*  mediaTUM - Medien- und Publikationsserver
Depletion of TXNL4A (Dib1) in yeast demonstrated reduced assembly of the tri-snRNP complex. Our results indicate that BMKS is ... The U5 spliceosomal complex of eight highly conserved proteins is critical for pre-mRNA splicing. We identified biallelic ... in the core promoter region on the other allele. In a single highly consanguineous family, formerly diagnosed as oculo-oto- ... The U5 spliceosomal complex of eight highly conserved proteins is critical for pre-mRNA splicing. We identified biallelic ...
  http://mediatum.ub.tum.de/1253575
*  Exon-skipping advances for Duchenne muscular dystrophy, Human Molecular Genetics | 10.1093/hmg/ddy171 | DeepDyve
The Sm core of the U7snRNP consists of seven proteins encircled around the snRNA binding site and forming a torus structure. ... The U7 Sm OPT modification leads to the replacement of two Sm proteins (represented in white in WT U7 snRNP figure), Lsm10 and ... The Sm core of the U7snRNP consists of seven proteins encircled around the snRNA binding site and forming a torus structure. ... The Sm core of the U7snRNP consists of seven proteins encircled around the snRNA binding site and forming a torus structure. ...
  https://www.deepdyve.com/lp/ou_press/exon-skipping-advances-for-duchenne-muscular-dystrophy-p0n8nhOu6j
*  Molecular mechanisms of eukaryotic pre-mRNA 3′ end processing regulation
The U170K subunit of the U1 snRNP (85) and the SR proteins, U2AF65 and SRp75 (86), share both a protein domain similar to the ... A core complex of CPSF73, CPSF100, and Symplekin may form two different cleavage factors for processing of poly(A) and histone ... The human U1 snRNP-specific U1A protein inhibits polyadenylation of its own pre-mRNA. Cell. 1993;72:881-892. [PubMed] ... The human U1A snRNP protein regulates polyadenylation via a direct interaction with poly(A) polymerase. Cell. 1994;76:531-541. ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2874999/
*  Anti-nuclear antibody - Wikipedia
Anti-nRNP antibodies recognise the A and C core units of the snRNPs and because of this they primarily bind to the U1-snRNP. ... CENP-E is a 312kDa protein from the kinesin motor protein family. CENP-F is a 367kDa protein from the nuclear matrix that ... The retroviral gag protein shows similarity to the La protein and is proposed as a possible example for molecular mimicry in ... CENP-B is an 80kDa DNA binding protein involved in the folding of heterochromatin. CENP-C is a 140kDa protein involved in ...
  https://en.wikipedia.org/wiki/Anti-nuclear_antibody
*  HARC Center: HIV Accessory and Regulatory Complexes | Global Research Projects
The EM Core will develop methods to determine structures of membrane protein complexes, and use Fabs to solve the structures of ... and inhibitory 7SK snRNP complexes. For Rev, we will determines the structures of Rev-RRE nuclear export complexes, map viral ... The Proteomics Core will extend mass spectrometry analyses to host protein complexes and map HIV-dependent host PTMs. The ... The Virology Core will measure effects of new host interactions on HIV replication and coupled activities of Tat and Rev. The ...
  http://globalprojects.ucsf.edu/node/80946
*  Gentaur Molecular :Gene Link \ D3 WellRed Dye Beckman 200 nmol scale \ 26-6577-02
... snRNP core protein D3). [SmD3 guf2 CG8427] Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3). [] Genome ... Pre C,C C core E PC pre-C pre-C/C PreC preC PreC/C preC/C precore-core HBVgp4] Capsid protein (Core antigen) (Core protein) ( ... snRNP core protein D3). [SMD3 YLR147C L9634.6] Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3). [NCAPD3 ... Snrpd3] Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3). [smd3 SPBC19C2.14] Small nuclear ...
