*  Research Grants - 2014
Tau protein plays an important role in the development of Alzheimer's and other neurodegenerative diseases, collectively known ... However, recent evidence suggests that abnormal tau protein may be able to be transported from one nerve cell to nearby cells ... Most of the accumulation of tau protein into neurofibrillary tangles occurs inside nerve cells. ... and colleagues have proposed a series of studies examining the mechanisms underlying the movement of abnormal tau protein ...
  https://www.actionalz.org/research/alzheimers_grants/for_researchers/overview-2014.asp?grants=2014ikezu
*  Downregulation of microtubule associated protein (MAP)-Tau sensitizes MCF7 and ZR75.1 breast cancer cell lines to taxanes |...
Microtubule associated protein (MAP)-Tau promotes tubulin assembly and stabilizes microtubules in a physiological manner. ... Downregulation of microtubule associated protein (MAP)-Tau sensitizes MCF7 and ZR75.1 breast cancer cell lines to taxanes. ... Downregulation of microtubule associated protein (MAP)-Tau sensitizes MCF7 and ZR75.1 breast cancer cell lines to taxanes ... Downregulation of microtubule associated protein (MAP)-Tau sensitizes MCF7 and ZR75.1 breast cancer cell lines to taxanes ...
  http://cancerres.aacrjournals.org/content/65/9_Supplement/774.4
*  Biomolecules | Free Full-Text | New Features about Tau Function and Dysfunction
Beyond its classical role as a microtubule-associated protein, recent advances in our understanding of tau cellular functions ... Prominent tau neurofibrillary pathology is a common feature in a number of neurodegenerative disorders, collectively referred ... Regulation of tau behavior and function under physiological and pathological conditions is mainly achieved through post- ... Under pathological conditions, tau self-assembles into filamentous structures that end up forming neurofibrillary tangles. ...
  http://www.mdpi.com/2218-273X/6/2/21
*  Lithium Treatment of APPSwDI/NOS2−/− Mice Leads to Reduced Hyperphosphorylated Tau, Increased Amyloid Deposition and Altered...
Because this mouse develops tau pathology, amyloid pathology and neuronal loss we were interested in the effect anti-tau ... We found that lithium significantly lowered hyperphosphorylated tau levels as measured by Western blot and immunocytochemistry ... We recently developed a mouse model that progresses from amyloid pathology to tau pathology and neurodegeneration due to the ... Lithium is an anti-psychotic that has been shown to prevent the hyperphosphorylation of tau protein through the inhibition of ...
  http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031993
*  An Extra Strain on the Brain-α-Synuclein Seeds Tau Aggregation | ALZFORUM
Chicago-ALS Protein SOD1 Painted as Disease Template 29 Dec 2012. * Do Tau 'Prions' Lead the Way From Concussions to ... The most interesting and novel finding is that strain B is able to induce misfolding and aggregation of tau, the protein that ... Researchers who spoke with Alzforum said α-synuclein may not be the only protein that separates into strains. Amyloid-β, tau, ... Protein fibrils in nature can enhance amyloid protein A amyloidosis in mice: Cross-seeding as a disease mechanism. Proc Natl ...
  http://www.alzforum.org/news/research-news/extra-strain-brain-synuclein-seeds-tau-aggregation
*  Recombinant Human Tau410 protein (ab72462) References
References for Abcam's Recombinant Human Tau410 protein (ab72462). Please let us know if you have used this product in your ... Neuroscience Neurology process Neurodegenerative disease Alzheimer's disease Tangles & Tau Share by email ... Proteins and Peptides. Proteomics tools. Agonists, activators, antagonists and inhibitors. Lysates. Multiplex miRNA assays. By ...
  http://www.abcam.com/recombinant-human-tau410-protein-ab72462-references.html
*  Increased acetylation of microtubules rescues human tau-induced microtubule defects and neuromuscular junction abnormalities in...
