type 1 11beta-hydroxysteroid dehydrogenase as universal drug target in metabolic diseases?
... gene transcription as well as on cell-type specific biotransformation between 11beta-hydroxy glucocorticoids and their 11-oxo ... metabolites. The latter effect is accomplished by two different 11beta-hydroxysteroid dehydrogenase isozymes, constituting a ... Importantly, 11beta-HSD1 activity appears to be intrinsically linked to all features of the metabolic syndrome, which could at ... Whereas the type 1 enzyme (11beta-HSD1) is in vitro a NADP(H)- dependent bidirectional enzyme, it reduces in most instances in ...
  https://oacentre.kennedy.ox.ac.uk/publications/108459
*  5 alpha-reductase and 11 beta-hydroxysteroid dehydrogenase activity in prepubertal Hispanic girls with premature adrenarche. -...
... hydroxy metabolite pairs as well as the ratios of the total 5 alpha/total 5 beta and total 11 oxo/total 11 hydroxy metabolites ... We studied C19 and C21 urinary steroid metabolites, 5 alpha/5 beta and 11 oxo/11 ... Total cortisol metabolites were not different in the girls with premature adrenarche, compared with the controls. In conclusion ... We found no differences in the 5 alpha-reductase or 11 beta-hydroxysteroid dehydrogenase activities in the prepubertal girls ...
  https://www.semanticscholar.org/paper/5-alpha-reductase-and-11-beta-hydroxysteroid-dehyd-Silfen-Shackleton/018ab3c0f96b12a4e7dcaa84e3ff157db6899159
*  Human Metabolome Database: Showing Protein 3-oxo-5-beta-steroid 4-dehydrogenase (HMDBP00550)
3-Beta-Hydroxysteroid Dehydrogenase Deficiency. *Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia due to 21- ... 7a-Hydroxy-5b-cholestan-3-one + NADP → 7a-Hydroxy-cholestene-3-one + NADPH + Hydrogen Ion. details ... 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7-alpha,12-alpha- ... Showing Protein 3-oxo-5-beta-steroid 4-dehydrogenase (HMDBP00550). IdentificationBiological propertiesGene propertiesProtein ...
  http://www.hmdb.ca/proteins/HMDBP00550
*  Human type 10 17 beta-hydroxysteroid dehydrogenase: molecular modelling and substrate docking.
However, it also mediates oxidation of 3 alpha-hydroxy groups of androgens, thereby reactivating androgen metabolites. Finally ... The human type 10 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD-10) is a multifunctional mitochondrial enzyme that ... it is involved in beta-oxidation of fatty acids by catalyzing the L-hydroxyacyl CoA dehydrogenase reaction of the beta- ... The structure obtained displays the properties of a one-domain, alpha/beta fold enzyme of the SDR family. The active site is ...
  https://oacentre.kennedy.ox.ac.uk/publications/108608
*  Human Metabolome Database: Showing metabocard for 17alpha,21-Dihydroxypregnenolone (HMDB0006762)
2. 3 beta-hydroxysteroid dehydrogenase/Delta 5--,4-isomerase type 1. General function:. Involved in 3-beta-hydroxy-delta5- ... It is then converted to 11beta,17alpha,21-Trihydroxypregnenolone via the enzyme cytochrome P450 (EC 1.14.15.4).. ... Metabolite Identification. Common Name. 17alpha,21-Dihydroxypregnenolone. Description. 17alpha,21-Dihydroxypregnenolone is an ... 3. 3 beta-hydroxysteroid dehydrogenase/Delta 5--,4-isomerase type 2. General function:. Involved in 3-beta-hydroxy-delta5- ...
  http://www.hmdb.ca/metabolites/HMDB06762
*  Human Metabolome Database: Showing metabocard for Dehydroepiandrosterone (HMDB0000077)
5. 3 beta-hydroxysteroid dehydrogenase/Delta 5--,4-isomerase type 1. General function:. Involved in 3-beta-hydroxy-delta5- ... Glucocorticoids inhibit interconversion of 7-hydroxy and 7-oxo metabolites of dehydroepiandrosterone: a role for 11beta- ... 6. 3 beta-hydroxysteroid dehydrogenase/Delta 5--,4-isomerase type 2. General function:. Involved in 3-beta-hydroxy-delta5- ... Adrenal hyperplasia, congenital, due to 3-beta-hydroxysteroid dehydrogenase 2 deficiency. *Hattori N, Ishihara T, Moridera K, ...
