*  MHC Haplotype Project
HLA-A HLA-B HLA-C HLA-DRB1 HLA-DQB1 HLA-DPB1 Links:. Vega UCSC. GRC ... A26-B18-DR3 26:01:01 18:01:01 05:01:01:01 03:01:01:02 02:01:01 02:02 Vega UCSC. GL000255.1 ... The table below lists the eight cell lines used in the project along with their HLA haplotypes and alleles. Links are given to ... It provides the genomic sequences and gene annotation of 8 different HLA-homozygous typing haplotypes (listed below), their ...
  http://www.ucl.ac.uk/cancer/research/department-cancer-biology/medical-genomics-group/past-projects/mhc-haplotype-project
*  HLA A1-B8-DR3-DQ2 - Wikipedia
"Correlation between acetylcholine receptor antibody titer and HLA-B8 and HLA-DRw3 antigens in myasthenia gravis". Trans Am ... There are two major DR3 haplotypes in Europe, A1::DQ2 and A30-B18-DR3-DQ2. Linkage with disease could more firmly be attributed ... Hammarström L, Smith E, Möller E, Franksson C, Matell G, Von Reis G (August 1975). "Myasthenia gravis: studies on HL-A antigens ... Hirsch TJ, Enlow RW, Bias WB, Arnett FC (October 1981). "HLA-D related (DR) antigens in various kinds of myositis". Hum. ...
  https://en.wikipedia.org/wiki/HLA_A1-B8-DR3-DQ2
*  The Influence of MHC and Immunoglobulins A and E on Host Resistance to Gastrointestinal Nematodes in Sheep
... the HLA-DR3-B18 haplotype is more common than the HLA-DR3-B8 haplotype, suggesting that the IgA deficiency susceptibility gene ... inhibits antigen processing and modulates antigen-specific immune response," Infection and Immunity, vol. 69, no. 12, pp. 7380- ... Antigens are transported from the intestinal lumen to the subepithelial dome, where the antigen-presenting cells interact with ... T. I. A. Roach, K. J. Else, D. Wakelin, D. J. McLaren, and R. K. Grencis, "Trichuris muris: antigen recognition and transfer of ...
  https://www.hindawi.com/journals/jpr/2011/101848/
*  Plus it
The HLA genotyping of the patients showed evidence of increased HLA-B7 (52%) and HLA-DR15 (55%) antigen frequency with other ... Abstract B18: Quantification of BTK engagement by ibrutinib in peripheral blood mononuclear cells in a phase I clinical study. ... HPV-positive tumor cells present antigens of the viral protein in the context of human leukocyte antigen (HLA) class I that can ... HLA Genotyping of Tumor Tissue.. HLA genotyping for HLA-A, -B, -C, -DR, and -DQ was performed by PCR-single-strand ...
  http://clincancerres.aacrjournals.org/content/8/12/3676
*  Immunoglobulin D Deficiency: Background, Pathophysiology, Epidemiology
9, 10] IgD deficiency is associated with the specific human leukocyte antigens HLA-B18, F1C30, and DR3 in a Spanish Basque ... The [HLA-B18, F1C30, DR3] conserved extended haplotype carries a susceptibility gene for IgD deficiency. J Clin Immunol. 2000 ... 11] and HLA-B8, SC01, DR3 in white subjects in an American study. [12] A 2008 report noted that depletion of circulating IgD+ ... Prospective analysis suggests susceptibility genes for deficiencies of IgA and several other immunoglobulins on the [HLA-B8, ...
  https://emedicine.medscape.com/article/136803-overview
*  Publications | KNH-UoN Ethics and Research Committee
Human Leukocyte Antigen (HLA) B*18 And Protection Against Mother- To-child HIV Type1 Transmission. Click to View Abstract ... HLA-A*6802 and HLA-B18. Estimates using a modified interferon-gamma Elispot assay indicate a circulating frequency of CTL to ... Human leukocyte antigen (HLA) molecules regulate the cellular immune system and may be determinants of infant susceptibility to ... The ABO blood group antigens are carbohydrate moieties expressed on human red blood cells however; these antigens can also be ...
