*  DPB1 Alleles Are Associated With Type 1 Diabetes Susceptibility in Multiple Ethnic Groups | Diabetes
The HLA-DPB1-associated component of the IDDM1 and its relationship to the major loci HLA-DQB1, -DQA1, and -DRB1. Diabetes50 : ... Type 1 diabetes associations of DPB1 alleles could either be due to changes in the encoded polypeptide chain or to linkage ... DRB1 and DQB1 genotypes were determined for all individuals in both datasets. Values were calculated for LD between DRB1-DQB1 ... This suggests that DPB1 associations observed in these data are not attributable solely to LD of DPB1 alleles with DRB1-DQB1 ...
  http://diabetes.diabetesjournals.org/content/53/8/2158
*  Plus it
DNA samples were typed for alleles of HLA-DRB1, -DQA1, and -DQB1 using the phototyping method (6,7). The insulin gene variable ... Sanjeevi CB, Kanungo A, Berzina L, Shtauvere-Brameus A, Ghaderi M, Samal KC: MHC class I chain-related gene a alleles ... The DRB1*04 and DQB1*0302 alleles were increased in frequency among the IA-2 autoantibody-positive diabetic (P = 0.020 and P = ... Heward JM, Mijovic CH, Kelly MA, Morrison E, Barnett AH: HLA-DQ and DRB1 polymorphism and susceptibility to type 1 diabetes in ...
  http://care.diabetesjournals.org/content/30/12/3088
*  HLA-DQ8 - Wikipedia
DQ8 β-chains combine with α-chains, encoded by genetically linked HLA-DQA1 alleles, to form the cis-haplotype isoforms. There ... Velickovic Z, Delahunt B, Carter J (2002). "HLA-DRB1 and HLA-DQB1 polymorphisms in Pacific Islands populations". Tissue ... and 2.Fu Y, Liu Z, Lin J, Jia Z, Chen W, Pan D, Liu Y, Zhu Y, Chen R, Xu A (2003). "HLA-DRB1, DQB1 and DPB1 polymorphism in the ... Lee K, Oh D, Lee C, Yang S (2005). "Allelic and haplotypic diversity of HLA-A, -B, -C, -DRB1, and -DQB1 genes in the Korean ...
  https://en.wikipedia.org/wiki/HLA-DQ8
*  HLA-A3 - Wikipedia
For A3, the alpha, "A", chain are encoded by the HLA-A*03 allele group and the β-chain are encoded by B2M locus. This group ... A*0301 : C*0702 : B*0702 : DRB1*1501 : DQA1*0102 : DQB1*0602 Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF ( ... Allele Query Form IMGT/HLA - European Bioinformatics Institute Machens A, Löliger C, Pichlmeier U, Emskötter T, Busch C, ... HLA-A3 (A3) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody ...
  https://en.wikipedia.org/wiki/HLA-A3
*  HLA-DQ1 - Wikipedia
1994). "HLA-DQA1, -DQB1 and -DRB1 genotyping in Japanese pemphigus vulgaris patients by the PCR-RFLP method". Tissue Antigens. ... HLA-DQ1 is a serotype that covers a broad range of HLA-DQ haplotypes. Historically it was identified as a DR-like alpha chain ... "HLA class II alleles in Japanese patients with Graves' disease: weak associations of HLA-DR and -DQ". Endocr. J. 41 (6): 599- ... 1995). "HLA DQA1 genotypes and its interaction with HLA DQB1 in Chinese IDDM living in Taiwan". Proc. Natl. Sci. Counc. Repub. ...
  https://en.wikipedia.org/wiki/HLA-DQ1
*  HLA A1-B8-DR3-DQ2 - Wikipedia
DRB1*0301 : DQA1*0501 : DQB1*0201 or shorthand A1::DQ2 There are many other gene-alleles within the haplotype, including more ... Starting from B8, immediately followed by the MICA and MICB which stand for MHC I-like chain A and B. These two functional ... Two-point haplotype analysis between TNFB(B*01 allele) and HLA show that the allele is in linkage disequilibrium with HLA-A1, ... "Meta-analysis of HLA-DRB1 and HLA-DQB1 polymorphisms in Latin American patients with systemic lupus erythematosus". Autoimmun ...
  https://en.wikipedia.org/wiki/HLA_A1-B8-DR3-DQ2
*  Frontiers | T Cell-Mediated Chronic Inflammatory Diseases Are Candidates for Therapeutic Tolerance Induction with Heat Shock...
