*  Innate Immune Activity Is Detected Prior to Seroconversion in Children With HLA-Conferred Type 1 Diabetes Susceptibility |...
Susceptibility to T1D is inherited, with the human leukocyte antigen (HLA) class II haplotypes encoding DR3-DQ2 (DRB1*03-DQA1* ... Autoantibodies against β-cell-specific antigens, such as proinsulin and insulin, GAD65, islet antigen-2, and zinc transporter 8 ... In this study, the matching of the case and control subjects was based on the HLA-DQB1 genotype. To take into account further ... J.I. was responsible for the DNA isolation and HLA screening of the study children. R.V. and M.K. were responsible for the ...
  http://diabetes.diabetesjournals.org/content/63/7/2402
*  Development of Celiac Disease; Pathogenesis and Strategies to Control: A Molecular Approach | OMICS International
DR5 haplotype (HLA DR5 is a broad antigen serotype that is further split into HLA DR11and DR12 antigens) with HLA-DQA1*0501 ... HLA- DQ2 molecules can be expressed in cis form or in trans form [14]. DR3 haplotype exists in cis form; where HLA-DQ alleles ... Human Leucocytic Antigen (HLA) - DQ2 and DQ8 in celiac disease: CD is one of the HLA-linked disorders. Two gluten/gliadin ... Tissue Antigens 61: 105-117.. *Megiorni F, Pizzuti A (2012) HLA-DQA1 and HLA-DQB1 in Celiac disease predisposition: practical ...
  https://www.omicsonline.org/open-access/development-of-celiac-disease-pathogenesis-and-strategies-to-control-a-molecular-approach-2155-9600.1000310.php?aid=32498
*  A30-Cw5-B18-DR3-DQ2 (HLA Haplotype) - Wikipedia
March 2000). "HLA genes in Arabic-speaking Moroccans: close relatedness to Berbers and Iberians". Tissue Antigens. 55 (3): 239- ... there is also the B18-DR3 component and the HLA DR3-DQ2.5. Other haplotypes such as Cw5-B16-DR3 or B8-DR3-DQ2.5 have been ... Müller CR, Ehninger G, Goldmann SF (January 2003). "Gene and haplotype frequencies for the loci hLA-A, hLA-B, and hLA-DR based ... HLA A30-Cw5-B18-DR3-DQ2 (A30::DQ2) is a multigene haplotype that extends across a majority of the major histocompatibility ...
  https://en.wikipedia.org/wiki/A30-Cw5-B18-DR3-DQ2_(HLA_Haplotype)
*  HLA-DR3 - Wikipedia
HLA-DR3 is composed of the HLA-DR17 and HLA-DR18 split 'antigens' serotypes. DR3 is a component gene-allele of the AH8.1 ... Type 1 diabetes mellitus is strongly associated with HLA-DR3 or HLA-DR4. Some DR3 also react with HLA-DR17 and/or HLA-DR18. The ... 2007). "Primary sclerosing cholangitis is associated with extended HLA-DR3 and HLA-DR6 haplotypes". Tissue Antigens. 69 (2): ... DR3 is genetically linked to HLA-DR52, DRB3*0202 allele, and HLA-DQ2 (DQ2.5). derived from IMGT/HLA Wiencke K, Karlsen TH, ...
  https://en.wikipedia.org/wiki/HLA-DR3
*  Relationship between increased relative birthweight and infections during pregnancy in children with a high-risk diabetes HLA...
Aims/hypothesis Children with high-risk type 1 diabetes HLA genotype have increased risk of high relative birthweight (HrBW), ... Samples positive for DQB1*02 were further analysed for DQA1*0201 and 05 alleles to separate subjects with DR3 from DR7. HLA- ... Our speculation is that certain infectious agents are taken up by antigen-presenting cells in the mother, processed by these ... neutral HLA (n = 5,188); (5) low-risk HLA (n = 2,373); (6) very-low-risk (n = 3,087); and (7) no-risk HLA (n = 4,820), as ...
  https://link.springer.com/article/10.1007%2Fs00125-007-0648-6
*  HLA-DR17 - Wikipedia
DR17 is part of the broader antigen group HLA-DR3 and is very similar to the group HLA-DR18. DR17 recognizes the DRB1*0301, * ... HLA-DR17 (DR17) is an HLA-DR serotype that recognizes the DRB1*0301 and *0304 gene products. DR17 is found at high frequency in ... 2007). "HLA class I and class II frequencies in patients with sarcoidosis from Croatia: role of HLA-B8, −DRB1*0301, and −DQB1* ... These serotypes are the result of gene products from the HLA-DRB3* and HLA DQA1*0501 and HLA DQB1*0201 alleles. DRB1*0301 is ...
