The risk is partially shared with the HLA-DR locus (DR3 and DR4 serotypes). Celiac1 is a genetic name for DQB1, the HLA DQB1* ... Certain HLA-DQB1 alleles are also linked to a modest increased risk of multiple sclerosis. Other HLA-DQB1 alleles are ... Major histocompatibility complex Human leukocyte antigen HLA-DQ ENSG00000206237, ENSG00000231286, ENSG00000206302, ... Several alleles of HLA-DQB1 are associated with an increased risk of developing type 1 diabetes. The locus also has the genetic ...

From 90% to 95% of young children with type 1 DM carry HLA-DR3 DQB1*0201, HLA-DR4 DQB1*0302, or both. Carriage of both ... Race-specific type 1 diabetes risk of HLA-DR7 haplotypes. Tissue Antigens. 2011 Nov. 78(5):348-51. [QxMD MEDLINE Link]. [Full ... is the location of several susceptibility loci for type 1 DM-in particular, class II HLA DR and DQ haplotypes. [23, 24, 25] ... 28] Different VNTR alleles may promote either resistance or susceptibility to type 1 DM through their effect on INS ...

The HLA-DQB1 gene provides instructions for making a protein that plays a critical role in the immune system. Learn about this ... HLA-DQ locus of the human leukocyte antigen complex and type 1 diabetes mellitus: a HuGE review. Epidemiol Rev. 2000;22(2):218- ... Researchers have identified hundreds of different versions (alleles) of the HLA-DQB1 gene, each of which is given a particular ... One haplotype, written as DRB1*03:01-DQA1*05:01-DQB1*02, is called DR3. The other haplotype, written as DRB1*04:01/02/04/05/08- ...

DR3/4-DQ8) siblings who share both major histocompatibility complex (MHC) haplotypes identical-by-descent wit ... including alleles of the HLA-DRB1, HLA-DQB1, HLA-B, HLA-C, and HLA-A genes (17,18). The 8.1 haplotype is a common haplotype ... Valdes AM, Erlich HA, Noble JA: Human leukocyte antigen class I B and C loci contribute to type 1 diabetes (T1D) susceptibility ... HLA-DQB1, HLA-B, HLA-A, and rs1233478 as explanatory variables. The final model included HLA-DRB1, HLA-DQB1, HLA-B, and ...

Data were technically validated using published algorithms to evaluate donor relatedness, ancestry, imputed HLA, and T1D ... HLA-A*24:02, HLA-DRB1*03:01 (DR3), HLA-DQA1*05:01-HLA-DQB1*02:01 (DQ2), HLA-DRB1*04:xx (DR4), HLA-DQA1*03:01-HLA-DQB1*03:02 ( ... where Pj is the probability for imputed alleles A1j,S and A2j,S at each HLA locus j of donor S. Concordance was determined as ... minor allele frequency (MAF) ,1%), dominated by Human Leukocyte Antigen (HLA) class II and insulin, and accompanied by 77 ...

From 90% to 95% of young children with type 1 DM carry HLA-DR3 DQB1*0201, HLA-DR4 DQB1*0302, or both. Carriage of both ... Polymorphisms of the class II human leukocyte antigen (HLA) genes that encode DR and DQ are the major genetic determinants of ... is the location of several susceptibility loci for type 1 DM-in particular, class II HLA DR and DQ haplotypes. [23, 24, 25] ... 28] Different VNTR alleles may promote either resistance or susceptibility to type 1 DM through their effect on INS ...

... with the HLA loci having the greatest impact on susceptibility. The association of T1D with alleles at HLA loci, especially the ... In this pilot study, we determined that there may be critical networking among different cytokines and HLA which may play a ... gene polymorphisms were considered in HLA DRDQ fixed patients with T1D. ... HLA class II genes DR and DQ, is well-established. However, other candidate genes may also have some significant impact on ...

