*  Immunogenetics of Hashimoto's thyroiditis | Springer for Research & Development
... non-HLA loci were contributing to the joint susceptibility to AITD and T1D. Among HLA-DR alleles, HLA-DR3 was detected as the ... Susceptibility and resistance alleles of human leukocyte antigen (HLA) DQA1 and HLA DQB1 are shared in endocrine autoimmune ... but not with the HLA-DP and HLA class I (HLA-A, HLA-B and HLA-C) genes [113, 114, 121]. However, some studies could not reveal ... but not HLA-DQ*0103/DQB1*0601 (DQ6), transgenic mice [52]. In summary, DR3 and DQ8 alleles are found to be susceptible, whereas ...
  https://rd.springer.com/article/10.1186/1740-2557-2-1
*  HLA-DQB1 - Wikipedia
The risk is partially shared with the HLA-DR locus (DR3 and DR4 serotypes). Celiac1 is a genetic name for DQB1, the HLA DQB1* ... Certain HLA-DQB1 alleles are also linked to a modest increased risk of multiple sclerosis. Other HLA-DQB1 alleles are ... Major histocompatibility complex Human leukocyte antigen HLA-DQ ENSG00000206237, ENSG00000231286, ENSG00000206302, ... Several alleles of HLA-DQB1 are associated with an increased risk of developing type 1 diabetes. The locus also has the genetic ...
  https://en.wikipedia.org/wiki/HLA-DQB1
*  HLA A1-B8-DR3-DQ2 - Wikipedia
DQB1*0201 or shorthand A1::DQ2 There are many other gene-alleles within the haplotype, including more than 250 coding loci that ... critical evaluation of an association with HLA-DR3". Tissue Antigens. 64 (5): 575-80. doi:10.1111/j.1399-0039.2004.00310.x. ... Linkage could not be extended to HLA-DPB1 locus. Outside of Europe the DRB1*0301 and DR3-DQ2 loci have been linked to disease ... Closer to DR3, C4A is null in B8-DR3 haplotype. In 1972, a link between "HLA A1,8" (current:HLA A1-B8) active chronic hepatitis ...
  https://en.wikipedia.org/wiki/HLA_A1-B8-DR3-DQ2
*  Endocrine Pathology - ACEMprimary.com
HLA-D). *95% Caucasians with type I DM have HLA-DR3, DR4 or both. DQB1*0302 allele considered the primary determinant of ... Most important is class II MHC (HLA) locus - 50% of total genetic susceptibility: on chromosome 6p21 ( ... the viruses produce antigens which mimic self-antigens with the immune response cross-reacting with self-tissue ... Genetic factors - not HLA linked, collection of multiple genetic defects, more important than Type I DM, concordance rates in ...
  http://acemprimary.com/pathology/endocrine/
*  HLA-A33 - Wikipedia
For A33, the alpha "A" chain are encoded by the HLA-A*33 allele group and the β-chain are encoded by B2M locus. A33 and A*33 ... DQB1 genes in the Korean population". Tissue Antigens. 65 (5): 437-47. doi:10.1111/j.1399-0039.2005.00386.x. PMID 15853898. ... So recent arrival into Asia that the level of HLA DR3-DQ2 in Korea of 2.9%. Korea is the major recent source of Japanese genes ... 2004). "Differentiation between African populations is evidenced by the diversity of alleles and haplotypes of HLA class I loci ...
  https://en.wikipedia.org/wiki/HLA-A33
*  DPB1 Alleles Are Associated With Type 1 Diabetes Susceptibility in Multiple Ethnic Groups | Diabetes
The HLA-DPB1-associated component of the IDDM1 and its relationship to the major loci HLA-DQB1, -DQA1, and -DRB1. Diabetes50 : ... The highest-risk HLA DR-DQ genotype (DR3/4-DQB1*0302; DR4≠DRB1*0403) was found in 2.3% (n = 713) of GPC and 10.1% (n = 90) of ... DPB1 alleles may act as markers of other HLA-complex susceptibility genes. Tissue Antigens61 :344 -351,2003. ... DPB1 allele frequency distribution among DR3/DR4-DQB1*0302 (DR4 ≠ DRB1*0403) samples from DAISY in the GPC and among ...
  http://diabetes.diabetesjournals.org/content/53/8/2158
*  Autoimmune Addison's Disease: Genetic Aetiology and Pathophysiology | Springer for Research & Development
An update of the HLA genomic region, locus information and disease associations: 2004. Tissue Antigens. 2004;64(6):631-49. ... Although DR3-DQB1*0201 may be associated with multiple component diseases of the autoimmune polyglandular syndromes, the human ... The HLA-DQ beta non-asp-57 allele: a predictor of future insulin-dependent diabetes mellitus in patients with autoimmune ... Multiple loci in the HLA complex are associated with Addison's disease. J Clin Endocrinol Metab. 2011;96(10):E1703-8.PubMed ...
  https://rd.springer.com/chapter/10.1007/978-3-319-62470-9_4
*  Staging Presymptomatic Type 1 Diabetes: A Scientific Statement of JDRF, the Endocrine Society, and the American Diabetes...
