Monnier VM, Sun W, Gao X, Sell DR, Cleary PA, Lachin JM, Genuth S; DCCT/EDIC Research Group ...

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SENS Research Foundation regularly funds external research with potential to accelerate the development of rejuvenation ... 2. Do you fund basic research? No, we will only fund proposals with a clear and direct path toward a clearly-conceived, ... A basic description of your research project,. *The SENS target to which it relates, and how the grant proposal would further ... SENS Research Foundation was founded to catalyze progress in the "damage-repair" approach for medical intervention in ...

New Peer-Reviewed Paper from SENS Research Foundation: Iron Homeostasis as a Senolytic Target SRF February 8, 2023 5:47 pm ... And with funding provided by the Wellcome Trust, the new Shared Ageing Research Models (ShARM) resource is now up and running. ... The MRC Harwell center for mouse genetics and the Centre for Integrated research into Musculoskeletal Ageing (CIMA) at the the ... Instead of providing more mice to the scientists that need them for research, ShARM gives more scientists access to the limited ...

Research Integrated Science Education. *Summer Scholars. *Post-Baccalaureate. *Graduate Programs. *SRF Education Program Alumni ...

Telomere length maintenance ensures self-renewal of human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs); however, the mechanisms governing telomere length homeostasis in these cell types are unclear. Here, we report that telomere length is determined by the balance between telomere elongation, which is mediated by telomerase, and telomere trimming, which is controlled by XRCC3 and Nbs1, homologous recombination proteins that generate single-stranded C-rich telomeric DNA and double-stranded telomeric circular DNA (T-circles), respectively. We found that reprogramming of differentiated cells induces T-circle and single-stranded C-rich telomeric DNA accumulation, indicating the activation of telomere trimming pathways that compensate telomerase-dependent telomere elongation in hiPSCs. Excessive telomere elongation compromises telomere stability and promotes the formation of partially single-stranded telomeric DNA circles (C-circles) in hESCs, suggesting heightened ...

New Peer-Reviewed Paper from SENS Research Foundation: Iron Homeostasis as a Senolytic Target SRF February 8, 2023 5:47 pm ... SENS Research Foundation welcomes the formation of Altos Labs and hopes that the ever-growing field of Rejuvenation ... "unfettered blue-sky research on how cells age and how to reverse that process." Milner, a billionaire investor and science ... "unfettered blue-sky research on how cells age and how to reverse that process." Milner, a billionaire investor and science ...

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We aimed to compare immunoreactivity patterns of four different anti-?-syn antibodies in surgical specimens of the gastrointestinal tract of Parkinson disease and control cases. Surgical specimens from stomach, small and large bowel of 6 PD cases and 12 controls were studied. Primary antibodies: anti-?-syn clone KM51, anti-phosphorylated ?-syn Ser129, anti-?-syn clone 15G7 and anti-nitrated ?-syn505. We found different immunoreactivity patterns: (a) coarse, Lewy-body-like aggregates labelled by the 4 antibodies and detected in 4/6 PD cases and in 1/12 controls; (b) distinct punctate cytoplasmic staining of ganglion cells labelled by anti-phosphorylated-?-syn and detected in 3/6 PD cases and 3/12 controls; (c) fine diffuse, synaptic-type staining of neural structures labelled by anti-?-syn-15G7 and anti-nitrated-?-syn505 and detected in all subjects. We conclude that different specific and non-specific immunoreactivity patterns are detected in surgical specimens of gastrointestinal tract when ...

Research Integrated Science Education. *Summer Scholars. *Post-Baccalaureate. *Graduate Programs. *SRF Education Program Alumni ...

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SENS Research Foundation. *More Studies on Metformin and Survival September 6, 2023. In this update, we review two recent ... SENS Research Foundation (SRF) is launching its campaign Sponsor a Student to increase charitable donations that will allow it ... We are thrilled to announce the launch of a joint PhD program between SENS Research Foundation and the University of Toledo ... June 23, 2023 - SRF had the Grand Opening of our expanded Research Center in Mountain View, CA. In attendance were local and ...