  http://www.hmdb.ca/metabolites/HMDB0000077
*  KEGG BRITE: KEGG Orthology (KO) - Tupaia chinensis (Chinese tree shrew)
102482283 HSD17B1; hydroxysteroid 17-beta dehydrogenase 1 102481564 HSD17B2; hydroxysteroid 17-beta dehydrogenase 2 102485005 ... steroid 11beta-monooxygenase [EC:1.14.15.4] K00251 AKR1D1; 3-oxo-5-beta-steroid 4-dehydrogenase [EC:1.3.1.3] K15680 HSD11B1; ... 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1] K00070 HSD3B; 3beta-hydroxy-Delta5- ... 102473205 HSD17B7; hydroxysteroid 17-beta dehydrogenase 7 102494154 HSD17B8; hydroxysteroid 17-beta dehydrogenase 8 102495234 ...
  http://www.genome.jp/kegg-bin/get_htext?tup00001+102491327
*  Papers with the keyword 7-keto DHEA | Read by QxMD
delta (5)3 beta hydroxysteroid dehydrogenase activity transforms biologically inactive delta (5)3 beta hydroxy steroids into ... 6-phosphate-dehydrogenase-modulates-11beta-hydroxysteroid-dehydrogenase-type-1-dependent-metabolism-of-7-keto-and-7beta-hydroxy ... The main metabolites of 7-keto-DHEA are 7-hydroxylated compounds. The commercial 1-androstenediol preparation was contaminated ... Hexose-6-phosphate dehydrogenase modulates 11beta-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7beta ...
  https://www.readbyqxmd.com/keyword/110574
*  Primary amenorrhoea with hypertension: undiagnosed 17-α-hydroxylase deficiency | The Medical Journal of Australia
HSD = hydroxysteroid dehydrogenase. OH = hydroxy. * Aldosterone is usually suppressed, owing to the salt-retaining and volume ... Pregnanediol (a progesterone metabolite), tetrahydrocorticosterone and tetrahydro compound A (deoxycorticosterone metabolites) ... This diagnosis was further supported by steroid metabolite levels in a spot urine sample. ... and decreased androstenedione metabolites (etiocholanolone and androsterone) were observed. ...
  https://www.mja.com.au/journal/2013/199/8/primary-amenorrhoea-hypertension-undiagnosed-17-hydroxylase-deficiency
*  Human Metabolome Database: Showing metabocard for 7alpha-Hydroxy-3-oxo-4-cholestenoate (HMDB0012458)
2. 3 beta-hydroxysteroid dehydrogenase type 7. General function:. Involved in 3-beta-hydroxy-delta5-steroid dehydrogenase ... Metabolite Identification. Common Name. 7alpha-Hydroxy-3-oxo-4-cholestenoate. Description. 7alpha-Hydroxy-3-oxo-4-cholestenoate ... 7alpha-Hydroxy-3-oxo-4-cholestenoate is involved in the primary bile acid biosynthesis pathway. 7alpha-Hydroxy-3-oxo-4- ... The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active ...
  http://www.hmdb.ca/metabolites/HMDB0012458
*  Human Metabolome Database: Showing metabocard for 7 alpha,26-Dihydroxy-4-cholesten-3-one (HMDB0012459)
2. 3 beta-hydroxysteroid dehydrogenase type 7. General function:. Involved in 3-beta-hydroxy-delta5-steroid dehydrogenase ... DrugBank Metabolite ID. Not Available. Phenol Explorer Compound ID. Not Available. Phenol Explorer Metabolite ID. Not Available ... 2R,9R,15R)-9-hydroxy-14-[(2R)-7-hydroxy-6-methylheptan-2-yl]-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-5-one. ... 2R,9R,15R)-9-hydroxy-14-[(2R)-7-hydroxy-6-methylheptan-2-yl]-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-5-one. ...
  http://www.hmdb.ca/metabolites/HMDB0012459
*  Human Metabolome Database: Showing metabocard for 7 alpha-Hydroxy-3-oxo-4-cholestenoate (HMDB0012458)
2. 3 beta-hydroxysteroid dehydrogenase type 7. General function:. Involved in 3-beta-hydroxy-delta5-steroid dehydrogenase ... Metabolite Identification. Common Name. 7 alpha-Hydroxy-3-oxo-4-cholestenoate. Description. 7 alpha-Hydroxy-3-oxo-4- ... 7 alpha-Hydroxy-3-oxo-4-cholestenoate is created from either 3 beta,7 alpha-Dihydroxy-5-cholestenoate or 7 alpha,26-Dihydroxy-4 ... 3 beta,7 alpha-Dihydroxy-5-cholestenoate + NAD → 7 alpha-Hydroxy-3-oxo-4-cholestenoate + NADH + Hydrogen Ion. details. ...
