And, after adjustment for all the confounders mentioned above, high-dose simvastatin was associated with a 44% increased risk ... The risk was dose-dependent for simvastatin and atorvastatin. Statin treatment significantly increased 2-h glucose (2hPG) at ... Furthermore, decreases in insulin sensitivity and insulin secretion were dose-dependent for simvastatin and atorvastatin. ... of participants were taking simvastatin, while 53% were taking atorvastatin. The authors say, "The association of statin use ...