Love and addiction: the devil is in the differences: a commentary on "The behavioral, anatomical and pharmacological parallels...
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Green tea extract enhances parieto-frontal connectivity during working memory processing | Psychopharmacology
Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate ...
Impact of Amphetamine Exposure During Adolescence on Neurobehavioral Endpoints | SpringerLink
Synapse 37:167-169. https://doi.org/10.1002/1098-2396(200008)37:2167::AID-SYN113.0.CO;2-B ...
Long-Term Safety and Tolerability of Daridorexant in Patients with Insomnia Disorder | CNS Drugs
Niethard N, Born J. Back to baseline: sleep recalibrates synapses. Nat Neurosci. 2019;22(2):149-51. https://doi.org/10.1038/ ...
Multilevel Computational Modelling in Epilepsy: Classical Studies and Recent Advances | SpringerLink
Emergent epileptiform activity in neural networks with weak excitatory synapses. IEEE Trans Neural Syst Rehabil. 2005;13:236-24 ...
Toxins from bacteria | SpringerLink
Jung N, Haucke V (2007) Clathrin-mediated endocytosis at synapses. Traffic 8: 1129-1136 ...
Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer's disease mouse model | Acta Neuropathologica
Hoe HS, Lee HK, Pak DT (2012) The upside of APP at synapses. CNS Neurosci Ther 18:47-56. doi:10.1111/j.1755-5949.2010.00221.x ... Weyer SW, Klevanski M, Delekate A et al (2011) APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial ... Terry RD, Masliah E, Salmon DP et al (1991) Physical basis of cognitive alterations in Alzheimers disease: synapse loss is the ... Marcello E, Gardoni F, Mauceri D et al (2007) Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and ...
Zinc and its effects on oxidative stress in Alzheimer's disease | SpringerLink
Paoletti P, Vergnano AM, Barbour B, Casado M (2009) Zinc at glutamatergic synapses. Neuroscience 158:126-136 ... A role for synaptic zinc in activity-dependent Abeta oligomer formation and accumulation at excitatory synapses. J Neurosci 29: ...
Advances in the Pathogenesis of Auto-antibody-Induced Cerebellar Synaptopathies | The Cerebellum
In contrast, PF inputs with unpaired CF induce LTD at IN-PC synapses and LTP at PF-PC synapses, resulting in Inhibition mode. ... excitatory synapses, (−): inhibitory synapses. (Cited from ref. Ishikawa et al. 2015 [87]) ... of IN-PC synapses and LTD of PF-PC synapses [34], whereas stimulation of PF inputs with unpaired CF activities induced LTD of ... Table 1 Auto-antibodies toward ion channel- and synapse-related antigens commonly found in immune-mediated cerebellar ataxias ...
ALMS1 and Alström syndrome: a recessive form of metabolic, neurosensory and cardiac deficits | Journal of Molecular Medicine
Stinchcombe JC, Griffiths GM (2014) Communication, the centrosome and the immunological synapse. Philos Trans R Soc Lond Ser B ... facilitate endocytic recycling and direct multiple events at the immunological synapse [24,25,26]. It also serves as a hub for ...
Biphasic Cholinergic Modulation of Reverberatory Activity in Neuronal Networks | Neuroscience Bulletin
3). When the EPSC is low, the synapse releases fewer vesicles per spike. Because the synapse has a limited vesicle pool size, a ... 3) describes the synaptic vesicle cycle dynamics within a synapse.. $$ \left\{ \begin{gathered} C \frac{{{\text{d}}V_{i} }}{{{\ ... It is also possible that low concentrations of ACh are due to diffusion to surrounding neurons or synapses belonging to ... that attention-related cholinergic activity results in a high ACh concentration in the vicinity of neurons and synapses ...
Visual motion sensitivity in descending neurons in the hoverfly | Journal of Comparative Physiology A
The output synapses of most LPTCs are found in the posterior slope of the brain (Namiki et al. 2018). Following retrograde ... Drosophila and blowfly VS cells synapse with the DNOVS2 neuron (Wertz et al. 2008, 2009b; Suver et al. 2016), which is also ... Descending neurons synapse with motor neurons or with interneurons that themselves connect with motor neurons ( ... Drosophila HS cells synapse with DNHS1 (Suver et al. 2016), which is also called DNp15 (Namiki et al. 2018). The receptive ...
Differential association of GABAB receptors with their effector ion channels in Purkinje cells | Brain Structure and Function
... including those establishing synapses with parallel and climbing fibres (Fig. 2a-d). Regardless of the neuronal compartment, ... particularly around the glutamatergic synapses between PC spines and parallel fibre axon terminals. These results correlate ... Contributions of calcium-dependent and calcium-independent mechanisms to presynaptic inhibition at a cerebellar synapse. J ... Compartmentalization of the GABAB receptor signaling complex is required for presynaptic inhibition at hippocampal synapses. J ...