  http://www.hmdb.ca/metabolites/HMDB12458
*  Human Metabolome Database: Showing metabocard for Progesterone (HMDB0001830)
3-Beta-Hydroxysteroid Dehydrogenase Deficiency. Not Available. Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia due ... 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7-alpha,12-alpha- ... dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4-cholesten-3-one can also act as substrates. Gene Name:. AKR1D1. Uniprot ID:. ... Adrenal hyperplasia, congenital, due to 3-beta-hydroxysteroid dehydrogenase 2 deficiency. *Hattori N, Ishihara T, Moridera K, ...
  http://www.hmdb.ca/metabolites/HMDB01830?pathways=2
*  4 Information Related to Biologic Plausibility | Veterans and Agent Orange: Update 2008 | The National Academies Press
... roid hydroxysteroid 17-beta dehydrogenase; plus a novel gene (Hectd2) with poorly defined function (Hayes et al., 2007). â ¢ ... As metabolism occurs, the initial (parent) chemical is converted to new chemicals called metabolites. When metabolites are ... Chronic exposure of ddY mice to DMAV at 400 ppm in drinking water increased staining for 4-hydroxy-2-nonenal adducts, which are ... Leukotriene A4 metabolites are endogenous ligands for the Ah receptor. Biochemistry 47(32):8445â 8455. Cohen SM, Arnold LL, ...
  https://www.nap.edu/read/12662/chapter/6
*  12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor | definition of 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor...
What is 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor? Meaning of 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid ... What does 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor mean? ... hydroxy-5,8,10,14-eicosatetraenoic acid receptor in the Medical Dictionary? 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid ... an arachidonic acid metabolite secreted by platelets and tumour cells; HETE induces endothelial cell retraction, allowing ...
  https://medical-dictionary.thefreedictionary.com/12-
*  A metabolomic approach to identifying platinum resistance in ovarian cancer | Journal of Ovarian Research | Full Text
Pyrimidine metabolites 5,6-dihydro uracil, beta-alanine, glutamine, urea, uridine 5-diphosphate and uridine 5-triphosphate were ... succinate dehydrogenase, lactate dehydrogenase; fatty acid oxidation: Carnitine palmitoyltransferase-1, Acetyl CoA Carboxylase ... Eleven networks were constructed as reported in Additional file 3: Table S3. The top network uses 19 molecules and focuses on ... 3-hydroxy-3-methyl-glutaryl-CoA; Acox: acyl CoA; Ces: cholesterol esters. ...
  https://ovarianresearch.biomedcentral.com/articles/10.1186/s13048-015-0140-8
*  Epiandrosterone - Wikipedia
Identification of 5 alpha-androstane-3 beta,17 beta-diol and 3 beta-hydroxy-5 alpha-androstan-17-one sulfates as quantitatively ... steroids androstanediol via 17β-hydroxysteroid dehydrogenase or from androstanedione via 3β-hydroxysteroid dehydrogenase.[ ... Changes in serum DHEA and eleven of its metabolites during 12-month percutaneous administration of DHEA. J Steroid Biochem Mol ... It is a metabolite of testosterone and dihydrotestosterone (DHT). It was first isolated in 1931, by Adolf Friedrich Johann ...
  https://en.wikipedia.org/wiki/Epiandrosterone
*  What does 11-beta-hydroxysteroid dehydrogenases stand for?
Beta' is one option -- get in to view more @ The Web's largest and most authoritative acronyms and abbreviations resource. ... Looking for the definition of 11-beta-hydroxysteroid dehydrogenases? Find out what is the full meaning of 11-beta- ... Hydroxysteroid dehydrogenases that catalyzes the reversible conversion of CORTISOL to the inactive metabolite CORTISONE. ... Beta Hydroxy Acid. Academic & Science » Chemistry. Rate it:. BHA. Beta Hydroxy Acid ...
  http://www.abbreviations.com/serp.php?st=11-beta-hydroxysteroid%20dehydrogenases&qtype=3
*  Frontiers | Therapeutic effects of progesterone and its metabolites in traumatic brain injury may involve non-classical...