  http://erc.uonbi.ac.ke/uon_publications/author/4139
*  Epitopes - Before the Transplant | Coursera
... we see that all epitopes on the HLA-B18. are also present on one or more of the HLA antigens of the patient. ... However, the patient carries more than one HLA antigen.. If we now have a look at two other HLA antigens carried by the patient ... If we now look at three other HLA antigens,. it is clear that some of these epitopes are shared between different HLA antigens. ... In this lecture, we have learnt that an HLA antigen. consist of a string of epitopes which can be shared between HLA antigens. ...
  https://pt.coursera.org/lecture/clinical-kidney-transplantation/epitopes-g6HBw
*  Untitled Document
... a gene HLA-AR which is similar to the antigen presenting HLA-A locus but which has been inactivated by several mutations. It ... In humans, some MHC alleles decrease the risk of contracting HIV (such as HLA-A2, A28, and B18) while others increase the risk ... HLA-E, HLA-F, HLA-G, HLA-H, and HLA-J), and class MHC II loci which form four families (HLA-DO, HLA-DP, HLA-DQ, and HLA-DR) ( ... including HLA-H, HLA-J, HLA-K, and HLA-L. The HLA-H pseudogene is homologous to a functional gene in gorillas. Human ...
  http://bio.sunyorange.edu/updated2/GENETICS/4%20MHC.htm
*  HLA class I histocompatibility antigen, B-53 alpha chain
HLA-B13:02, HLA-B38:02, HLA-B44:03, and HLA-B56:01 alleles were significantly increased in autistic subjects. HLA-B18:02 and ... Involved in the presentation of foreign antigens to the immune system. HLA-B belongs to the HLA class I heavy chain paralogues ... The HLA-B*35 antigen contributes to endoplasmic reticulum stress and inflammation in limited cutaneous systemic sclerosis ... HLA-B alleles are associated with dermatitis herpetiformis in Chinese population.. 26841353. KIR-3DL2 binding to HLA-B27 ...
  https://pharos.nih.gov/idg/targets/P30491
*  Plus it
... recognized minor H antigens presented by MHC alleles such as HLA-A2 (five clones), HLA-A3 (one clone), and HLA-B7 (one clone), ... Abstract B18: Quantification of BTK engagement by ibrutinib in peripheral blood mononuclear cells in a phase I clinical study. ... as well as allogeneic HLA-B51+ or HLA-A2+ individuals, respectively (A, C, and E), and against HLA-B51+ or HLA-A2+ RCC tumor ... This analysis was sufficient to establish that all but one of the HLA-A2-, HLA-A3-, and HLA-B7-restricted clones in Table 3⇓ ...
  http://clincancerres.aacrjournals.org/content/10/23/7799
*  Viruses | Free Full-Text | How much of Virus-Specific CD8 T Cell Reactivity is Detected with a Peptide Pool when Compared to...
The presence of such T cells with very high functional avidity for the viral antigens can explain why the effect of peptide ... can compete for HLA binding sites. What impact such competition has on functional T cell stimulation, however, is not clear. ... Peptides, when restricted by the same HLA allele, and presented from within the same peptide pool, ... elicited a stronger recall response than the HLA-A2-restricted HCMV peptide CEF-7, though this donor was HLA-B18-negative, but ...
  http://www.mdpi.com/1999-4915/4/11/2636/htm
*  JCI - Autoreactive T cells in type 1 diabetes
Selected HLA-I variants such as HLA-A2, HLA-A24, HLA-B39, HLA-B57, and HLA-B18 contribute to T1D risk (3, 6). HLA-A2 is also ... Using HLA multimers, investigators demonstrated the antigen specificity of autoreactive CD8+ T cells in insulitis lesions of ... such as HLA-DQ8/DQ2, who can express HLA-DQ trans-dimers (HLA-DQ8trans, DQA1*05:01/DQB1*03:02 or HLA-DQ2trans, DQA1*03:01/DQB1* ... Strong predisposition for T1D derives from selected HLA class II (HLA-II) haplotypes, especially HLA-DRB1*04 (DR4), DQA1*03:01- ...
  https://jinxiuwang.net.insight.mobile.jci.org/articles/view/94549
*  A Phase I Study of Active Immunotherapy with Carcinoembryonic Antigen Peptide (CAP-1)-pulsed, Autologous Human Cultured...