  https://en.wikipedia.org/wiki/HLA-DR17
*  HLA-DRB1 gene - Genetics Home Reference
The HLA-DRB1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the ... People at highest risk of developing type 1 diabetes have one copy of the DR3 haplotype and one copy of the DR4 haplotype in ... is most increased by two specific combinations of variations of the HLA-DRB1 gene and other HLA genes called HLA-DQA1 and HLA- ... which is produced from the HLA-DRA gene. Together, they form a functional protein complex called the HLA-DR antigen-binding ...
  https://ghr.nlm.nih.gov/gene/HLA-DRB1
*  Histocompatibility leucocyte antigens and closely linked immunomodulatory genes in autoimmune thyroid disease - Murdoch...
... or B8/DR3) whereas autoimmune hypothyroidism (AIH) has been weakly associated with HLA DRB1*03, *04 and *11/*12 alleles (or DR3 ... Graves' disease (GD) is associated with the histocompatibility leucocyte antigen (HLA) haplotype A*01-B*0801-DRB1*0301-DQA1* ... Histocompatibility leucocyte antigens and closely linked immunomodulatory genes in autoimmune thyroid disease ... Genotyping was performed using polymerase chain reaction and sequence specific primers for HLA Class I and II alleles and ...
  http://researchrepository.murdoch.edu.au/id/eprint/5656/
*  HLA DR3-DQ2 - Wikipedia
Sirén M, Sareneva H, Lokki M, Koskimies S (1996). "Unique HLA antigen frequencies in the Finnish population". Tissue Antigens. ... HLA-DR3-DQ2 is found in HLA A1-B8-DR3-DQ2 haplotype in Northern Europeans (including the British Ilse, Ireland, Iceland). HLA ... HLA DR3-DQ2 encodes DQ2.5cis isoform of HLA-DQ, this isoform is described frequently as 'the DQ2 isoform', but in actuality ... HLA DR3-DQ2 is double serotype that specifically recognizes cells from individuals who carry a multigene HLA DR, DQ haplotype. ...
  https://en.wikipedia.org/wiki/HLA_DR3-DQ2
*  HLA-DQ2 - Wikipedia
This haplotype, HLA A1-B8-DR3-DQ2, is associated with diseases in which HLA-DQ2 has suspect involvement. Direct involvement of ... high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans". Tissue Antigens. 62 (4): ... HLA-DR3 plays a prominent role in autoimmune diabetes. However, DQ2 presence with DR3 decreases the age of onset and the ... HLA-DQ2 and HLA-DQB1*02 are almost synonymous in meaning. DQ2 β-chains combine with α-chains, encoded by genetically linked HLA ...
  https://en.wikipedia.org/wiki/HLA-DQ2
*  HLA-DQA1 gene - Genetics Home Reference
The HLA-DQA1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the ... People at highest risk of developing type 1 diabetes have one copy of the DR3 haplotype and one copy of the DR4 haplotype in ... HLA class II histocompatibility antigen, DQ alpha 1 chain. *HLA class II histocompatibility antigen, DQ alpha 1 chain precursor ... is most increased by two HLA haplotypes involving variations of the HLA-DQA1 and HLA-DQB1 genes and another HLA gene called HLA ...
  https://ghr.nlm.nih.gov/gene/HLA-DQA1
*  HLA-A33 - Wikipedia
HLA-A33 (A33) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody ... So recent arrival into Asia that the level of HLA DR3-DQ2 in Korea of 2.9%. Korea is the major recent source of Japanese genes ... "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 ... A33 is a split antigen of the broad antigen serotype A19. A33 is a sister serotype of A29, A30, A31, A32, and A74. A33 is more ...
  https://en.wikipedia.org/wiki/HLA-A33
*  Assessing of Celiac Disease and Nonceliac Gluten Sensitivity
Human leukocyte antigen (HLA) haplotypes DR3-DQ2.5, DR5-DQ7/DR7-DQ2.2, and DR4-DQ8 are the main genetic risk factors associated ... HLA Typing. Genetic associations with CD include more than 39 non-HLA risk genes, but HLA genes provide the strongest genetic ... Some studies have shown that more than 99% of CD patients carry genes that encode the HLA-DQ2.5, HLA-DQ2.2, and/or HLA-DQ8 ... "Differences in the risk of celiac disease associated with HLA-DQ2.5 or HLA-DQ2.2 are related to sustained gluten antigen ...
