High rates of midazolam injection and associated harms in Bangkok, Thailand. - Semantic Scholar
AIMS To identify the prevalence and correlates of midazolam injection among injecting drug users in Thailand. DESIGN Serial cross-sectional mixed-methods study. SETTING Bangkok, Thailand. PARTICIPANTS A total of 435 adults who had injected drug(s) in the past 6 months were recruited through peer outreach and word of mouth in Bangkok in 2011. MEASUREMENTS Multivariable logistic regression was used to analyze self-reported data collected through an interviewer-administered survey in July-October 2011 (n = 435). Additionally, qualitative data were collected in June-July 2009 (n = 10) and analyzed to explore the health problems attributable to midazolam injection. FINDINGS Among 435 survey participants, the prevalence of daily midazolam injection in the past 6 months was 37.0% (95% confidence interval: 32-42). While 75.8% of the daily midazolam injectors identified heroin as their drug of choice, 91.8% of these individuals reported ...https://www.semanticscholar.org/paper/High-rates-of-midazolam-injection-and-associated-h-Hayashi-Suwannawong/4a8fbf09665cec1e4610a2e71fd890c9a20220d8
Pharmacokinetics Alterations of Midazolam Infusion versus Bolus Administration in Mechanically Ventilated Critically Ill...
There is no randomized study carried out in order to compare their pharmacokinetic parameters although midazolam, as a sedative, has been widely administered via continuous infusion as well as intermittent bolus doses in mechanically ventilated critically ill patients. We prospectively investigated the effect of these two principal methods on pharmacokinetic parameters in 23 of mentioned patients (16 males, 7 females) with the mean (± SD) age of 41.22 ± 17.5. All patients received total dose of 72 mg throughout the test days, 9 of whom received 1 mg/h (continuous infusion) and the rest obtained 4 mg / 4 h (intermittent bolus doses). Blood samples were collected at 8 and 4 h prior to the end time of drug administration (zero time), zero time and 4, 8, 12, 20 and 30 h after it. APACHE (Acute Physiology and Chronic Health Evaluation) II required data was recorded daily and the patients' mean score was 16.26 ± 4.38. The mean (± SD) value of ...http://ijpr.sbmu.ac.ir/article_1319.html
1994 - Review: Sedative recovery rate with midazolam is no faster than with diazepam | 1995 Mar-Apr : Volume 122, Number 2,...
Through a qualitative review of the literature, Ariano and colleagues concluded that no clinically important difference in recovery rates from sedation existed between diazepam and midazolam. Clinicians must not assume from this study, however, that diazepam and midazolam can be interchanged freely for short-term sedation. The lack of a validated sedation assessment tool makes it difficult to know if the degrees of recovery were similar in the compared studies (1). Also, the question of whether equipotent doses of drugs were used still remains. In most of the reviewed studies, midazolam was considered to be approximately twice as potent as diazepam; however, recent clinical evidence indicates that this ratio may be too low. According to 1 study, the diazepam-to-midazolam potency ratio may be closer to between 3:1 and 6:1 than to 2:1 (2). This study does raise an important point about short-term sedation. Elimination half-lives of ...http://www.acpjc.org/Content/122/2/issue/ACPJC-1995-122-2-040.htm
Clinical Pharmacology of Midazolam in Neonates and Children: Effect of Disease-A Review : Table 1
Note B: midazolam was administered via a central or peripheral venous catheter; Note C: midazolam was administered intravenously as a continuous infusion to 109 infants, as a bolus dose to 22 infants, and as a combination of both to 56 infants. The bolus dose was 210 ± 239 µg/kg. The continuous infusion was 69 ± 63 µg/kg per h; Note D: all neonates received midazolam during artificial ventilation; Note E: neonates undergoing mechanical ventilation had a body weight ,1,500 g ...https://www.hindawi.com/journals/ijpedi/2014/309342/tab1/
Clinical Trial of Oral Midazolam in Pediatric Endoscopy - Full Text View - ClinicalTrials.gov
Although gastrointestinal endoscopy is widely accepted as fundamental to the diagnosis and treatment of digestive disorders in children, considerable controversy and practice differences persist with respect to the methods and agents used to achieve optimal endoscopic sedation.. Comparison:oral midazolam vs midazolam IV in sedation and comfort scale of pediatric endoscopy. ...https://clinicaltrials.gov/ct2/show/NCT00636428
