HLA-DQB1 - Wikipedia
The risk is partially shared with the HLA-DR locus (DR3 and DR4 serotypes). Celiac1 is a genetic name for DQB1, the HLA DQB1* ... Major histocompatibility complex Human leukocyte antigen HLA-DQ ENSG00000206237, ENSG00000231286, ENSG00000206302, ... 0302 encode genes that mediate the autoimmune coeliac disease. Homozygotes of DQB1*0201 have a higher risk of developing the ... HLA-DQB1 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DQA ...
HLA similarities indicate shared genetic risk in 21-hydroxylase autoantibody positive South African and United States Addison's...
SA-AD (n = 73), SA healthy controls (N = 78), and US-AD patients (N = 83) were genotyped for DQA1, DQB1, DRB1, and HLA-B ... Keywords: Addisons disease; autoantibody serology; autoimmune polyendocrine syndrome type 2; human leukocyte antigen genetics ... SA-AD and US-AD 21OH-AA + patients share common HLA risk haplotypes including DR4 (with HLA-B7) and DR3 (with HLA-B8), ... Apart from the class II DR3 haplotype, HLA-B8 did not have an independent effect; however together DR3 and HLA-B8 conferred the ...
HLA-DQA1 gene: MedlinePlus Genetics
The HLA-DQA1 gene provides instructions for making a protein that plays a critical role in the immune system. Learn about this ... The HLA-DQA1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the ... Autoimmune disorders. Certain normal variations of the HLA-DQA1 gene have been associated with increased risk of autoimmune ... People at highest risk of developing type 1 diabetes have one copy of the DR3 haplotype and one copy of the DR4 haplotype in ...
HLA-DQA1 gene: MedlinePlus Genetics
The HLA-DQA1 gene provides instructions for making a protein that plays a critical role in the immune system. Learn about this ... The HLA-DQA1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the ... Autoimmune disorders. Certain normal variations of the HLA-DQA1 gene have been associated with increased risk of autoimmune ... People at highest risk of developing type 1 diabetes have one copy of the DR3 haplotype and one copy of the DR4 haplotype in ...
Coeliac disease in Dutch patients with Hashimoto’s thyroiditis and vice versa
Susceptibility and resistance alleles of human leukocyte antigen (HLA) DQA1 and HLA DQB1 are shared in endocrine autoimmune ... HLA) genes on autoimmune thyroid disease (AITD): results of studies in HLA-DR3 positive AITD families. Clin Endocrinol (Oxf). ... The association of goitrous autoimmune thyroiditis with HLA-DR5. Tissue Antigens. 1981;17:265-268. [PubMed] [DOI] [Cited in ... HLA-DQ2 is common in the healthy population and is carried by approximately 30% of Caucasians[43]. HLA-DQ2 and HLA-DQ8 are ...
OUH - Publications
Complexes of two cohorts of CLIP peptides and HLA-DQ2 of the autoimmune DR3-DQ2 haplotype are poor substrates for HLA-DM. J ... Novel HLA-DR2 and -DR3 haplotypes among Norwegian Caucasians. Tissue Antigens, 37 (4), 165-7. DOI 10.1111/j.1399-0039.1991. ... Differences in the risk of celiac disease associated with HLA-DQ2.5 or HLA-DQ2.2 are related to sustained gluten antigen ... a model for posttranslational modification of antigens and HLA association in the pathogenesis of autoimmune disorders. Curr ...