The HLA dictionary 2008: a summary of HLA-A,-B,-C,-DRB1/3/4/5, and-DQB1 alleles and their association with serologically ... The SE is a five amino-acid sequence motif found in residues 70-74 of the HLA-DRβ chain that encodes a conserved positively ... 0301-DQB1*0201 have been associated with T1D susceptibility whereas the haplotypes HLA-DRB1*1501 and HLA-DQA1*0102-DQB1*0602 ... HLA-B27 encompasses around 105 known subtypes (HLA-B*27:01 to HLA-B*27:106 thus far identified) that are encoded by 132 alleles ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.01408/full
*  HLA-DR4 - Wikipedia
"Anti-caspase-8 autoantibody response in silicosis patients is associated with HLA-DRB1, DQB1 and DPB1 alleles". J Occup Health ... "A possible association between basic amino acids of position 13 of DRB1 chains and autoimmune hepatitis". Immunogenetics. 36 (1 ... HLA-DR4 (DR4) is an HLA-DR serotype that recognizes the DRB1*04 gene products. The DR4 serogroup is large and has a number of ... 2007). "Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta- ...
  https://en.wikipedia.org/wiki/HLA-DR4
*  HLA-DQ9 - Wikipedia
2004). "HLA-DQA1 and DQB1 alleles are associated with genetic susceptibility to psoriasis vulgaris in Chinese Han". Int. J. ... Tsuchiya N, Kobayashi S, Hashimoto H, Ozaki S, Tokunaga K (2006). "Association of HLA-DRB1*0901-DQB1*0303 haplotype with ... Törn C, Gupta M, Sanjeevi CB, Aberg A, Frid A, Landin-Olsson M (2004). "Different HLA-DR-DQ and MHC class I chain-related gene ... The recognition of DQB1*0303 by DQ9 and or DQ3 is poorest, DQ2 which recognizes a different DQB1 subgroup recognizes DQB1*0303 ...
  https://en.wikipedia.org/wiki/HLA-DQ9
*  HLA-DR3 - Wikipedia
Pera C, Delfino L, Longo A, Pistillo MP, Ferrara GB (March 2000). "Novel associations among HLA-DQA1 and -DQB1 alleles, ... Some DR3 also react with HLA-DR17 and/or HLA-DR18. The DRB1*0304 primarily reacts with DR3. The serotypes of *0305, *0306, * ... DR3-DR2 is the serological marker for HLA-DQ2.5cis isoform. Although it cannot identify the alpha ".5" chain of HLA DQ, DQA1* ... HLA-DR3 is composed of the HLA-DR17 and HLA-DR18 split 'antigens' serotypes. DR3 is a component gene-allele of the AH8.1 ...
  https://en.wikipedia.org/wiki/HLA-DR3
*  Protocols and Video Articles Authored by André Baruchel
HLA-A*0101/B*0801/Cw*0701/DRB1*0301/DQB1*0201; A*0301/B*0702/Cw*0702/DRB1*1501/DQB1*0602 (both of Indo-Celtic origin); A*2902/B ... DRB1/DQB1 or B/Cw/DRB1/DQB1 haplotypes. The results also revealed that the four most frequent five-allele haplotypes in ... CMV-polymerase chain reaction (PCR) was programmed weekly until month +3 post-HSCT. Immunomonitoring consisted of sequential ... a higher diversity in the distribution of HLA-A and -DRB1 alleles; (2) lower frequencies of alleles common in our region, such ...
  https://www.jove.com/author/Andr%C3%A9_Baruchel
*  HLA-A33 - Wikipedia
DRB1*0301 : DQA1*0501 : DQB1*0201 It is interesting that the Cw allele in the Pakistani population is the same as the allele in ... For A33, the alpha "A" chain are encoded by the HLA-A*33 allele group and the β-chain are encoded by B2M locus. A33 and A*33 ... Lee KW, Oh DH, Lee C, Yang SY (2005). "Allelic and haplotypic diversity of HLA-A, -B, -C, -DRB1, and -DQB1 genes in the Korean ... Allele Query Form IMGT/HLA - European Bioinformatics Institute Mohyuddin A, Mehdi SQ (2005). "HLA analysis of the Parsi ( ...
  https://en.wikipedia.org/wiki/HLA-A33
*  HLA-A*02 - Wikipedia
DRB1*0401 : DQA1*0301 : DQB1*0302 Another haplotype that is more common in Central Europe is the (A2-B44-DR7-DQ2) A*0201 : C* ... HLA-A02, and HLA-A*2. HLA-A*02 is one particular class I major histocompatibility complex (MHC) allele group at the HLA-A locus ... For A*02, the α chain is encoded by the HLA-A*02 gene and the β chain is encoded by the B2M locus. In 2010 the World Health ... "HLA Nomenclature @ hla.alleles.org". Anthony Nolan Research Institute. 10 Nov 2013. Retrieved 8 Dec 2013. "Allele Search Tool ...
  https://en.wikipedia.org/wiki/HLA-A*02
*  In silicoanalysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy...
