Interleukin-1 receptor type 1 (IPR004076) | InterPro | EMBL-EBI
... these have been termed type I and type II receptors [PMID: 8702856]. The receptors both exist in transmembrane (TM) and soluble ... Type I, activating receptor activity Cellular Component. No terms assigned in this category. ... Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA.. J. Biol. Chem. 271 20965 ... including the interleukin-6 receptor. A novel method for virus immune evasion has been proposed in which the product of one or ...http://www.ebi.ac.uk/interpro/entry/IPR004076
IL1R2 Gene - GeneCards | IL1R2 Protein | IL1R2 Antibody
Interleukin 1 Receptor Type 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The ... type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to ... this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. *IL1R2_HUMAN, ... Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to ...http://www.genecards.org/cgi-bin/carddisp.pl?gene=IL1R2
Alberto Mantovani - Wikipedia
Mantovani was able to identify the operating principle of the decoy receptor for interleukin - 1. In 1993, his team showed ... His works revealed the existence of decoy receptors in cell-signalling. He has been the most cited scientist in Italy, and one ... His team demonstrated in 2005 that the chemokine receptor D6 acts as a decoy and scavenger receptor for inflammatory chemokines ... His works help to establish the concept of "decoy receptors". From the study of the regulation of the cytokines, ...https://en.wikipedia.org/wiki/Alberto_Mantovani
Expression of TOLLIP in cancer - Summary - The Human Protein Atlas
GO:0045092 [interleukin-18 receptor complex]. GO:0045321 [leukocyte activation]. GO:0045323 [interleukin-1 receptor complex]. ... The cancer types are color-coded according to which type of normal organ the cancer originates from.. Read more ... GO:0004871 [signal transducer activity]. GO:0005150 [interleukin-1, Type I receptor binding]. GO:0005515 [protein binding]. GO: ... G-protein coupled receptors. Mapped to UniProt SWISS-PROT. Nuclear receptors. Plasma proteins. Potential drug targets. ...http://www.proteinatlas.org/ENSG00000078902-TOLLIP/pathology
Standardization of methods to record Vagus nerve activity in mice | SpringerLink
To study the receptor dependency of LPS-induced responses, we used LPS-receptor TLR4 knock out (TLR4 KO) mice. Wild type mice ... Malinowsky D, Chai Z, Bristulf J, Simoncsits A, Bartfai T. The type I interleukin-1 receptor mediates fever in the rat as shown ... Characterization of cholecystokininA and cholecystokininB receptors expressed by vagal afferent neurons. Neuroscience. 1997;79: ... Importantly, vagus neurogramactivity in wild type and TLR4 receptor knock out mice exhibits receptor dependency of endotoxin ...https://link.springer.com/article/10.1186/s42234-018-0002-y
Anti-Interleukin 10 Receptor Monoclonal Antibody Is an Adjuvant for T Helper Cell Type 1 Responses to Soluble Antigen Only in...
1986) A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-gamma. J. Immunol. 136:949-954 ... this will require signaling through Toll receptors as well as neutralization of endogenous suppressive molecules such as IL-10. ... Anti-Interleukin 10 Receptor Monoclonal Antibody Is an Adjuvant for T Helper Cell Type 1 Responses to Soluble Antigen Only in ... Anti-Interleukin 10 Receptor Monoclonal Antibody Is an Adjuvant for T Helper Cell Type 1 Responses to Soluble Antigen Only in ...http://jem.rupress.org/content/192/10/1529
Interleukin 1 receptor, type II - Wikipedia
Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this ... Larregina A, Morelli A, Kolkowski E, Fainboim L (Feb 1996). "Flow cytometric analysis of cytokine receptors on human Langerhans ... Gomez E, Morel G, Cavalier A, Liénard MO, Haour F, Courtens JL, Jégou B (Jun 1997). "Type I and type II interleukin-1 receptor ... type II (IL-1R2) also known as CD121b (Cluster of Differentiation 121b) is an interleukin receptor. IL1R2 also denotes its ...https://en.wikipedia.org/wiki/Interleukin_1_receptor,_type_II
Loss of Biphasic Effect on Na/K-ATPase Activity by Angiotensin II Involves Defective Angiotensin Type 1 Receptor-Nitric Oxide...
Kaschina E, Unger T. Angiotensin AT1/AT2 receptors: regulation, signalling and function. Blood Press. 2003; 12: 70-88. ... NF-κB-dependent reporter constructs demonstrated rapid activation of NF-κB with interleukin 1β, which was paralleled by ... Hakam AC, Hussain T. Angiotensin II type 2 receptor agonist directly inhibits proximal tubule sodium pump activity in obese but ... Some studies suggest the involvement of AT1R in stimulation and Ang type 2 receptor in inhibition.27 Our study indicates that, ...http://hyper.ahajournals.org/content/52/6/1099
A Pilot, Prospective, Non-randomized Evaluation of the Safety of Anakinra Plus Standard Chemotherapy - Full Text View -...
