Viruses | Special Issue : In Memory of Michael Rossmann
Concomitantly, bile alters the conformation of the P domain itself from one that binds antibodies to one that recognizes ... SS, signal sequence; NTD, N-terminal domain; CTD1/2/3, C-terminal domains 1/2/3; RBD: receptor binding domain; S1/S2: S1/S2 ... These binding sites often correspond to "weak points" on the capsid lattice. Because of their unique abilities to bind virus ... domain that is loosely attached to the shell via a single-polypeptide tether. Small molecules found in the gut, such as bile ...
Vaccines | Free Full-Text | Dendritic Cell Tumor Vaccination via Fc Gamma Receptor Targeting: Lessons Learned from Pre-Clinical...
FcγRs bind-albeit, with different affinities [60]-to the Fc (fragment, crystallizable) portion of IgG antibodies [58]. On DCs, ... Critically, it bound to DCs, which predominantly expressed FcγRI, FcγRIIA, and FcγRIIB. There was minimal binding to B cells, ... Most of the more advanced recombinant therapeutic IC candidates have a valency between three and six IgG Fc domains linked to ... In addition, tumor vaccines aim to educate the IS to recognize and eliminate cells that express tumor-associated Ags, which are ...
Vaccines | Free Full-Text | Adjuvants in the Driver's Seat: How Magnitude, Type, Fine Specificity and Longevity of Immune...
Mannan-Binding Protein, MBP); receptors for viral RNA are located inside the cell (cytoplasm and phagosome). Binding of PRR to ... Influence of maternal antibodies, malnutrition, and concurrent illnesses. N. Engl. J. Med. 1985, 313, 544-549. [Google Scholar ... An only recently recognized modulator of immune responses is an organisms microbiome. In the case of laboratory animals, the ... On such scaffolds, the impact of incremental changes in molecular distances between molecules (epitope density) can be studied ...
Pharmaceutics | Free Full-Text | Affibody-Derived Drug Conjugates Targeting HER2: Effect of Drug Load on Cytotoxicity and...
The affibody carrier was recombinantly expressed as a fusion to an albumin-binding domain (ABD) for plasma half-life extension ... To achieve a higher in vivo bioavailability of the AffiDCs, an albumin-binding domain (ABD) was included that can bind to serum ... We found that ZHER2-ABD-AA3 could recognize an additional binding site on SKOV3 cells with lower affinity (Figure 6). The ... Antibody-drug conjugates (ADCs), where a monoclonal antibody (mAb) is linked to a cytotoxic drug, have been the most successful ...
Toxins | Free Full-Text | Venom Proteins of the Parasitoid Wasp Nasonia vitripennis: Recent Discovery of an Untapped Pharmacopee
The highly acidic C domain binds the clotting factors IX, X and prothrombin [48]. Kuwabara S. and colleagues suggested that ... Insect angiotensin I-converting enzyme (ACE) is a soluble single-domain peptidyl-dipeptidase of which the role in insects ... When venom calreticulin is bound with antibodies, most injected flies could complete pharate adult development to eclosion. ... Therefore, the potential targets of the venom proteins can represent a combination of protein domains that are assembled in a ...
Genes | November 2018 - Browse Articles
Then, polyclonal antibodies recognizing the recombinant TmAnxB2 (rTmAnxB2) and rTmAnxB3 were prepared for localization of ... In this study, both mitochondrial DNA (mtDNA) control region domain I and nuclear single nucleotide polymorphisms (SNPs) were ... provide a promising scaffold for the development of a novel drug class owing to their adjustable and expandable ability to bind ... sites in secondary structures; and (iii) inter-domain linker sites vs. sites in functional domains. Additionally, within ...