... a summary of HLA-A, -B, -C, -DRB1/3/4/5 and -DQB1 alleles and their association with serologically defined HLA-A, -B, -C, -DR ... KIR, Killer-cell immunoglobulin-like receptors; MIC, MHC class I chain related (MIC) genes. ... HLA-A:HLA-B, HLA-B:HLA-C, HLA-B:HLA-DRB1, HLA-DRB1:HLA-DQB1. Additionally, we included the HLA-DQB1:HLA-DQA1 haplotype, which ... HLA-DRB1:HLA-DQB1 (D' = 0.95), HLA-B:HLA-C (D' = 0.94), HLA-B:HLA-DRB1 (D' = 0.68), HLA-A:HLA-B (D' = 0.60) and C:DRB1 (D' = ...
  https://genomemedicine.biomedcentral.com/articles/10.1186/gm350
*  JCI - Autoreactive T cells in type 1 diabetes
HLA-II) haplotypes, especially HLA-DRB1*04 (DR4), DQA1*03:01-DQB1*03:02 (DQ8), HLA-DRB1*03:01 (DR3), and DQA1*05:01-DQB1*02:01 ... The HLA-DRB1 chain is also involved in the presentation of diabetogenic epitopes, but DRB1*04 variants differ in their disease ... Accordingly, 50%-60% of the genetic risk for T1D derives from HLA alleles encoding molecules involved in the presentation of ... Selected HLA-I variants such as HLA-A2, HLA-A24, HLA-B39, HLA-B57, and HLA-B18 contribute to T1D risk (3, 6). HLA-A2 is also ...
  https://jinxiuwang.net.insight.mobile.jci.org/articles/view/94549
*  The first large population based twin study of coeliac disease | Gut
HLA typing. Each individual was typed for HLA class II DRB1 and DQB1 molecules. A Dynal AllSet+ SSP DR low resolution kit and a ... DZ twins sharing 0 or 1 alleles at the critical HLA region served as the reference category, and the risk of the non-index twin ... 28 The polymerase chain reaction products were then analysed by capillary electrophoresis on the ABI Prism 310 apparatus (PE ... DRB1*03 and DRB1*05/07 which are both linked to DQA1*0501/ DQB1*0201 (DQ2), and DRB1*04 which is linked to DQA1*0301/DQB1*0302 ...
  http://gut.bmj.com/content/50/5/624
*  Immunogenetics of Hashimoto's thyroiditis | Springer for Research & Development
... but not HLA-DQ*0103/DQB1*0601 (DQ6), transgenic mice [52]. In summary, DR3 and DQ8 alleles are found to be susceptible, whereas ... and HLA-DRB1*1502 (DR2) transgenes [85]. A role for HLA-DQ polymorphism was shown with human thyroglobulin-induced EAT in HLA- ... Association of HLA antigen and restriction fragment length polymorphism of T cell receptor beta-chain gene with Graves' disease ... but not with the HLA-DP and HLA class I (HLA-A, HLA-B and HLA-C) genes [113, 114, 121]. However, some studies could not reveal ...
  https://rd.springer.com/article/10.1186/1740-2557-2-1
*  Marko Boqaris der Leonidas - Seite 3
South Tunisian HLA gene profile has studied for the first time. HLA-A, -B, -DRB1 and. -DQB1 allele frequencies of Ghannouch ... Weinberg equilibrium was tested at each locus by applying a Markov chain approach with. 100.000 steps [10]. The linkage ... DRB1 and DQB1 loci. Fifteen alleles were examined for HLA-A locus in Ghannouch. population (Table 2). The most frequent allele ... Only Individuals with defined DRB1 subtypes are considered.. 4. HLA-A, -B, -DRB1 and -DQB1 linkage disequilibria in Ghannouch. ...
  http://www.balkanforum.info/f16/marko-boqaris-leonidas-52241/index3.html
*  Heterogeneity in the Magnitude of the Insulin Gene Effect on HLA Risk in Type 1 Diabetes | Diabetes
HLA typing.. The whole sample set was typed through PCR amplification of the polymorphic second exon of the HLA-DRB1 and -DQB1 ... Cucca F, Frau F, Lampis R, Floris M, Argiolas L, Macis D, Cao A, De Virgiliis S, Congia M: HLA-DQB1*0305 and -DQB1*0304 alleles ... Nepom BS, Nepom GT, Coleman M, Kwok WW: Critical contribution of beta chain residue 57 in peptide binding ability of both HLA- ... Within the HLA complex, variation at the HLA-DQB1 and -DRB1 loci dominates the association with the disease (3,4). The two loci ...
  http://diabetes.diabetesjournals.org/content/53/12/3286
*  ANTIBODIES WITH T-CELL RECEPTOR LIKE SPECIFICITY TOWARDS NATIVE COMPLEXES OF MHC CLASS II AND DIABETES-ASSOCIATED...