The methodological role of mechanistic-computational models in cognitive science | Synthese
At the lowest, there are basic component and circuit analysis-how do transistors, neurons, diodes, and synapses work?" (Marr ... which in turn is explained by a long-term potentiation of synapses of pyramidal cells in this region (C), which in turn is ...
De novo missense variants disrupting protein-protein interactions affect risk for autism through gene co-expression and protein...
Monteiro P, Feng G. SHANK proteins: roles at the synapse and in autism spectrum disorder. Nat Rev Neurosci. 2017;18(3):147-57. ... Ebrahimi-Fakhari D, Sahin M. Autism and the synapse: emerging mechanisms and mechanism-based therapies. Curr Opin Neurol. 2015; ... synapse organization) over the three cell types (Fig. 4i, Additional file 6: Table 5). These processes are inter-related and ... neurotransmitter receptor binding at the post-synapse, from ionotropic receptors (e.g., glutamate receptors encoded by GRIA2 [ ...
NPD1 Plus RvD1 Mediated Ischemic Stroke Penumbra Protection Increases Expression of Pro-homeostatic Microglial and Astrocyte...
Astrocytes induce excitatory synapse formation through the secretion of glypicans (Gpc4) and thrombospondins (Thbs1 and Thbs2 ... Ji K, Akgul G, Wollmuth LP, Tsirka SE (2013) Microglia actively regulate the number of functional synapses. PloS One 8:e56293. ... H2-D1, involved in antigen processing and presentation, participates in synapse alterations and reflects neurotoxic astrocyte ... A1-associated gene that participates in the negative regulation of programmed cell death and as a positive regulator of synapse ...
Neuronal Basis of Non-Invasive Functional Imaging: From Microscopic Neurovascular Dynamics to BOLD fMRI | SpringerLink
Synchronous activity of inhibitory networks in neocortex requires electrical synapses containing connexin36. Neuron 31:477-485 ...
The PRDM9 KRAB domain is required for meiosis and involved in protein interactions | Chromosoma
1c and 2c). However, spermatocytes never progressed to the normal pachytene stage where all autosomes are fully synapsed and ... Sun F et al (2015) Nuclear localization of PRDM9 and its role in meiotic chromatin modifications and homologous synapsis. ... d Immunofluorescent detection of SYCP1 (synapsis marker), SYCP3 (meiotic chromosomes axial elements marker), and γH2AX (sex ... and synapsis in both female and male mice. In addition, we identified proteins that interact with the KRAB domain of mouse and ...
Homology of neocortical areas in rats and primates based on cortical type analysis: an update of the Hypothesis on the Dual...
... synapse formation, myelination, synapse pruning…) take place in FMUs. The time-course and intensity of secondary events, like ...
Evaluation of the computational efficacy in GPU-accelerated simulations of spiking neurons | Computing
... synapses. In: IEEE computer society, pp. 1-12 ...
Genetic and environmental factors of schizophrenia and autism spectrum disorder: insights from twin studies | Journal of Neural...
Previous studies have shown excessively pruned synapses in SCZ and inappropriately pruned ones in ASD, which are believed to ... which includes synapse formation, synaptic pruning, microglial regulation, oligodendrocyte function and myelination, will need ... occasionally lead to excessive synapse formation (Liu et al. 2017). In synaptic pruning, microglia have been reported to play ...
Effects of psychotropic drugs on inflammation: consequence or mediator of therapeutic effects in psychiatric treatment? |...
Viviani B, Boraso M, Valero M et al (2013) Early maternal deprivation immunologically primes hippocampal synapses by ...
A next generation mathematical model for the in vitro to clinical translation of T-cell engagers | Journal of Pharmacokinetics...
The formation of this trimolecular complex (i.e. trimer) mimics the immune synapse, leading to therapeutic-dependent T-cell ... Functional anatomy of T cell activation and synapse formation. Annu Rev Immunol 28:79-105 ...
Non-invasive imaging of tau-targeted probe uptake by whole brain multi-spectral optoacoustic tomography | European Journal of...
... the Synapsis foundation, and the Vontobel foundation. RN received funding from the Synapsis Foundation career development award ...
Nabilone for non-motor symptoms of Parkinson's disease: a randomized placebo-controlled, double-blind, parallel-group, enriched...
In animal studies, a high density of CB1 receptors is found in presynaptic nerve terminals of GABA-ergic synapses as well as ...
Flexible Learning-Free Segmentation and Reconstruction of Neural Volumes | Scientific Reports
... allowing one to resolve fine-grained details such as dendritic spines and individual synapses. Genetically targeted markers ...
How many angels can dance on the head of a pin? Understanding 'alien' thought | AI & SOCIETY
Pointing to the fact that contingency exists in human and computer synapses alike they go on to suggest that at the time when ...
Modulation of motor cortex excitability by sustained peripheral stimulation: The interaction between the motor cortex and the...
Are the after-effects of low-frequency rTMS on motor cortex excitability due to changes in the efficacy of cortical synapses? ...