Allele and haplotypefrequencies for HLA class II (DQA1 and DQB1) loci in patients withceliac disease from Spain. Hum Immunol ... encoded byHLA-DR3-DQA1�0501-DQB1�0201) or the trans configuration(encoded by HLA-DR11-DQA1�0505 DQB1 0301/DR7-DQA1�0201 DQB1 ... HLA class II alleles associatedwith celiac disease susceptibility in a southern European population.Tissue Antigens 1992;40:90- ... HLAFull HLA-DQ2 (in cis or trans) or HLA-DQ8 heterodimers present 1No HLA performed OR half DQ2 (only HLA-DQB1�0202) present ...

HLA-DPB1*0402 protects against type 1A diabetes autoimmunity in the highest risk DR3-DQB1*0201/DR4DQB1*0302 DAISY population. ... Reijonen H, Kwok WW (2003). Use of HLA class II tetramers in tracking antigen-specific T cells and mapping T-cell epitopes. ... HLA alleles and sustained peanut consumption promote IgG4 responses in subjects protected from peanut allergy. J Clin Invest, ... The MALT1 locus and Peanut Avoidance in the Risk for Peanut Allergy. J Allergy Clin Immunol, 19, 30279. http://dx.doi.org/ ...

BACKGROUND: HLA-DR4, a common antigen of HLA-DRB1, has multiple subtypes that are strongly associated with risk of type 1 ... Such an alignment would be useful to precisely define KIR haplotypes and loci, provide context for assigning alleles ( ... In an independent birth cohort of HLA-DR3 and HLA-DR4 subjects, those having the "KAG" motif had increased risk for time-to- ... HLA-DQA1 and -DQB1 are strongly associated with type 1 diabetes (T1D), and DQ8.1 and DQ2.5 are major risk haplotypes. Next- ...

On Asian DR4 haplotypes, not only DQB1*0302, but also DQB1*0401 confer susceptibility to T1D, which is mediated … ... The HLA DQB1*0302 allele on DR4 haplotypes is a well-known marker for T1D susceptibility. The contribution of this DQ molecule ... 65 and islet cell antigen 512/IA-2 autoantibodies in relation to human leukocyte antigen class II DR and DQ alleles and ... the immune response to different beta cell autoantigens is mediated via varying HLA class II molecules from different loci. ...

From 90% to 95% of young children with type 1 DM carry HLA-DR3 DQB1*0201, HLA-DR4 DQB1*0302, or both. Carriage of both ... Race-specific type 1 diabetes risk of HLA-DR7 haplotypes. Tissue Antigens. 2011 Nov. 78(5):348-51. [QxMD MEDLINE Link]. [Full ... is the location of several susceptibility loci for type 1 DM-in particular, class II HLA DR and DQ haplotypes. [23, 24, 25] ... 28] Different VNTR alleles may promote either resistance or susceptibility to type 1 DM through their effect on INS ...

From 90% to 95% of young children with type 1 DM carry HLA-DR3 DQB1*0201, HLA-DR4 DQB1*0302, or both. Carriage of both ... Race-specific type 1 diabetes risk of HLA-DR7 haplotypes. Tissue Antigens. 2011 Nov. 78(5):348-51. [QxMD MEDLINE Link]. [Full ... is the location of several susceptibility loci for type 1 DM-in particular, class II HLA DR and DQ haplotypes. [23, 24, 25] ... 28] Different VNTR alleles may promote either resistance or susceptibility to type 1 DM through their effect on INS ...

From 90% to 95% of young children with type 1 DM carry HLA-DR3 DQB1*0201, HLA-DR4 DQB1*0302, or both. Carriage of both ... Race-specific type 1 diabetes risk of HLA-DR7 haplotypes. Tissue Antigens. 2011 Nov. 78(5):348-51. [QxMD MEDLINE Link]. [Full ... is the location of several susceptibility loci for type 1 DM-in particular, class II HLA DR and DQ haplotypes. [23, 24, 25] ... 28] Different VNTR alleles may promote either resistance or susceptibility to type 1 DM through their effect on INS ...