In addition to reducing fracture risk, zoledronate has been found in some studies to decrease mortality in humans and extend lifespan and healthspan in animals. Because senescent cells accumulate with aging and contribute to multiple co-morbidities, the non-skeletal actions of zoledronate could be due to senolytic (killing of senescent cells) or senomorphic (inhibition of the secretion of the senescence-associated secretory phenotype [SASP]) actions. To test this, we first performed in vitro senescence assays using human lung fibroblasts and DNA repair-deficient mouse embryonic fibroblasts, which demonstrated that zoledronate killed senescent cells with minimal effects on non-senescent cells. Next, in aged mice treated with zoledronate or vehicle for 8 weeks, zoledronate significantly reduced circulating SASP factors, including CCL7, IL-1β, TNFRSF1A, and TGFβ1 and improved grip strength. Analysis of publicly available RNAseq data from CD115+ (CSF1R/c-fms+) pre-osteoclastic cells isolated from ...

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Fundraising for Research at experiment.com. July 16, 2023. May 31, 2023. by SRF ... SRF has launched a fundraising campaign on experiment.com to fund projects in damage repair research. Find out more about our ... Research Departments amazing projects, and be a part of our quest by donating today. ...

Human DNA-methylation data have been used to develop highly accurate biomarkers of aging ("epigenetic clocks"). Recent studies demonstrate that similar epigenetic clocks for mice (Mus Musculus) can be slowed by gold standard anti-aging interventions such as calorie restriction and growth hormone receptor knock-outs. Using DNA methylation data from previous publications with data collected in house for a total 1189 samples spanning 193,651 CpG sites, we developed 4 novel epigenetic clocks by choosing different regression models (elastic net- versus ridge regression) and by considering different sets of CpGs (all CpGs vs highly conserved CpGs). We demonstrate that accurate age estimators can be built on the basis of highly conserved CpGs. However, the most accurate clock results from applying elastic net regression to all CpGs. While the anti-aging effect of calorie restriction could be detected with all types of epigenetic clocks, only ridge regression based clocks replicated the finding of slow ...

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SENS Research Foundation has established a new research center at Cambridge University and a collaboration with scientists at ... ShARM: The Miracle of the Loaves and Fishes comes to Aging Research Aging laboratory rodents are the foundation of our ability ... And how is SENS Research Foundation targeting that connection to prevent and cure these diseases? ...

Since then, many research teams have become interested in determining the hallmarks of cell senescence, the factors that induce ... This has also prompted many research groups to investigate how we might be able to remove senescent cells around the body with ... While there are ongoing research projects to define new markers or causes of senescence, we do know that senescence can be ...

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New Peer-Reviewed Paper from SENS Research Foundation: Iron Homeostasis as a Senolytic Target SRF February 8, 2023 5:47 pm ... NextWe are thrilled to announce the expansion of our Research CenterNext ...

... has become an increasingly popular approach in biomedical research. Here, tissue cultures are used to test potential therapies ...

... has become crucial in clinical and research aspects. In this study, we aimed to develop a classifier that predicts the ...

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Research Integrated Science Education. *Summer Scholars. *Post-Baccalaureate. *Graduate Programs. *SRF Education Program Alumni ...

If you are a research scientist working in a SENS-related field, you may wish to submit a grant proposal for consideration by ... These programs are the best way for early-career researchers to get involved with research in rejuvenation biotechnology. ... at the center of the rejuvenation biotechnology industry and supports the mission to end age-related disease through Research, ...

My research experience prior to SENS Research Foundation has focused on neurodegenerative disease, so the SENS mission to ... At the SRF Research Center, I am working on the Oncology team with Dr. Haroldo Silva. My project is to develop new high- ... My research on neurodegenerative disease began as a summer intern at Biogen, where I worked in the Neurology Department ... I would like to pursue a career in either research or medicine-at this point Im undecided, but I definitely want to continue ...