2008). Histone deacetylase 6 interacts with the microtubule-associated protein tau. J. Neurochem. 106, 2119-2130. doi:10.1111/j ... F) Neuronal overexpression of tauV337M (elav-Gal4/tauV337M). (G) α-tubK40Q. (H) Overexpression of tauV337M in α-tubK40Q ... B,B′) Muscular overexpression of tauV337M (C57-Gal4/tauV337M) resulted in decreased MT density. (C,C′) Overexpression of tau ... HDAC6 binds with tau directly, maintains site-specific tau phosphorylation and promotes tau accumulation (Cook et al., 2012; ...
  http://dmm.biologists.org/content/10/10/1245?utm_source=FA&utm_campaign=DMMHomeBox&utm_content=10-1245
*  Anti-Human Tau Antibody | Human Tau Antibody | Tau Antibody
Microtubule-associated protein tau, MAPT, neurofibrillary tangle protein, paired helical filament-tau, PHF-tau, G protein beta1 ... Tau is also known as microtubule-associated protein tau (MAPT), neurofibrillary tangle protein, paired helical filament-tau ( ... Human Tau Antibody. The Human Tau Antibody products are affinity-purified IgG antibodies that recognize human tau protein ... Tau proteins promote the assembly and stability of microtubules in neuronal cells, and primarily in the distal portions of ...
  http://www.clontech.com/US/Products/Cell_Biology_and_Epigenetics/Alzheimers_Disease/Tau?sitex=10020:22372:US&PEBCL1=zK1S80p8OVGYFzcUkgwFjNxh2e&PEBCL1_pses=ZG89CC5176D9CF8EC879E0A0314A1617ABAD6D0839390D8C26F429741BE341B96A325E6B545F50516E3C7710F8A2BF8EB3B4BAB300792B1124
*  Recombinant Human Tau383 protein (ab84766) | Abcam
Ab84766 is a full length protein produced in Escherichia coli and has been validated in WB, SDS-PAGE. Abcam provides… ... Tau383 is a memeber of the family of neuronal microtubule-associated proteins. Tau promotes assembly and stabilizes neuronal ... Proteins and Peptides. Proteomics tools. Agonists, activators, antagonists and inhibitors. Lysates. Multiplex miRNA assays. By ... Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm; cytoskeleton. Cell projection; axon. Note: Mostly ...
  http://www.abcam.com/recombinant-human-tau383-protein-ab84766.html
*  Both total and phosphorylated tau are increased in Alzheimer's disease
Microtubule-associated protein tau is a substrate of ATP/Mg2+-dependent proteasome protease system. Zhang, J. Y.; Liu, S. J.; ... The microtubule-associated protein tau, which is abundantly expressed in neurons, is deposited in cells in an abnormally ... The microtubule-binding protein, tau, is the major component of neurofibrillary inclusions characteristic of Alzheimer's ... The Cellular Distribution and Ser262 Phosphorylation of Tau Protein Are Regulated by BDNF In Vitro. Chen, Qian; Zhou, Zhou; ...
  http://connection.ebscohost.com/c/articles/66898709/both-total-phosphorylated-tau-are-increased-alzheimers-disease
*  PLOS ONE: Trans-Synaptic Spread of Tau Pathology In Vivo
Relocalization of tau from axons to somatodendritic compartments and propagation of tauopathy to regions outside of the EC ... In relatively young mice (10-11 months old), human tau was present in some cell bodies, but it was mostly observed in axons ... In old mice (,22 months old), intense human tau immunoreactivity was readily detected not only in neurons in the superficial ... In old mice, axonal human tau immunoreactivity, especially at the endzones of the perforant pathway, was greatly reduced. ...
  http://journals.plos.org/plosone/article/email?id=10.1371/journal.pone.0031302
*  Transgenic Mice Accumulate Human Tau in Degenerating Hippocampal Neurons | ALZFORUM
Human tau mRNA expression was almost the same level as endogenous mouse tau, despite the fact that human tau protein level was ... the mutant tau protein in only a very few cells in the brain: that is, in. some of the pyramidal cells of the hippocampus. ... The authors state that up to 70 percent of the tau in the hippocampus is the mutant protein, and this would suggest that the ... High levels of a mutant tau protein are probably bad for cells. It is unclear what relevance these mice may have for studies of ...