Dendritic cells (DCs), antigen-presenting cells capable of priming naive T cells to specific antigens in an HLA-restricted ... Abstract B18: Quantification of BTK engagement by ibrutinib in peripheral blood mononuclear cells in a phase I clinical study. ... loaded with an HLA-A2-restricted peptide fragment of the tumor antigen carcinoembryonic antigen (CEA), for the treatment of ... Con-sistent with prior descriptions of in vitro-generated DCs, the cells expressed high levels of CD54, CD86, HLA-DR, and HLA ...
  http://clincancerres.aacrjournals.org/content/5/6/1331
*  Plus it
Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201-binding ... Abstract B18: Quantification of BTK engagement by ibrutinib in peripheral blood mononuclear cells in a phase I clinical study. ... for antigen suggesting that epitope dominance may be the result of competitive interactions between antigen-bearing antigen- ... cells compete for access to antigen-bearing antigen-presenting cells. J. Exp. Med., 192: 1105-1113, 2000. ...
  http://clincancerres.aacrjournals.org/content/9/15/5559
*  Defining the Role of the MHC in Autoimmunity: A Review and Pooled Analysis
HLA-DR7, and HLA-DRB3*0301 (Figure 2, middle). We also confirm previously reported association signals with HLA-B18 and HLA-B21 ... Tissue Antigens 63: 237-247.HF HarboBA LieS. SawcerEG CeliusKZ Dai2004Genes in the HLA class I region may contribute to the HLA ... and identify novel associations to HLA-DR6 (encompassing HLA-DRB1*1401), HLA-DR8 (including HLA-DRB1*0802 and *0803), and HLA- ... Other novel associations in UC are demonstrated for HLA-DR5 (and its subspecificities HLA-DR11 and -DR12), HLA-A19 and HLA-A24. ...
  http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1000024
*  Human Gene HLA-C (uc011gww.1) Description and Page Index
U31971 - Human MHC class I antigen HLA-B precursor (HLA-B) mRNA, complete cds.. U35431 - Human MHC class I antigen HLA-B (HLA-B ... HLA-B gene, HLA-B44Null allele).. AM711637 - Homo sapiens partial mRNA for HLA-B protein.. D25275 - Homo sapiens HLA-B18 mRNA, ... U36492 - Human MHC class I antigen (HLA-B) allele HLA-B-8201 mRNA, complete cds.. U38800 - Human HLA class I antigen (HLA-B), B ... X61706 - Human RNA for HLA-Bw50 antigen.. X61707 - Human RNA for HLA-Bw57.2 antigen.. X61708 - Human RNA for HLA-Bw78 antigen. ...
  http://rohsdb.cmb.usc.edu/GBshape/cgi-bin/hgGene?hgg_gene=uc011gww.1&hgg_prot=Q30194&hgg_chrom=chr6_mann_hap4&hgg_start=2585738&hgg_end=2671188&hgg_type=knownGene&db=hg19&hgsid=1289098_rEYyzmWZ9Xw4hhMOGbGzlYRwArae
*  Plus it
Of the 37 who were HLA typed, 20 or 54% were found to be HLA-A2 positive. Of the 14 potential subjects identified, 2 were ... Abstract B18: Quantification of BTK engagement by ibrutinib in peripheral blood mononuclear cells in a phase I clinical study. ... Because the antigens encoded by ZYC101 are highly specific to HPV-16, minimal cross-reactivity may be expected outside the ... Kast W. M., Brandt R. M., Sidney J., Drijfhout J. W., Kubo R. T., Grey H. M., Melief C. J., Sette A. Role of HLA-A motifs in ...
  http://clincancerres.aacrjournals.org/content/8/5/1028
*  Expression of Classic and Nonclassic HLA Class I Antigens in Uveal Melanoma | IOVS | ARVO Journals
HLA-A2, A28, and A29) and three the HLA-B locus (HLA-B18, B35, B55). In two tumor specimens (2 and 8) a haplotype (HLA-A2, B44 ... HLA-A. HLA-A. HLA-B. HLA-B. HLA-C. HLA-C. HLA-A2. ... HLA-A. HLA-A. HLA-B. HLA-B. HLA-C. HLA-C. HLA-A2. ... with known HLA-A, -B, and -C phenotypes. 14 The HLA-C typing of the cell lines covered HLA-C allotypes from HLA-C*01 to HLA-C* ... Therefore, we looked in addition for the expression of these HLA antigens in our tumor specimens. HLA-C antigens were not ...