  https://www.hindawi.com/journals/grp/2015/723954/
*  Human leukocyte antigen - Wikipedia
HLA-DR3 and. -DR4 combined. Diabetes mellitus type 1. 15[4]. HLA-DQ2 and HLA-DQ8. Coeliac disease. 7[6]. ... "Frequencies of HLA-A, HLA-B, HLA-DR, and HLA-DQ phenotypes in the United Arab Emirates population". Tissue Antigens. 66 (2): ... HLA-C. Minor genes are HLA-E, HLA-F and HLA-G. β2-microglobulin binds with major and minor gene subunits to produce a ... HLA-DR *α-chain encoded by HLA-DRA locus. *4 β-chains (only 3 possible per person), encoded by HLA-DRB1, DRB3, DRB4, DRB5 loci ...
  https://en.wikipedia.org/wiki/Human_leucocyte_antigen
*  Research Papers On Diabetes Type 1. 16 Hot Topics in Diabetes Research Today | Diabetic Living Online
Human Leucocyte Antigen (HLA) Genes. An association between HLA class I alleles and type 1 diabetes were first discovered by ... Main predisposing haplotypes in Caucasians (95%) are:HLA-DR2: With 0102, 0502 and 1601;HLA-DR3: also associated with Xp11 locus ... However, population studies suggest that , 95% of type 1 diabetes have HLA-DR3 or DR4, or both, and in family studies, sibling ... The studies demonstrate that DR3 and DQ2 are positively associated with type 1 diabetes.[26,98] The Indian samples show HLA-C* ...
  http://ujwntbo.mysteria.cz/285-research-papers-on-diabetes-type-1.php
*  Type 1 Diabetes Mellitus: Practice Essentials, Background, Pathophysiology
... of young children with type 1 DM carry HLA-DR3 DQB1*0201, HLA-DR4 DQB1*0302, or both. Carriage of both haplotypes (ie, DR3/4 ... Race-specific type 1 diabetes risk of HLA-DR7 haplotypes. Tissue Antigens. 2011 Nov. 78(5):348-51. [Medline]. [Full Text]. ... Approximately 95% of patients with type 1 DM have either HLA-DR3 or HLA-DR4. Heterozygotes for those haplotypes are at ... Polymorphisms of the class II human leukocyte antigen (HLA) genes that encode DR and DQ are the major genetic determinants of ...
  https://emedicine.medscape.com/article/117739-overview
*  MHC Haplotype Project
HLA-A HLA-B HLA-C HLA-DRB1 HLA-DQB1 HLA-DPB1 Links:. Vega UCSC. GRC ... A26-B18-DR3 26:01:01 18:01:01 05:01:01:01 03:01:01:02 02:01:01 02:02 Vega UCSC. GL000255.1 ... The table below lists the eight cell lines used in the project along with their HLA haplotypes and alleles. Links are given to ... It provides the genomic sequences and gene annotation of 8 different HLA-homozygous typing haplotypes (listed below), their ...
  http://www.ucl.ac.uk/cancer/research/department-cancer-biology/medical-genomics-group/past-projects/mhc-haplotype-project
*  Association between human leucocyte antigen subtypes and risk of end stage renal disease in Taiwanese: a retrospective study |...
The current work suggests that HLA-DR3 (odds ratio = 1.91, 95 % CI = 1.098-3.324, P = 0.024, Pc = 0.312) and HLA-DR11 (odds ... HLA-A and -B antigens did not show any contribution of progression to ESRD. However, we note that the significance of all these ... The polymorphisms of HLA class I and II antigens in ESRD patients and a healthy control group were retrospectively analyzed. ... Human leukocyte antigens (HLA) have been found to be associated with the pathogenesis of autoimmune diseases, allergies and ...
  https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-015-0165-7
*  Most recent papers with the keyword HLA DQ2 DQ8 | Read by QxMD
... they strongly bind to human leucocyte antigens (HLAs), especially HLA-DQ2 and HLA-DQ8, expressed on antigen-presenting cells. ... and were accompanied by reduced HLA-DR protein expression in immune cells with the HLA-DR3-DQ2 haplotype... ... METHODS: From 2004 to 2010 infants from the general population who tested positive for HLA DR3-DQ2 or DR4-DQ8 were enrolled in ... Human leukocyte antigen (HLA) allele frequencies in North African populations show some differences in their distribution ...