Increased abuse of opioids is contributing to an escalation in overdose deaths. Benzodiazepines are frequently abused with opioids, possibly because they increase the potency and/or effectiveness of opioids to produce reinforcing effects. This study used a concurrent-choice procedure to determine whether monkeys would choose to self-administer a mixture of the opioid remifentanil and the benzodiazepine midazolam over remifentanil alone. Initially, three monkeys could respond on one lever for saline and on a second lever for either remifentanil alone or midazolam alone. Thereafter, monkeys chose between a dose of remifentanil (0.32 µg/kg/infusion) that did not change and a dose of remifentanil that varied across sessions; for some sessions, midazolam was combined with varying doses of remifentanil. All monkeys received more infusions of remifentanil (0.0032-0.32 µg/kg/infusion) than saline, whereas only two monkeys responded more for ...http://jpet.aspetjournals.org/content/362/1/59
Midazolam Accord Healthcare - Drugs.com
Midazolam Accord Healthcare is a medicine available in a number of countries worldwide. A list of US medications equivalent to Midazolam Accord Healthcare is available on the Drugs.com website.https://www.drugs.com/international/midazolam-accord-healthcare.html
Midazolam Lafedar - Drugs.com
Midazolam Lafedar is a medicine available in a number of countries worldwide. A list of US medications equivalent to Midazolam Lafedar is available on the Drugs.com website.https://www.drugs.com/international/midazolam-lafedar.html
Most recent papers with the keyword Apache | Read by QxMD
OBJECTIVE: To investigate the influence of analgesic-based midazolam sedation on delirium and outcomes in critically ill patients and to analyze the risk factors of delirium. DESIGN: Single center, prospective randomized controlled trial. SETTING: A surgical intensive care unit (ICU) in a tertiary care hospital in China. PATIENTS: Mechanically ventilated patients requiring sedation. MEASUREMENTS AND MAIN RESULTS: Patients admitted to the surgical intensive care unit who required sedation and were undergoing mechanical ventilation for longer than 24 hours were randomly divided into three groups: 1) the remifentanil group received remifentanil and midazolam, 2) the fentanyl group received fentanyl and midazolam, and 3) the control group received only midazolam ...https://www.readbyqxmd.com/keyword/19582
Drugs | wmpcg
Drugs. Midazolam 2.5-5mg SC hourly PRN. Morphine 2.5-5mg SC 1-2 hourly PRN (higher doses of morphine may be appropriate in patients who are already receiving regular strong opioids. In patients who need repeated (hourly) doses seek specialist palliative care advice.) SeePalliation of Breathlessness and Symptom control in patients with renal disease and cardiac failure.. Patients who are persistently breathless and distressed may benefit from a continuous infusion of morphine and/or midazolam - in practice try to ascertain the required dose(s) by observing and titrating according to usage of morphine or midazolam over the previous 24-48 hours.. For some patients in the dying phase it may be more practical to commence an infusion of morphine or midazolam at an earlier stage alongside the provision of additional PRN medication.. ...http://wmpcg.co.uk/?page_id=846
新光急診: Ketamine 用於急診是安全的
Results: 210 patients were included of whom 85 (40%) were given ketamine, 107 (51%) midazolam and 18 (9%) propofol. The median time to full orientation was 25 min for ketamine, 30 min for midazolam and 10 min for propofol. Complications occurred in 15.9% of sedations overall (14.6% of those given ketamine, 15.8% given midazolam and 22.2% given propofol). Apnoea and hypoxia most often occurred with midazolam and propofol, while hypertension and hypertonicity were encountered more frequently with ketamine. In addition, 19.5% of patients given ketamine suffered the re-emergence phenomenon. The association between deep sedation with no response to pain and adverse events encountered with midazolam does not occur with ketamine ...http://er119org.blogspot.com/2008/08/ketamine.html
Study of Dolutegravir (DTG) on PK of Cenicriviroc (CVC), and CVC on PK of DTG & on a Single Dose of Midazolam - Full Text View ...