  http://iovs.arvojournals.org/article.aspx?articleid=2163235
*  WiDr ATCC ® CCL-218™ Homo sapiens colon colorectal adenocar
HLA A24, A32, B15, B18. The cells are positive for keratin by immunoperoxidase staining. The cells expressed p53 antigen (the ... carcinoembryonic antigen (CEA) 118 ng/10 exp6 cells/10 days; Colon Specific Antigen (CSAp); transforming growth factor beta; ... carcinoembryonic antigen (CEA) 118 ng/10 exp6 cells/10 days; Colon Specific Antigen (CSAp); transforming growth factor beta; ... The cells expressed p53 antigen (the p53 produced has a G -> A mutation resulting in Arg -> His at position 273). ...
  https://www.atcc.org/products/all/CCL-218.aspx?slp=1
*  Association between human leucocyte antigen subtypes and risk of end stage renal disease in Taiwanese: a retrospective study |...
HLA-A and -B antigens did not show any contribution of progression to ESRD. However, we note that the significance of all these ... The polymorphisms of HLA class I and II antigens in ESRD patients and a healthy control group were retrospectively analyzed. ... Human leukocyte antigens (HLA) have been found to be associated with the pathogenesis of autoimmune diseases, allergies and ... In order to standardize the HLA designation of prior low-resolution typings with the more advanced DNA based typings, all HLA-A ...
  https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-015-0165-7
*  Method for identifying and validating dominant T helper cell epitopes using an HLA-DM-assisted class II binding assay - The...
Rational design of immunotherapeutics relies on clear knowledge of the immunodominant epitopes of antigens. Current methods for ... a viral antigen, a bacterial antigen, a fungal antigen, a protozoal antigen, a plasmodial antigen, a helminthic antigen, and a ... such as an HLA-DR allele, such as HLA-DR1, HLA-DR2, HLA-DR3, HLA-DR4, HLA-DR5, HLA-DR6, HLA-DR7, HLA-DR8, HLA-DR9, or HLA-DR15 ... The DR molecule may comprise HLA-DRB1, HLA-DRB2, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DRB6, HLA-DRB7, HLA-DRB8, HLA-DRB9, or HLA- ...
  http://www.freepatentsonline.com/8916340.html
*  Hitchhiker's Guide to the Galaxy on Linkage disequilibrium
Example: Human leukocyte antigen (HLA) alleles HLA constitutes a group of cell surface antigens as MHC of humans. Because HLA ... Table 2. Linkage disequilibrium among HLA alleles in Pan-europeans[10] HLA-A alleles i. HLA-B alleles j. Δ. i. j. {\ ... B18. 0.006. 2.2. A2. Bw35. -0.009. -2.3. A29. B12. 0.013. 6.0. A10. Bw16. 0.013. 5.9. ... Antigen i. +. {\displaystyle +}. A. 1. +. {\displaystyle A1^{+}}. a. =. 376. {\displaystyle a=376}. b. =. 237. {\displaystyle b ...
  http://hitchhikersgui.de/Linkage_disequilibrium
*  SCOP: Family: C1 set domains (antibody constant domain-like)
SQ P30685 25-300 ! SQ P30443 25-298 # 1A01_HUMAN HLA class I histocompatibility antigen, A-1 alpha chain precursor ! SQ P30481 ... Ig heavy chain V region B1-8/186-2) and SQ P01864 (Ig gamma-2A chain C region secreted form) ! SQ P01868 # GC1_MOUSE Ig gamma-1 ... probably orthologous to the human HLA-DM *Human (Homo sapiens), HLA-DR group [TaxId: 9606] [88621] (29) SQ P01903 28-207 ... probably orthologous to the human HLA-DM *Human (Homo sapiens), HLA-DR group [TaxId: 9606] [88628] (48) SQ P04229 30-219 ...
  http://scop.mrc-lmb.cam.ac.uk/scop/data/scop.b.c.b.b.c.html