  http://www.antibody-antibodies.com/product_det.php?id=1075908&supplier=search&name=D3%20WellRed%20Dye%20Beckman%20200%20nmol%20scale
*  Publications | Max Planck Institute for Biophysical Chemistry
Protein-protein and protein-RNA contacts both contribute to the 15.5K-mediated assembly of the U4/U6 snRNP and the box C/D ... Organization of Core Spliceosomal Components U5 snRNA Loop I and U4/U6 Di-snRNP within U4/U6.U5 Tri-snRNP as Revealed by ... Odronitz, F.; Kollmar, M.: Pfarao: a web application for protein family analysis customized for cytoskeletal and motor proteins ... Nuclear translocation of the calcium-binding protein ALG-2 induced by the RNA-binding protein RBM22. Biochimica et Biophysica ...
  http://www.mpibpc.mpg.de/publications?year=2006
*  RNA-binding protein - Wikipedia
... namely U1 snRNP and U2AF snRNP. However, RBPs are also part of the splicesome itself. The splicesome is a complex of snRNA and ... Other than core splicesome complex, RBPs also bind to the sites of Cis-acting RNA elements that influence exons inclusion or ... These structures illustrate the intricacy of protein-RNA recognition of RRM as it entails RNA-RNA and protein-protein ... These proteins then recruit splicesomal proteins to this target site. SR proteins are also well known for their role in ...
  https://en.wikipedia.org/wiki/RNA-binding_protein
*  Research - The Sun Laboratory
... we found both loss of function of mutant FUS/TLS by decreased interaction with U1 snRNP (recognize 5' splice site as a core ... This could sequester certain RNA-binding proteins and lead to their loss of function. An alternative but not mutually exclusive ... A third hypothesis is the expansions cause gene silencing and lead to haploid insufficiency of C9orf72 protein. Till today, ... These steps are regulated by RNA-binding proteins (RBPs) and dysfunctions of RNA metabolism causes various human diseases. In ...
  http://labs.pathology.jhu.edu/sun/research/
*  U1 spliceosomal RNA - Wikipedia
Stem-loop I binds to the U1-70K protein, stem-loop II binds to the U1 A protein, stem-loops III and IV bind to the core RNP ... U1 spliceosomal RNA is the small nuclear RNA (snRNA) component of U1 snRNP (small nuclear ribonucleoprotein), an RNA-protein ... U1 C interacts primarily through protein-protein interactions. Experimentation has demonstrated that the binding of U1 snRNA to ... U1 snRNP, decreasing its availability. This model is supported experimentally, as reducing U1 snRNP levels with antisense ...
  https://en.wikipedia.org/wiki/U1_spliceosomal_RNA
*  UC Irvine - Faculty Profile System
2006) PP1/PP2A phosphatases are required for the second step of pre-mRNA splicing and target specific snRNP proteins. Mol Cell ... this complex consists of more than 85 proteins, including the core 3' processing factors and many peripheral factors that may ... 2015) The end of the message: multiple protein-RNA interactions define the mRNA polyadenylation site. Genes & Dev. 29: 889-897. ... We have mapped the RNA interactions for some of the core mRNA 3' processing factors (Yao et al., PNAS 2012; Yao et al., RNA ...
  https://www.faculty.uci.edu/profile.cfm?faculty_id=5699
*  LSM10 - Wikipedia
"A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre- ... Pillai RS, Grimmler M, Meister G, Will CL, Lührmann R, Fischer U, Schümperli D (Sep 2003). "Unique Sm core structure of U7 ... U7 snRNA-associated Sm-like protein LSm10 is a protein that in humans is encoded by the LSM10 gene. LSM10 has been shown to ... "Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein". The EMBO Journal. 20 (19 ...
  https://en.wikipedia.org/wiki/LSM10
*  Requirements for nuclear localization of the Lsm2-8p complex and competition between nuclear and cytoplasmic Lsm complexes |...
A role for the yeast La protein in U6 snRNP assembly: evidence that the La protein is a molecular chaperone for RNA polymerase ... a novel U6 snRNA-associated protein with significant similarity to core proteins of small nuclear ribonucleoproteins. EMBO J. ... J. L. (1995). Structurally related but functionally distinct yeast SmD core small nuclear ribonucleoprotein particle proteins. ... Séraphin, B. (1995). Sm and Sm-like proteins belong to a large family: identification of proteins of the U6 as well as the U1, ...
  http://jcs.biologists.org/content/120/24/4310.full
*  Repositório da Universidade de Lisboa: Transcription dynamics prevents RNA-mediated genomic instability through SRPK2-dependent...