Physical examinations, vital signs, ECGs, clinical laboratory tests, and AEs or serious AEs (SAEs) will be assessed at specified time points according to the Schedule of Procedures in the protocol. In addition, arterial oxygen saturation will be monitored by pulse oximetry for at least 2 hours after administration of midazolam on Days -1 and 9 in Group 1.. For both groups, a final follow-up visit will occur 14 days (±3 days) after the last dose of study medication, or at the time of early termination (if applicable) to evaluate any remaining safety issue(s). ...https://clinicaltrials.gov/show/NCT01827540?order=17
Midazolam hcl syrup dosage - Answers on HealthTap
Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Novitzky on midazolam hcl syrup dosage: Expired meds, including hydrocodone, still have potency, but perhaps not as much as the fresh medication. There is no danger in taking them, with rare exceptions.https://www.healthtap.com/topics/midazolam-hcl-syrup-dosage
Intranasal Sufentanil/Midazolam Versus Ketamine/ Midazolam for Analgesia/Sedation: Result
Patients in the 2 groups were similar with respect to age, height, weight, gender distribution, and length of surgery, and the number of teeth removed (Table 1). There were no significant differences (P = .05) in the physiological parameters, namely blood pressures (systolic, diastolic, mean arterial), heart rates, respiratory rates, and oxygen saturation between the 2 groups at the various time intervals measured (Table 2). With regard to the preoperative sedation and anxiety levels at the intervals post-drug administration, no significant differences were found between the 2 groups (P = 0.05) (Figures 1 and 2). Significantly more patients in the S/ M group accepted the nasal premedication (chi-square test = 7.718, P = .021; Table 3). No significant differences were found in the ease of mask induction (P = .05; Table 4). No adverse effects like nausea, vomiting, itching, and excessive sedation were observed in either group. There were no significant differences seen between the 2 groups as far ...http://www.anesthesiaprogress.com/intranasal-sufentanilmidazolam-versus-ketamine-midazolam-for-analgesiasedation-result.html
Midazolam, molecular model. Benzodiazepine class drug used to treat acute seizures, insomnia and for inducing sedation and...
Stock Photo 4128R-16892: Download Midazolam, molecular model. Benzodiazepine class drug used to treat acute seizures, insomnia and for inducing sedation and amnesia before medical procedures. Atoms are represented as spheres and are colour_coded: carbon grey, hydrogen white, nitrogen blue Stock Photos. Search over 12 million royalty free images and rights managed stock photographyhttps://www.superstock.com/stock-photos-images/4128R-16892
Intranasal Sufentanil/Midazolam Versus Ketamine/ Midazolam for Analgesia/Sedation: METHODS
The University Ethics Committee approved the study, and the parents signed written consent forms. Fifty healthy ASA status 1 children, free of any nasopharyngeal or respiratory problems, aged 5-7 years, weighing 15-20 kg, and having 6 or more teeth extracted, were eligible for participation in the study. Exclusion criteria were as follows: the use of analgesics or central nervous system depressants over the previous 24 hours; the use of anticoagulants; hypersensitivity to opioids, benzodiazepines, and ketamine, or any other medication likely to interfere with the study drugs. At a presurgery visit, patients were evaluated for inclusion, and baseline assessments (including a medical history) were performed. Patients were randomly allocated before surgery according to a computer-generated randomization list to 1 of 2 treatment groups. Children were fasted for 8 hours beforehand with only sips of clear fluid allowed 3-4 hours preinduction. In the S/M group, 25 children received intranasal ...http://www.anesthesiaprogress.com/intranasal-sufentanilmidazolam-versus-ketamine-midazolam-for-analgesiasedation-methods.html
Study to Evaluate the Safety and Efficacy of USL261 (Intranasal Midazolam) in Patients With Seizure Clusters - Full Text View -...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...https://clinicaltrials.gov/ct2/show/NCT01390220?term=USL261&rank=2
