*  TRAF1 - Wikipedia
Wajant H, Henkler F, Scheurich P (2001). "The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors ... bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2". Proc ... TNF receptor-associated factor 1 is a protein that in humans is encoded by the TRAF1 gene. The protein encoded by this gene is ... "Entrez Gene: TRAF1 TNF receptor-associated factor 1". Abdul-Sater, Ali A; Edilova, Maria I; Clouthier, Derek L; Mbanwi, Achire ...
  https://en.wikipedia.org/wiki/TRAF1
*  TRAF3 - Wikipedia
... bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2". ... "The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators". Cellular ... TNF receptor-associated factor is a protein that in humans is encoded by the TRAF3 gene. The protein encoded by this gene is a ... "Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell ...
  https://en.wikipedia.org/wiki/TRAF3
*  TNF receptor superfamily - Wikipedia
The tumor necrosis factor receptor superfamily (TNFRSF) is a protein superfamily of cytokine receptors characterized by the ... May 1993). "Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor ... most TNF receptors require specific adaptor protein such as TRADD, TRAF, RIP and FADD for downstream signalling. TNF receptors ... the majority of TNF receptors form trimeric complexes in the plasma membrane. Accordingly, most TNF receptors contain ...
  https://en.wikipedia.org/wiki/TNF_receptor_superfamily
*  TRADD - Wikipedia
"The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 ... Hsu H, Huang J, Shu HB, Baichwal V, Goeddel DV (1996). "TNF-dependent recruitment of the protein kinase RIP to the TNF receptor ... "The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 ... "Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death ...
  https://en.wikipedia.org/wiki/TRADD
*  Tumor necrosis factor receptor 1 - Wikipedia
... specific TNF receptor blockade may be advantageous to anti-TNF treatments". Cytokine Growth Factor Rev. 13 (4-5): 315-21. doi: ... "The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 ... Hsu H, Huang J, Shu HB, Baichwal V, Goeddel DV (1996). "TNF-dependent recruitment of the protein kinase RIP to the TNF receptor ... This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate the transcription ...
  https://en.wikipedia.org/wiki/Tumor_necrosis_factor_receptor_1
*  Tumor necrosis factor receptor 2 - Wikipedia
... tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B ... Tumor necrosis factor receptor 2 (TNFR2), also known as tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) and ... specific TNF receptor blockade may be advantageous to anti-TNF treatments". Cytokine Growth Factor Rev. 13 (4-5): 315-21. doi: ... c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2 ...
  https://en.wikipedia.org/wiki/Tumor_necrosis_factor_receptor_2
*  Death Domain database - Wikipedia
Tartaglia, LA; Ayres, TM; Wong, GHW; Goeddel, DV (1993), "A novel domain within the 55 kd TNF receptor signals cell death", ... to the tumor necrosis factor-related apoptosis-inducing ligand receptor DR5 is regulated by the death effector domain of FADD ... Adapter proteins involved in signal transduction by toll-like receptors", Journal of Endotoxin Research, 9 (1): 55-59, doi: ... doi:10.1016/0092-8674(95)90071-3. PMID 7538907. Hofmann, K; Bucher, P; Tschopp, J (1997). "The CARD domain: A new apoptotic ...
  https://en.wikipedia.org/wiki/Death_Domain_database
*  MATH domain - Wikipedia
TRAF proteins were first isolated through their ability to interact with TNF receptors. They promote cell survival by the ... Various growth factors, cytokines, and extracellular matrix proteins are substrates for meprins. They are composed of five ... The oligomerisation is essential for establishing appropriate connections to form signalling complexes with TNF receptor-1. The ... Ye H, Park YC, Kreishman M, Kieff E, Wu H (September 1999). "The structural basis for the recognition of diverse receptor ...
  https://en.wikipedia.org/wiki/MATH_domain
*  Fas receptor - Wikipedia
Micheau O, Tschopp J (July 2003). "Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes". Cell ... or tumor necrosis factor receptor superfamily member 6 (TNFRSF6) is a protein that in humans is encoded by the FAS gene. The ... FAS receptor is located on the long arm of chromosome 10 (10q24.1) in humans and on chromosome 19 in mice. The gene lies on the ... Apoptosis-inducing Fas receptor is dubbed isoform 1 and is a type 1 transmembrane protein. Many of the other isoforms are rare ...
