MicroRNA-34a: A Key Regulator in the Hallmarks of Renal Cell Carcinoma
... and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens. Clinicopathological parameter correlation and ... and Ki67 protein expression and absent Tp53 staining. These findings indicate miR-34a along with its putative target genes ... study aimed to evaluate the expression levels of miR-34a and 11 of its bioinformatically selected target genes and proteins to ... It binds to DNA and regulates transcription of target genes that induce cell cycle arrest, apoptosis, and DNA repair [150-152 ...
High Mobility Group B Proteins, Their Partners, and Other Redox Sensors in Ovarian and Prostate Cancer
This review describes recent advances in the role of human HMGB proteins and other proteins interacting with them, in cancerous ... The protein HMGB1 behaves as a redox sensor and its structural changes, which are conditioned by the oxidative environment, are ... High mobility group B (HMGB) proteins have been previously related to the onset and progressions of cancers of different ... In the nucleus, HMGB proteins interact with a number of transcription factors, among them tumour suppressors like P53 [51-53] ...
"One Ring to Bind Them All"-Part I: The Efficiency of the Macrocyclic Scaffold for G-Quadruplex DNA...
In this review we summarize the current state of the art in detailing the three main categories of quadruplex-binding ... rapidly leading to a large diversity of macrocyclic structures with remarkable-quadruplex binding properties and biological ... Y. Xu, Y. Hirao, Y. Nishimura, and H. Sugiyama, "I-motif and quadruplex-based device that can control a protein release or bind ... M. Gunaratnam, S. Swank, S. M. Haider et al., "Targeting human gastrointestinal stromal tumor cells with a quadruplex-binding ...
Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease
... cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)-ATF composite site to ... It was reported that OXPHOS deregulation stabilizes the transcription factor HIF1α promoting tumor growth [43]. Also, it was ... receptor and the retinoblastoma protein (Rb) [35]. However, later studies revealed that TRAP1 localizes in the mitochondrial ... an important role in metabolic reprogramming and cellular senescence and it also increases the oncogenic potential of tumor ...
Curcumin, a Multifaceted Hormetic Agent, Mediates an Intricate Crosstalk between Mitochondrial Turnover, Autophagy, and...
Protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. ... curcumin induces epigenetic alterations by modulating the expression of several other oncogenic and tumor suppressor miRs ( ... P. Puigserver, J. Ribot, F. Serra et al., "Involvement of the retinoblastoma protein in brown and white adipocyte cell ... pathway and the phosphorylation of p70 ribosomal protein S6 kinase (p70S6K) and eukaryotic initiation factor 4E-binding protein ...