From 90% to 95% of young children with type 1 DM carry HLA-DR3 DQB1*0201, HLA-DR4 DQB1*0302, or both. Carriage of both ... Race-specific type 1 diabetes risk of HLA-DR7 haplotypes. Tissue Antigens. 2011 Nov. 78(5):348-51. [QxMD MEDLINE Link]. [Full ... is the location of several susceptibility loci for type 1 DM-in particular, class II HLA DR and DQ haplotypes. [23, 24, 25] ... 28] Different VNTR alleles may promote either resistance or susceptibility to type 1 DM through their effect on INS ...

The HLA-DQB1 gene provides instructions for making a protein that plays a critical role in the immune system. Learn about this ... HLA-DQ locus of the human leukocyte antigen complex and type 1 diabetes mellitus: a HuGE review. Epidemiol Rev. 2000;22(2):218- ... Researchers have identified hundreds of different versions (alleles) of the HLA-DQB1 gene, each of which is given a particular ... One haplotype, written as DRB1*03:01-DQA1*05:01-DQB1*02, is called DR3. The other haplotype, written as DRB1*04:01/02/04/05/08- ...

We identified 17 HLA-A, 28 HLA-B, 14 HLA-C, 13 HLA-DRB1, and 5 HLA-DQB1 alleles, of which HLA-A*02 (22.2%), -B*51 (19.5%), -C* ... Background: HLA class II (DR and DQ) alleles and antigens have historically shown strong genetic predisposition to type 1 ... DQB1*02 (4.2%) were the most frequent two- and five-locus HLA haplotypes. Correspondence analysis and dendrograms showed that ... followed by DR3/DR3 [0.094 vs. 0.010, OR = 8.72 (3.17-25.32), Pc = 3.18 × 10-8] diplotypes. Conclusion: While DRB1 and DQB1 ...

From 90% to 95% of young children with type 1 DM carry HLA-DR3 DQB1*0201, HLA-DR4 DQB1*0302, or both. Carriage of both ... Race-specific type 1 diabetes risk of HLA-DR7 haplotypes. Tissue Antigens. 2011 Nov. 78(5):348-51. [QxMD MEDLINE Link]. [Full ... is the location of several susceptibility loci for type 1 DM-in particular, class II HLA DR and DQ haplotypes. [23, 24, 25] ... 28] Different VNTR alleles may promote either resistance or susceptibility to type 1 DM through their effect on INS ...

A collaborative European search for non-DQA1*05-DQB1*02 celiac disease loci on HLA-DR3 haplotypes: analysis of transmission ... Novel HLA-DR2 and -DR3 haplotypes among Norwegian Caucasians. Tissue Antigens, 37 (4), 165-7. DOI 10.1111/j.1399-0039.1991. ... HLA class II alleles in Norwegian patients with coexisting type 1 diabetes and celiac disease. HLA, 89 (5), 278-284. DOI ... Coeliac disease patients carry conserved HLA-DR3-DQ2 haplotypes revealed by association of TNF alleles. Immunogenetics, 55 (5) ...

Susceptibility and resistance alleles of human leukocyte antigen (HLA) DQA1 and HLA DQB1 are shared in endocrine autoimmune ... HLA) genes on autoimmune thyroid disease (AITD): results of studies in HLA-DR3 positive AITD families. Clin Endocrinol (Oxf). ... Identification of susceptibility loci for autoimmune thyroid disease to 5q31-q33 and Hashimotos thyroiditis to 8q23-q24 by ... Alleles DQA1*05 and DQB1*02 (encoding the HLA-DQ2 heterodimer) and alleles DQA1*03 and DQB1*0302 (encoding the HLA-DQ8 ...

HLA-DQ allele competition in narcolepsy: a comment on Tafti et al. DQB1 locus alone explains most of the risk and protection in ... Closer association of IA-2 humoral autoreactivity with HLA DR3/4 than DQB1*0201/*0302 in Korean T1D patients. Annals of the New ... Tissue antigens 2008 May 71 (5): 453-7. Al-Ola K, Mahdi N, Al-Subaie A M, Ali M E, Al-Absi I K, Almawi W ... Query Trace: Disease Susceptibility and HLA-DQB1[original query]. HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for ...