  http://www.alzforum.org/news/research-news/transgenic-mice-accumulate-human-tau-degenerating-hippocampal-neurons?id=348
*  Increased tau messenger RNA in Alzheimer's disease hippocampus. - Department of Psychiatry
Increased hippocampal expression of tau mRNA also was present in cases of non-Alzheimer's dementia. Enhanced tau mRNA may be a ... The amount of tau mRNA also was determined as a ratio of total polyadenylated mRNA in each area. A significant and gene- ... We detected tau mRNA using in situ hybridization histochemistry in the hippocampus, visual cortex, and cerebellum, and compared ... specific increase in tau mRNA hybridization was found in hippocampal fields CA4 and CA3, with a similar trend in the dentate ...
  https://www.psych.ox.ac.uk/publications/719355
*  Tau protein phosphorylated at threonine 181 in CSF as a neurochemical biomarker in Alzheimer's disease | SpringerLink
Blennow K., Vanmechelen E., and Hampel H. (2001) CSF total tau, Abeta42 and phosphorylated tau protein as biomarkers for ... 2000) CSF phosphorylated tau protein and mild cognitive impairment: a prospective study. Exp. Neurol. 166, 201-203.PubMed ... Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc. Natl. Acad ... 1994) Altered microtubule organization in small-calibre axons of mice lacking tau protein. Nature 369, 488-491.PubMedCrossRef ...
  https://link.springer.com/article/10.1385%2FJMN%3A23%3A1-2%3A115
*  Inflammation Boosts Brain CDK5 Activity, Tau Phosphorylation | ALZFORUM
Tau protein kinase I converts normal tau protein into A68-like component of paired helical filaments. J Biol Chem. 1992 May 25; ... Tau protein kinase II is involved in the regulation of the normal phosphorylation state of tau protein. J Neurochem. 1993 Feb; ... p25 was first purified from microtubule fractions of bovine brain and the complex CDK5/p25 was isolated and named tau protein ... Interaction of Tau with Fe65 links tau to APP. Neurobiol Dis. 2005 Mar;18(2):399-408. PubMed. ...
  http://www.alzforum.org/news/research-news/inflammation-boosts-brain-cdk5-activity-tau-phosphorylation
*  CCR - Page 3 - Polo-Like Kinases and Aurora Kinases in Cancer Therapy
These results show that alpha-Amyloid Precursor Protein Modulator passive immunization with tau antibodies can decrease tau ... PHF1/total tau < 0.0001) and 34-45% (CP13 or CP13/total tau < 0.05). Levels of soluble tau and sarkosyl soluble tau were ... Targeting hyperphosphorylated tau by immunotherapy is usually emerging as a promising. Targeting hyperphosphorylated tau by ... Another important target for immunization in AD patients is usually pathological tau protein that is also the primary target in ...
  http://technumber.com/category/ccr/page/3/
*  "Tau-Directed Immunotherapy for Alzheimer's Disease" by Sulana Kay Schroeder
Tau is a protein normally found in neurons. It functions as a stabilizer for microtubules, and has a role in the trafficking of ... An emerging area of research is to identify antibodies that target tau as a way to clear tau pathology and hopefully reduce ... composed of hyperphosphorylated tau protein, neuron loss, and evidence of inflammation indicated by the presence of reactive ... to identify short-term clearance of tau pathology and NFTs. Next, we examined a more robust tau-producing mouse line, to ...
  http://scholarcommons.usf.edu/etd/6757/
*  "The Effects of Molecular Chaperones on Tau Fibril Assembly" by Ahmed Omran
In yeast, the AAA+ chaperone HSP104 processes the reactivation of protein aggregates and is responsible for fragmentation of ... Indeed, HSP104 inhibits the aggregation of soluble tau into aggregates. However, tau fibril breakage and dissociation were not ... and suggest that fragmentation is a critical part of tau assembly. This knowledge should be valuable for understanding tau ... Tau fibrils were either formed with a cofactor, heparin, to accelerate assembly or without a cofactor. In the process of ...