... with the greatest association with HLA class II haplotypes DRB1*0301-DQB1*0201 (DR3-DQ2) and DRB1*0401-DQB1*0302 (DR4-DQ8) ( ... Effect of HLA class I and class II alleles on progression from autoantibody positivity to overt type 1 diabetes in children ... The remaining genetic risk for type 1 diabetes can be attributed to the approximately 50 non-HLA genes or loci identified via ... Antigen targets of type 1 diabetes autoimmunity. Cold Spring Harb Perspect Med 2012;2:a007781. ...
  http://care.diabetesjournals.org/content/38/10/1964.full
*  Most recent papers with the keyword HLA DQ2 DQ8 | Read by QxMD
... between carriers of the type 1 diabetes risk haplotypes HLA-DRB1*03-DQA1*0501-DQB1*0201 (DR3-DQ2) and HLA-DRB1*04-DQA1*0301- ... Human leukocyte antigen (HLA) allele frequencies in North African populations show some differences in their distribution ... We tested whether HLA and non-HLA loci associate with such clustering of autoimmunity. We included 1,745 children with type 1 ... they strongly bind to human leucocyte antigens (HLAs), especially HLA-DQ2 and HLA-DQ8, expressed on antigen-presenting cells. ...
  https://www.readbyqxmd.com/keyword/85996
*  MHC Haplotype Project
HLA-A HLA-B HLA-C HLA-DRB1 HLA-DQB1 HLA-DPB1 Links:. Vega UCSC. GRC ... The table below lists the eight cell lines used in the project along with their HLA haplotypes and alleles. Links are given to ... alternate loci', are constructed so that they begin with additional anchor sequence derived from the reference. The fasta ... A26-B18-DR3 26:01:01 18:01:01 05:01:01:01 03:01:01:02 02:01:01 02:02 Vega UCSC. GL000255.1 ...
  http://www.ucl.ac.uk/cancer/research/department-cancer-biology/medical-genomics-group/past-projects/mhc-haplotype-project
*  HLA-DQ8 - Wikipedia
These split antigens are the allele products of the DQB1*0302 and DQB1*0305, respectively. DQB1*0302 and is found most often in ... "Allele frequencies and haplotypic associations defined by allelic DNA typing at HLA class I and class II loci in the Japanese ... "Closer association of IA-2 humoral autoreactivity with HLA DR3/4 than DQB1*0201/*0302 in Korean T1D patients". Annals of the ... "Frequencies of HLA-A, HLA-B, HLA-DR, and HLA-DQ phenotypes in the United Arab Emirates population". Tissue Antigens. 66 (2): ...
  https://en.wikipedia.org/wiki/HLA-DQ8
*  HLA-DR4 - Wikipedia
"Susceptibility alleles and haplotypes of human leukocyte antigen DRB1, DQA1, and DQB1 in autoimmune polyglandular syndrome type ... "Closer association of IA-2 humoral autoreactivity with HLA DR3/4 than DQB1*0201/*0302 in Korean T1D patients". Ann N Y Acad Sci ... 2006). "Investigation of the HLA-DRB1 locus in alopecia areata". European Journal of Dermatology. 16 (4): 363-7. PMID 16935791 ... "HLA-DR antigens in pemphigus among Japanese". Tissue Antigens. 17 (2): 238-9. doi:10.1111/j.1399-0039.1981.tb00689.x. PMID ...
  https://en.wikipedia.org/wiki/HLA-DR4
*  Defining the Role of the MHC in Autoimmunity: A Review and Pooled Analysis
... that exists among alleles throughout this locus, coupled with inadequate study design whereby only a limited subset of about 20 ... is one of the most extensively studied regions in the human genome because of the association of variants at this locus with ... 2007) HLA-DPB1*0402 protects against type 1A diabetes autoimmunity in the highest risk DR3-DQB1*0201/DR4-DQB1*0302 DAISY ... Dorman JS, Bunker CH (2000) HLA-DQ locus of the human leukocyte antigen complex and type 1 diabetes mellitus: a HuGE review. ...
  http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1000024
*  HLA-??????????????? ???? ??????