HLA-DP, HLA-DQ, and HLA-DR. [0053] According to some embodiments of the invention, the beta chain of the MHC class II is DR-B1* ... 0093] Non-limiting examples of DQ B1 alleles include 0201, 0202, 0402, 0501, 0502, 0503, 0504, 0601, 0602, 0603, 0604, 0609, ... Examples include, but are not limited to HLA-DM, HLA-DO, HLA-DP, HLA-DQ (e.g., DQ2, DQ4, DQ5, DQ6, DQ7, DQ8, DQ9), HLA-DR (e.g ... light chain; SEQ ID NOs:177-179 CDRs 1-3 for heavy chain (CDRs 1-3 of heavy chain and light chain of G3H8). [0202] According to ...
  http://www.patentsencyclopedia.com/app/20130189284
*  Human Gene HLA-DPB1 (uc011hgd.2) Description and Page Index
HLA-DPB1-DPB1*1901new allele, complete cds.. X03067 - Human mRNA for HLA-D class II antigen DPW2 beta chain.. AY804140 - Homo ... These findings suggest that the HLA-DRB1(*)1302-DQB1(*)0609-DPB1(*)0201 may be a strong genetic marker to determine the aspirin ... beta chain precursor.. X01426 - Human mRNA for HLA class II antigen SB 2-beta chain.. J03041 - Human HLA DP4 beta-chain mRNA, ... allele HLA-DPB1*16:01.. FR775797 - Homo sapiens mRNA for MHC class II antigen (HLA-DPB1 gene), HLA-DPB1*1701_new allele.. ...
  http://rohsdb.cmb.usc.edu/GBshape/cgi-bin/hgGene?hgg_gene=uc011hgd.2&hgg_prot=P04440&hgg_chrom=chr6_mann_hap4&hgg_start=4501242&hgg_end=4515019&hgg_type=knownGene&db=hg19&hgsid=1289098_rEYyzmWZ9Xw4hhMOGbGzlYRwArae
*  HLA-DQA1 gene - Genetics Home Reference
... increased by two HLA haplotypes involving variations of the HLA-DQA1 and HLA-DQB1 genes and another HLA gene called HLA-DRB1. ... HLA class II histocompatibility antigen, DQ alpha 1 chain. *HLA class II histocompatibility antigen, DQ alpha 1 chain precursor ... HLA-DR and HLA-DQ alleles in patients from the south of Brazil: markers for leprosy susceptibility and resistance. BMC Infect ... 01 or HLA-DQA1*05:05 bound to the protein produced from HLA-DQB1 gene variants known as HLA-DQB1*02:01 or HLA-DQB1*02:02. The ...
  https://ghr.nlm.nih.gov/gene/HLA-DQA1
*  Genetic and Immunologic Biomarkers in Type 1 Diabetes
HLA DQ, and HLA DR. Genes encoding the HLA DP apha and beta chains may have as m any as 23 and 120 alleles circulating in a ... Evidence of at least two type 1 diabetes susceptibility genes in the HLA complex distinct from HLA DQB1, DQA1 and DRB1 Genes ... MHC class II alleles are expressed as transmembrane heterodimers composed of an alpha chain and a beta chain (Figure 1 3) These ... respectively HLA DR has but one locus for the alpha chain, which is largely invariable, but nine loci for the beta chain, ...
  http://ufdc.ufl.edu/UFE0045760/00001
*  Protocols and Video Articles Authored by Eddie A. James
... are strongly associated to a specific set of HLA-DR alleles including HLA-DRB1*04:01, *04:04, and *01:01. Here, we first ... particularly HLA-DQ8 (DQ8: DQA1*03:01/DQB1*03:02). Monitoring T1D-specific T cell responses to DQ8-restricted epitopes may be ... approach was used to identify CD4+ T-cell epitopes within the TT heavy chain restricted by 10 different class II alleles. Of ... A total of 112 epitopes restricted by seven common HLA-DRB1 alleles were identified. Epitopes were present within all YFV ...
  https://www.jove.com/author/Eddie++A._James
*  Defining the Role of the MHC in Autoimmunity: A Review and Pooled Analysis
... that exists among alleles throughout this locus, coupled with inadequate study design whereby only a limited subset of about 20 ... The remaining association signals largely arise from alleles of the class II genes HLA-DRB1, HLA-DQA1, and HLA-DQB1 (see ... Li2005MHC class I chain-related gene A-A5.1 allele is associated with ulcerative colitis in Chinese population.Clin Exp ... HLA-DRB1*07, HLA-DRB1*0103, HLA-DRB1*04, and HLA-DRB3*0301 [67]. HLA-DRB1*07 is the most consistently replicated association ...
  http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1000024