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*  HLA-DRB1 - HLA class II histocompatibility antigen, DRB1-3 chain precursor - Homo sapiens (Human) - HLA-DRB1 gene & protein
In B-cells; the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) ... class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta ... HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to ... also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II ...
  https://www.uniprot.org/uniprot/P01912
*  HLA-DQ8 - Wikipedia
DQ8 β-chains combine with α-chains, encoded by genetically linked HLA-DQA1 alleles, to form the cis-haplotype isoforms. There ... Velickovic Z, Delahunt B, Carter J (2002). "HLA-DRB1 and HLA-DQB1 polymorphisms in Pacific Islands populations". Tissue ... "Frequencies of HLA-A, HLA-B, HLA-DR, and HLA-DQ phenotypes in the United Arab Emirates population". Tissue Antigens. 66 (2): ... "HLA class II polymorphism in Aka Pygmies and Bantu Congolese and a reassessment of HLA-DRB1 African diversity". Tissue Antigens ...
  https://en.wikipedia.org/wiki/HLA-DQ8
*  DPB1 Alleles Are Associated With Type 1 Diabetes Susceptibility in Multiple Ethnic Groups | Diabetes
The HLA-DPB1-associated component of the IDDM1 and its relationship to the major loci HLA-DQB1, -DQA1, and -DRB1. Diabetes50 : ... Type 1 diabetes associations of DPB1 alleles could either be due to changes in the encoded polypeptide chain or to linkage ... This suggests that DPB1 associations observed in these data are not attributable solely to LD of DPB1 alleles with DRB1-DQB1 ... Genetic associations between type 1 diabetes and alleles at the HLA class II locus DPB1 have been previously reported. Observed ...
  http://diabetes.diabetesjournals.org/content/53/8/2158
*  HLA-DR3 - Wikipedia
HLA-DR3 is composed of the HLA-DR17 and HLA-DR18 split 'antigens' serotypes. DR3 is a component gene-allele of the AH8.1 ... Some DR3 also react with HLA-DR17 and/or HLA-DR18. The DRB1*0304 primarily reacts with DR3. The serotypes of *0305, *0306, * ... DR3-DR2 is the serological marker for HLA-DQ2.5cis isoform. Although it cannot identify the alpha ".5" chain of HLA DQ, DQA1* ... DR3 is genetically linked to HLA-DR52, DRB3*0202 allele, and HLA-DQ2 (DQ2.5). derived from IMGT/HLA Wiencke K, Karlsen TH, ...
  https://en.wikipedia.org/wiki/HLA-DR3
*  HLA-A36 - Wikipedia
For A36, the alpha "A" chain are encoded by the HLA-A*36 allele group and the β-chain are encoded by B2M locus. This group ... notably DRB1*0302) and A*33-B*58 haplotypes were carried into and redistributed from Central Asia into the surrounding ... Allele Query Form IMGT/HLA - European Bioinformatics Institute Sasazuki, Takehiko; Tsuji, Kimiyoshi; Aizawa, Miki (1992). HLA ... A36 is rare HLA-A allele group. A36 has a high false serotyping rate to A1. A36 is largely limited to Africa. Outside Africa ...
  https://en.wikipedia.org/wiki/HLA-A36
*  Plus it
DNA samples were typed for alleles of HLA-DRB1, -DQA1, and -DQB1 using the phototyping method (6,7). The insulin gene variable ... Sanjeevi CB, Kanungo A, Berzina L, Shtauvere-Brameus A, Ghaderi M, Samal KC: MHC class I chain-related gene a alleles ... Heward JM, Mijovic CH, Kelly MA, Morrison E, Barnett AH: HLA-DQ and DRB1 polymorphism and susceptibility to type 1 diabetes in ... Alleles of the GCT microsatellite in the major histocompatibility complex class I chain-related gene-A (MIC-A) gene were typed ...
  http://care.diabetesjournals.org/content/30/12/3088
*  HLA-A3 - Wikipedia
For A3, the alpha, "A", chain are encoded by the HLA-A*03 allele group and the β-chain are encoded by B2M locus. This group ... A*0301 : C*0702 : B*0702 : DRB1*1501 : DQA1*0102 : DQB1*0602 Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF ( ... Allele Query Form IMGT/HLA - European Bioinformatics Institute Machens A, Löliger C, Pichlmeier U, Emskötter T, Busch C, ... HLA-A3 (A3) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody ...