  https://digitalcommons.du.edu/etd/1045/
*  The level of cerebrospinal fluid tau correlates with neurofibrillary tangles in Alzheimer's disease. - Semantic Scholar
... scores as well as glial fibrillary acidic protein (GFAP) expression as a marker of astrocytosis in the brain post-mortem. The ... while GFAP immmunoreactivity did not correlate with CSF tau. This study reveals a high variation in CSF tau values in patients ... We measured tau concentrations in cerebrospinal fluid (CSF) samples taken during the lifetime of 43 patients with Alzheimer's ... CSF tau values showed a positive correlation with neocortical NFT scores (r = 0.44, p , 0.005), ...
  https://www.semanticscholar.org/paper/The-level-of-cerebrospinal-fluid-tau-correlates-wi-Tapiola-Overmyer/d0eb4ce8d212d4311143798703234f96e960829e
*  TAU protein in Alzheimer disease
... Bruno Silva etbrunos at info.ua.pt Mon Mar 2 13:44:15 EST 1998 *Previous message: Genes and ... Does anybody knows The role of TAU protein and foforiltion in Alzheimer disease? please reply me by email Bruno Silva in U. ...
  http://www.bio.net/bionet/mm/neur-sci/1998-March/030642.html
*  What is a Tau Protein? (with pictures)
A tau protein is a substance found in neurons that's important to keep nerves functioning properly. Problems with tau proteins ... These proteins were first identified in the 1970s, and research on tau protein is continuing in many areas of the world, as ... A tau protein is a protein found in neurons, primarily in the central nervous system. Several different versions or isoforms of ... When tau proteins become chemically altered, the alteration changes the way in which they fold. Alterations in protein folding ...
  http://www.wisegeek.com/what-is-a-tau-protein.htm
*  A role for FKBP52 in Tau protein function | PNAS
A role for FKBP52 in Tau protein function. Béatrice Chambraud, Elodie Sardin, Julien Giustiniani, Omar Dounane, Michael ... A role for FKBP52 in Tau protein function. Béatrice Chambraud, Elodie Sardin, Julien Giustiniani, Omar Dounane, Michael ... A role for FKBP52 in Tau protein function. Béatrice Chambraud, Elodie Sardin, Julien Giustiniani, Omar Dounane, Michael ... Tau is a microtubule-associated protein, which is widely expressed in the central nervous system, predominantly in neurons, ...
  http://www.pnas.org/content/early/2010/01/22/0914957107
*  tau protein binding Gene Ontology Term (GO:0048156)
The Gene Ontology (GO) project is a collaborative effort to address the need for consistent descriptions of gene products across databases. You can use this browser to view terms, definitions, and term relationships in a hierarchical display. Links to summary annotated gene data at MGI are provided in Term Detail reports.
  http://www.informatics.jax.org/vocab/gene_ontology/GO:0048156
*  Tau Protein: Its Presence and Metabolism in Human Neuroblastoma Cells | SpringerLink
"Tau" represents a class of several proteins which will be referred to collectively as Tau protein. ... Lindwall, G., and Cole, D. The purification of Tau protein and the occurrence of two phosphorylation states of Tau in brain. J ... Other microtubular components include the microtubule associated proteins (MAPS), MAP I and MAP II, and Tau proteins, which co- ... Drubin, D.G., Kirschner, M.W. "Tau Protein Function in Living Cells" J. Cell. Biol. 1986 103 (No.6 Pt. 2) p. 2739-2746.CrossRef ...
  https://link.springer.com/chapter/10.1007/978-1-4757-5876-4_27
*  Tau protein - Wikipedia
Tau protein is a highly soluble microtubule-associated protein (MAP). Through its isoforms and phosphorylation tau protein ... Tau proteins (or τ proteins, after the Greek letter with that name) are proteins that stabilize microtubules. They are abundant ... Tau protein is a highly soluble microtubule-associated protein (MAP). In humans, these proteins are found mostly in neurons ... The binding of these phosphatases to tau affects tau's association with MTs. In humans, the MAPT gene for encoding tau protein ...
  https://en.wikipedia.org/wiki/Tau_protein