Items where Subject is "Medicine | KMC Mangalore | Anaesthesiology" - MU Digital Repository
Santha, Neeta and Upadya, Madhusudan and *, Padmini Viswanath (2017) Anesthetic management of a case of insulinoma. Anaesthesia, Pain and Intensive Care, 21 (2). pp. 272-274. *, Neeta S. and Rao, Rammoorthi and Upadya, Madhusudan and *, Keerthi P (2017) Arteriovenous Malformation of Face: A Challenge to Anesthesiologists. Anesthesia: Essays and Researches, 11 (3). pp. 784-786. ISSN 0259-1162 *, Keerthi P and Kamath, Shaila S (2017) Comparative study of dexmedetomidine, butorphanol and tramadol for post-spinal anesthesia shivering. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 8 (1). pp. 1801-1809. ISSN 0975-8585 Gupta, Roshni and *, Neeta Santha and Upadya, Madhusudan and Manissery, Jesni Joseph (2017) Effect of Different Dosages of Intravenous Midazolam Premedication on Patients Undergoing Head and Neck Surgeries- A Double Blinded Randomized Controlled Study. Journal of Clinical and Diagnostic Research, 11 (8). UC01-UC04. ISSN 0973 - 709X *, Trishna Pradeep and ...http://eprints.manipal.edu/view/subjects/ME-KMG1.html
Midazolam (Oral Route) Description and Brand Names - Mayo Clinic
Midazolam is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system. This medicine is given only by or under the immediate supervision of a doctor trained to use this medicine. This product is available in the following dosage forms:. ...http://www.mayoclinic.org/drugs-supplements/midazolam-oral-route/description/DRG-20072182
... is a drug that can be used as a sedative before and during surgeries and medical procedures. This eMedTV resource offers a more in-depth look at this medication and its effects, dosage guidelines, and general precautions.http://drugs.emedtv.com/midazolam/midazolam-p3.html
MIDAZOLAM INJECTION BP 2MG/ML SOLUTION FOR INJECTION OR INFUSION | Drugs.com
Patient information for MIDAZOLAM INJECTION BP 2MG/ML SOLUTION FOR INJECTION OR INFUSION Including dosage instructions and possible side effects.https://www.drugs.com/uk/midazolam-injection-bp-2mg-ml-solution-for-injection-or-infusion-leaflet.html
Dormicum (Midazolam) 15 mg Online - Link pharma Online
Dormicum (Midazolam) 15 mg Online, we have all kind of medicines, you can visit our website if you need anything we are provide everything.http://linkpharma.org/product/dormicum-15mg/
The current study was designed to evaluate whether clarithromycin altered the in vivo activity of CYP1A2, CYP2C9, and CYP2D6 in addition to its established effects on CYP3A4. These four enzymes are the principle drug-metabolizing enzymes in humans and account for the metabolism of ,90% of administered drugs that require biotransformation for elimination. Each of the probe drugs used, tolbutamide, caffeine, and dextromethorphan, have been validated individually as effective and specific probes for CYP1A2, CYP2C9, and CYP2D6, respectively.. It is clear that macrolide antibiotics such as troleandomycin, erythromycin, and clarithromycin are potent irreversible inhibitors of CYP3A-mediated biotransformations both in vitro and in vivo. We have previously demonstrated that clarithromycin significantly inhibits CYP3A activity in vivo (Gorski et al., 1998). In that study, we used intravenous midazolam, and an oral solution of the stable isotope15N3-midazolam was administered ...http://dmd.aspetjournals.org/content/29/7/1023
Sedation Woes... - pg.2 | allnurses
Page 2 - What do you use routinely for sedation on patiently requiring mechanical ventilation? Our first line routine is fentanyl @ 1mcg/kg/hr and midazolam at 1mcg/kg/min and we increase as patient needs tohttp://allnurses.com/picu-nursing-pediatric/sedation-woes-672311-page2.html
Phase I, randomised, open-label study evaluating the pharmacokinetics, pharmacodynamics and tolerability of intranasal...
This study investigated the pharmacokinetics, pharmacodynamics and tolerability of intranasal midazolam [USL 261] in patients with epilepsy on stablehttp://adisinsight.springer.com/trials/700225946