... beta, gamma, delta and epsilon) in the brain that are distinct from Pgr, although the role of these receptors in the normal ... In the brain, P4 is converted to a metabolite, allopregnanolone (ALLO), whose beneficial effects equal or exceed those of P4 in ... beta, gamma, delta and epsilon) in the brain that are distinct from Pgr, although the role of these receptors in the normal ... and the effects of P4 and its metabolite ALLO in TBI may involve Pgr, membrane progesterone receptors and other signaling ...
  https://www.frontiersin.org/articles/10.3389/fnins.2013.00108/full
*  John Weisz | Harvard Catalyst Profiles | Harvard Catalyst
Orth J, Weisz J. Development of delta 5 -3 beta hydroxysteroid dehydrogenase and glucose-6-phosphate dehydrogenase activity in ... Effects of prolactin and LH on the activity of delta5-3beta hydroxy-steroid dehydrogenase, dihydro-orotic dehydrogenase, b- ... Kao LW, Weisz J. Direct effect of testosterone and its 5alpha-reduced metabolites on pituitary LH and FSH release in vitro: ... A quantitative cytochemical study of glucose-6-phosphate dehydrogenase and delta 5-3 beta-hydroxysteroid dehydrogenase activity ...
  https://connects.catalyst.harvard.edu/profiles/display/Person/77736
*  COMBINATION THERAPY FOR SKIN DISORDERS - Patent application
... hydroxy-steroid dehydrogenase inhibitor, a PPARα ligand, a dual acting PPAR ligand, PN-2034, PPAR δ, a 17-ketoreductase ... hydroxysteroid dehydrogenase inhibitors, PPARα ligands such as bezafibrate, fenofibrate, gemfibrozil; PPARγ ligands such as ... inhibitor, a 3.beta.-DHΔ4,6-isomerase inhibitor, a 3.beta.-DHΔ4,5-isomerase inhibitor, a 17,20 desmolase inhibitor, a p450c17 ... metabolites, derivatives, pharmaceutically acceptable salts, N-oxides, hydrates or any combination thereof. Anti-Androgen ...
  http://www.patentsencyclopedia.com/app/20140199375
*  HSD11B1 ELISA & Assay Kits
38 products from 11 suppliers. Compare and order HSD11B1 ELISA Kits. View citations, images, detection ranges, sensitivity, ... 7-alpha-hydroxycholesterol dehydrogenase , 11beta-HSD-1 , 11beta-HSD1A , 11beta-hydroxysteroid dehydrogenase type 1 , ... Hydroxy-delta-5-Steroid Dehydrogenase, 3 beta- and Steroid delta-Isomerase 1 ELISA Kits ... by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite ...
  https://www.antibodies-online.com/metabolism-of-steroid-hormones-and-vitamin-d-pathway-32/hsd11b1-elisa-kit-8338/
*  Cancers | Free Full-Text | The Endometriotic Tumor Microenvironment in Ovarian Cancer | HTML
... and 17β-hydroxysteroid-dehydrogenase (17β-HSD) type 1 and the absence of 17β-HSD type 2 [107,116]. Aromatase converts ... Young, V.J.; Brown, J.K.; Saunders, P.T.; Duncan, W.C.; Horne, A.W. The peritoneum is both a source and target of TGF-Beta in ... Roca, F.J.; Loomans, H.A.; Wittman, A.T.; Creighton, C.J.; Hawkins, S.M. Ten-eleven translocation genes are downregulated in ... and 8-hydroxy-2′-deoxyguanosine. High expression of these markers of oxidative stress link endometriosis, high iron, and higher ...
  https://www.mdpi.com/2072-6694/10/8/261/htm
*  Human Metabolome Database: Showing Protein 3-hydroxyacyl-CoA dehydrogenase type-2 (HMDBP00379)
17-beta-hydroxysteroid dehydrogenase 10. *3-hydroxy-2-methylbutyryl-CoA dehydrogenase. *3-hydroxyacyl-CoA dehydrogenase type II ... IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 20 metabolites ... He XY, Schulz H, Yang SY: A human brain L-3-hydroxyacyl-coenzyme A dehydrogenase is identical to an amyloid beta-peptide- ... Submicroscopic duplications of the hydroxysteroid dehydrogenase HSD17B10 and the E3 ubiquitin ligase HUWE1 are associated with ...
  http://www.hmdb.ca/proteins/HMDBP00379
*  Norethisterone - Wikipedia
These transformations are catalyzed by 5α- and 5β-reductase and 3α- and 3β-hydroxysteroid dehydrogenase both in the liver and ... Whether these metabolites of norethisterone interact with the GABAA receptor similarly to the 3,5-tetrahydro metabolites of ... and simultaneously of the keto group at C17 to a hydroxy group, which is then oxidized back to a keto group by chromium ... "Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta". ...
  https://en.wikipedia.org/wiki/Norethisterone