  https://en.wikipedia.org/wiki/Fas_receptor
*  Tumor necrosis factor superfamily - Wikipedia
Such membrane-bound TNF ligands frequently signal back to the immune cells when they contact and bind their cognate receptors ... Tumor necrosis factor (TNF), formerly known as TNFα or TNF alpha, is the best-known member of this class. TNF is a monocyte- ... They include: Tumor necrosis factor (TNF) (also known as cachectin or TNF alpha) is a cytokine that has a wide variety of ... The tumor necrosis factor (TNF) superfamily refers to a superfamily of cytokines that can cause cell death (apoptosis). The ...
  https://en.wikipedia.org/wiki/Tumor_necrosis_factor_superfamily
*  KHDRBS1 - Wikipedia
... hepatocyte growth factor (HGF)/Met receptor (c-Met), leptin and tumor necrosis factor (TNF) receptors. While the role of Sam68 ... Sam68 is also downstream of the epidermal growth factor receptor (EGFR), ... "Sam68 is required for both NF-κB activation and apoptosis signaling by the TNF receptor". Mol Cell. 43 (2): 167-79. doi:10.1016 ... Nunès JA, Truneh A, Olive D, Cantrell DA (1996). "Signal transduction by CD28 costimulatory receptor on T cells. B7-1 and B7-2 ...
  https://en.wikipedia.org/wiki/KHDRBS1
*  Caspase 10 - Wikipedia
Micheau, Olivier; Tschopp Jürg (July 2003). "Induction of TNF receptor I-mediated apoptosis via two sequential signaling ... Zheng, L; Schickling O; Peter M E; Lenardo M J (August 2001). "The death effector domain-associated factor plays distinct ... Wang, J; Chun H J; Wong W; Spencer D M; Lenardo M J (November 2001). "Caspase-10 is an initiator caspase in death receptor ... Caspase 10 has been shown to interact with FADD, CFLAR, Caspase 8, Fas receptor, RYBP, TNFRSF1A and TNFRSF10B. The Proteolysis ...
  https://en.wikipedia.org/wiki/Caspase_10
*  Erythropoietin receptor - Wikipedia
"Activation of the erythropoietin receptor promoter by transcription factor GATA-1". Proceedings of the National Academy of ... "Multiple members of the TNF superfamily contribute to IFN-gamma-mediated inhibition of erythropoiesis". Journal of Immunology. ... Zang H, Sato K, Nakajima H, McKay C, Ney PA, Ihle JN (Jun 2001). "The distal region and receptor tyrosines of the Epo receptor ... Socolovsky M, Dusanter-Fourt I, Lodish HF (May 1997). "The prolactin receptor and severely truncated erythropoietin receptors ...
  https://en.wikipedia.org/wiki/Erythropoietin_receptor
*  Lymphotoxin alpha - Wikipedia
"The genes for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) are tandemly arranged on chromosome 17 of the mouse ... As a member of the TNF family, LT-α binds to various receptors and activates the NF-κB pathway, thus promoting immune ... As years progressed, its name was changed to tumor necrosis factor-beta (TNF-β). Later discovery of LT-β and LT-α1-β2 complex ... Lymphotoxin-alpha (LT-α) or tumor necrosis factor-beta (TNF-β) is a protein that in humans is encoded by the LTA gene. ...
  https://en.wikipedia.org/wiki/Lymphotoxin_alpha
*  TACI-CRD2 protein domain - Wikipedia
Tumor necrosis factor (TNF) (also known as TNF-alpha or cachectin) is a cytotoxin which is derived from a form of white blood ... complexes that are recognised by their specific receptors. TACI is a member of the tumor necrosis factor receptor superfamily ... Members of this family are predominantly found in tumour necrosis factor receptor superfamily, member 13b (TACI), and are ... Kriegler M, Perez C, DeFay K, Albert I, Lu SD (April 1988). "A novel form of TNF/cachectin is a cell surface cytotoxic ...
  https://en.wikipedia.org/wiki/TACI-CRD2_protein_domain
*  Lymphotoxin beta receptor - Wikipedia
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the ... 1997). "Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in ... "Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell ... Lymphotoxin beta receptor (LTBR), also known as tumor necrosis factor receptor superfamily member 3 (TNFRSF3), is a cell ...
  https://en.wikipedia.org/wiki/Lymphotoxin_beta_receptor
*  Baculoviral IAP repeat-containing protein 3 - Wikipedia
... inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors". ... Li X, Yang Y, Ashwell JD (2002). "TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2". Nature. 416 (6878): 345- ... inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors". ... Li X, Yang Y, Ashwell JD (2002). "TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2". Nature. 416 (6878): 345- ...