  https://en.wikipedia.org/wiki/HLA-A3
*  HLA A1-B8-DR3-DQ2 - Wikipedia
"B*0801:DRB1*0301"" Loci. Gene. Allele. Isoform centomeric Class I region HLA-B B*0801 B8 ... Starting from B8, immediately followed by the MICA and MICB which stand for MHC I-like chain A and B. These two functional ... B*01 allele) and HLA show that the allele is in linkage disequilibrium with HLA-A1, Cw7, B8, C4A(Null), DR3, DQ2.5.[32] The ... "Meta-analysis of HLA-DRB1 and HLA-DQB1 polymorphisms in Latin American patients with systemic lupus erythematosus". Autoimmun ...
  https://en.wikipedia.org/wiki/HLA_A1-B8-DR3-DQ2
*  HLA-DQ1 - Wikipedia
HLA-DQ1 is a serotype that covers a broad range of HLA-DQ haplotypes. Historically it was identified as a DR-like alpha chain ... "HLA class II alleles in Japanese patients with Graves' disease: weak associations of HLA-DR and -DQ". Endocr. J. 41 (6): 599- ... 1994). "HLA-DQA1, -DQB1 and -DRB1 genotyping in Japanese pemphigus vulgaris patients by the PCR-RFLP method". Tissue Antigens. ... "Sequences related to HLA-DR alpha chain on human chromosome 6: restriction enzyme polymorphism detected with DC alpha chain ...
  https://en.wikipedia.org/wiki/HLA-DQ1
*  What is the Likelihood of Finding a Suitable Stem Cell Donor
The frequencies of HLA-A, -B, -C and -DRB1 alleles were calculated from the number of observed genotype. Hardy-Weinberg ... HLA-A, -B, -C and -DRB1 genotypes were obtained using polymerase chain-reaction sequence-specific oligonucleotide probe methods ... HLA-A, HLA-B, HLA-C, and HLA-DRB1) were used for adult donors. The HF and effective adult-donor registry size for each group ... HLA-A, -B, -C and -DRB1. Deviation from HWEP detected at the HLA-A locus is derived primary from an excess of A*02:01 + A*02:03 ...
  https://www.ukessays.com/essays/sciences/likelihood-finding-suitable-stem-cell-3708.php
*  HLA-DR4 - Wikipedia
"Anti-caspase-8 autoantibody response in silicosis patients is associated with HLA-DRB1, DQB1 and DPB1 alleles". J Occup Health ... "A possible association between basic amino acids of position 13 of DRB1 chains and autoimmune hepatitis". Immunogenetics. 36 (1 ... HLA-DR4 (DR4) is an HLA-DR serotype that recognizes the DRB1*04 gene products. The DR4 serogroup is large and has a number of ... derived from IMGT/HLA Roudier J (2006). "HLA-DRB1 genes and extraarticular rheumatoid arthritis". Arthritis Research & Therapy ...
  https://en.wikipedia.org/wiki/HLA-DR4
*  HLA-DQ9 - Wikipedia
Törn C, Gupta M, Sanjeevi CB, Aberg A, Frid A, Landin-Olsson M (2004). "Different HLA-DR-DQ and MHC class I chain-related gene ... 2004). "HLA-DQA1 and DQB1 alleles are associated with genetic susceptibility to psoriasis vulgaris in Chinese Han". Int. J. ... Tsuchiya N, Kobayashi S, Hashimoto H, Ozaki S, Tokunaga K (2006). "Association of HLA-DRB1*0901-DQB1*0303 haplotype with ... HLA-DQ9 (DQ9) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ9 is a split antigen of the DQ3 ...
  https://en.wikipedia.org/wiki/HLA-DQ9
*  Frontiers | T Cell-Mediated Chronic Inflammatory Diseases Are Candidates for Therapeutic Tolerance Induction with Heat Shock...