Cyst fluid interleukin-1beta (IL1beta) levels predict the risk of carcinoma in intraductal papillary mucinous neoplasms of the ... Neoplasms by Histologic Type. Neoplasms. Digestive System Neoplasms. Neoplasms by Site. Endocrine Gland Neoplasms. Digestive ... Gather preliminary information on the immune modulation and clinical activity of this therapy [ Time Frame: 6 month ]. *Blood ... T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced ...https://clinicaltrials.gov/ct2/show/study/NCT02021422?view=record
Interleukin-1 receptor - Wikipedia
... while type II receptors may act as a suppressor of IL-1 activity by competing for IL-1 binding. Also opposing the effects of IL ... The type I receptor is primarily responsible for transmitting the inflammatory effects of interleukin-1 (IL-1) ... Receptors, Interleukin-1 at the US National Library of Medicine Medical Subject Headings (MeSH). ... is a cytokine receptor which binds interleukin 1. Two forms of the receptor exist. ...https://en.wikipedia.org/wiki/Interleukin-1_receptor
KAKEN - Research Projects | Development of IL-1 with selective activities by introduction of carbohydrates (KAKENHI-PROJECT...
Type I and type II interferons up-regulate functional type I interleukin 1 receptor in a human fibroblast cell line TIG-1.' J. ... TypeI and typeII interferons up-regulate functional typeI interleukin1 receptor in a fibroblast cell lineTIG-1.' Journal of ... Type I and type II interferons up-regulate functional type I interleukin 1 receptor in a human fibroblast cell line TIG-1.' ... Type I and type II interferons up-regulate functional type I interleukin 1 receptor in a human fibroblast cell line TIG-1.' ...https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07557159/
CCK-induced inhibition of presympathetic vasomotor neurons: dependence on subdiaphragmatic vagal afferents and central NMDA...
Functional and neurochemical characterization of angiotensin type 1A receptor-expressing neurons in the nucleus of the solitary ... it is likely that the NMDA receptors located in the NTS and/or caudal ventrolateral medulla play a role. NMDA receptor blockade ... Kurosawa M, Uvnas-Moberg K, Miyasaka K, and Lundeberg T. Interleukin-1 increases activity of the gastric vagal afferent nerve ... Role of cardiopulmonary and carotid sinus baroreceptors in regulating renal sympathetic nerve activity during water immersion ...http://ajpregu.physiology.org/content/287/4/R809
Interleukin-1 receptor associated kinase - Wikipedia
Toll-like receptors (TLRs) are important innate immune receptors that recognize pathogen associated molecular patterns (PAMPs) ... "The kinase activities of interleukin-1 receptor associated kinase (IRAK)-1 and 4 are redundant in the control of inflammatory ... Inflammation signalling is known to be a major factor in many cancer types, and an inflammatory microclimate is a key aspect of ... that functions downstream of a Toll receptor. Cao's lab confirmed the kinase's activity as necessarily associated with the IL-1 ...https://en.wikipedia.org/wiki/Interleukin-1_receptor_associated_kinase
Soluble ST2 and Interleukin-33 Levels in Coronary Artery Disease: Relation to Disease Activity and Adverse Outcome.
ST2 is a receptor for interleukin (IL)-33. We investigated an association of soluble ST2 (sST2) and IL-33 serum levels with ... OBJECTIVES: ST2 is a receptor for interleukin (IL)-33. We investigated an association of soluble ST2 (sST2) and IL-33 serum ... ST2 is established as a selective marker of T helper type 2 (Th2) lymphocytes . In addition, ST2 is also expressed on mast ... induces profibrotic responses in cardiac fibroblasts by activation of P2Y2 receptors. J Mol Cell Cardiol49: 362-36920471392. ...http://www.biomedsearch.com/nih/Soluble-ST2-Interleukin-33-Levels/24751794.html
KAKEN - Research Projects | Functional roles of glycans for interaction between cytokines and receptors (KAKENHI-PROJECT...