... core components of the U5 1 2 snRNP, does not drive genomic instability. Altogether, we found that phosphorylation of DDX23 by ... Phosphorylation/de phosphorylation cycles regulate the function of SR-proteins and the timely binding to cis regulatory ... DDX23 is part of the spliceosomal U5 small nuclear ribonucleoprotein complex (U5 snRNP). We found that the role of DDX23 in ... Embora a proteína DDX23 faça parte do complexo ribonucleoproteíco U5 snRNP do spliceossoma, demonstrámos que o seu papel na ...
  http://repositorio.ul.pt/handle/10451/34144?locale=pt_PT
*  3cun - Proteopedia, life in 3D
The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein- ... Together with randomization of ribozyme core residues and reselection, this structure shows that very few nucleotides are ... This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may ... In modern organisms, protein enzymes are solely responsible for the aminoacylation of transfer RNA. However, the evolution of ...
  http://proteopedia.org/wiki/index.php/3cun
*  U7 small nuclear RNA - Wikipedia
"A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre- ... Schümperli D, Pillai RS (2004). "The special Sm core structure of the U7 snRNP: far-reaching significance of a small nuclear ... Azzouz TN, Gruber A, Schümperli D (2005). "U7 snRNP-specific Lsm11 protein: dual binding contacts with the 100 kDa zinc finger ... Godfrey AC, White AE, Tatomer DC, Marzluff WF, Duronio RJ (2009). "The Drosophila U7 snRNP proteins Lsm10 and Lsm11 are ...
  https://en.wikipedia.org/wiki/U7_small_nuclear_RNA
*  Gentaur Molecular :GenWay \ U6 snRNA-associated Sm-like protein LSm1 - Small nuclear ribonuclear CaSm; Cancer-associated Sm...
U6 snRNA-associated Sm-like protein LSm1 - Small nuclear ribonuclear CaSm; Cancer-associated Sm-like \ 10-288-22100F for more ... snRNP core Sm-like protein Sm-x5). [LSM3 SMX4 USS2 YLR438C-A] U6 snRNA-associated Sm-like protein LSm3 (SmX4 protein). [LSM4] ... U4/U6.U5 snRNP 27 kDa protein) (U4/U6.U5-27K) (Nucleic acid-binding protein RY-1) (U4/U6.U5 tri-snRNP-associated 27 kDa protein ... U4/U6 snRNP 61 kDa protein) (Protein 61K). [LSM8 YJR022W J1464 YJR83.16] U6 snRNA-associated Sm-like protein LSm8. [LSM3 MDS017 ...
  http://www.antibody-antibodies.com/product_det.php?id=1880858&supplier=search&name=U6%20snRNA_associated%20Sm_like%20protein%20LSm1%20_%20Small%20nuclear%20ribonuclear%20CaSm%3B%20Cancer_associated%20Sm_like%20
*  U6 spliceosomal RNA - Wikipedia
Shannon KW, Guthrie C (May 1991). "Suppressors of a U4 snRNA mutation define a novel U6 snRNP protein with RNA-binding motifs ... Butcher SE, Brow DA (June 2005). "Towards understanding the catalytic core structure of the spliceosome". Biochem. Soc. Trans. ... U6 snRNA is the non-coding small nuclear RNA (snRNA) component of U6 snRNP (small nuclear ribonucleoprotein), an RNA-protein ... The association of U6 snRNP with U2 snRNP via base-pairing forms the U6-U2 complex, a structure that comprises the active site ...