The HLA dictionary 2008: a summary of HLA-A,-B,-C,-DRB1/3/4/5, and-DQB1 alleles and their association with serologically ... The SE is a five amino-acid sequence motif found in residues 70-74 of the HLA-DRβ chain that encodes a conserved positively ... HLA-B27 encompasses around 105 known subtypes (HLA-B*27:01 to HLA-B*27:106 thus far identified) that are encoded by 132 alleles ... HLA-B27 subtypes and HLA class II alleles in Japanese patient with anterior uveitis. Invest Ophthalmol Vis Sci (1999) 40(8): ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.01408/full
*  Plus it
HLA DR3 was defined as DRB1*03:01 - DQA1*05:01 - DQB1*02:01, and HLA DR4-DQ8 was defined as DQA1*03:01 - DQB1*03:02 with DRB1* ... zero minor alleles) and also homozygous for the minor allele (two minor alleles) versus not (zero or one minor alleles). All ... Recent studies suggest a possible regulatory role of a TCF7L2 variant on acyl-CoA synthetase long-chain family member 5 (ACSL5 ... The protective HLA DRB1*15:01-DQB1*0602 haplotype was found in four noncarriers and in three carriers of the type 2 diabetes- ...
  http://care.diabetesjournals.org/content/41/2/311
*  HLA-A33 - Wikipedia
For A33, the alpha "A" chain are encoded by the HLA-A*33 allele group and the β-chain are encoded by B2M locus. A33 and A*33 ... DRB1*0301 : DQA1*0501 : DQB1*0201 It is interesting that the Cw allele in the Pakistani population is the same as the allele in ... Allele Query Form IMGT/HLA - European Bioinformatics Institute Mohyuddin A, Mehdi SQ (2005). "HLA analysis of the Parsi ( ... 2007). "Genetic link between Chaoshan and other Chinese Han populations: Evidence from HLA-A and HLA-B allele frequency ...
  https://en.wikipedia.org/wiki/HLA-A33
*  HLA-A*02 - Wikipedia
HLA-A02, and HLA-A*2. HLA-A*02 is one particular class I major histocompatibility complex (MHC) allele group at the HLA-A locus ... For A*02, the α chain is encoded by the HLA-A*02 gene and the β chain is encoded by the B2M locus. In 2010 the World Health ... DRB1*0401 : DQA1*0301 : DQB1*0302 Another haplotype that is more common in Central Europe is the (A2-B44-DR7-DQ2) A*0201 : C* ... "HLA Nomenclature @ hla.alleles.org". Anthony Nolan Research Institute. 10 Nov 2013. Retrieved 8 Dec 2013. "Allele Search Tool ...
  https://en.wikipedia.org/wiki/HLA-A*02
*  In silicoanalysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy...
01 and HLA-DRB1 alleles. All haplotype combinations (colored lines) of the HLA-B*57:01 allele with HLA-DRB1 alleles reported in ... KIR, Killer-cell immunoglobulin-like receptors; MIC, MHC class I chain related (MIC) genes. ... HLA-A:HLA-B, HLA-B:HLA-C, HLA-B:HLA-DRB1, HLA-DRB1:HLA-DQB1. Additionally, we included the HLA-DQB1:HLA-DQA1 haplotype, which ... HLA-DRB1:HLA-DQB1 (D' = 0.95), HLA-B:HLA-C (D' = 0.94), HLA-B:HLA-DRB1 (D' = 0.68), HLA-A:HLA-B (D' = 0.60) and C:DRB1 (D' = ...
  https://genomemedicine.biomedcentral.com/articles/10.1186/gm350
*  JCI - Autoreactive T cells in type 1 diabetes
The HLA-DRB1 chain is also involved in the presentation of diabetogenic epitopes, but DRB1*04 variants differ in their disease ... Accordingly, 50%-60% of the genetic risk for T1D derives from HLA alleles encoding molecules involved in the presentation of ... Selected HLA-I variants such as HLA-A2, HLA-A24, HLA-B39, HLA-B57, and HLA-B18 contribute to T1D risk (3, 6). HLA-A2 is also ... Strong predisposition for T1D derives from selected HLA class II (HLA-II) haplotypes, especially HLA-DRB1*04 (DR4), DQA1*03:01- ...
  https://jinxiuwang.net.insight.mobile.jci.org/articles/view/94549
*  Pathogenic Mechanisms in Type 1 Diabetes: The Islet is Both Target and Driver of Disease
More than 90% of Caucasians with T1D carry the DR3-DQ2 (HLA DRB1*0301-DQB1*0201) or DR4-DQ8 (HLA DRB1*0401-DQB1*0302) ... T cells in human T1D is underscored by the observation that some HLA alleles, HLA DQB1*0602 for example, confer a reduced risk ... Mannering SI, Pang SH, Williamson NA, Naselli G, Reynolds EC, O'Brien-Simpson NM, Purcell AW, Harrison LC. The A-chain of ... A diabetes-susceptible HLA haplotype is best defined by a combination of HLA-DR and -DQ alleles. J Clin Invest 1989. 83:830-835 ...