Balducci-Silano PL, Layrisse Z, Dominguez E, Amaro R, Gunczler P, Lanes R, Zaro R: HLA-DQA1 and DQB1 allele and genotype ... HLA associations in type 1 diabetes among patients not carrying high-risk DR3-DQ2 or DR4-DQ8 haplotypes. Tissue Antigens 1999, ... Reijonen H, Ilonen J, Akerblom HK, Knip M, Dosch HM: Multi-locus analysis of HLA class II genes in DR2-positive IDDM haplotypes ... Mbanya JC, Sobngwi E, Mbanya DN: HLA-DRB1, -DQA1, -DQB1 and DPB1 susceptibility alleles in Cameroonian type 1 diabetes patients ...
  http://www.ld.ru/reviews/ilist-4446.html
*  Plus it
HLA-DRB1, HLA-DQA1, and HLA-DQB1 alleles were typed using PCR-amplified DNA and nonradioactive sequence-specific ... DQA1*0401-DQB1*0402, DR3-DQA1*0501-DQB1*0201/DR3-DQA1*0501-DQB1*0201; DR4-DQA1*030X-DQB1*0302@/DR4-DQA1*030X-DQB1*020X; DR4- ... A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase ( ... evaluation of assays for autoantibodies to glutamic acid decarboxylase and islet antigen-2. Diabetologia 2008;51:846-852pmid: ...
  http://diabetes.diabetesjournals.org/content/60/2/685
*  An Interferon-Induced Helicase (IFIH1) Gene Polymorphism Associates With Different Rates of Progression From Autoimmunity to...
HLA-DRB1, HLA-DQA1, and HLA-DQB1 alleles were typed using PCR-amplified DNA and nonradioactive sequence-specific ... DQA1*0401-DQB1*0402, DR3-DQA1*0501-DQB1*0201/DR3-DQA1*0501-DQB1*0201; DR4-DQA1*030X-DQB1*0302@/DR4-DQA1*030X-DQB1*020X; DR4- ... A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase ( ... evaluation of assays for autoantibodies to glutamic acid decarboxylase and islet antigen-2. Diabetologia 2008;51:846-852pmid: ...
  http://diabetes.diabetesjournals.org/content/60/2/685.long
*  Genetic and Immunologic Biomarkers in Type 1 Diabetes
... these are HLA DP, HLA DQ, and HLA DR. Genes encoding the HLA DP apha and beta chains may have as m any as 23 and 120 alleles ... interaction may be taking place between the HLA locus and nonHLA loci, as evidence suggests that risks at nonHLA loci may be ... The HLA DR/DQ haplotypes that account for 30 50% of genetic risk of type 1 diabetes are DR3 DQA1*0501*0201 (DR3) and DR4A DQA1* ... Evidence of at least two type 1 diabetes susceptibility genes in the HLA complex distinct from HLA DQB1, DQA1 and DRB1 Genes ...
  http://ufdc.ufl.edu/UFE0045760/00001
*  ANTIBODIES WITH T-CELL RECEPTOR LIKE SPECIFICITY TOWARDS NATIVE COMPLEXES OF MHC CLASS II AND DIABETES-ASSOCIATED...
HLA-DO, HLA-DP, HLA-DQ (e.g., DQ2, DQ4, DQ5, DQ6, DQ7, DQ8, DQ9), HLA-DR (e.g., DR1, DR2, DR3, DR4, DR5, DR7, DRB, DR9, DR10, ... 0093] Non-limiting examples of DQ B1 alleles include 0201, 0202, 0402, 0501, 0502, 0503, 0504, 0601, 0602, 0603, 0604, 0609, ... refers to a complex of antigens encoded by a group of linked loci, which are collectively termed H-2 in the mouse and human ... HLA-DR3 and/or HLA-DR4, including over-representation of the HLA-DR3/DR4 heterozygosity in diabetics as compared with non- ...
  http://www.patentsencyclopedia.com/app/20130189284
*  JCI - Autoreactive T cells in type 1 diabetes
HLA-DRB1*03:01 (DR3), and DQA1*05:01-DQB1*02:01 (DQ2). Approximately 80%-90% of patients carry at least one high-risk haplotype ... of the genetic risk for T1D derives from HLA alleles encoding molecules involved in the presentation of antigen peptides to T ... Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Nat Genet. 1997;15(3):289-292.. View ... Selected HLA-I variants such as HLA-A2, HLA-A24, HLA-B39, HLA-B57, and HLA-B18 contribute to T1D risk (3, 6). HLA-A2 is also ...
  https://jinxiuwang.net.insight.mobile.jci.org/articles/view/94549
*  Coeliac disease - Wikipedia
The two subunits of the HLA-DQ protein are encoded by the HLA-DQA1 and HLA-DQB1 genes, located on the short arm of the sixth ... Almost all people (95%) with coeliac disease have either the variant HLA-DQ2 allele or (less commonly) the HLA-DQ8 allele. ... Only the HLA-DQ loci show a consistent involvement over the global population. Many of the loci detected have been found in ... HLA-DQ is part of the MHC class II antigen-presenting receptor (also called the human leukocyte antigen) system and ...
  https://en.wikipedia.org/wiki/Coeliac_disease