  https://en.wikipedia.org/wiki/U6_spliceosomal_RNA
*  Frontiers | Interplay between the alpharetroviral Gag protein and SR Proteins SF2 and SC35 in the nucleus | Microbiology
The full-length viral RNA can be used for the translation of the Gag and Gag-Pol structural proteins or as the genomic RNA ( ... When the nuclear export signal of RSV Gag is mutated (Gag.L219A), the protein accumulates in discrete subnuclear foci ... When the nuclear export signal of RSV Gag is mutated (Gag.L219A), the protein accumulates in discrete subnuclear foci ... for encapsidation into new virions by the Gag protein. The mechanism by which Gag selectively incorporates unspliced gRNA into ...
  https://www.frontiersin.org/articles/10.3389/fmicb.2015.00925/full
*  Produktübersicht anti-ZCRB1 Antikörper
It was identified as one of the protein components of U11/U12 snRNPs. This protein and many other U11/U12 snRNP proteins are ... The 5'-flanking region contains an enhancer core motif and binding sites for AP-1 (zeige FOSB Antikörper), AP-2 (zeige GTF3A ... U11/U12 small nuclear ribonucleoprotein 31 kDa protein , U11/U12 snRNP 31 kDa protein , U11/U12 snRNP 31K , U11/U12-31K ... Protein Überblick Pre-mRNA splicing is catalyzed by the spliceosome. U12-type spliceosome binds U12-type pre-mRNAs and ...
  http://www.antikoerper-online.de/abstract/Zinc+Finger+CCHC-Type+and+RNA+Binding+Motif+1+
*  Frontiers | GIGANTEA - an emerging story | Plant Science
Although it is known that both GI transcript and GI protein are clock controlled, the regulation of its abundance and functions ... Although it is known that both GI transcript and GI protein are clock controlled, the regulation of its abundance and functions ... is a plant specific nuclear protein and functions in diverse physiological processes such as flowering time regulation, light ... is a plant specific nuclear protein and functions in diverse physiological processes such as flowering time regulation, light ...
  https://www.frontiersin.org/articles/10.3389/fpls.2015.00008/full
*  Death, autoantigen modifications, and tolerance | Arthritis Research & Therapy | Full Text
... which include Smith complex proteins found in several snRNPs, as well as U1-snRNP-specific proteins such as U1-70 kD and U1A, ... unique region protein 6 (UL6), and infected cell protein (ICP)27. All three viral RNA binding proteins have been shown to ... Several antigens including Ro, small nuclear ribonuclear protein (snRNP), and Smith complex relocalized from their normal ... First, many host proteins specifically interact with viral nucleic acid. The La protein, for example, binds to hepatitis C ...
  https://arthritis-research.biomedcentral.com/articles/10.1186/ar75
*  HNRNPA2B1 - Wikipedia
"U1 SnRNP association with HnRNP involves an initial non-specific splice-site independent interaction of U1 SnRNP protein with ... Kumar A, Williams KR, Szer W (1986). "Purification and domain structure of core hnRNP proteins A1 and A2 and their relationship ... The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM ... and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts". Proc. Natl. Acad. Sci. U.S.A. 86 ( ...
  https://en.wikipedia.org/wiki/HNRNPA2B1
*  U2 spliceosomal RNA - Wikipedia
Kramer, A (1988). "Presplicing complex formation requires two proteins and U2 snRNP". Genes Dev. 2 (9): 1155-1167. doi:10.1101/ ... "Core structure of the U6 small nuclear ribonucleoprotein at 1.7-Å resolution". Nature Structural & Molecular Biology. 21 (6): ... and the snRNP proteins. Previous studies indicated that the stem I in 5′ terminus of the U2 snRNA has a function in early steps ... Moreover, U2 snRNP undergoes several rearrangements along with the recognition of the branch point adenosine and formation of ...
  https://en.wikipedia.org/wiki/U2_spliceosomal_RNA
*  STRAP - Wikipedia
"Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome ... Pillai RS, Grimmler M, Meister G, Will CL, Lührmann R, Fischer U, Schümperli D (2003). "Unique Sm core structure of U7 snRNPs: ... "Unrip is a component of SMN complexes active in snRNP assembly". FEBS Lett. 579 (11): 2348-54. doi:10.1016/j.febslet.2005.03. ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. doi:10.1038/ ...
  https://en.wikipedia.org/wiki/STRAP