  https://en.wikipedia.org/wiki/Baculoviral_IAP_repeat-containing_protein_3
*  Frontiers | Role of Cytokines in Thymus- Versus Peripherally Derived-Regulatory T Cell Differentiation and Function | Immunology
Knowledge on the role of TNF-α on the biology of Tregs is fragmentary and inconsistent between mice and humans. Moreover, ... Knowledge on the role of TNF-α on the biology of Tregs is fragmentary and inconsistent between mice and humans. Moreover, ... emerging results from the clinical use of TNF-α inhibitors indicate that part of their anti-inflammatory effect may be ... emerging results from the clinical use of TNF-α inhibitors indicate that part of their anti-inflammatory effect may be ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2013.00155/full
*  RIPK1 - Wikipedia
... tumor necrosis factor) ligand to its membrane receptor, the TNFR (tumor necrosis factor receptor). Once activated, the ... "TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex". Immunity. 4 (4): 387-96. doi: ... receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-kappaB activation". The ... "TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex". Immunity. 4 (4): 387-96. doi: ...
  https://en.wikipedia.org/wiki/RIPK1
*  TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Severe liver degeneration and...
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Severe liver degeneration and ... Mice that lack the TNF receptor-associated factor 6 (TRAF6) are osteopetrotic with defects in tooth eruption and bone ... Thus they show greater sensitivity to TNF(alpha)induced apoptosis. It appears that NEMO/IKK(gamma) is the first essential ... Abstracts: Spt5 and Spt6 are associated with active transcription and have characteristics of general elongation factors in D. ...
  http://www.readabstracts.com/Biological-sciences/TRAF6-deficiency-results-in-osteopetrosis-and-defective-interleukin-1-CD40-and-LPS-signaling.html
*  Frontiers | The Role of IFN-β during the Course of Sepsis Progression and Its Therapeutic Potential | Immunology
As anti-inflammatory treatments in humans with antibodies to TNF- or IL1- resulted disappointing, cytokine modulation ... As anti-inflammatory treatments in humans with antibodies to TNF- or IL1- resulted disappointing, cytokine modulation ... An inflammatory triangle in psoriasis: TNF, type I IFNs and IL-17. Cytokine Growth Factor Rev (2015) 26:25-33. doi:10.1016/j. ... Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on toll-like receptors. Nat Immunol ( ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.00493/full
*  POU2F1 - Wikipedia
Host cell factor C1, Ku80, MNAT1 NPAT, Nuclear receptor co-repressor 2, POU2AF1, RELA, Retinoid X receptor alpha, SNAPC4, Sp1 ... "Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B ... "Silencing mediator for retinoid and thyroid hormone receptors interacts with octamer transcription factor-1 and acts as a ... "Recruitment of octamer transcription factors to DNA by glucocorticoid receptor". Mol. Cell. Biol. 18 (6): 3416-30. PMC 108923 ...
  https://en.wikipedia.org/wiki/POU2F1
*  HRB (gene) - Wikipedia
... and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-kappa B activation". J. Biol. Chem. 277 (18): 15985-91. doi: ... Chen D, Li X, Zhai Z, Shu HB (2002). "A novel zinc finger protein interacts with receptor-interacting protein (RIP) ... Yang J, Bogerd HP, Wang PJ, Page DC, Cullen BR (2001). "Two closely related human nuclear export factors utilize entirely ... doi:10.1016/0092-8674(95)90437-9. PMID 7634337. Fridell RA, Bogerd HP, Cullen BR (1996). "Nuclear export of late HIV-1 mRNAs ...
  https://en.wikipedia.org/wiki/HRB_(gene)
*  BIRC3 - Wikipedia
... inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors". ... Li X, Yang Y, Ashwell JD (2002). "TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2". Nature 416 (6878): 345-7 ... inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors". ... 1999). "Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic ...
  https://sh.wikipedia.org/wiki/BIRC3
*  Rhomboid protease - Wikipedia
Genetic analysis later proved that this group of genes were members of the epidermal growth factor (EGF) receptor signalling ... iRhoms are thus required for the TNF-alpha and EGF receptor signalling, making them medically highly attractive. Phylogenetic ... of EGF receptor ligands in Drosophila, thus providing a mechanism for regulating EGF receptor activity in the brain. This ... 2008). "Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin". Dis Model Mech ...
  https://en.wikipedia.org/wiki/Rhomboid_protease