  http://www.soc-bdr.org/content/rds/archive/9/4_winter/chapter_i_pathogenesis/pathogenic_mechanisms_in_t1d/?showfulltext=1
*  The first large population based twin study of coeliac disease | Gut
HLA typing. Each individual was typed for HLA class II DRB1 and DQB1 molecules. A Dynal AllSet+ SSP DR low resolution kit and a ... DZ twins sharing 0 or 1 alleles at the critical HLA region served as the reference category, and the risk of the non-index twin ... 28 The polymerase chain reaction products were then analysed by capillary electrophoresis on the ABI Prism 310 apparatus (PE ... The pairs in this group were: DRB1*07/07 (CD concordant), DRB1*07/08 (CD concordant), and DRB1*07/07 (CD discordant). ...
  http://gut.bmj.com/content/50/5/624
*  Significant Association of HLA-B Alleles and Genotypes in Thai Children with Autism Spectrum Disorders: A Case-Control Study
Y.-L. Chien, Y.-Y. Wu, C.-H. Chen et al., "Association of HLA-DRB1 alleles and neuropsychological function in autism," ... HLA-B Typing. HLA-B genotyping was carried out based on Polymerase Chain Reaction-sequence-specific oligonucleotides (PCR-SSO) ... In HLA-. 13:02 (. , OR = 2.229), HLA-. 38:02 (. , OR = 1.628), HLA-. 44:03 (. , OR = 1.645), and HLA-. 56:01 (. = 1.78 × 10−4 ... In our study, the findings obtained have shown that HLA-. 13:02, HLA-. 38:02, HLA-. 44:03, and HLA-. 56:01 alleles were ...
  https://www.hindawi.com/journals/dm/2015/724935/
*  Immunogenetics of Hashimoto's thyroiditis | Springer for Research & Development
... and HLA-DRB1*1502 (DR2) transgenes [85]. A role for HLA-DQ polymorphism was shown with human thyroglobulin-induced EAT in HLA- ... non-HLA loci were contributing to the joint susceptibility to AITD and T1D. Among HLA-DR alleles, HLA-DR3 was detected as the ... Association of HLA antigen and restriction fragment length polymorphism of T cell receptor beta-chain gene with Graves' disease ... but not with the HLA-DP and HLA class I (HLA-A, HLA-B and HLA-C) genes [113, 114, 121]. However, some studies could not reveal ...
  https://rd.springer.com/article/10.1186/1740-2557-2-1
*  Diagnostic value of anti-cyclic citrullinated peptides and association with HLA-DRB1 shared epitope alleles in African...
Genotyping of HLA-DRB1 alleles was performed by polymerase chain reaction and hybridization with sequence-specific ... and to determine the prevalence of HLA-DRB1 shared epitope alleles (SE) in African patients with rheumatoid arthritis (RA). ... Thirty percent of RA patients were carrying at least one copy of the HLA-DRB1 shared epitope (SE) compared to 10% and 14% of ... HLA-DRB1*0102, HLA-DRB1*0401, HLA-DRB1*0404, HLA-DRB1*0405, HLA-DRB1*0408, HLA-DRB1*0410, HLA-DRB1*1001, HLA-DRB1*1402 are ...
  https://arthritis-research.biomedcentral.com/articles/10.1186/ar2945
*  Protocols and Video Articles Authored by Eddie A. James
... are strongly associated to a specific set of HLA-DR alleles including HLA-DRB1*04:01, *04:04, and *01:01. Here, we first ... approach was used to identify CD4+ T-cell epitopes within the TT heavy chain restricted by 10 different class II alleles. Of ... A total of 112 epitopes restricted by seven common HLA-DRB1 alleles were identified. Epitopes were present within all YFV ... Oct, 2010 , Pubmed ID: 20533291 HLA-DRB1*1001 (DR1001) is a shared epitope allele associated with rheumatoid arthritis (RA). ...
  https://www.jove.com/author/Eddie++A._James