  https://www.readbyqxmd.com/keyword/85996
*  JCI - Autoreactive T cells in type 1 diabetes
HLA-II) haplotypes, especially HLA-DRB1*04 (DR4), DQA1*03:01-DQB1*03:02 (DQ8), HLA-DRB1*03:01 (DR3), and DQA1*05:01-DQB1*02:01 ... Using HLA multimers, investigators demonstrated the antigen specificity of autoreactive CD8+ T cells in insulitis lesions of ... Selected HLA-I variants such as HLA-A2, HLA-A24, HLA-B39, HLA-B57, and HLA-B18 contribute to T1D risk (3, 6). HLA-A2 is also ... such as HLA-DQ8/DQ2, who can express HLA-DQ trans-dimers (HLA-DQ8trans, DQA1*05:01/DQB1*03:02 or HLA-DQ2trans, DQA1*03:01/DQB1* ...
  https://jinxiuwang.net.insight.mobile.jci.org/articles/view/94549
*  Plus it
HLA DR3/DR4-DQ8), C-peptide AUC, and subgroup (Fig. 1). Additional multivariable models demonstrated that HLA DR3 alone or ... association of TCF7L2 rs7903146 TT and low-risk human leukocyte antigen (HLA) genotypes. Diabet Med 2017;34:286-290. ... HLA DR3 was defined as DRB1*03:01 - DQA1*05:01 - DQB1*02:01, and HLA DR4-DQ8 was defined as DQA1*03:01 - DQB1*03:02 with DRB1* ... not), mean AUC for C-peptide at diagnosis, presence of HLA DR3 and DR4 (vs. absence), and subgroup (PTP progressors vs. New ...
  http://care.diabetesjournals.org/content/41/2/311
*  Plus it
HLA-DRB1, HLA-DQA1, and HLA-DQB1 alleles were typed using PCR-amplified DNA and nonradioactive sequence-specific ... Early expression and high prevalence of islet autoantibodies for DR3/4 heterozygous and DR4/4 homozygous offspring of parents ... evaluation of assays for autoantibodies to glutamic acid decarboxylase and islet antigen-2. Diabetologia 2008;51:846-852pmid: ... Do non-HLA genes influence development of persistent islet autoimmunity and type 1 diabetes in children with high-risk HLA-DR, ...
  http://diabetes.diabetesjournals.org/content/60/2/685
*  An Interferon-Induced Helicase (IFIH1) Gene Polymorphism Associates With Different Rates of Progression From Autoimmunity to...
HLA-DRB1, HLA-DQA1, and HLA-DQB1 alleles were typed using PCR-amplified DNA and nonradioactive sequence-specific ... Early expression and high prevalence of islet autoantibodies for DR3/4 heterozygous and DR4/4 homozygous offspring of parents ... evaluation of assays for autoantibodies to glutamic acid decarboxylase and islet antigen-2. Diabetologia 2008;51:846-852pmid: ... Do non-HLA genes influence development of persistent islet autoimmunity and type 1 diabetes in children with high-risk HLA-DR, ...
  http://diabetes.diabetesjournals.org/content/60/2/685.long
*  Celiac Disease: Molecular Basis
Additional factor in some HLA DR3/DQ2 haplotypes confers a fourfold increased genetic risk of celiac disease. Tissue Antigens ... Several gluten peptides (as p123-132) are able to bind to HLA‐class I molecules (in particular to HLA‐A1, A2 and B8) expressed ... 2016) HLA‐DQ2.5 genes associated with celiac disease risk are preferentially expressed with respect to non‐predisposing HLA ... 2003) The HLA‐DQ2 gene dose effect in celiac disease is directly related to the magnitude and breadth of gluten‐specific T cell ...
  http://www.els.net/WileyCDA/ElsArticle/refId-a0027650.html
*  Autoimmune polyendocrine syndrome type 2 - Wikipedia
... the human leukocyte antigen involved in this condition are HLA-DQ2(DR3 (DQB*0201)) and HLA-DQ8(DR4 (DQB1*0302)), genetically ... Rather, individuals are at a higher risk when they carry a particular human leukocyte antigen (HLA-DQ2, HLA-DQ8 and HLA-DR4). ... Moreover, autoantibodies reacting to specific antigens is common, in the immune system of an affected individual In terms of ... Michels, A. W.; Eisenbarth, G. S. (2009-05-01). "Autoimmune polyendocrine syndrome type 1 (APS-1) as a model for understanding ...
  https://en.wikipedia.org/wiki/Autoimmune_polyendocrine_syndrome_type_2