... interleukin-2 (IL-2) binds to both high-mannnose type glycan and a specific peptide sequence in IL-2 receptor α (IL-2Rα), and ... cytokine receptor glycan / IL-2 / IL-18 / TNF-α / carbohydrate recognition activity / IL-8 / チロシンリン酸化 / ガレクチン-4 / 硫酸化コレステロール / ... Interleukin-18 (IL-18) and IL-18 receptor α (IL-18Rα) recognize the distinct GPI-anchored glycan portion of CD48, and the high- ... and following high affinity complex formation with receptor subunits triggers various physiological activities as follows, 1) ...https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14082208/
Interleukin 12 receptor, beta 1 subunit - Wikipedia
1997). "A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits". Proc. Natl. Acad ... 1995). "Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity". J. Immunol. 154 (1): 116 ... Gubler U, Presky DH (1997). "Molecular biology of interleukin-12 receptors". Ann. N. Y. Acad. Sci. 795: 36-40. doi:10.1111/j. ... "Genetic variations in the interleukin-12/interleukin-23 receptor (beta1) chain, and implications for IL-12 and IL-23 receptor ...https://en.wikipedia.org/wiki/Interleukin_12_receptor,_beta_1_subunit
Neuronal calcium sensor-1 - Wikipedia
... type III phosphatidylinositol 4-kinase β) IP3 receptor (this activity is inhibited by lithium - a drug used for the treatment ... G-protein-coupled receptor kinase 2) D2 dopamine receptor IL1RAPL1 (interleukin-1 receptor accessory protein-like 1 protein) ... A type (Kv4.3; Shal-related subfamily, member 3) voltage-gated potassium channels Nitric oxide synthase TRPC5 channel Ric8a Frq ... came from the assumption that the protein was expressed only in neuronal cell types, which is not the case. GRCh38: Ensembl ...https://en.wikipedia.org/wiki/Neuronal_calcium_sensor-1
The Pathogenesis of Brain Abscess - Tammy Kielian
Vidlak, Debbie; Kielian, Tammy (2012) Differential effects of interleukin-17 receptor signaling on innate and adaptive immunity ... Hanke, Mark L; Kielian, Tammy (2011) Toll-like receptors in health and disease in the brain: mechanisms and therapeutic ... signalling is essential for host defence and hemichannel activity during acute central nervous system bacterial infection. ASN ... Type. Schools of Medicine. DUNS #. 168559177. City. Omaha. State. NE. Country. United States. Zip Code. 68198. ...http://grantome.com/grant/NIH/R01-NS040730-15
Protein type: EC 184.108.40.206; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE-Unique ... Molecular Function: ATP binding; kinase activity; MAP kinase kinase kinase activity; NF-kappaB-inducing kinase activity; ... It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF ... family and to the interleukin-1 type-I receptor. Note: This description may include information from UniProtKB. ...https://www.phosphosite.org/proteinAction?id=2486&showAllSites=true
IL-1 RI Antibody (40101) (NBP1-50304): Novus Biologicals
Mouse Monoclonal Anti-IL-1 RI Antibody (40101). Validated: ELISA, IHC-P, RIA, WB (-). Tested Reactivity: Human, Sheep. 100% ... type I. *interleukin receptor 1. *interleukin-1 receptor type 1 ... and they do not cross-react with receptors for human IL-2 or IL ... The Interleukin 1 receptor type I (IL-1R1) belongs to the IL-1 receptor family (1). IL-1R1 binds to IL-1 alpha, IL-1 beta, and ... IL-1 RI Antibody (40101) Summary. Immunogen. The extracellular domain of the type I human IL-1 receptor. ...https://www.novusbio.com/products/il-1-ri-antibody-40101_nbp1-50304
IL-1 elisa kit | Chicken Interleukin 1 (IL-1) ELISA Kit-NP 001248348.1
Chicken Interleukin 1 (IL-1) ELISA Kit-NP_001248348.1 (MBS261118) product datasheet at MyBioSource, ELISA Kits ... type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to ... this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Belongs to the ... Type II, blocking receptor activity; interleukin-1 receptor activity. Biological Process: cytokine and chemokine mediated ...https://www.mybiosource.com/prods/ELISA-Kit/Chicken/Interleukin-1-IL-1/IL-1/datasheet.php?products_id=261118
MAP3K14 & CASP3 Protein Protein Interaction Antibody Pair - (DI0597) - Products - Abnova
It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF ... This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. ... family and to the interleukin-1 type-I receptor. [provided by RefSeq ... OTTHUMP00000165054,PARP cleavage protease,SREBP cleavage activity 1,Yama,apopain,caspase 3,caspase 3, apoptosis-related ...http://www.abnova.com/products/products_detail.asp?catalog_id=DI0597
Anakinra - Wikipedia
... receptor antagonist. It is produced by Swedish Orphan Biovitrum. Anakinra is a recombinant version of the interleukin 1 ... "New type of drug helpful in type 2 diabetes". Reuters. 2007-04-12. Retrieved 2011-04-28. Dostert, Catherine; Virginie Pétrilli ... Enhanced production by monocytes and correlation with disease activity". Arthritis and Rheumatism. 38 (8): 1055-1059. doi: ... "Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 ...https://en.wikipedia.org/wiki/Anakinra
NF-κB - Wikipedia
Receptor activator of NF-κB (RANK), which is a type of TNFR, is a central activator of NF-κB. Osteoprotegerin (OPG), which is a ... activity in and interleukin-8 (IL-8) release from bovine mammary epithelial cells". Veterinary Immunology and Immunopathology. ... Many bacterial products and stimulation of a wide variety of cell-surface receptors lead to NF-κB activation and fairly rapid ... Concerning known protein inhibitors of NF-κB activity, one of them is IFRD1, which represses the activity of NF-κB p65 by ...https://en.wikipedia.org/wiki/NF-%CE%BAB
MAP3K14 - Wikipedia
This kinase binds to TRAF2 and stimulates NF-κB activity. It is a critical kinase of the alternative NF-κB activation pathway. ... It participates in an NF-κB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF ... Kumar A, Eby MT, Sinha S, Jasmin A, Chaudhary PM (2001). "The ectodermal dysplasia receptor activates the nuclear factor-kappaB ... family and to the interleukin-1 type-I receptor. MAP3K14 has been shown to interact with: CHUK, IKK2, and TRAF2. ...https://en.wikipedia.org/wiki/MAP3K14